ATE537153T1 - Arylspirolactamverbindungen als antagonisten des cgrp-rezeptors - Google Patents
Arylspirolactamverbindungen als antagonisten des cgrp-rezeptorsInfo
- Publication number
- ATE537153T1 ATE537153T1 AT05793937T AT05793937T ATE537153T1 AT E537153 T1 ATE537153 T1 AT E537153T1 AT 05793937 T AT05793937 T AT 05793937T AT 05793937 T AT05793937 T AT 05793937T AT E537153 T1 ATE537153 T1 AT E537153T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- antagonists
- arylspirolactam
- cgrp receptor
- cgrp
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 108010078311 Calcitonin Gene-Related Peptide Receptors Proteins 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title abstract 2
- 102000008323 calcitonin gene-related peptide receptor activity proteins Human genes 0.000 title 1
- 108090000932 Calcitonin Gene-Related Peptide Proteins 0.000 abstract 2
- 102100025588 Calcitonin gene-related peptide 1 Human genes 0.000 abstract 2
- 102000014468 Calcitonin Gene-Related Peptide Receptors Human genes 0.000 abstract 1
- 208000006561 Cluster Headache Diseases 0.000 abstract 1
- 206010019233 Headaches Diseases 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 208000018912 cluster headache syndrome Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 231100000869 headache Toxicity 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60848904P | 2004-09-09 | 2004-09-09 | |
| PCT/US2005/031712 WO2006031513A2 (en) | 2004-09-09 | 2005-09-06 | Aryl spirolactam cgrp receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE537153T1 true ATE537153T1 (de) | 2011-12-15 |
Family
ID=36060525
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05793937T ATE537153T1 (de) | 2004-09-09 | 2005-09-06 | Arylspirolactamverbindungen als antagonisten des cgrp-rezeptors |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7989624B2 (de) |
| EP (1) | EP1794133B1 (de) |
| JP (1) | JP2008512459A (de) |
| CN (1) | CN101014576B (de) |
| AT (1) | ATE537153T1 (de) |
| AU (1) | AU2005285292B2 (de) |
| CA (1) | CA2580020A1 (de) |
| WO (1) | WO2006031513A2 (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005285083B2 (en) * | 2004-09-13 | 2011-03-10 | Merck Sharp & Dohme Corp. | Tricyclic anilide spirohydantoin CGRP receptor antagonists |
| US7968540B2 (en) | 2005-11-18 | 2011-06-28 | Merck Sharp & Dohme Corp. | Spirohydantoin tricyclic CGRP receptor antagonists |
| CA2629406A1 (en) | 2005-11-18 | 2007-05-31 | Merck & Co., Inc. | Spirohydantoin aryl cgrp receptor antagonists |
| EP1951042B1 (de) | 2005-11-18 | 2012-10-10 | Merck Sharp & Dohme Corp. | Spirolactam tricyclische cgrp-rezeptor-antagonisten |
| EP1954135B1 (de) * | 2005-11-18 | 2012-10-10 | Merck Sharp & Dohme Corp. | Spirolactam-aryl cgrp-rezeptor-antagonisten |
| WO2007133491A1 (en) | 2006-05-09 | 2007-11-22 | Merck & Co., Inc. | Substituted spirocyclic cgrp receptor antagonists |
| US7951795B2 (en) * | 2006-12-08 | 2011-05-31 | Merck Sharp & Dohme Corp. | Constrained spirocyclic compounds as CGRP receptor antagonists |
| US8372859B2 (en) * | 2007-04-11 | 2013-02-12 | Merck, Sharp & Dohme Corp. | CGRP receptor antagonists with tertiary amide, sulfonamide, carbamate and urea end groups |
| CA2683745A1 (en) * | 2007-04-16 | 2008-10-30 | Merck & Co., Inc. | Bicyclic anilide heterocyclic cgrp receptor antagonists |
| WO2008130524A1 (en) * | 2007-04-16 | 2008-10-30 | Merck & Co., Inc. | Aryl heterocyclic cgrp receptor antagonists |
| CA2689217C (en) * | 2007-06-05 | 2016-02-16 | Merck & Co., Inc. | Carboxamide heterocyclic cgrp receptor antagonists |
| US8163752B2 (en) * | 2007-06-07 | 2012-04-24 | Merck, Sharp & Dohme Corp. | Tricyclic anilide heterocyclic CGRP receptor antagonists |
| NZ585347A (en) | 2007-10-18 | 2011-09-30 | Boehringer Ingelheim Int | Cgrp antagonists |
| EP2065386A1 (de) * | 2007-10-18 | 2009-06-03 | Boehringer Ingelheim Pharma GmbH & Co. KG | CGRP Antagonisten |
| EP2065381A1 (de) | 2007-10-18 | 2009-06-03 | Boehringer Ingelheim Pharma GmbH & Co. KG | CGRP Antagonisten |
| EP2225223B1 (de) | 2007-11-22 | 2017-01-11 | Boehringer Ingelheim International GmbH | Organische verbindungen |
| EP2331101A4 (de) * | 2008-09-08 | 2012-08-29 | Merck Sharp & Dohme | Monozyklische amid-cgrp-rezeptorantagonisten |
| WO2010077752A1 (en) | 2008-12-17 | 2010-07-08 | Merck Sharp & Dohme Corp. | Imidazolinone derivatives as cgrp receptor antagonists |
| EP2379529B1 (de) | 2008-12-19 | 2015-06-10 | Boehringer Ingelheim International Gmbh | Cgrp-antagonisten |
| US8778957B2 (en) | 2009-03-18 | 2014-07-15 | Merck Sharp & Dohme Corp. | CGRP receptor antagonists |
| TW201118069A (en) * | 2009-10-28 | 2011-06-01 | Lundbeck & Co As H | Spirolactam derivatives and uses of same |
| CN105308049A (zh) * | 2013-01-29 | 2016-02-03 | 阿普廷伊克斯股份有限公司 | 螺-内酰胺nmda受体调节剂及其用途 |
| EP3366286A1 (de) | 2017-02-22 | 2018-08-29 | Johannes Keller | Verbindungen zur behandlung von sepsis |
| GB201707938D0 (en) * | 2017-05-17 | 2017-06-28 | Univ Sheffield | Compounds |
| GB201818651D0 (en) * | 2018-11-15 | 2019-01-02 | Univ Sheffield | Compounds |
| CN116730905B (zh) * | 2023-06-08 | 2025-10-03 | 江苏海洋大学 | 一种含羰全碳季碳螺环假吲哚的合成方法 |
| CN116813528B (zh) * | 2023-06-30 | 2026-02-27 | 江苏海洋大学 | 一种全碳季碳环酮螺环假吲哚衍生物的合成方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA9711376B (en) * | 1996-12-20 | 1998-07-21 | Lundbeck & Co As H | Indole or dihydroindole derivatives |
| DE19952147A1 (de) * | 1999-10-29 | 2001-05-03 | Boehringer Ingelheim Pharma | Neue Cyclopropane, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| ES2616539T3 (es) * | 2002-06-05 | 2017-06-13 | Bristol-Myers Squibb Company | Antagonistas de receptores de péptidos relacionados con el gen de calcitonina |
| DE10250080A1 (de) * | 2002-10-25 | 2004-05-13 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
| EP1606286B1 (de) | 2003-03-14 | 2011-05-11 | Merck Sharp & Dohme Corp. | Benzodiazepinspirohydantoine als cgrp-rezeptorantagonisten |
| AU2004222328B2 (en) | 2003-03-14 | 2009-10-08 | Merck Sharp & Dohme Corp. | Aryl spirohydantoin CGRP receptor antagonists |
| JP4673294B2 (ja) | 2003-03-14 | 2011-04-20 | メルク・シャープ・エンド・ドーム・コーポレイション | 二環式アニリドスピロヒダントインｃｇｒｐ受容体拮抗物質 |
| EP1606264B1 (de) * | 2003-03-14 | 2012-05-02 | Merck Sharp & Dohme Corp. | Monocyclische anilidspirohydantoine als cgrp-rezeptorantagonisten |
| JP2008512460A (ja) | 2004-09-08 | 2008-04-24 | メルク エンド カムパニー インコーポレーテッド | 単環式アニリドスピロラクタムｃｇｒｐ受容体拮抗薬 |
| CA2579717A1 (en) * | 2004-09-09 | 2006-03-23 | Merck & Co., Inc. | Tricyclic anilide spirolactam cgrp receptor antagonists |
| US7390798B2 (en) * | 2004-09-13 | 2008-06-24 | Merck & Co., Inc. | Carboxamide spirolactam CGRP receptor antagonists |
| US8003792B2 (en) | 2004-09-13 | 2011-08-23 | Merck Sharp & Dohme Corp. | Bicyclic anilide spirolactam CGRP receptor antagonists |
| WO2007133491A1 (en) * | 2006-05-09 | 2007-11-22 | Merck & Co., Inc. | Substituted spirocyclic cgrp receptor antagonists |
-
2005
- 2005-09-06 JP JP2007531267A patent/JP2008512459A/ja not_active Withdrawn
- 2005-09-06 US US11/662,424 patent/US7989624B2/en active Active
- 2005-09-06 CN CN2005800302104A patent/CN101014576B/zh not_active Expired - Fee Related
- 2005-09-06 EP EP05793937A patent/EP1794133B1/de not_active Expired - Lifetime
- 2005-09-06 AT AT05793937T patent/ATE537153T1/de active
- 2005-09-06 AU AU2005285292A patent/AU2005285292B2/en not_active Ceased
- 2005-09-06 CA CA002580020A patent/CA2580020A1/en not_active Abandoned
- 2005-09-06 WO PCT/US2005/031712 patent/WO2006031513A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US20080004304A1 (en) | 2008-01-03 |
| WO2006031513A2 (en) | 2006-03-23 |
| CN101014576A (zh) | 2007-08-08 |
| EP1794133A4 (de) | 2010-01-27 |
| US7989624B2 (en) | 2011-08-02 |
| CA2580020A1 (en) | 2006-03-23 |
| WO2006031513A3 (en) | 2006-07-13 |
| CN101014576B (zh) | 2011-05-25 |
| JP2008512459A (ja) | 2008-04-24 |
| AU2005285292A1 (en) | 2006-03-23 |
| EP1794133A2 (de) | 2007-06-13 |
| EP1794133B1 (de) | 2011-12-14 |
| AU2005285292B2 (en) | 2011-03-10 |
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