ATE537169T1 - Piperidin- und piperazinderivate als p2x3- antagonisten - Google Patents

Piperidin- und piperazinderivate als p2x3- antagonisten

Info

Publication number: ATE537169T1
Authority: AT; Austria
Prior art keywords: lower alkyl; substituted; phenyl; methyl; oxazol
Prior art date: 2005-08-15

Application number

AT06778156T

Other languages

English (en)

Inventor

Christine E Brotherton-Pleiss

Michael Patrick Dillon

Shelley K Gleason

Clara Jeou Jen Lin

Ryan Craig Schoenfeld

Marzia Villa

Yansheng Zhai

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-08-15

Filing date

2006-08-03

Publication date

2011-12-15

2006-08-03 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2011-12-15 Application granted granted Critical

2011-12-15 Publication of ATE537169T1 publication Critical patent/ATE537169T1/de

Links

102100040460 P2X purinoceptor 3 Human genes 0.000 title abstract 2
101710189970 P2X purinoceptor 3 Proteins 0.000 title abstract 2
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 2
GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical class C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 14
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 8
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 4
229910052799 carbon Inorganic materials 0.000 abstract 4
125000004432 carbon atom Chemical group C* 0.000 abstract 4
125000001475 halogen functional group Chemical group 0.000 abstract 4
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 4
125000004304 oxazol-5-yl group Chemical group O1C=NC=C1* 0.000 abstract 4
125000003545 alkoxy group Chemical group 0.000 abstract 3
125000004414 alkyl thio group Chemical group 0.000 abstract 3
125000000623 heterocyclic group Chemical group 0.000 abstract 3
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 abstract 2
-1 furylcarbonyl Chemical group 0.000 abstract 2
125000004076 pyridyl group Chemical group 0.000 abstract 2
125000005420 sulfonamido group Chemical group S(=O)(=O)(N*)* 0.000 abstract 2
125000001544 thienyl group Chemical group 0.000 abstract 2
125000001054 5 membered carbocyclic group Chemical group 0.000 abstract 1
125000004008 6 membered carbocyclic group Chemical group 0.000 abstract 1
208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
235000010290 biphenyl Nutrition 0.000 abstract 1
239000004305 biphenyl Substances 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
125000002541 furyl group Chemical group 0.000 abstract 1
230000002496 gastric effect Effects 0.000 abstract 1
125000004043 oxo group Chemical group O=* 0.000 abstract 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
125000003373 pyrazinyl group Chemical group 0.000 abstract 1
125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 abstract 1
125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
208000023504 respiratory system disease Diseases 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000003831 tetrazolyl group Chemical group 0.000 abstract 1
125000000335 thiazolyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Diabetes (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Gynecology & Obstetrics (AREA)
Hematology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Hydrogenated Pyridines (AREA)

AT06778156T 2005-08-15 2006-08-03 Piperidin- und piperazinderivate als p2x3- antagonisten ATE537169T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US70872205P	2005-08-15	2005-08-15
PCT/EP2006/065024 WO2007020194A1 (en)	2005-08-15	2006-08-03	Piperidine and piperazine derivatives as p2x3 antagonists

Publications (1)

Publication Number	Publication Date
ATE537169T1 true ATE537169T1 (de)	2011-12-15

Family

ID=37260239

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06778156T ATE537169T1 (de)	2005-08-15	2006-08-03	Piperidin- und piperazinderivate als p2x3- antagonisten

Country Status (13)

Country	Link
US (1)	US7491821B2 (de)
EP (1)	EP1917262B1 (de)
JP (1)	JP4987871B2 (de)
KR (1)	KR100997549B1 (de)
CN (2)	CN101282972A (de)
AT (1)	ATE537169T1 (de)
AU (1)	AU2006281497B2 (de)
BR (1)	BRPI0614577A2 (de)
CA (1)	CA2618340C (de)
ES (1)	ES2376642T3 (de)
IL (1)	IL189069A0 (de)
MX (1)	MX2008002014A (de)
WO (1)	WO2007020194A1 (de)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR20080105092A (ko) *	2006-02-20	2008-12-03	아스텔라스세이야쿠 가부시키가이샤	피롤 유도체 또는 그의 염
PT1847524E (pt) *	2006-04-21	2009-12-18	Cellzome Ltd	Derivados de terfenilo para o tratamento da doença de alzheimer
EP2592070B1 (de) *	2006-06-29	2016-08-31	F. Hoffmann-La Roche AG	Tetrazolsubstituierte Arylamide
US7501438B2 (en) *	2006-07-07	2009-03-10	Forest Laboratories Holdings Limited	Pyridoimidazole derivatives
EP2089389A2 (de) *	2006-11-01	2009-08-19	Bristol-Myers Squibb Company	Heterocyclische verbindungen als modulatoren der glucocorticoidrezeptor,- ap1- und/oder nf-kappa-b-aktivität
US8501933B2 (en)	2006-11-09	2013-08-06	Roche Palo Alto Llc	Thiazole and oxazole-substituted arylamides as P2X3 and P2X2/3 antagonists
EP2096923B1 (de) *	2006-11-27	2014-01-22	H. Lundbeck A/S	Heteroarylamidderivate
US9187485B2 (en)	2007-02-02	2015-11-17	Baylor College Of Medicine	Methods and compositions for the treatment of cancer and related hyperproliferative disorders
TW200843739A (en)	2007-03-30	2008-11-16	Shionogi & Co	Novel pyrrolinone derivative and composition containing the same
CN101772498A (zh) *	2007-04-10	2010-07-07	H.隆德贝克有限公司	作为p2x7拮抗剂的杂芳基酰胺类似物
SG187396A1 (en) *	2007-07-19	2013-02-28	Lundbeck & Co As H	5-membered heterocyclic amides and related compounds
EP2215049B1 (de) *	2007-10-31	2019-06-12	Merck Sharp & Dohme Corp.	P2x3-rezeptorantagonisten zur schmerzbehandlung
ES2553412T3 (es)	2007-10-31	2015-12-09	Merck Sharp & Dohme Corp.	Antagonistas del receptor P2X3 para el tratamiento del dolor
AU2013270522B2 (en) *	2007-12-17	2016-04-21	F. Hoffmann-La Roche Ag	Tetrazole-substituted arylamide derivatives and their use as P2X3 and/or P2X2/3 purinergic receptor antagonists
AU2013273626B2 (en) *	2007-12-17	2016-04-28	F.Hoffmann-La Roche Ag	Triazole-substituted arylamide derivatives and their use as P2X3 and /or P2X2/3 purinergic receptor antagonists
ES2542245T3 (es) *	2007-12-17	2015-08-03	F. Hoffmann-La Roche Ag	Derivados de arilamida sustituido con triazol y su utilización como antagonistas del receptor purinérgico P2x3 y/o P2x2/3
JP5318882B2 (ja)	2007-12-17	2013-10-16	エフ．ホフマン−ラロシュアーゲー	新規なイミダゾール置換アリールアミド
WO2009077371A1 (en) *	2007-12-17	2009-06-25	F. Hoffmann-La Roche Ag	Tetrazole-substituted arylamide derivatives and their use as p2x3 and/or p2x2/3 purinergic receptor antagonists
SI2234976T1 (sl)	2007-12-17	2013-07-31	F. Hoffmann-La Roche Ag	Novi s pirazolom substituirani arilamidi
CN104058999A (zh) *	2008-02-29	2014-09-24	伊沃泰克股份公司	酰胺化合物、组合物及其应用
US8293917B2 (en) *	2008-05-06	2012-10-23	Boehringer Ingelheim International Gmbh	Pyrazole compounds as CCR1 antagonists
JP5608655B2 (ja) *	2008-09-18	2014-10-15	エヴォテックアーゲー	Ｐ２ｘ３受容体活性のモジュレーター
WO2010035727A1 (ja)	2008-09-25	2010-04-01	塩野義製薬株式会社	新規ピロリノン誘導体およびそれを含有する医薬組成物
WO2010038948A2 (en) *	2008-10-02	2010-04-08	Green Cross Corporation	Arylpiperazine-containing pyrrole 3-carboxamide derivatives for treating depressive disorders
EP2358371B1 (de) *	2008-10-31	2015-02-11	Merck Sharp & Dohme Corp.	P2x3-rezeptorantagonisten zur schmerzbehandlung
CA2745290A1 (en) *	2008-12-16	2010-06-24	F. Hoffmann-La Roche Ag	Thiadiazole-substituted arylamides as p2x3 and p2x2/3 antagonists
KR101422901B1 (ko)	2009-02-13	2014-07-23	시오노기 앤드 컴파니, 리미티드	신규 트라이아진 유도체 및 그것을 함유하는 의약 조성물
WO2010111060A1 (en) *	2009-03-23	2010-09-30	Merck Sharp & Dohme Corp.	P2x3, receptor antagonists for treatment of pain
AU2010229142A1 (en) *	2009-03-23	2011-10-13	Merck Sharp & Dohme Corp.	P2X3, receptor antagonists for treatment of pain
WO2010111059A1 (en) *	2009-03-23	2010-09-30	Merck Sharp & Dohme Corp.	P2x3 receptor antagonists for treatment of pain
EP2445868B1 (de) *	2009-06-22	2013-12-18	F.Hoffmann-La Roche Ag	Biphenylamide verwenbar als p2x3- und/oder p2x2/3-rezeptoren modulatoren
CA2754654A1 (en)	2009-06-22	2010-12-29	F. Hoffmann-La Roche Ag	Novel oxazolone and pyrrolidinone-substituted arylamides
ES2457543T3 (es)	2009-06-22	2014-04-28	F. Hoffmann-La Roche Ag	Nuevas arilamidas de indazol como antagonistas de P2X3 y/o P2X2/3
EP2604595B1 (de)	2010-08-10	2016-03-16	Shionogi&Co., Ltd.	Triazinderivat und pharmazeutische schmerzmittelverbindung damit
JP6075621B2 (ja) *	2010-08-10	2017-02-08	塩野義製薬株式会社	新規複素環誘導体およびそれらを含有する医薬組成物
EP2649075B1 (de) *	2010-12-08	2018-04-25	The U.S.A. As Represented By The Secretary, Department Of Health And Human Services	Substituierte pyrazolopyrimidine als glucocerebrosidase aktivatoren
AR086113A1 (es)	2011-04-30	2013-11-20	Abbott Lab	Isoxazolinas como agentes terapeuticos
WO2013003711A1 (en)	2011-06-30	2013-01-03	Abbott Point Of Care Inc.	Methods and devices for sensing device signal correction
CN103748459B (zh)	2011-06-30	2015-11-25	雅培医护站股份有限公司	用于确定传感装置可用性的方法和装置
EP2726860A1 (de)	2011-06-30	2014-05-07	Abbott Point of Care Inc.	Verfahren und vorrichtungen zur bestimmung der brauchbarkeit einer erfassungsvorrichtung
JP2014533258A (ja)	2011-11-15	2014-12-11	ゼンション・リミテッドＸｅｎｔｉｏｎＬｉｍｉｔｅｄ	カリウムチャネル阻害剤としてのチエノ［２，３−ｃ］ピラゾールの使用
US9550763B2 (en)	2012-02-09	2017-01-24	Shionogi & Co., Ltd.	Heterocyclic ring and carbocyclic derivative
CN103387531A (zh) *	2012-05-10	2013-11-13	广州医学院	酰胺类芳基哌嗪衍生物及其制备方法和在抗良性前列腺增生中的应用
US9409895B2 (en)	2012-12-19	2016-08-09	Novartis Ag	Autotaxin inhibitors
ES2715682T3 (es)	2012-12-19	2019-06-05	Novartis Ag	Inhibidores de la autotaxina
TWI637949B (zh)	2013-06-14	2018-10-11	塩野義製藥股份有限公司	胺基三衍生物及含有其等之醫藥組合物
WO2015031710A1 (en) *	2013-08-29	2015-03-05	Baylor College Of Medicine	Compositions and methods for the treatment of metabolic and body weight related disorders
WO2016084922A1 (ja) *	2014-11-28	2016-06-02	塩野義製薬株式会社	１，２，４－トリアジン誘導体およびその医薬組成物
CN105061315B (zh) *	2015-08-06	2017-10-24	大连理工大学	一类1,5‑二苯基吡唑‑3‑羧酸类化合物及其应用
RU2650780C1 (ru)	2016-12-06	2018-04-17	Общество с ограниченной ответственностью "Анальгетики будущего"	Пептидный модулятор пуринергических рецепторов
US10290004B1 (en)	2017-12-02	2019-05-14	M-Fire Suppression, Inc.	Supply chain management system for supplying clean fire inhibiting chemical (CFIC) totes to a network of wood-treating lumber and prefabrication panel factories and wood-framed building construction job sites
BR112021001608A2 (pt)	2018-09-10	2021-04-27	Kaken Pharmaceutical Co., Ltd.	derivado de amida heteroaromático inovador e medicamento contendo o mesmo
MA54386B1 (fr)	2018-12-06	2023-08-31	Constellation Pharmaceuticals Inc	Modulateurs de trex1
KR102921974B1 (ko) *	2019-05-31	2026-02-05	키에시 파르마슈티시 엣스. 피. 에이.	P2x3 억제제로서 아미노 퀴나졸린 유도체
WO2021016317A1 (en) *	2019-07-23	2021-01-28	Constellation Pharmaceuticals, Inc.	Modulators of trex1
AU2020390377B2 (en) *	2019-11-29	2023-12-21	Wuhan Ll Science And Technology Development Co., Ltd.	Compound containing benzene ring and application thereof
CN111892585A (zh) *	2020-08-05	2020-11-06	杭州维坦医药科技有限公司	作为p2x3受体拮抗剂的n-甲酰胺基吡唑啉类衍生物及应用
WO2022063205A1 (zh) *	2020-09-24	2022-03-31	中国医药研究开发中心有限公司	芳基甲酰胺类化合物及其制备方法和医药用途

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1279843A (en) *	1969-05-23	1972-06-28	Science Union & Cie	Benzamidoethyl-piperazines and process for their preparation
JPS61100566A (ja) *	1984-10-22	1986-05-19	Dainippon Pharmaceut Co Ltd	桂皮酸アミド誘導体およびその塩
DK623586A (da) *	1985-12-27	1987-06-28	Eisai Co Ltd	Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne
CA1340113C (en) *	1988-05-24	1998-11-03	Magid A. Abou-Gharbia	Aryl-and heteroaryl piperazinyl carboxamides having central nervous system activity
IE64038B1 (en) *	1989-04-22	1995-06-28	Wyeth John & Brother Ltd	Tertiary alkyl functionalized piperazine derivatives
IE911774A1 (en)	1990-06-11	1991-12-18	Akzo Nv	Pyridinylpiperazine derivatives
IL99320A (en)	1990-09-05	1995-07-31	Sanofi Sa	Arylalkylamines, their preparation and pharmaceutical compositions containing them
EP0760850A1 (de) *	1994-05-27	1997-03-12	Glaxo Group Limited	P2x REZEPTOREN (PURINOCEPTORENFAMILIE)
EP0709375B1 (de)	1994-10-25	2005-05-18	AstraZeneca AB	Therapeutisch wirksame Heterocyclen
US5696267A (en) *	1995-05-02	1997-12-09	Schering Corporation	Substituted oximes, hydrazones and olefins as neurokinin antagonists
GB9514384D0 (en)	1995-07-13	1995-09-13	American Home Prod	Medical treatment
US5945428A (en) *	1996-11-01	1999-08-31	Schering Corporation	Substituted oximes, hydrazones and olefins as neurokinin antagonists
US6133434A (en) *	1997-04-28	2000-10-17	Glaxo Group Limited	Purinergic receptor
AU8130298A (en)	1997-07-15	1999-02-10	Sankyo Company Limited	Piperazine derivatives
WO2000052002A1 (en)	1999-03-02	2000-09-08	American Home Products Corporation	N-substituted imide derivatives with serotonergic activity
ES2220422T3 (es)	1999-03-03	2004-12-16	Wyeth	Nuevos derivados de diazol como agentes serotonergicos.
US6239134B1 (en) *	1999-03-03	2001-05-29	American Home Products Corp.	Diazole derivatives as serotonergic agents
JP2004500021A (ja)	1999-04-21	2004-01-08	アボット・ラボラトリーズ	Ｐ２ｘ３受容体、ｐ２ｘ３受容体活性を変える方法およびその使用
AUPQ968700A0 (en) *	2000-08-28	2000-09-21	Intreat Pty Limited	Treatment of urinary incontinence
US6831193B2 (en) *	2001-05-18	2004-12-14	Abbott Laboratories	Trisubstituted-N-[(1S)-1,2,3,4-Tetrahydro-1-naphthalenyl]benzamides which inhibit P2X3 and P2X2/3 containing receptors
DE60206164T2 (de) *	2001-05-18	2006-06-22	Abbott Laboratories, Abbott Park	Trisubstituierte-n-((1s)-1,2,3,4-tetrahydro-1-naphthalenyl) benzamide welche p2x3 und p2x2/3 enthaltende rezeptoren inhibieren
WO2003099266A2 (en) *	2002-05-23	2003-12-04	Abbott Laboratories	Acetamides and benzamides that are useful in treating sexual dysfunction
US20040029887A1 (en) *	2002-05-23	2004-02-12	Bhatia Pramila A.	Acetamides and benzamides that are useful in treating sexual dysfunction
JP2006511197A (ja) *	2002-05-31	2006-04-06	スローン − ケッタリングインスティチュートフォーキャンサーリサーチ	異種刺激依存性イオンチャンネル及びその使用方法

2006
- 2006-08-03 ES ES06778156T patent/ES2376642T3/es active Active
- 2006-08-03 AT AT06778156T patent/ATE537169T1/de active
- 2006-08-03 CN CNA2006800375792A patent/CN101282972A/zh active Pending
- 2006-08-03 JP JP2008526476A patent/JP4987871B2/ja not_active Expired - Fee Related
- 2006-08-03 CA CA2618340A patent/CA2618340C/en active Active
- 2006-08-03 KR KR1020087003538A patent/KR100997549B1/ko not_active Expired - Fee Related
- 2006-08-03 EP EP06778156A patent/EP1917262B1/de active Active
- 2006-08-03 WO PCT/EP2006/065024 patent/WO2007020194A1/en not_active Ceased
- 2006-08-03 AU AU2006281497A patent/AU2006281497B2/en not_active Expired - Fee Related
- 2006-08-03 BR BRPI0614577-9A patent/BRPI0614577A2/pt not_active IP Right Cessation
- 2006-08-03 CN CN2011102400876A patent/CN102659774A/zh active Pending
- 2006-08-03 MX MX2008002014A patent/MX2008002014A/es active IP Right Grant
- 2006-08-11 US US11/502,797 patent/US7491821B2/en active Active
2008
- 2008-01-28 IL IL189069A patent/IL189069A0/en unknown

Also Published As

Publication number	Publication date
KR20080027943A (ko)	2008-03-28
CA2618340A1 (en)	2007-02-22
MX2008002014A (es)	2008-03-27
IL189069A0 (en)	2008-08-07
KR100997549B1 (ko)	2010-11-30
JP2009504705A (ja)	2009-02-05
ES2376642T3 (es)	2012-03-15
EP1917262B1 (de)	2011-12-14
CN101282972A (zh)	2008-10-08
WO2007020194A1 (en)	2007-02-22
CN102659774A (zh)	2012-09-12
US20070037974A1 (en)	2007-02-15
EP1917262A1 (de)	2008-05-07
JP4987871B2 (ja)	2012-07-25
US7491821B2 (en)	2009-02-17
CA2618340C (en)	2013-11-19
AU2006281497B2 (en)	2012-06-07
AU2006281497A1 (en)	2007-02-22
BRPI0614577A2 (pt)	2011-04-05

Publication	Publication Date	Title
ATE537169T1 (de)	2011-12-15	Piperidin- und piperazinderivate als p2x3- antagonisten
RU2416603C9 (ru)	2012-06-20	Производные аминодигидротиазина
NO20074071L (no)	2007-09-17	Hydrazinometyl, hydrozonometyl og 5-leddete heterocykliske forbindelser som virker som MTOR inhibitorer og anvendelse derav som anti-cancer midler
MEP22008A (en)	2010-06-10	Derivatives of n-[heteroaryl(piperidine-2-yl)methyl]benzamide, preparation method thereof and application of same in therapeutics
MX2012015023A (es)	2013-04-03	Derivado novedoso de nicotinamida o sal del mismo.
RU2007139453A (ru)	2009-04-27	Гетеробициклические ингибиторы вируса гепатита с (hcv)
NZ589670A (en)	2013-01-25	Pyrrolidine inhibitors of iap
MX339668B (es)	2016-06-02	Compuestos de piridil amida sustituidos como moduladores del receptor h3 de la histamina.
DE602004031722D1 (de)	2011-04-21	Kondensierte bizyklisch substituierte amine als histamin 3 rezeptor liganden
HRP20090533T1 (hr)	2009-11-30	Derivati indolila kao modulatori x-receptora
AR049418A1 (es)	2006-08-02	Derivados de heteroarilaminopirazol y composiciones farmaceuticas para el tratamiento de la diabetes.
HRP20120523T1 (hr)	2012-07-31	Inhibitori virusa hepatitisa c
TNSN08372A1 (en)	2009-12-29	Heterocyclic amides for use as pharmaceuticals
NO20074296L (no)	2007-11-26	4-cyklopropyl-1,2,3-tiadiazolforbindelse, agrohortikulturelt plantesykdoms-kontrollmiddel og fremgangsmate for anvendelse av det samme
MY141245A (en)	2010-03-31	Macrocylic inhibitors of hepatitis c virus
JP2010504286A5 (de)	2010-10-21
HRP20070430T3 (en)	2007-11-30	(3-oxo-3,4-dihydro-quinoxalin-2-yl-amino)-benzamide derivatives and related compounds as glycogen phosphorylase inhibitors for the treatment of diabetes and obesity
WO2008155668A3 (en)	2009-03-12	Heteroarylamide pyrimidone compounds
MY169179A (en)	2019-02-25	Novel piperidine compound or salt thereof
MX2010008362A (es)	2010-08-30	Derivados de heteroarilamida diazepinopirimidona sustituidos.
DK1633340T3 (da)	2011-02-07	Forbindelser til behandling af stofskifteforstyrrelser
RU2013157860A (ru)	2015-07-10	Производные бензотиазинтиона, способы их получения и применение
HRP20050628A2 (en)	2006-07-31	Substituted benzoyl derivatives uses as herbicides
AR045791A1 (es)	2005-11-16	Derivados de triazol sustituidos como antagonistas de oxitocina
TW200700007A (en)	2007-01-01	N-(4-pyridyl)methylsulfonamides for combating arthropodal pests