ATE538099T1 - 2-ä1-phenyl-5-hydroxy-4-alpha-methyl- hexahydrocyclopentaäfüindazol-5- ylüethylphenylderivate als glucocorticoidrezeptorliganden - Google Patents

2-ä1-phenyl-5-hydroxy-4-alpha-methyl- hexahydrocyclopentaäfüindazol-5- ylüethylphenylderivate als glucocorticoidrezeptorliganden

Info

Publication number: ATE538099T1
Authority: AT; Austria
Prior art keywords: phenyl; hydroxy; methyl; derivatives; glucocorticoid receptor
Prior art date: 2006-10-23

Application number

AT07867264T

Other languages

English (en)

Inventor

Christopher J Bungard

Jesse J Manikowski

James J Perkins

Robert Meissner

Original Assignee

Merck Sharp & Dohme

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-10-23

Filing date

2007-10-23

Publication date

2012-01-15

2007-10-23 Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme

2012-01-15 Application granted granted Critical

2012-01-15 Publication of ATE538099T1 publication Critical patent/ATE538099T1/de

Links

102000003676 Glucocorticoid Receptors Human genes 0.000 title abstract 2
108090000079 Glucocorticoid Receptors Proteins 0.000 title abstract 2
239000003446 ligand Substances 0.000 title abstract 2
208000023275 Autoimmune disease Diseases 0.000 abstract 1
230000001363 autoimmune Effects 0.000 abstract 1
125000004537 indazol-5-yl group Chemical group N1N=CC2=CC(=CC=C12)* 0.000 abstract 1
208000027866 inflammatory disease Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

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- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
- C—CHEMISTRY; METALLURGY
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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AT07867264T 2006-10-23 2007-10-23 2-ä1-phenyl-5-hydroxy-4-alpha-methyl- hexahydrocyclopentaäfüindazol-5- ylüethylphenylderivate als glucocorticoidrezeptorliganden ATE538099T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US85365506P	2006-10-23	2006-10-23
US92333707P	2007-04-13	2007-04-13
PCT/US2007/022449 WO2008060391A2 (en)	2006-10-23	2007-10-23	2- [l-phenyl-5-hydr0xy-4alpha-methyl-hexahydr0cycl0penta[f] indaz0l-5-yl] ethyl phenyl derivatives as glucocorticoid receptor ligands

Publications (1)

Publication Number	Publication Date
ATE538099T1 true ATE538099T1 (de)	2012-01-15

Family

ID=39030900

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07867264T ATE538099T1 (de)	2006-10-23	2007-10-23	2-ä1-phenyl-5-hydroxy-4-alpha-methyl- hexahydrocyclopentaäfüindazol-5- ylüethylphenylderivate als glucocorticoidrezeptorliganden

Country Status (19)

Country	Link
US (1)	US8119681B2 (de)
EP (2)	EP2091922B1 (de)
JP (1)	JP5271911B2 (de)
KR (1)	KR20090068345A (de)
CN (1)	CN101528707B (de)
AT (1)	ATE538099T1 (de)
AU (1)	AU2007309507A1 (de)
BR (1)	BRPI0718505A2 (de)
CA (1)	CA2667007A1 (de)
CO (1)	CO6190517A2 (de)
CR (1)	CR10771A (de)
EA (1)	EA200970401A1 (de)
IL (1)	IL198226A0 (de)
MA (1)	MA30870B1 (de)
MX (1)	MX2009004385A (de)
NO (1)	NO20092004L (de)
SV (1)	SV2009003233A (de)
TN (1)	TN2009000149A1 (de)
WO (2)	WO2008060391A2 (de)

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EP2532350A1 (de) *	2007-10-17	2012-12-12	Laboratoire HRA Pharma	Pharmazeutische Kombinationen mit einem Glucocorticoid Rezeptorantagonist und einem Cortisol Synthasehemmer zur Behandlung des Cushing-Syndroms
AU2008317484A1 (en) *	2007-10-23	2009-04-30	Merck Sharp & Dohme Corp.	Process for making glucocorticoid receptor ligands
UY31832A (es)	2008-05-20	2010-01-05	Astrazeneca Ab	Derivados de indazol sustituidos con fenilo y benzodioxinilo
WO2010138421A1 (en) *	2009-05-27	2010-12-02	Merck Sharp & Dohme Corp.	HEXAHYDROCYCLOPENTYL[f]INDAZOLE REVERSED AMIDES AND DERIVATIVES AS SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS
WO2010141247A1 (en)	2009-06-02	2010-12-09	Merck Sharp & Dohme Corp.	Hexahydrocyclopentyl[∫]indazole 5-hydroxymethyl ethanols and derivatives thereof as selective glucocorticoid receptor modulators
US20120172397A1 (en) *	2009-09-08	2012-07-05	Merck Sharp & Dohme Corp.	HEXAHYDROCYCLOPENTA[f]INDAZOLE 5-YL ETHANOLS AND DERIVATIVES THEREOF AS SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS
US20120214847A1 (en) *	2009-10-30	2012-08-23	Merck Sharp & Dohme Corp.	2-[1-PHENYL-5-HYDROXY-4a-SUBSTITUTED-HEXAHYDROCYCLOPENTA[F]INDAZOL-5-YL]ETHYL PHENYL DERIVATIVES AS GLUCOCORTICOID RECEPTOR LIGANDS
US9012450B2 (en)	2011-12-28	2015-04-21	Global Blood Therapeutics, Inc.	Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
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2007
- 2007-10-23 EP EP07867264A patent/EP2091922B1/de not_active Withdrawn - After Issue
- 2007-10-23 EA EA200970401A patent/EA200970401A1/ru unknown
- 2007-10-23 WO PCT/US2007/022449 patent/WO2008060391A2/en not_active Ceased
- 2007-10-23 CN CN2007800392434A patent/CN101528707B/zh not_active Expired - Fee Related
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- 2007-10-23 MX MX2009004385A patent/MX2009004385A/es unknown
- 2007-10-23 AU AU2007309507A patent/AU2007309507A1/en not_active Abandoned
- 2007-10-23 CA CA002667007A patent/CA2667007A1/en not_active Abandoned
- 2007-10-23 EP EP07839748A patent/EP2097385B1/de active Active
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- 2007-10-23 AT AT07867264T patent/ATE538099T1/de active
- 2007-10-23 BR BRPI0718505-7A patent/BRPI0718505A2/pt not_active Application Discontinuation
- 2007-10-23 KR KR1020097008368A patent/KR20090068345A/ko not_active Withdrawn
2009
- 2009-04-19 IL IL198226A patent/IL198226A0/en unknown
- 2009-04-21 TN TNP2009000149A patent/TN2009000149A1/fr unknown
- 2009-04-21 SV SV2009003233A patent/SV2009003233A/es not_active Application Discontinuation
- 2009-04-22 CO CO09040679A patent/CO6190517A2/es not_active Application Discontinuation
- 2009-05-06 CR CR10771A patent/CR10771A/es not_active Application Discontinuation
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Also Published As

Publication number	Publication date
EA200970401A1 (ru)	2009-10-30
WO2008051532A1 (en)	2008-05-02
CA2667007A1 (en)	2008-05-02
EP2097385A1 (de)	2009-09-09
EP2091922A2 (de)	2009-08-26
SV2009003233A (es)	2009-10-19
AU2007309507A1 (en)	2008-05-02
US20100311709A1 (en)	2010-12-09
CN101528707B (zh)	2012-11-07
EP2097385B1 (de)	2012-08-01
US8119681B2 (en)	2012-02-21
WO2008060391A3 (en)	2008-09-25
KR20090068345A (ko)	2009-06-26
IL198226A0 (en)	2009-12-24
MX2009004385A (es)	2009-05-22
WO2008060391A2 (en)	2008-05-22
NO20092004L (no)	2009-07-22
MA30870B1 (fr)	2009-11-02
BRPI0718505A2 (pt)	2013-11-12
CO6190517A2 (es)	2010-08-19
EP2091922B1 (de)	2011-12-21
JP2010507663A (ja)	2010-03-11
CR10771A (es)	2009-05-25
TN2009000149A1 (en)	2010-10-18
CN101528707A (zh)	2009-09-09
JP5271911B2 (ja)	2013-08-21

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