ATE538129T1 - Nicht natürliches proteinöses gerüst aus drei nicht kovalent assoziierten peptiden - Google Patents

Nicht natürliches proteinöses gerüst aus drei nicht kovalent assoziierten peptiden

Info

Publication number
ATE538129T1
ATE538129T1 AT08803854T AT08803854T ATE538129T1 AT E538129 T1 ATE538129 T1 AT E538129T1 AT 08803854 T AT08803854 T AT 08803854T AT 08803854 T AT08803854 T AT 08803854T AT E538129 T1 ATE538129 T1 AT E538129T1
Authority
AT
Austria
Prior art keywords
residues
natural
core
amino acid
peptide sequences
Prior art date
Application number
AT08803854T
Other languages
English (en)
Inventor
Johan Desmet
Ignace Lasters
Original Assignee
Complix N V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Complix N V filed Critical Complix N V
Application granted granted Critical
Publication of ATE538129T1 publication Critical patent/ATE538129T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT08803854T 2007-09-07 2008-09-08 Nicht natürliches proteinöses gerüst aus drei nicht kovalent assoziierten peptiden ATE538129T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97060707P 2007-09-07 2007-09-07
PCT/EP2008/061886 WO2009030780A2 (en) 2007-09-07 2008-09-08 Non-natural proteinaceous scaffold made of three non-covalently associated peptides

Publications (1)

Publication Number Publication Date
ATE538129T1 true ATE538129T1 (de) 2012-01-15

Family

ID=40349228

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08803854T ATE538129T1 (de) 2007-09-07 2008-09-08 Nicht natürliches proteinöses gerüst aus drei nicht kovalent assoziierten peptiden

Country Status (4)

Country Link
US (1) US9217011B2 (de)
EP (1) EP2188303B1 (de)
AT (1) ATE538129T1 (de)
WO (1) WO2009030780A2 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2161278B1 (de) * 2008-09-08 2012-05-23 Complix N.V. Gewundenes Spulengerüst aus einer einzelnen Kette
CA2749558C (en) 2008-12-08 2019-01-15 Complix Nv Single-chain antiparallel coiled coil proteins
JP5501439B2 (ja) 2009-04-02 2014-05-21 ロシュ グリクアート アクチェンゲゼルシャフト 完全長抗体と単鎖Ｆａｂフラグメントとを含む多重特異的抗体
GB2471692A (en) * 2009-07-08 2011-01-12 Complix Nv HIV gp41-binding single-chain coiled-coil peptide comprising heptad repeats
GB2471693A (en) * 2009-07-08 2011-01-12 Complix Nv Parathyroid hormone related protein antagonists
SG10201408401RA (en) * 2009-09-16 2015-01-29 Genentech Inc Coiled coil and/or tether containing protein complexes and uses thereof
WO2012025530A1 (en) 2010-08-24 2012-03-01 F. Hoffmann-La Roche Ag Bispecific antibodies comprising a disulfide stabilized - fv fragment
EP2656079A2 (de) 2010-12-20 2013-10-30 Universiteit Gent Kristallstruktur eines flt3-ligand-rezeptorkomplexes
EP2655413B1 (de) 2010-12-23 2019-01-16 F.Hoffmann-La Roche Ag Polypeptid-polynukleotid-komplex und verwendung bei der gezielten effektorrest-bereitstellung
EP2661446B1 (de) * 2011-01-06 2015-09-30 Complix SA Alphakörperbibliotheken und verfahren zu ihrer herstellung
WO2012092971A1 (en) * 2011-01-06 2012-07-12 Complix Nv Alphabodies specifically binding to viral proteins and methods for producing the same
CN104105711B (zh) 2012-02-10 2018-11-30 弗·哈夫曼-拉罗切有限公司 单链抗体及其他异多聚体
MX2014014804A (es) 2012-06-27 2015-02-12 Hoffmann La Roche Metodo para la elaboracion de conjugados de la region fc de anticuerpos que comprenden por lo menos una entidad de union que se une especificamente a un objetivo y usos del mismo.
HK1207864A1 (zh) 2012-06-27 2016-02-12 F. Hoffmann-La Roche Ag 用於选择并产生含有至少两种不同结合实体的定制高度选择性和多特异性靶向实体的方法及其用途
CA2899274A1 (en) 2013-01-29 2014-08-07 The University Court Of The University Of Glasgow Methods and means for increasing stress tolerance and biomass in plants
CA2917105C (en) 2013-07-01 2023-09-26 Bayer Cropscience Nv Methods and means for modulating flowering time in monocot plants
WO2016050512A1 (en) 2014-10-03 2016-04-07 Bayer Cropscience Nv Methods and means for increasing stress tolerance and biomass in plants
ES2764111T3 (es) 2014-12-03 2020-06-02 Hoffmann La Roche Anticuerpos multiespecíficos
US20190153456A1 (en) 2015-10-16 2019-05-23 Bayer Cropscience Nv Brassica plants with altered properties in seed production
CN106831997B (zh) * 2015-12-03 2020-04-24 中国科学院苏州纳米技术与纳米仿生研究所 多肽、脂蛋白样纳米粒子及其应用
CN112512552B (zh) * 2018-07-12 2024-10-22 海克斯麦治疗公司 自组装肽支架
JP2022505866A (ja) 2018-11-02 2022-01-14 ユニバーシティ オブ ワシントン 直交タンパク質ヘテロ二量体
CN113943353B (zh) * 2021-10-27 2024-05-03 百葵锐(深圳)生物科技有限公司 一种宽应激范围的智能多肽及其应用
KR20240149030A (ko) 2023-04-04 2024-10-14 주식회사 지놈앤컴퍼니 항-bcam 항체 및 항체-약물 접합체

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824483A (en) 1994-05-18 1998-10-20 Pence Inc. Conformationally-restricted combinatiorial library composition and method
US6303317B1 (en) 1997-01-28 2001-10-16 The Regents Of The University Of California Peptide probes and methods for making the same
ATE282092T1 (de) 1997-06-11 2004-11-15 Borean Pharma As Trimerisierendes modul
CA2305341C (en) 1997-10-01 2009-01-06 Dana-Farber Cancer Institute, Inc. Stabilization of envelope glycoprotein trimers by disulfide bonds introduced into a gp41 glycoprotein ectodomain
US6828106B2 (en) * 1999-02-26 2004-12-07 Cyclacel Limited Methods and compositions using coiled binding partners
US6872806B1 (en) 1999-06-25 2005-03-29 The Governors Of The University Of Alberta Polypeptide compositions formed using a coiled-coil template and methods of use
ES2296665T3 (es) 1999-12-16 2008-05-01 Whitehead Institute For Biomedical Research Proteina cinco-helice.
CA2410604A1 (en) 2000-06-14 2001-12-20 Cytovax Biotechnologies, Inc. Use of coiled-coil structural scaffold to generate structure-specific peptides
AU2003265420A1 (en) 2003-08-14 2005-03-10 The Government Of The United States Of America, As Represented By The Department Of Health And Human Services Polypeptide multimers having antiviral activity
WO2005077103A2 (en) 2004-02-12 2005-08-25 Regents Of The University Of Colorado Compositions and methods for modification and prevention of sars coronavirus infectivity
US7811577B2 (en) 2004-06-01 2010-10-12 Merck Sharp & Dohme Corp. Covalently stabilized chimeric coiled-coil HIV gp41 N-peptides with improved antiviral activity
CA2749558C (en) 2008-12-08 2019-01-15 Complix Nv Single-chain antiparallel coiled coil proteins
GB2471692A (en) 2009-07-08 2011-01-12 Complix Nv HIV gp41-binding single-chain coiled-coil peptide comprising heptad repeats

Also Published As

Publication number Publication date
US9217011B2 (en) 2015-12-22
EP2188303B1 (de) 2011-12-21
US20100305304A1 (en) 2010-12-02
EP2188303A2 (de) 2010-05-26
WO2009030780A3 (en) 2009-04-30
WO2009030780A2 (en) 2009-03-12

Similar Documents

Publication Publication Date Title
ATE538129T1 (de) Nicht natürliches proteinöses gerüst aus drei nicht kovalent assoziierten peptiden
IN2014CN02050A (de)
UA103154C2 (uk) Hla-a*1101-обмежений пептид wt1 і фармацевтична композиція, яка містить його
WO2009155258A3 (en) Glucagon/glp-1 receptor co-agonists
DOP2009000194A (es) Glucagon/co-agonistas receptores de glp-1
RU2016146198A (ru) Терапевтические dll4-связывающие белки
HRP20100644T1 (hr) Cijepivo kombinacije peptida protiv alergije na macke
DK2162462T3 (da) Cxc-chemokin-receptor-4 (cxcr4) antagonistisk polypeptid
JP2010510315A5 (de)
RU2013128896A (ru) Сконструированные белки повторов, которые связываются с сывороточным альбумином
NO20071369L (no) Antimikrobiske peptider omfattende et arginin- og/eller lysin-inneholdende motiv
JP2006149395A5 (de)
ES2531142T3 (es) Péptidos WT1 de unión a HLA de clase II, y composiciones y métodos que los comprenden
EA023303B1 (ru) Пептидная композиция для формирования толерантности к клещам домашней пыли и ее применение
PE20210376A1 (es) Peptidos y combinacion de peptidos de origen no canonico para el uso en la inmunoterapia contra diferentes tipos de cancer
DE602005020165D1 (de) Verfahren zur herstellung von l-arginin, l-ornithin oder l-citrullin
NO20084008L (no) HLA-A 3303-begrenset WT1-peptid og farmasoytisk preparat omfattende det samme
JP2019500414A5 (de)
MX2008009493A (es) Peptido novedoso y uso del mismo.
CY1109631T1 (el) Χρησιμοποιηση πεπτιδιων, τα οποια εχουν παραχθει απο την αα- ή ββ-αλυσιδα του ανθρωπινου ινωδογονου, για τη θεραπεια σοκ
MX2009007261A (es) Vacuna de peptido foxp3.
WO2008113536A8 (en) Neurotrophic peptides
JP2010512326A5 (de)
NZ586074A (en) LCLRP peptides, constructs and uses thereof
NZ594481A (en) Truncated cystine-knot proteins