UA103154C2 - Hla-a*1101-обмежений пептид wt1 і фармацевтична композиція, яка містить його - Google Patents

Hla-a*1101-обмежений пептид wt1 і фармацевтична композиція, яка містить його

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UA103154C2
UA103154C2 UAA200907944A UAA200907944A UA103154C2 UA 103154 C2 UA103154 C2 UA 103154C2 UA A200907944 A UAA200907944 A UA A200907944A UA A200907944 A UAA200907944 A UA A200907944A UA 103154 C2 UA103154 C2 UA 103154C2
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amino acid
pharmaceutical composition
peptide
hla
restricted
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UAA200907944A
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Russian (ru)
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Харуо Сугіяма
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Інтернешнл Інстітьют Оф Кенсер Іммунолоджи, Інк.
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Publication of UA103154C2 publication Critical patent/UA103154C2/uk

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4242—Transcription factors, e.g. SOX or c-MYC
    • A61K40/4243—Wilms tumor 1 [WT1]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Abstract

Винахід належить до пептиду, здатному зв'язуватися з молекулою HLA-A* 1101 і здатному індукувати цитотоксичний Т-лімфоцит (CTL), який складається з амінокислотної послідовності Thr Gly Val Lys Pro Phe Gin Cys Lys (SEQ ID NО:7), в якій від однієї амінокислоти до п'яти амінокислот можуть бути заміщені іншою (ими) амінокислотою (ами), а також до фармацевтичної композиції для лікування або профілактики злоякісного новоутворення, яка містить зазначений поліпептид, до способу індукції WT1-специфічного цитотоксичного Т-лімфоцита, набору, що містить зазначений поліпептид.
UAA200907944A 2006-12-28 2007-12-14 Hla-a*1101-обмежений пептид wt1 і фармацевтична композиція, яка містить його UA103154C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006355356 2006-12-28
PCT/JP2007/074146 WO2008081701A1 (ja) 2006-12-28 2007-12-14 Ｈｌａ－ａ＊１１０１拘束性ｗｔ１ペプチド、およびそれを含む医薬組成物

Publications (1)

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UA103154C2 true UA103154C2 (uk) 2013-09-25

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EP (6) EP2479275B1 (uk)
JP (1) JP5484734B2 (uk)
KR (1) KR101525261B1 (uk)
CN (5) CN102295682A (uk)
AR (1) AR064555A1 (uk)
AU (1) AU2007340679B2 (uk)
BR (1) BRPI0720988A2 (uk)
CA (5) CA2886621A1 (uk)
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ES (4) ES2554775T3 (uk)
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RU (1) RU2481398C2 (uk)
SG (1) SG177222A1 (uk)
SI (1) SI2341142T1 (uk)
TW (3) TWI417103B (uk)
UA (1) UA103154C2 (uk)
WO (1) WO2008081701A1 (uk)
ZA (1) ZA200903633B (uk)

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TWI417103B (zh) 2013-12-01
TW201345544A (zh) 2013-11-16
ES2554775T3 (es) 2015-12-23
EP2098595A4 (en) 2010-03-17
CN102335439B (zh) 2015-04-22
CN102302788A (zh) 2012-01-04
EP2341142A3 (en) 2011-09-07
CN102302788B (zh) 2016-06-15
AR064555A1 (es) 2009-04-08
DK2479275T3 (en) 2015-12-14
US20180064795A1 (en) 2018-03-08
NZ601175A (en) 2012-12-21
RU2009128979A (ru) 2011-02-10
CY1116011T1 (el) 2017-01-25
ES2556831T3 (es) 2016-01-20
ES2629578T3 (es) 2017-08-11
CN102659924A (zh) 2012-09-12
SG177222A1 (en) 2012-01-30
RU2481398C2 (ru) 2013-05-10
EP2479275A1 (en) 2012-07-25
BRPI0720988A2 (pt) 2014-03-18
ES2526425T3 (es) 2015-01-12
EP2479275B1 (en) 2015-10-28
TWI599367B (zh) 2017-09-21
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CN102335439A (zh) 2012-02-01
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IL215332A0 (en) 2011-11-30
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JPWO2008081701A1 (ja) 2010-04-30
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PH12014500902B1 (en) 2018-08-10
CN102659924B (zh) 2015-11-25
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DK2341142T3 (en) 2014-12-08
EP2341142B1 (en) 2014-11-26
EP2098595A1 (en) 2009-09-09
EP2479276A1 (en) 2012-07-25
US20110098233A1 (en) 2011-04-28
EP2980219A1 (en) 2016-02-03
EP2980219B1 (en) 2018-11-14
CA2886622A1 (en) 2008-07-10
NZ592510A (en) 2012-11-30
TWI554280B (zh) 2016-10-21
PH12014500902A1 (en) 2016-01-11
EP2341142A2 (en) 2011-07-06
US20140134200A1 (en) 2014-05-15
TW200835513A (en) 2008-09-01
ZA200903633B (en) 2010-02-24
AU2007340679B2 (en) 2013-09-12
NZ577443A (en) 2011-12-22
CA2886619A1 (en) 2008-07-10
WO2008081701A1 (ja) 2008-07-10
IL215333A0 (en) 2011-11-30
JP5484734B2 (ja) 2014-05-07
IL199052A0 (en) 2010-03-28
PT2341142E (pt) 2015-02-13
US9272026B2 (en) 2016-03-01
CA2886620A1 (en) 2008-07-10
CA2886621A1 (en) 2008-07-10
PL2341142T3 (pl) 2015-04-30

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