ATE538378T1 - Verfahren zur überwachung der immunantwort und vorhersage der klinischen resultate bei empfängern von transplantaten - Google Patents
Verfahren zur überwachung der immunantwort und vorhersage der klinischen resultate bei empfängern von transplantatenInfo
- Publication number
- ATE538378T1 ATE538378T1 AT03746717T AT03746717T ATE538378T1 AT E538378 T1 ATE538378 T1 AT E538378T1 AT 03746717 T AT03746717 T AT 03746717T AT 03746717 T AT03746717 T AT 03746717T AT E538378 T1 ATE538378 T1 AT E538378T1
- Authority
- AT
- Austria
- Prior art keywords
- immune response
- predicting clinical
- clinical results
- transplant recipients
- monitoring immune
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 230000028993 immune response Effects 0.000 title abstract 2
- 238000012544 monitoring process Methods 0.000 title abstract 2
- ZKHQWZAMYRWXGA-KQYNXXCUSA-J ATP(4-) Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-J 0.000 abstract 2
- ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 abstract 2
- 239000003018 immunosuppressive agent Substances 0.000 abstract 1
- 229940124589 immunosuppressive drug Drugs 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 210000004698 lymphocyte Anatomy 0.000 abstract 1
- 239000003550 marker Substances 0.000 abstract 1
- 238000005259 measurement Methods 0.000 abstract 1
- 230000002503 metabolic effect Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/24—Immunology or allergic disorders
- G01N2800/245—Transplantation related diseases, e.g. graft versus host disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/827—Lectins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Physiology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37140202P | 2002-04-11 | 2002-04-11 | |
| PCT/US2003/011117 WO2003086177A2 (en) | 2002-04-11 | 2003-04-11 | Method for monitoring the immune response and predicting clinical outcomes in transplant recipients |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE538378T1 true ATE538378T1 (de) | 2012-01-15 |
Family
ID=29250671
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03746717T ATE538378T1 (de) | 2002-04-11 | 2003-04-11 | Verfahren zur überwachung der immunantwort und vorhersage der klinischen resultate bei empfängern von transplantaten |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7476514B2 (de) |
| EP (2) | EP2322928A1 (de) |
| AT (1) | ATE538378T1 (de) |
| AU (1) | AU2003226067A1 (de) |
| ES (1) | ES2379252T3 (de) |
| WO (1) | WO2003086177A2 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE538378T1 (de) * | 2002-04-11 | 2012-01-15 | Cylex Inc | Verfahren zur überwachung der immunantwort und vorhersage der klinischen resultate bei empfängern von transplantaten |
| EP1800124B1 (de) * | 2004-03-16 | 2011-12-21 | Amnis Corporation | Auf bildlicher darstellung beruhende quantifizierung molekularer translokation |
| US7855074B2 (en) * | 2004-04-28 | 2010-12-21 | Vaxdesign Corp. | Artificial immune system: methods for making and use |
| US8071373B2 (en) | 2004-04-28 | 2011-12-06 | Sanofi Pasteur Vaxdesign Corp. | Co-culture lymphoid tissue equivalent (LTE) for an artificial immune system (AIS) |
| US7771999B2 (en) | 2004-04-28 | 2010-08-10 | Vaxdesign Corp. | Disease model incorporation into an artificial immune system (AIS) |
| US7709256B2 (en) * | 2004-04-28 | 2010-05-04 | Vaxdesign Corp. | Disease model incorporation into an artificial immune system (AIS) |
| US8030070B2 (en) * | 2004-04-28 | 2011-10-04 | Sanofi Pasteur Vaxdesign Corp. | Artificial lymphoid tissue equivalent |
| US7785883B2 (en) * | 2004-04-28 | 2010-08-31 | Vax Design Corp. | Automatable artificial immune system (AIS) |
| US7785806B2 (en) * | 2004-04-28 | 2010-08-31 | Vaxdesign Corporation | Method for determining the immunogenicity of an antigen |
| US8298824B2 (en) | 2004-04-28 | 2012-10-30 | Sanofi Pasteur Vaxdesign Corporation | Methods of evaluating a test agent in a diseased cell model |
| WO2006119018A2 (en) * | 2005-04-29 | 2006-11-09 | Atrium Medical Corporation | Drug delivery coating for use with a medical device and methods of treating vascular injury |
| EP2199384B1 (de) * | 2005-12-21 | 2011-11-02 | Sanofi Pasteur VaxDesign Corporation | Eine poröse Membran Gerät, das die Differenzierung von Monozyten in dendritische Zellen fördert |
| EP1969366B1 (de) | 2005-12-21 | 2015-10-21 | Sanofi Pasteur VaxDesign Corporation | In-vitro-keimzentren |
| MX2008014110A (es) * | 2006-05-02 | 2008-11-14 | Therakos Inc | Metodos y reactivos para detectar la susceptibilidad a la enfermedad del injerto versus el hospedero o mortalidad relacionada con el transplante. |
| EP2409714A1 (de) * | 2006-06-27 | 2012-01-25 | Sanofi Pasteur VaxDesign Corporation | Modelle für die Bewertung von Impfstoffen |
| US20090062237A1 (en) * | 2007-06-15 | 2009-03-05 | Mayo Foundation For Medical Education And Research | Evaluating immune competence |
| US8647837B2 (en) | 2007-07-16 | 2014-02-11 | Sanofi Pasteur Vaxdesign Corp. | Artificial tissue constructs comprising alveolar cells and methods for using the same |
| US9459253B2 (en) | 2009-12-23 | 2016-10-04 | Cellestis Limited | Assay for measuring cell-mediated immunoresponsiveness |
| EP3090263A4 (de) | 2013-12-31 | 2017-08-23 | Yeda Research and Development Co., Ltd. | Verfahren zum testen einer immunologischen kompetenz |
| WO2015101988A1 (en) | 2013-12-31 | 2015-07-09 | Yeda Research And Development Co. Ltd. | Diagnosis of systemic lupus erythematosus using oligonucleotides antigens |
| WO2016139659A1 (en) | 2015-03-01 | 2016-09-09 | Immunarray Ltd. | Diagnosis of systemic lupus erythematosus using protein, peptide and oligonucleotide antigens |
| CN116559464A (zh) * | 2023-04-26 | 2023-08-08 | 广州市雷德医学检验实验室有限公司 | 一种免疫应答评估系统 |
| CN119397492B (zh) * | 2024-10-16 | 2025-11-07 | 重庆邮电大学 | 一种基于多模态的肝移植用药剂量预测方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4677061A (en) * | 1984-10-19 | 1987-06-30 | Genetic Systems Corporation | T-cell lymphocyte subset monitoring of immunologic disease |
| US4778750A (en) | 1986-02-19 | 1988-10-18 | Imreg, Inc. | Diagnostic methods for immune function |
| US5292636A (en) * | 1986-03-31 | 1994-03-08 | T Cell Diagnostics, Inc. | Therapeutic and diagnostic methods using soluble T cell surface molecules |
| CA1296622C (en) * | 1986-08-12 | 1992-03-03 | Jeffrey E. Anderson | Method and apparatus for automated assessment of the immunoregulatory status of the mononuclear leukocyte immune system |
| US4959302A (en) * | 1987-08-20 | 1990-09-25 | Endogen, Inc. | Method of evaluating immune system response to allografts, viral infection and immunosuppressive therapy |
| US5344755A (en) * | 1990-04-21 | 1994-09-06 | The United States Of America As Represented By The Department Of Health And Human Services | Method for detecting immune system dysfunction in asymptomatic, HIV-scropositive individuals |
| EP0688223A4 (de) * | 1993-03-12 | 1998-05-13 | Cellcor Inc | -i(IN VITRO) 'ASSAY' ZUM MESSEN DES GRADES DER AKTIVIERUNG VON IMMUNZELLEN |
| EP1019546B1 (de) | 1996-03-26 | 2004-12-15 | Cylex, Inc. | Verfahren zur messung der lymphozytenfunktion |
| AU1533099A (en) * | 1998-08-25 | 2000-03-14 | Immune Response Corporation, The | Methods for evaluating immune function |
| US6251616B1 (en) * | 1999-01-14 | 2001-06-26 | Biocrystal Ltd. | Methods and assay kits for detecting altered mononuclear cell phenotype related to a pro-tumor immune response |
| US6150121A (en) * | 1999-02-16 | 2000-11-21 | Wisconsin Alumni Research Foundation | Assessing immunological state of transplant recipients |
| WO2002084289A1 (en) * | 2001-04-17 | 2002-10-24 | Cylex, Inc. | Methods for measuring lymphocyte activation by mitogens and antigens |
| ATE538378T1 (de) * | 2002-04-11 | 2012-01-15 | Cylex Inc | Verfahren zur überwachung der immunantwort und vorhersage der klinischen resultate bei empfängern von transplantaten |
-
2003
- 2003-04-11 AT AT03746717T patent/ATE538378T1/de active
- 2003-04-11 EP EP11000891A patent/EP2322928A1/de not_active Withdrawn
- 2003-04-11 ES ES03746717T patent/ES2379252T3/es not_active Expired - Lifetime
- 2003-04-11 AU AU2003226067A patent/AU2003226067A1/en not_active Abandoned
- 2003-04-11 EP EP03746717A patent/EP1495134B1/de not_active Expired - Lifetime
- 2003-04-11 WO PCT/US2003/011117 patent/WO2003086177A2/en not_active Ceased
- 2003-04-11 US US10/411,353 patent/US7476514B2/en not_active Expired - Lifetime
-
2008
- 2008-12-05 US US12/328,854 patent/US20090081716A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2379252T3 (es) | 2012-04-24 |
| WO2003086177A2 (en) | 2003-10-23 |
| AU2003226067A8 (en) | 2003-10-27 |
| EP1495134A2 (de) | 2005-01-12 |
| US7476514B2 (en) | 2009-01-13 |
| WO2003086177A3 (en) | 2004-10-21 |
| EP1495134B1 (de) | 2011-12-21 |
| EP2322928A1 (de) | 2011-05-18 |
| AU2003226067A1 (en) | 2003-10-27 |
| US20030199006A1 (en) | 2003-10-23 |
| EP1495134A4 (de) | 2008-02-13 |
| US20090081716A1 (en) | 2009-03-26 |
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