ATE544073T1 - Verfahren zur messung immunsuppressiver tacrolimus-, sirolimus- und cyclosporin-a- komplexe in einer blutprobe - Google Patents

Verfahren zur messung immunsuppressiver tacrolimus-, sirolimus- und cyclosporin-a- komplexe in einer blutprobe

Info

Publication number: ATE544073T1
Authority: AT; Austria
Prior art keywords: sirolimus; tacrolimus; complexes; immunosupressive; cyclosporin
Prior art date: 2005-04-06

Application number

AT10151541T

Other languages

English (en)

Inventor

Susan M Drengler

Bennet W Baugher

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-04-06

Filing date

2006-04-05

Publication date

2012-02-15

2006-04-05 Application filed by Abbott Lab filed Critical Abbott Lab

2012-02-15 Application granted granted Critical

2012-02-15 Publication of ATE544073T1 publication Critical patent/ATE544073T1/de

Links

238000000034 method Methods 0.000 title abstract 4
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical class CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 2
QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 title abstract 2
239000008280 blood Substances 0.000 title abstract 2
210000004369 blood Anatomy 0.000 title abstract 2
230000001506 immunosuppresive effect Effects 0.000 title abstract 2
ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 title abstract 2
229960002930 sirolimus Drugs 0.000 title abstract 2
QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 title abstract 2
229960001967 tacrolimus Drugs 0.000 title abstract 2
QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 title abstract 2
238000003556 assay Methods 0.000 abstract 2
239000003018 immunosuppressive agent Substances 0.000 abstract 2
229940124589 immunosuppressive drug Drugs 0.000 abstract 2
229930105110 Cyclosporin A Natural products 0.000 abstract 1
108010036949 Cyclosporine Proteins 0.000 abstract 1
238000009007 Diagnostic Kit Methods 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
238000002651 drug therapy Methods 0.000 abstract 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9493—Immunosupressants
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Physics & Mathematics (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Food Science & Technology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Analytical Chemistry (AREA)
Cell Biology (AREA)
General Health & Medical Sciences (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Investigating Or Analysing Biological Materials (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT10151541T 2005-04-06 2006-04-05 Verfahren zur messung immunsuppressiver tacrolimus-, sirolimus- und cyclosporin-a- komplexe in einer blutprobe ATE544073T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US66871405P	2005-04-06	2005-04-06

Publications (1)

Publication Number	Publication Date
ATE544073T1 true ATE544073T1 (de)	2012-02-15

Family

ID=36888889

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT06740696T ATE456801T1 (de)	2005-04-06	2006-04-05	Verfahren zur messung immunsuppressiver tacrolimus-, sirolimus- und cyclosporin-a- komplexe in einer blutprobe
AT10151541T ATE544073T1 (de)	2005-04-06	2006-04-05	Verfahren zur messung immunsuppressiver tacrolimus-, sirolimus- und cyclosporin-a- komplexe in einer blutprobe

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT06740696T ATE456801T1 (de)	2005-04-06	2006-04-05	Verfahren zur messung immunsuppressiver tacrolimus-, sirolimus- und cyclosporin-a- komplexe in einer blutprobe

Country Status (9)

Country	Link
US (2)	US7592186B2 (de)
EP (2)	EP2180323B1 (de)
JP (1)	JP4862038B2 (de)
AT (2)	ATE456801T1 (de)
CA (1)	CA2602732A1 (de)
DE (1)	DE602006012033D1 (de)
ES (1)	ES2380207T3 (de)
MX (1)	MX2007012447A (de)
WO (1)	WO2006108130A2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8022188B2 (en) *	2006-04-24	2011-09-20	Abbott Laboratories	Immunosuppressant binding antibodies and methods of obtaining and using same
US20080081379A1 (en) *	2006-07-13	2008-04-03	Sigler Gerald F	Homogeneous double receptor agglutination assay for immunosuppressant drugs
US7883855B2 (en) *	2006-07-21	2011-02-08	Abbott Laboratories	Immunosuppressant drug extraction reagent for immunoassays
ES2393135T3 (es)	2006-12-29	2012-12-18	Abbott Laboratories	Ensayo mejorado para fármacos inmunosupresores
US7914999B2 (en)	2006-12-29	2011-03-29	Abbott Laboratories	Non-denaturing lysis reagent
ES2405364T3 (es) *	2006-12-29	2013-05-30	Abbott Laboratories	Ensayo diagnóstico para la detección de una molécula o fármaco en sangre entera
WO2008082984A2 (en)	2006-12-29	2008-07-10	Abbott Laboratories	Non-denaturing lysis reagent for use with capture-in-solution immunoassay
ATE535813T1 (de) *	2007-05-24	2011-12-15	Abbott Lab	Reduzierte kreuzreaktivität mit hydrophoben arzneistoffanalyt-stoffwechselprodukten zeigende immuntestverfahren
US9164090B2 (en) *	2007-08-17	2015-10-20	Korea Advanced Institute Of Science And Technology	Methods for detecting molecular interactions
US8409807B2 (en)	2010-10-22	2013-04-02	T2 Biosystems, Inc.	NMR systems and methods for the rapid detection of analytes
EP3974831A1 (de)	2010-10-22	2022-03-30	T2 Biosystems, Inc.	Verfahren zum nachweis eines bakteriums in einer vollblutprobe
US8563298B2 (en)	2010-10-22	2013-10-22	T2 Biosystems, Inc.	NMR systems and methods for the rapid detection of analytes
US8586322B2 (en) *	2012-03-07	2013-11-19	Siemens Healthcare Diagnostics, Inc	Sandwich assay for immunosuppressant drugs
WO2013158281A1 (en)	2012-04-20	2013-10-24	T2 Biosystems, Inc.	Compositions and methods for detection of candida species
WO2017074703A1 (en)	2015-10-29	2017-05-04	Siemens Healthcare Diagnostics Inc.	Sandwich assay for small molecules
US11519016B2 (en)	2016-01-21	2022-12-06	T2 Biosystems, Inc.	NMR methods and systems for the rapid detection of bacteria

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5525461A (en) *	1991-11-01	1996-06-11	T Cell Diagnostics, Inc.	Therapeutic and diagnostic methods using total leukocyte surface antigens
EP0651752A1 (de) *	1992-07-20	1995-05-10	Behringwerke Ag	Chemilumineszierende derivate und methoden deren anwendung
EP0672756B1 (de) *	1992-08-12	2002-02-13	Fujisawa Pharmaceutical Co., Ltd.	Monoklonaler antikörper spezifisch für das fk-506-bindende protein, methode zur bestimmung des gehaltes an fk-506-bindendem protein in einer probe und reagenzsatz dafür
US5756301A (en) *	1993-03-03	1998-05-26	The Trustees Of Columbia University In The City Of New York	Endogenous taxol-like substance in human serum, monoclonal antibodies directed thereto and methods of assaying therefor
AU686762B2 (en) *	1994-03-10	1998-02-12	Fujisawa Pharmaceutical Co., Ltd.	Method for assaying immunosuppressant
AU3993695A (en) *	1994-12-07	1996-06-26	Fujisawa Pharmaceutical Co., Ltd.	Method of measuring the concentration of fk506-binding protein
DE69832984T2 (de) *	1997-10-08	2006-09-21	Isotechnika, Inc., Edmonton	DEUTERIERtE und undeuterierte CYCLOSPORIN-ANALOGA UND IHRE VERWENDUNG ALS IMMUNMODULIERENDE AGENtIEN
US20060014677A1 (en) *	2004-07-19	2006-01-19	Isotechnika International Inc.	Method for maximizing efficacy and predicting and minimizing toxicity of calcineurin inhibitor compounds

2006
- 2006-04-05 ES ES10151541T patent/ES2380207T3/es not_active Expired - Lifetime
- 2006-04-05 CA CA002602732A patent/CA2602732A1/en not_active Abandoned
- 2006-04-05 JP JP2008505563A patent/JP4862038B2/ja not_active Expired - Fee Related
- 2006-04-05 AT AT06740696T patent/ATE456801T1/de not_active IP Right Cessation
- 2006-04-05 DE DE602006012033T patent/DE602006012033D1/de not_active Expired - Lifetime
- 2006-04-05 WO PCT/US2006/012988 patent/WO2006108130A2/en not_active Ceased
- 2006-04-05 AT AT10151541T patent/ATE544073T1/de active
- 2006-04-05 EP EP10151541A patent/EP2180323B1/de not_active Expired - Lifetime
- 2006-04-05 EP EP06740696A patent/EP1875250B1/de not_active Expired - Lifetime
- 2006-04-05 MX MXMX07012447A patent/MX2007012447A/es active IP Right Grant
- 2006-04-06 US US11/398,997 patent/US7592186B2/en not_active Expired - Fee Related
2009
- 2009-08-12 US US12/539,825 patent/US7923210B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
MX2007012447A (es)	2007-10-19
EP1875250A2 (de)	2008-01-09
WO2006108130A3 (en)	2006-11-23
EP1875250B1 (de)	2010-01-27
US20060257957A1 (en)	2006-11-16
CA2602732A1 (en)	2006-10-12
DE602006012033D1 (de)	2010-03-18
US7923210B2 (en)	2011-04-12
ES2380207T3 (es)	2012-05-09
ATE456801T1 (de)	2010-02-15
JP4862038B2 (ja)	2012-01-25
US20090298090A1 (en)	2009-12-03
EP2180323B1 (de)	2012-02-01
JP2008536126A (ja)	2008-09-04
WO2006108130A2 (en)	2006-10-12
US7592186B2 (en)	2009-09-22
EP2180323A1 (de)	2010-04-28

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ATE456801T1 (de)	2010-02-15	Verfahren zur messung immunsuppressiver tacrolimus-, sirolimus- und cyclosporin-a- komplexe in einer blutprobe
CA2465800A1 (en)	2003-05-15	Instrument
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ATE540319T1 (de)	2012-01-15	Verfahren für die bestimmung von fk506
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