ATE538380T1 - Nukleinsäure-programmierbare protein-arrays - Google Patents

Nukleinsäure-programmierbare protein-arrays

Info

Publication number
ATE538380T1
ATE538380T1 AT02707542T AT02707542T ATE538380T1 AT E538380 T1 ATE538380 T1 AT E538380T1 AT 02707542 T AT02707542 T AT 02707542T AT 02707542 T AT02707542 T AT 02707542T AT E538380 T1 ATE538380 T1 AT E538380T1
Authority
AT
Austria
Prior art keywords
nucleic acid
protein arrays
acid programmable
programmable protein
arrays
Prior art date
Application number
AT02707542T
Other languages
English (en)
Inventor
Joshua Labaer
Albert Lau
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Application granted granted Critical
Publication of ATE538380T1 publication Critical patent/ATE538380T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
AT02707542T 2001-01-23 2002-01-22 Nukleinsäure-programmierbare protein-arrays ATE538380T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26360701P 2001-01-23 2001-01-23
PCT/US2002/001882 WO2002059601A1 (en) 2001-01-23 2002-01-22 Nucleic-acid programmable protein arrays

Publications (1)

Publication Number Publication Date
ATE538380T1 true ATE538380T1 (de) 2012-01-15

Family

ID=23002490

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02707542T ATE538380T1 (de) 2001-01-23 2002-01-22 Nukleinsäure-programmierbare protein-arrays

Country Status (6)

Country Link
US (2) US6800453B2 (de)
EP (1) EP1360490B1 (de)
JP (3) JP4880188B2 (de)
AT (1) ATE538380T1 (de)
CA (1) CA2434139C (de)
WO (1) WO2002059601A1 (de)

Families Citing this family (143)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2266224T3 (es) 2000-08-15 2007-03-01 Discerna Limited Series de proteinas funcionales.
ATE538380T1 (de) * 2001-01-23 2012-01-15 Harvard College Nukleinsäure-programmierbare protein-arrays
DK1392342T3 (en) * 2001-05-11 2015-12-21 Univ Yale Global analysis of protein activities using proteomchips
US20030143576A1 (en) * 2001-08-22 2003-07-31 Heman Chao Method and device for integrated protein expression, purification and detection
US20030162179A1 (en) * 2002-02-27 2003-08-28 General Electric Company Fabrication, performance testing, and screening of three dimensional arrays of materials
US20030228709A1 (en) * 2002-03-25 2003-12-11 Kozlowski Roland Zbignieiw Arrays
US20030235814A1 (en) * 2002-06-19 2003-12-25 Los Alamos National Laboratory Compositions and methods for selecting open reading frames
US20040043384A1 (en) * 2002-08-28 2004-03-04 Oleinikov Andrew V. In vitro protein translation microarray device
KR100523212B1 (ko) * 2003-01-04 2005-10-24 한국과학기술원 반응 단백질과 그의 기질 펩타이드간의 반응분석을 위한단백질 칩
WO2004063337A2 (en) 2003-01-07 2004-07-29 Dyax Corporation Kunitz domain library
TW200412373A (en) * 2003-01-15 2004-07-16 Univ Nat Taiwan RCA combined nanoparticle-based optical detection technique for protein microarray
US7429472B2 (en) 2003-01-31 2008-09-30 Promega Corporation Method of immobilizing a protein or molecule via a mutant dehalogenase that is bound to an immobilized dehalogenase substrate and linked directly or indirectly to the protein or molecule
EP2455457B1 (de) 2003-01-31 2015-03-11 Promega Corporation Kovalentes Anbinden von Funktionsgruppen an Proteine
US7585815B2 (en) * 2003-07-24 2009-09-08 Lawrence Livermore National Security, Llc High throughput protein production screening
JP4754352B2 (ja) * 2003-08-29 2011-08-24 株式会社リバース・プロテオミクス研究所 タンパク質の固定化方法
US8293503B2 (en) * 2003-10-03 2012-10-23 Promega Corporation Vectors for directional cloning
CA2541177A1 (en) * 2003-10-03 2005-09-22 Promega Corporation Vectors for directional cloning
US20050214890A1 (en) * 2003-11-26 2005-09-29 Zhiqun Tan Novel "Cleave-N-Read" system for protease activity assay and methods of use thereof
US20050260653A1 (en) * 2004-04-14 2005-11-24 Joshua Labaer Nucleic-acid programmable protein arrays
NZ551782A (en) 2004-06-03 2010-03-26 Athlomics Pty Ltd Agents and methods for diagnosing stress
US20090054255A1 (en) 2004-07-01 2009-02-26 The Regents Of The University Of California Microfluidic devices and methods
US20070087400A1 (en) * 2004-07-30 2007-04-19 Aldis Darzins Covalent tethering of functional groups to proteins and substrates therefor
US7425436B2 (en) 2004-07-30 2008-09-16 Promega Corporation Covalent tethering of functional groups to proteins and substrates therefor
US7786261B2 (en) * 2004-09-02 2010-08-31 National Research Council Of Canada Coiled-coil fusion proteins comprising cell receptor domains
JP4868731B2 (ja) * 2004-11-17 2012-02-01 独立行政法人理化学研究所 哺乳動物培養細胞由来の無細胞タンパク質合成システム
JP4686682B2 (ja) * 2004-12-02 2011-05-25 国立大学法人名古屋大学 リガンド親和性複合タンパク質の取得方法、抗体スクリーニング方法、抗体スクリーニング用キット、医療方法、抗体医薬、非免疫反応性抗体医薬、投薬方法
JPWO2006062200A1 (ja) * 2004-12-09 2008-06-12 ユニバーサル・バイオ・リサーチ株式会社 核酸ライブラリー及びタンパク質ライブラリー
US20060234265A1 (en) * 2005-03-21 2006-10-19 Jim Richey Microarrays having multi-functional, compartmentalized analysis areas and methods of use
EP1869219A4 (de) * 2005-03-31 2010-06-23 Perkinelmer Las Inc Multiplex-testsystem
US20070003954A1 (en) * 2005-05-12 2007-01-04 The Board Of Regents Of The University Of Texas System Protein and antibody profiling using small molecule microarrays
JP2006337153A (ja) * 2005-06-01 2006-12-14 Toppan Printing Co Ltd Ｄｎａ合成判定装置、核酸タンク装置、ｄｎａチップ装置及びｄｎａ判定システム
GB0511717D0 (en) 2005-06-09 2005-07-13 Babraham Inst Repeatable protein arrays
CN101501215A (zh) 2005-07-07 2009-08-05 阿什洛米克斯控股有限公司 用于诊断内毒素血症的多核苷酸标记基因及它们的表达
WO2007061981A2 (en) 2005-11-21 2007-05-31 Lumera Corporation Surface plasmon resonance spectrometer with an actuator-driven angle scanning mechanism
US7463358B2 (en) * 2005-12-06 2008-12-09 Lumera Corporation Highly stable surface plasmon resonance plates, microarrays, and methods
EP1989548A2 (de) * 2006-02-08 2008-11-12 Promega Corporation Zusammensetzungen und verfahren zum erfassen und auswerten von verknüpften biomolekülen
US8178316B2 (en) 2006-06-29 2012-05-15 President And Fellows Of Harvard College Evaluating proteins
JP4546578B2 (ja) 2006-07-05 2010-09-15 カタリスト・バイオサイエンシーズ・インコーポレイテッド プロテアーゼスクリーニング方法およびそれにより同定されるプロテアーゼ
WO2008054821A2 (en) 2006-10-30 2008-05-08 Promega Corporation Mutant hydrolase proteins with enhanced kinetics and functional expression
WO2008127702A2 (en) 2007-04-13 2008-10-23 Catalyst Biosciences, Inc. Modified factor vii polypetides and uses thereof
CA2704226A1 (en) * 2007-11-01 2009-05-07 The Arizona Board Of Regents On Behalf Of The University Of Arizona Cell-free methods for detecting protein-ligand interctions
US20090305899A1 (en) * 2007-11-16 2009-12-10 Invitrogen Incorporated Compositions and methods for determining immune status
US9328172B2 (en) * 2008-04-05 2016-05-03 Single Cell Technology, Inc. Method of obtaining antibodies of interest and nucleotides encoding same
US20100081575A1 (en) * 2008-09-22 2010-04-01 Robert Anthony Williamson Methods for creating diversity in libraries and libraries, display vectors and methods, and displayed molecules
AU2009293640A1 (en) * 2008-09-22 2010-03-25 Calmune Corporation Methods and vectors for display of 2G12 -derived domain exchanged antibodies
DE102009012169B3 (de) * 2009-03-06 2010-11-04 Albert-Ludwigs-Universität Freiburg Vorrichtung und Verfahren zum Herstellen eines Replikats oder eines Derivats aus einem Array von Molekülen und Anwendungen derselben
WO2010127186A1 (en) 2009-04-30 2010-11-04 Prognosys Biosciences, Inc. Nucleic acid constructs and methods of use
MX2011012680A (es) * 2009-05-29 2012-03-06 Univ Texas Ligandos peptoides para aislamiento y tratamiento de celulas-t autoinmune.
AU2010256880B2 (en) * 2009-06-02 2015-01-22 Opko Health, Inc. Identification of small molecules recognized by antibodies in subjects with neurodegenerative diseases
WO2011035205A2 (en) 2009-09-18 2011-03-24 Calmune Corporation Antibodies against candida, collections thereof and methods of use
WO2011047257A1 (en) * 2009-10-16 2011-04-21 The Board Of Regents Of The University Of Texas System Compositions and methods for producing cyclic peptoid libraries
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
DK2556171T3 (en) 2010-04-05 2015-12-14 Prognosys Biosciences Inc Spatially CODED BIOLOGICAL ASSAYS
WO2011139806A2 (en) * 2010-04-27 2011-11-10 Diomics Corporation Integrated methods and systems for processing a molecular profile
DE102011010307A1 (de) 2011-02-03 2012-08-09 Albert-Ludwigs-Universität Freiburg Vorrichtung und Verfahren zur Erzeugung von Protein-Mikroarrays
US20120258871A1 (en) 2011-04-08 2012-10-11 Prognosys Biosciences, Inc. Peptide constructs and assay systems
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
JP6041154B2 (ja) * 2011-08-12 2016-12-07 国立大学法人 筑波大学 並列反応方法およびスクリーニング方法
DE102011054101A1 (de) 2011-09-30 2013-04-04 Albert-Ludwigs-Universität Freiburg Verfahren zur räumlichen Anordnung von Probenfragmenten zur Amplifikation und Immobilisierung für weitere Derivatisierungen
EP4230288A3 (de) * 2011-10-25 2023-11-15 Arizona Board of Regents, a Body Corporate of the State of Arizona acting for and on behalf of Arizona State University Programmierbare arrays
US8987174B2 (en) 2011-10-28 2015-03-24 Prognosys Biosciences, Inc. Methods for manufacturing molecular arrays
US9442111B2 (en) 2011-12-14 2016-09-13 Arizona Board Of Regents Method and apparatus for measuring phosphorylation kinetics on large arrays
WO2014060483A1 (en) 2012-10-17 2014-04-24 Spatial Transcriptomics Ab Methods and product for optimising localised or spatial detection of gene expression in a tissue sample
CN104903727B (zh) 2012-11-08 2019-10-22 马克法兰伯尼特医学研究与公共健康协会有限公司 诊断、预后、治疗和筛选方案
CN105051270B (zh) * 2013-03-15 2019-05-07 代表亚利桑那大学的亚利桑那校董会 生物传感器微阵列构成和方法
WO2014145458A1 (en) * 2013-03-15 2014-09-18 Arizona Board Of Regents On Behalf Of Arizona State University Nucleic acid-tagged compositions and methods for multiplexed protein-protein interaction profiling
WO2014145047A1 (en) 2013-03-15 2014-09-18 Prognosys Biosciences, Inc. Methods for detecting peptide/mhc/tcr binding
US9868979B2 (en) 2013-06-25 2018-01-16 Prognosys Biosciences, Inc. Spatially encoded biological assays using a microfluidic device
WO2015070037A2 (en) 2013-11-08 2015-05-14 Prognosys Biosciences, Inc. Polynucleotide conjugates and methods for analyte detection
WO2015175755A1 (en) * 2014-05-15 2015-11-19 Arizona Board Of Regents On Behalf Of Arizona State University Nucleic acid-guided ordered protein assemblies and methods
US20160195546A1 (en) 2015-01-07 2016-07-07 Arizona Board Of Regents On Behalf Of Arizona State University Type 1 Diabetes Biomarkers
EP4282977B1 (de) 2015-04-10 2024-06-05 10x Genomics Sweden AB Räumlich getrennte multiplex-nukleinsäureanalyse von biologischen proben
WO2017054058A1 (en) 2015-09-30 2017-04-06 Immunexpress Pty Ltd Pathogen biomarkers and uses therefor
US20200371099A1 (en) 2015-12-24 2020-11-26 Immunexpress Pty Ltd Triage biomarkers and uses therefor
CN119574873A (zh) 2016-05-02 2025-03-07 Encodia公司 采用核酸编码的大分子分析
US10055620B2 (en) * 2017-01-13 2018-08-21 International Business Machines Corporation Baggage handling
US10648978B2 (en) 2017-02-09 2020-05-12 Mayo Foundation For Medical Education And Research Methods for detecting novel autoantibodies in Crohn's disease
CN111480079A (zh) * 2017-10-16 2020-07-31 伊纳诺生物股份有限公司 疾病蛋白质组蛋白质阵列及其应用
SG11202003923PA (en) 2017-10-31 2020-05-28 Encodia Inc Methods and kits using nucleic acid encoding and/or label
US11513126B2 (en) 2017-10-31 2022-11-29 Encodia, Inc. Kits for analysis using nucleic acid encoding and/or label
WO2019217916A1 (en) 2018-05-10 2019-11-14 The Methodist Hospital Methods for prognosis and management of disease
US11519033B2 (en) 2018-08-28 2022-12-06 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
WO2020123311A2 (en) 2018-12-10 2020-06-18 10X Genomics, Inc. Resolving spatial arrays using deconvolution
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
WO2020243579A1 (en) 2019-05-30 2020-12-03 10X Genomics, Inc. Methods of detecting spatial heterogeneity of a biological sample
EP4055185A1 (de) 2019-11-08 2022-09-14 10X Genomics, Inc. Räumlich markierte analytfänger für analyt-multiplexing
EP4025711A2 (de) 2019-11-08 2022-07-13 10X Genomics, Inc. Erhöhung der spezifität einer analytbindung
CN115135984B (zh) 2019-12-23 2025-12-23 10X基因组学有限公司 可逆固定试剂及其使用方法
US12241890B2 (en) 2019-12-23 2025-03-04 10X Genomics, Inc. Methods for generating barcoded nucleic acid molecules using fixed cells
DK3891300T3 (da) 2019-12-23 2023-05-22 10X Genomics Inc Fremgangsmåder til rumlig analyse ved anvendelse af rna-template-ligering
US12365942B2 (en) 2020-01-13 2025-07-22 10X Genomics, Inc. Methods of decreasing background on a spatial array
US12405264B2 (en) 2020-01-17 2025-09-02 10X Genomics, Inc. Electrophoretic system and method for analyte capture
US11702693B2 (en) 2020-01-21 2023-07-18 10X Genomics, Inc. Methods for printing cells and generating arrays of barcoded cells
US11732299B2 (en) 2020-01-21 2023-08-22 10X Genomics, Inc. Spatial assays with perturbed cells
US20210230681A1 (en) 2020-01-24 2021-07-29 10X Genomics, Inc. Methods for spatial analysis using proximity ligation
US11821035B1 (en) 2020-01-29 2023-11-21 10X Genomics, Inc. Compositions and methods of making gene expression libraries
US12076701B2 (en) 2020-01-31 2024-09-03 10X Genomics, Inc. Capturing oligonucleotides in spatial transcriptomics
US11898205B2 (en) 2020-02-03 2024-02-13 10X Genomics, Inc. Increasing capture efficiency of spatial assays
US12110541B2 (en) 2020-02-03 2024-10-08 10X Genomics, Inc. Methods for preparing high-resolution spatial arrays
US11732300B2 (en) 2020-02-05 2023-08-22 10X Genomics, Inc. Increasing efficiency of spatial analysis in a biological sample
US12129516B2 (en) 2020-02-07 2024-10-29 10X Genomics, Inc. Quantitative and automated permeabilization performance evaluation for spatial transcriptomics
US11835462B2 (en) 2020-02-11 2023-12-05 10X Genomics, Inc. Methods and compositions for partitioning a biological sample
US12399123B1 (en) 2020-02-14 2025-08-26 10X Genomics, Inc. Spatial targeting of analytes
US12281357B1 (en) 2020-02-14 2025-04-22 10X Genomics, Inc. In situ spatial barcoding
US11891654B2 (en) 2020-02-24 2024-02-06 10X Genomics, Inc. Methods of making gene expression libraries
US11926863B1 (en) 2020-02-27 2024-03-12 10X Genomics, Inc. Solid state single cell method for analyzing fixed biological cells
US11768175B1 (en) 2020-03-04 2023-09-26 10X Genomics, Inc. Electrophoretic methods for spatial analysis
ES3014967T3 (en) 2020-04-22 2025-04-28 10X Genomics Inc Methods for spatial analysis using targeted rna depletion
US12416603B2 (en) 2020-05-19 2025-09-16 10X Genomics, Inc. Electrophoresis cassettes and instrumentation
EP4153776B1 (de) 2020-05-22 2025-03-05 10X Genomics, Inc. Räumliche analyse zur erkennung von sequenzvarianten
EP4414459B1 (de) 2020-05-22 2025-09-03 10X Genomics, Inc. Simultane räumlich-zeitliche messung der genexpression und der zellaktivität
WO2021242834A1 (en) 2020-05-26 2021-12-02 10X Genomics, Inc. Method for resetting an array
EP4025692A2 (de) 2020-06-02 2022-07-13 10X Genomics, Inc. Nukleinsäure-bibliotheksverfahren
EP4158054B1 (de) 2020-06-02 2025-04-16 10X Genomics, Inc. Räumliche transkriptomik für antigenrezeptoren
US12265079B1 (en) 2020-06-02 2025-04-01 10X Genomics, Inc. Systems and methods for detecting analytes from captured single biological particles
US12031177B1 (en) 2020-06-04 2024-07-09 10X Genomics, Inc. Methods of enhancing spatial resolution of transcripts
EP4421186B1 (de) 2020-06-08 2025-08-13 10X Genomics, Inc. Verfahren zur bestimmung eines chirurgischen randes und verfahren zur verwendung davon
WO2021252747A1 (en) 2020-06-10 2021-12-16 1Ox Genomics, Inc. Fluid delivery methods
US12435363B1 (en) 2020-06-10 2025-10-07 10X Genomics, Inc. Materials and methods for spatial transcriptomics
WO2021252591A1 (en) 2020-06-10 2021-12-16 10X Genomics, Inc. Methods for determining a location of an analyte in a biological sample
EP4450639B1 (de) 2020-06-25 2025-10-15 10X Genomics, Inc. Räumliche analyse der dna-methylierung
US11761038B1 (en) 2020-07-06 2023-09-19 10X Genomics, Inc. Methods for identifying a location of an RNA in a biological sample
US11981960B1 (en) 2020-07-06 2024-05-14 10X Genomics, Inc. Spatial analysis utilizing degradable hydrogels
US12209280B1 (en) 2020-07-06 2025-01-28 10X Genomics, Inc. Methods of identifying abundance and location of an analyte in a biological sample using second strand synthesis
US12553898B1 (en) 2020-08-10 2026-02-17 10X Genomics, Inc. Fluorescent hybridization of antibody-oligonucleotide for multiplexing and signal amplification
US11981958B1 (en) 2020-08-20 2024-05-14 10X Genomics, Inc. Methods for spatial analysis using DNA capture
EP4214678B1 (de) 2020-09-18 2024-11-06 10X Genomics, Inc. Probenhandhabungsvorrichtung und bildregistrierungsverfahren
US11926822B1 (en) 2020-09-23 2024-03-12 10X Genomics, Inc. Three-dimensional spatial analysis
US11827935B1 (en) 2020-11-19 2023-11-28 10X Genomics, Inc. Methods for spatial analysis using rolling circle amplification and detection probes
WO2022140028A1 (en) 2020-12-21 2022-06-30 10X Genomics, Inc. Methods, compositions, and systems for capturing probes and/or barcodes
WO2022178267A2 (en) 2021-02-19 2022-08-25 10X Genomics, Inc. Modular assay support devices
WO2022198068A1 (en) 2021-03-18 2022-09-22 10X Genomics, Inc. Multiplex capture of gene and protein expression from a biological sample
EP4305196B1 (de) 2021-04-14 2025-04-02 10X Genomics, Inc. Verfahren zur messung der fehllokalisierung eines analyten
WO2022236054A1 (en) 2021-05-06 2022-11-10 10X Genomics, Inc. Methods for increasing resolution of spatial analysis
EP4582555A3 (de) 2021-06-03 2025-10-22 10X Genomics, Inc. Verfahren, zusammensetzungen, kits und systeme zur verbesserung der analyterfassung zur räumlichen analyse
US12553805B2 (en) 2021-08-02 2026-02-17 10X Genomics, Inc. Methods of preserving a biological sample
EP4196605B1 (de) 2021-09-01 2024-12-04 10X Genomics, Inc. Verfahren zur blockierung einer erfassungssonde auf einer räumlichen anordnung
WO2023086880A1 (en) 2021-11-10 2023-05-19 10X Genomics, Inc. Methods, compositions, and kits for determining the location of an analyte in a biological sample
WO2023102118A2 (en) 2021-12-01 2023-06-08 10X Genomics, Inc. Methods, compositions, and systems for improved in situ detection of analytes and spatial analysis
EP4441711A1 (de) 2021-12-20 2024-10-09 10X Genomics, Inc. Selbsttest für eine pathologie-/histologie-objektträgerbildgebungsvorrichtung
EP4482979B1 (de) 2022-11-09 2025-10-01 10X Genomics, Inc. Verfahren, zusammensetzungen und kits zur bestimmung der position mehrerer analyten in einer biologischen probe

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2028165A (en) * 1978-08-17 1980-03-05 Pilkington Brothers Ltd Treatment of flat glass
NL8102178A (nl) * 1981-05-02 1982-12-01 Stichting Centraal Lab Werkwijze voor het aantonen van tegen bepaalde antigenen gerichte antistoffen, alsmede inrichting en reagentia voor het uitvoeren van deze werkwijze.
SE8801070D0 (sv) * 1988-03-23 1988-03-23 Pharmacia Ab Method for immobilizing a dna sequence on a solid support
US4868311A (en) * 1988-04-02 1989-09-19 The Trustees Of Columbia University In The City Of New York Biotinylated psoralens
JPH04504651A (ja) * 1988-11-18 1992-08-20 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 自然に存在しないアミノ酸をタンパク質に部位特異的に導入する方法
US6919211B1 (en) * 1989-06-07 2005-07-19 Affymetrix, Inc. Polypeptide arrays
US5744101A (en) * 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5800992A (en) * 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US6346413B1 (en) * 1989-06-07 2002-02-12 Affymetrix, Inc. Polymer arrays
US5874564A (en) * 1990-03-21 1999-02-23 Isis Pharmaceuticals, Inc. Reagents and methods for modulating gene expression through RNA mimicry
US5283179A (en) * 1990-09-10 1994-02-01 Promega Corporation Luciferase assay method
US6399296B1 (en) * 1994-07-20 2002-06-04 The General Hospital Corporation Interaction trap systems for detecting protein interactions
US6143557A (en) * 1995-06-07 2000-11-07 Life Technologies, Inc. Recombination cloning using engineered recombination sites
NZ312332A (en) * 1995-06-07 2000-01-28 Life Technologies Inc Recombinational cloning using engineered recombination sites
US5691152A (en) * 1995-11-09 1997-11-25 E. R. Squibb & Sons, Inc. Stable avidin composition
US5854033A (en) * 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
JPH1025299A (ja) 1996-07-12 1998-01-27 Nec Corp 整列ペプチド、及びそれを用いたタンパク質の結合・相互作用部位検出方法
SE9604108D0 (sv) * 1996-11-08 1996-11-08 Maans Ehrenberg A method for the labelling of polypeptides and novel labelled polypeptides
ATE529509T1 (de) 1997-01-21 2011-11-15 Gen Hospital Corp Selektion von proteinen unter verwendung von rna- protein-fusionen
WO1999006833A1 (en) 1997-07-29 1999-02-11 Huston James S Methods for obtaining probes of peptide function
US6207370B1 (en) * 1997-09-02 2001-03-27 Sequenom, Inc. Diagnostics based on mass spectrometric detection of translated target polypeptides
JP4524445B2 (ja) * 1997-09-03 2010-08-18 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング タンパク質のスクリーニング方法
US6511803B1 (en) 1997-10-10 2003-01-28 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
US6303323B1 (en) * 1997-10-21 2001-10-16 Cancer Research Campaign Technology Limited Detection of dysplastic or neoplastic cells using anti-MCM5 antibodies
US5922617A (en) * 1997-11-12 1999-07-13 Functional Genetics, Inc. Rapid screening assay methods and devices
US6914137B2 (en) * 1997-12-06 2005-07-05 Dna Research Innovations Limited Isolation of nucleic acids
AU3463699A (en) * 1998-04-03 1999-10-25 Phylos, Inc. Addressable protein arrays
US6406921B1 (en) 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US6780582B1 (en) * 1998-07-14 2004-08-24 Zyomyx, Inc. Arrays of protein-capture agents and methods of use thereof
EP1018408B1 (de) * 1998-12-28 2002-10-02 Adolf Mohr Maschinenfabrik GmbH & Co. KG Planschneidmaschine zum Schneiden von gestapeltem, blattförmigem Gut
US6251601B1 (en) 1999-02-02 2001-06-26 Vysis, Inc. Simultaneous measurement of gene expression and genomic abnormalities using nucleic acid microarrays
US6225061B1 (en) * 1999-03-10 2001-05-01 Sequenom, Inc. Systems and methods for performing reactions in an unsealed environment
AU773291B2 (en) 1999-03-10 2004-05-20 Government of The United States of America, as represented by The Secretary Department of Health & Human Services, The National Institutes of Health, The UPA, a universal protein array system
GB9917027D0 (en) 1999-07-20 1999-09-22 Affibody Technology Sweeden Ab In vitro selection and optional identification of polypeptides using solid support carriers
GB9928787D0 (en) 1999-12-03 2000-02-02 Medical Res Council Direct screening method
CA2396320A1 (en) 2000-01-11 2001-07-19 Maxygen, Inc. Integrated systems and methods for diversity generation and screening
US7816098B2 (en) * 2000-01-31 2010-10-19 Sense Proteomic Limited Methods of making and using a protein array
CA2369742A1 (en) 2000-01-31 2001-08-09 Sense Proteomic Limited Methods of generating protein expression arrays and the use thereof in rapid screening
WO2001079849A2 (en) * 2000-04-17 2001-10-25 Trans Tech Pharma Protein expression system arrays and use in biological screening
CA2408291C (en) 2000-05-04 2014-07-15 Yale University High density protein arrays for screening of protein activity
US20020049152A1 (en) 2000-06-19 2002-04-25 Zyomyx, Inc. Methods for immobilizing polypeptides
PT1292710E (pt) 2000-06-23 2007-12-04 Domantis Ltd Método de rastreio de matriz
US6706474B1 (en) * 2000-06-27 2004-03-16 Board Of Trustees Of The University Of Illinois Nucleic acid enzyme biosensors for ions
EP1307285A2 (de) * 2000-08-03 2003-05-07 Massachusetts Institute Of Technology Mikroarrays von funktionellen biomolekülen und deren verwendung
ES2266224T3 (es) 2000-08-15 2007-03-01 Discerna Limited Series de proteinas funcionales.
AU2001285252A1 (en) 2000-08-25 2002-03-13 Gendaq, Ltd. Analysis of binding interactions
US6420150B1 (en) * 2000-11-27 2002-07-16 Pe Corporation (Ny) Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof
US6551786B2 (en) * 2001-01-04 2003-04-22 Myriad Genetics, Inc. Screen assay for selecting protein-protein interaction modulators
ATE538380T1 (de) 2001-01-23 2012-01-15 Harvard College Nukleinsäure-programmierbare protein-arrays
US20020168640A1 (en) * 2001-02-22 2002-11-14 Min Li Biochips comprising nucleic acid/protein conjugates
EP1412725B1 (de) * 2001-06-29 2019-01-09 Meso Scale Technologies LLC Multi-well-platten für lumineszenz-testmessungen
US6929944B2 (en) 2001-08-31 2005-08-16 Beckman Coulter, Inc. Analysis using a distributed sample
WO2003031591A2 (en) 2001-10-10 2003-04-17 Superarray Bioscience Corporation Detecting targets by unique identifier nucleotide tags
JP2005528612A (ja) 2002-06-03 2005-09-22 パムジーン ビー．ブイ． 生体分子の相互作用をモニターするための新規方法
JP2005538108A (ja) 2002-07-29 2005-12-15 ポトマック， ファーマ， エルエルシー α−２アドレナリン作動性レセプターアンタゴニストと非定型抗精神病薬精神安定薬との抗精神病薬組み合わせ治療および組成物
AU2003301253A1 (en) 2002-10-18 2004-05-04 Massachusetts Mental Health Institute TREATING ALCOHOL AND OR SUBSTANCE ABUSE BY ANTAGONIZING Alpha 2 ADRENERGIC RECEPTORS WITH WEAK DOPAMINE BLOCKING
US20040076961A1 (en) * 2002-10-21 2004-04-22 Lewis Mark A. Biomolecule retaining material and methods for attaching biomolecules to a surface
US7276283B2 (en) * 2004-03-24 2007-10-02 Wisconsin Alumni Research Foundation Plasma-enhanced functionalization of carbon-containing substrates
US20050260653A1 (en) * 2004-04-14 2005-11-24 Joshua Labaer Nucleic-acid programmable protein arrays
US20060099704A1 (en) * 2004-07-14 2006-05-11 Predki Paul F Method for providing protein microarrays
US20060207467A1 (en) * 2005-03-19 2006-09-21 Bailey Samuel W Low voltage pyrotechnic igniter assembly
GB0511717D0 (en) * 2005-06-09 2005-07-13 Babraham Inst Repeatable protein arrays
US8178316B2 (en) * 2006-06-29 2012-05-15 President And Fellows Of Harvard College Evaluating proteins

Also Published As

Publication number Publication date
EP1360490A4 (de) 2007-11-28
JP2004536565A (ja) 2004-12-09
US6800453B2 (en) 2004-10-05
JP4880188B2 (ja) 2012-02-22
EP1360490B1 (de) 2011-12-21
JP2010119392A (ja) 2010-06-03
CA2434139A1 (en) 2002-08-01
US20050048580A1 (en) 2005-03-03
CA2434139C (en) 2014-05-27
EP1360490A1 (de) 2003-11-12
US8609344B2 (en) 2013-12-17
JP2009150897A (ja) 2009-07-09
WO2002059601A1 (en) 2002-08-01
US20020192673A1 (en) 2002-12-19

Similar Documents

Publication Publication Date Title
ATE538380T1 (de) Nukleinsäure-programmierbare protein-arrays
DK1448595T3 (da) Antimikrobielle polypeptider
DK1214097T3 (da) Nukleinsyrer kodende for polyepitop-polypeptider
IL199259A0 (en) Artificial receptors, building blocks, and methods
BR0308735B1 (pt) escova de dente acionada.
DE50200723D1 (de) Ansteuerschaltung für ein LED-Array
EP1423136A4 (de) Polypeptid-konjugate mit verlängerten zirkulierenden halbwertszeiten
DE602004016101D1 (de) Antennenanordnung
DK1436309T3 (da) BGL3-beta-glukosidase og nukleinsyrer kodende derfor
BR0316733B1 (pt) transportador linear de catodo.
DK0981631T3 (da) Polypeptider, som har aminopeptidase-aktivitet, og nukleinsyrer, som koder for samme
BR9916507A (pt) Proteìnas
DK1379695T3 (da) Nye polynukleotider og polypeptider af IFNalfa-21-genet
ITMI20021038A1 (it) Disposizione di elettrodi
DE60330489D1 (de) Schnell abgebaute reporter-fusionsproteine
IL158984A0 (en) Use of duckweed in high throughput screening
AU2003284127A8 (en) Nucleic acid supported protein complementation
ITWX20020018A1 (it) Apparato di localizzazioone sonar.
DK1558640T3 (da) Trimerbindende proteiner til trimer-cytokiner
DK1196607T3 (da) Antibakterielt chlamysin B-protein, gen kodende derfor samt ekspressionssystem
DE10303540A8 (de) Antennenanordnung
DE60039708D1 (de) Menschliches chordin und polynukleotiden die dafür kodieren
DE60209984D1 (de) Verlustfreier optischer Verteiler
NL1012028A1 (nl) Aminozuursequentie.
NO20024029L (no) Nytt protein og gen som koder for proteinet