ATE538780T1 - Medizinische zusammensetzung, enthaltend ein hmg- coa reduktase inhibitor und ein aminoalkohol derivat, als immunsuppressivum - Google Patents

Medizinische zusammensetzung, enthaltend ein hmg- coa reduktase inhibitor und ein aminoalkohol derivat, als immunsuppressivum

Info

Publication number: ATE538780T1
Authority: AT; Austria
Prior art keywords: hmg; coa reductase; amino alcohol; alcohol derivative; immunosupressant
Prior art date: 2004-07-29

Application number

AT05767088T

Other languages

English (en)

Inventor

Takahide Nishi

Takaichi Shimozato

Takashi Kagari

Hiromi Doi

Original Assignee

Daiichi Sankyo Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-07-29

Filing date

2005-07-28

Publication date

2012-01-15

2005-07-28 Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd

2012-01-15 Application granted granted Critical

2012-01-15 Publication of ATE538780T1 publication Critical patent/ATE538780T1/de

Links

229940121710 HMGCoA reductase inhibitor Drugs 0.000 title abstract 2
150000001414 amino alcohols Chemical class 0.000 title abstract 2
239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 title abstract 2
239000001257 hydrogen Substances 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
230000003053 immunization Effects 0.000 abstract 1
238000002649 immunization Methods 0.000 abstract 1
150000002829 nitrogen Chemical class 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 abstract 1
230000003449 preventive effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/133—Amines having hydroxy groups, e.g. sphingosine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Emergency Medicine (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biophysics (AREA)
Transplantation (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyrrole Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT05767088T 2004-07-29 2005-07-28 Medizinische zusammensetzung, enthaltend ein hmg- coa reduktase inhibitor und ein aminoalkohol derivat, als immunsuppressivum ATE538780T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2004222420		2004-07-29
PCT/JP2005/013843 WO2006011554A1 (ja)	2004-07-29	2005-07-28	免疫抑制剤としての医薬組成物

Publications (1)

Publication Number	Publication Date
ATE538780T1 true ATE538780T1 (de)	2012-01-15

Family

ID=35786302

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05767088T ATE538780T1 (de)	2004-07-29	2005-07-28	Medizinische zusammensetzung, enthaltend ein hmg- coa reduktase inhibitor und ein aminoalkohol derivat, als immunsuppressivum

Country Status (10)

Country	Link
US (1)	US20070149597A1 (de)
EP (1)	EP1782804B1 (de)
KR (1)	KR20070042986A (de)
CN (1)	CN101027048A (de)
AT (1)	ATE538780T1 (de)
BR (1)	BRPI0513888A (de)
CA (1)	CA2575518A1 (de)
ES (1)	ES2377975T3 (de)
TW (1)	TW200611687A (de)
WO (1)	WO2006011554A1 (de)

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MXPA04006709A (es) *	2002-01-11	2004-10-04	Sankyo Co	Derivados de aminoalcohol o derivados de acido fosfonico y composiciones farmaceuticas que los contienen.
KR20110136901A (ko)	2004-02-24	2011-12-21	상꾜 가부시키가이샤	아미노 알코올 화합물
CN101905023B (zh) *	2004-07-16	2012-07-11	杏林制药株式会社	有效的医药使用方法及与副作用发生的防御相关的方法
PL1806338T3 (pl)	2004-10-12	2016-07-29	Kyorin Seiyaku Kk	Sposób wytwarzania chlorowodorku 2-amino-2-[2-[4-(3-benzyloksyfenylotio)-2-chlorofenyio]etylo]-1,3-propanodioiu i jego hydratów oraz produkty pośrednie w ich wytwarzaniu
TWI418350B (zh) *	2005-06-24	2013-12-11	Sankyo Co	含有ｐｐａｒ調節劑之醫藥組成物的用途
SI1932522T1 (sl) *	2005-10-07	2012-08-31	Kyorin Seiyaku Kk	Terapevtsko sredstvo za jetrno bolezen, ki vsebuje 2-amino-1,3- propandiolni derivat kot aktivno sestavino
RU2433117C2 (ru) *	2005-12-15	2011-11-10	Мицубиси Танабе Фарма Корпорейшн	Аминное соединение и его применение в медицинских целях
TWI389683B (zh) *	2006-02-06	2013-03-21	Kyorin Seiyaku Kk	A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient
RU2430925C2 (ru) *	2006-08-08	2011-10-10	Киорин Фармасьютикал Ко., Лтд.	Производное аминофосфата и модулятор рецептора s1p, содержащий его в качестве активного ингредиента
CA2659599C (en) *	2006-08-08	2014-06-17	Kyorin Pharmaceutical Co., Ltd.	Amino alcohol derivative and immunosuppressive agent having same as an active ingredient
EP2217561A2 (de) *	2007-11-02	2010-08-18	Concert Pharmaceuticals, Inc.	Deuteriertes fingolimod
JP5452237B2 (ja) *	2008-02-07	2014-03-26	杏林製薬株式会社	アミノアルコール誘導体を有効成分とする炎症性腸疾患の治療剤又は予防剤
CN104311472B9 (zh)	2008-07-23	2020-03-17	艾尼纳制药公司	经取代的1,2,3,4-四氢环戊并[b]吲哚-3-基乙酸衍生物
PL2342205T4 (pl)	2008-08-27	2016-12-30		Podstawione tricykliczne pochodne kwasowe jako antagoniści receptora S1P1 użyteczni w leczeniu zaburzeń autoimmunologicznych i zapalnych
EP2528894A1 (de)	2010-01-27	2012-12-05	Arena Pharmaceuticals, Inc.	Verfahren zur herstellung von (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)essigsäure und salzen daraus
TW201130488A (en) *	2010-02-03	2011-09-16	Daiichi Sankyo Co Ltd	Pyrrole compound
CN105503882B (zh)	2010-03-03	2019-07-05	艾尼纳制药公司	制备s1p1受体调节剂及其晶体形式的方法
BE1019432A3 (fr) *	2010-07-23	2012-07-03	Auriga Internat	Utilisation d'isothiocyanates et derives pour le traitement et/ou la prevention des lucites.
CA3002540C (en)	2015-01-06	2023-11-07	Arena Pharmaceuticals, Inc.	Use of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid for treating conditions related to the s1p1 receptor
JP6838744B2 (ja)	2015-06-22	2021-03-03	アリーナファーマシューティカルズ，インコーポレイテッド	Ｓ１Ｐ１レセプター関連障害における使用のための（Ｒ）−２−（７−（４−シクロペンチル−３−（トリフルオロメチル）ベンジルオキシ）−１，２，３，４−テトラヒドロシクロペンタ［ｂ］インドール−３−イル）酢酸（化合物１）の結晶性Ｌ−アルギニン塩
CN110520124A (zh)	2017-02-16	2019-11-29	艾尼纳制药公司	用于治疗原发性胆汁性胆管炎的化合物和方法
KR20190113955A (ko)	2017-02-16	2019-10-08	아레나 파마슈티칼스, 인크.	장-외 증상을 갖는 염증성 장질환의 치료를 위한 화합물 및 방법
JP7397011B2 (ja)	2018-06-06	2023-12-12	アリーナファーマシューティカルズ，インコーポレイテッド	Ｓ１ｐ１受容体に関連する状態を治療する方法
EP3847158B1 (de)	2018-09-06	2026-06-24	Arena Pharmaceuticals, Inc.	Verbindungen zur behandlung von autoimmun- und entzündungserkrankungen
CN115697953B (zh)	2020-06-08	2025-07-08	公立大学法人富山县立大学	用作Toll样受体7的活化抑制剂的新型化合物

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KR0155015B1 (ko) *	1992-10-21	1998-12-01	고우야 마사시	2-아미노-1,3-프로판디올 화합물 및 면역 억제제
DE69524962T4 (de) *	1994-08-22	2003-08-28	Mitsubishi Pharma Corp., Osaka	Benzolderivate und deren medizinische verwendung
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CZ200350A3 (cs) *	2000-07-13	2003-05-14	Sankyo Company Limited	Aminoalkoholové deriváty
US20030060500A1 (en) *	2001-09-19	2003-03-27	Francois Mach	Facilitating organ transplantation with statins (HMG-CoA reductase inhibitors)
JP4152884B2 (ja) *	2001-09-27	2008-09-17	杏林製薬株式会社	ジアリールエーテル誘導体とその付加塩及び免疫抑制剤
KR100913269B1 (ko) *	2001-09-27	2009-08-21	교린 세이야꾸 가부시키 가이샤	디아릴 황화물 유도체, 그의 염 및 이를 이용한 면역억제제
MXPA04006709A (es) *	2002-01-11	2004-10-04	Sankyo Co	Derivados de aminoalcohol o derivados de acido fosfonico y composiciones farmaceuticas que los contienen.
CN100516024C (zh) *	2002-09-13	2009-07-22	诺瓦提斯公司	氨基-丙醇衍生物
KR20110136901A (ko) *	2004-02-24	2011-12-21	상꾜 가부시키가이샤	아미노 알코올 화합물
WO2005105146A1 (en) *	2004-05-03	2005-11-10	Novartis Ag	Combinations comprising a s1p receptor agonist and a jak3 kinase inhibitor
CN101905023B (zh) *	2004-07-16	2012-07-11	杏林制药株式会社	有效的医药使用方法及与副作用发生的防御相关的方法
TWI418350B (zh) *	2005-06-24	2013-12-11	Sankyo Co	含有ｐｐａｒ調節劑之醫藥組成物的用途

2005
- 2005-07-27 TW TW094125360A patent/TW200611687A/zh unknown
- 2005-07-28 CA CA002575518A patent/CA2575518A1/en not_active Abandoned
- 2005-07-28 KR KR1020077002005A patent/KR20070042986A/ko not_active Withdrawn
- 2005-07-28 BR BRPI0513888-4A patent/BRPI0513888A/pt not_active IP Right Cessation
- 2005-07-28 AT AT05767088T patent/ATE538780T1/de active
- 2005-07-28 EP EP05767088A patent/EP1782804B1/de not_active Expired - Lifetime
- 2005-07-28 WO PCT/JP2005/013843 patent/WO2006011554A1/ja not_active Ceased
- 2005-07-28 CN CNA2005800323933A patent/CN101027048A/zh active Pending
- 2005-07-28 ES ES05767088T patent/ES2377975T3/es not_active Expired - Lifetime
2007
- 2007-01-26 US US11/698,698 patent/US20070149597A1/en not_active Abandoned

Also Published As

Publication number	Publication date
BRPI0513888A (pt)	2008-05-20
US20070149597A1 (en)	2007-06-28
EP1782804A1 (de)	2007-05-09
TW200611687A (en)	2006-04-16
CA2575518A1 (en)	2006-02-02
CN101027048A (zh)	2007-08-29
KR20070042986A (ko)	2007-04-24
EP1782804B1 (de)	2011-12-28
EP1782804A4 (de)	2010-12-15
WO2006011554A1 (ja)	2006-02-02
ES2377975T3 (es)	2012-04-03

Publication	Publication Date	Title
EP1782804A4 (de)	2010-12-15	Medizinische zusammensetzung als immunsuppressivum
WO2008146871A1 (ja)	2008-12-04	グルココルチコイド受容体結合活性を有する、スルホン酸エステル又はスルホン酸アミド構造を導入したフェニル基を置換基として有する新規１，２，３，４－テトラヒドロキノキサリン誘導体
EP1780209A4 (de)	2009-06-03	Oximesterverbindung und photopolymerisationsinitiator, der eine solche verbindung enthält
ATE556058T1 (de)	2012-05-15	1-(2h)-isochinolonderivat
DK1265606T3 (da)	2007-02-12	Celleadhæsionsinhibitorer
ATE488490T1 (de)	2010-12-15	Tripentylcitrate und deren verwendung als weichmacher
WO2005105732A8 (en)	2007-04-19	Substituted methyl aryl or heteroaryl amide compounds
DE60043349D1 (de)	2009-12-31	Chinazolin-derivate und ihre verwendung als arzneimittel
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