ATE540016T1 - Verfahren zur herstellung von 21-4'- (nitrooxyalkyl)benzoatü corticosteroidderivaten und für deren synthese geeignete zwischenprodukte - Google Patents

Verfahren zur herstellung von 21-4'- (nitrooxyalkyl)benzoatü corticosteroidderivaten und für deren synthese geeignete zwischenprodukte

Info

Publication number: ATE540016T1
Authority: AT; Austria
Prior art keywords: nitrooxyalkyl; benzoate; synthesis; producing; intermediate products
Prior art date: 2001-05-22

Application number

AT02771861T

Other languages

English (en)

Inventor

Donald Mcintyre

Original Assignee

Nicox Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-05-22

Filing date

2002-05-22

Publication date

2012-01-15

2002-05-22 Application filed by Nicox Sa filed Critical Nicox Sa

2012-01-15 Application granted granted Critical

2012-01-15 Publication of ATE540016T1 publication Critical patent/ATE540016T1/de

Links

229940051868 antimigraine drug corticosteroid derivative Drugs 0.000 title abstract 3
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 title abstract 3
230000015572 biosynthetic process Effects 0.000 title 1
239000013067 intermediate product Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
239000000543 intermediate Substances 0.000 abstract 2

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT02771861T 2001-05-22 2002-05-22 Verfahren zur herstellung von 21-4'- (nitrooxyalkyl)benzoatü corticosteroidderivaten und für deren synthese geeignete zwischenprodukte ATE540016T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US29279201P	2001-05-22	2001-05-22
US10/152,433 US6696592B2 (en)	2001-05-22	2002-05-21	Methods of making 21-[4′-(nitrooxyalkyl)benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof
PCT/US2002/016107 WO2002094758A1 (en)	2001-05-22	2002-05-22	Methods of making 21-[4'-(nitrooxyalkyl) benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof

Publications (1)

Publication Number	Publication Date
ATE540016T1 true ATE540016T1 (de)	2012-01-15

Family

ID=26849555

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02771861T ATE540016T1 (de)	2001-05-22	2002-05-22	Verfahren zur herstellung von 21-4'- (nitrooxyalkyl)benzoatü corticosteroidderivaten und für deren synthese geeignete zwischenprodukte

Country Status (6)

Country	Link
US (1)	US6696592B2 (de)
EP (1)	EP1395544B1 (de)
AT (1)	ATE540016T1 (de)
CA (1)	CA2448296C (de)
ES (1)	ES2379871T3 (de)
WO (1)	WO2002094758A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2006008196A1 (en) *	2004-07-20	2006-01-26	Nicox S.A.	Process for preparing nitrooxy esters, nitrooxy thioesters, nitrooxy carbonates and nitrooxy thiocarbonates, intermediates useful in said process and preparation thereof
US8277780B2 (en) *	2005-05-27	2012-10-02	Taro Pharmaceutical North America, Inc.	Stable liquid desoximethasone compositions with reduced oxidized impurity
US20090087425A1 (en) *	2007-08-10	2009-04-02	Topigen Pharmaceuticals Inc.	Combination of nitroderivatized steroid and bronchodilator for treating respiratory disease
US8208860B2 (en) *	2009-11-03	2012-06-26	International Business Machines Corporation	Reducing multipath signal degradation effects in a wireless transmission system
ES2359708B1 (es) *	2009-11-16	2012-03-30	Ferrer Internacional S.A.	Procedimiento de preparación de la (11beta,16alfa)-9-fluoro-11-hidroxi-16,17-[1-metil-etilidenebis(oxi)]-21-[1-oxo-[4-(nitrooximetil)benzoxi]]preña-1,4-dien-3,20-diona.

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB834400A (en)	1957-10-04	1960-05-04	Chimiotherapie Lab Franc	Steroid compounds and their preparation
DE2703543C2 (de)	1977-01-26	1985-06-05	Schering AG, 1000 Berlin und 4709 Bergkamen	2l-(3-Benzoylpropionyloxy)-11β,17α-dihydroxy-1,4-pregnadien-3,20-dion, Verfahren zu seiner Herstellung und diese Verbindung enthaltende pharmazeutische Präparate
DE3434448A1 (de)	1984-09-17	1986-03-27	Schering AG, 1000 Berlin und 4709 Bergkamen	Verfahren zur herstellung von pregnan-derivaten
IT1256450B (it)	1992-11-26	1995-12-05	Soldato Piero Del	Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
DE4321306A1 (de) *	1993-06-26	1995-01-05	Sanol Arznei Schwarz Gmbh	Disulfide
JP3775796B2 (ja)	1993-10-06	2006-05-17	ニコックスエスエイ	抗炎症活性及び／又は鎮痛活性を有する硝酸エステル類及びそれらの製造方法
CA2136803A1 (en)	1993-12-22	1995-06-23	Kazumi Ogata	Steroid derivatives
RU2145595C1 (ru)	1994-05-10	2000-02-20	Никокс С.А.	Нитроксисоединения и фармацевтическая композиция на их основе, имеющие противовоспалительную, анальгетическую и антитромбоцитарную активности
IT1276071B1 (it)	1995-10-31	1997-10-24	Nicox Ltd	Compositi ad attivita' anti-infiammatoria
US5985862A (en)	1996-05-02	1999-11-16	G.D. Searle & Co.	Pharmaceutical compositions having steroid nitrate ester derivatives useful as anti-inflammatory drugs
IT1285770B1 (it)	1996-10-04	1998-06-18	Nicox Sa	Composti corticoidei
IT1311922B1 (it)	1999-04-13	2002-03-20	Nicox Sa	Composti farmaceutici.

2002
- 2002-05-21 US US10/152,433 patent/US6696592B2/en not_active Expired - Fee Related
- 2002-05-22 WO PCT/US2002/016107 patent/WO2002094758A1/en not_active Ceased
- 2002-05-22 EP EP02771861A patent/EP1395544B1/de not_active Expired - Lifetime
- 2002-05-22 ES ES02771861T patent/ES2379871T3/es not_active Expired - Lifetime
- 2002-05-22 CA CA2448296A patent/CA2448296C/en not_active Expired - Fee Related
- 2002-05-22 AT AT02771861T patent/ATE540016T1/de active

Also Published As

Publication number	Publication date
US6696592B2 (en)	2004-02-24
ES2379871T3 (es)	2012-05-04
EP1395544A4 (de)	2009-05-27
WO2002094758A1 (en)	2002-11-28
CA2448296A1 (en)	2002-11-28
US20030153545A1 (en)	2003-08-14
EP1395544B1 (de)	2012-01-04
EP1395544A1 (de)	2004-03-10
CA2448296C (en)	2011-07-05

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