ATE540932T1 - Hydantoin-derivate als antibakterielle wirkstoffe - Google Patents
Hydantoin-derivate als antibakterielle wirkstoffeInfo
- Publication number
- ATE540932T1 ATE540932T1 AT07811615T AT07811615T ATE540932T1 AT E540932 T1 ATE540932 T1 AT E540932T1 AT 07811615 T AT07811615 T AT 07811615T AT 07811615 T AT07811615 T AT 07811615T AT E540932 T1 ATE540932 T1 AT E540932T1
- Authority
- AT
- Austria
- Prior art keywords
- active ingredients
- antibacterial active
- hydantoin derivatives
- hydantoin
- derivatives
- Prior art date
Links
- 239000004480 active ingredient Substances 0.000 title 1
- 230000000844 anti-bacterial effect Effects 0.000 title 1
- 229940053195 antiepileptics hydantoin derivative Drugs 0.000 title 1
- WJRBRSLFGCUECM-UHFFFAOYSA-N hydantoin Chemical class O=C1CNC(=O)N1 WJRBRSLFGCUECM-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
- C07D233/78—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84188306P | 2006-08-31 | 2006-08-31 | |
| PCT/US2007/019063 WO2008027466A1 (en) | 2006-08-31 | 2007-08-29 | Hydantoin derivatives useful as antibacterial agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE540932T1 true ATE540932T1 (de) | 2012-01-15 |
Family
ID=38829662
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07811615T ATE540932T1 (de) | 2006-08-31 | 2007-08-29 | Hydantoin-derivate als antibakterielle wirkstoffe |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7998961B2 (de) |
| EP (1) | EP2057127B1 (de) |
| JP (1) | JP2010502617A (de) |
| CN (1) | CN101528711A (de) |
| AT (1) | ATE540932T1 (de) |
| CA (1) | CA2661605A1 (de) |
| MX (1) | MX2009002347A (de) |
| WO (1) | WO2008027466A1 (de) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7504424B2 (en) * | 2004-07-16 | 2009-03-17 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
| US7488745B2 (en) * | 2004-07-16 | 2009-02-10 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
| BRPI0513433A (pt) | 2004-07-16 | 2008-05-06 | Schering Corp | derivados de hidantoìna para o tratamento de distúrbios inflamatórios |
| WO2007021803A1 (en) * | 2005-08-12 | 2007-02-22 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
| PE20071241A1 (es) * | 2006-01-17 | 2008-01-14 | Schering Corp | Compuestos derivados de hidantoina para el tratamiento de trastornos inflamatorios |
| WO2008027466A1 (en) | 2006-08-31 | 2008-03-06 | Schering Corporation | Hydantoin derivatives useful as antibacterial agents |
| JP5539864B2 (ja) | 2007-06-12 | 2014-07-02 | アカオゲン，インコーポレーテッド | 抗菌剤 |
| US20110212078A1 (en) | 2008-06-25 | 2011-09-01 | Reddy Panduranga Adulla P | Synthesis and use of heterocyclic antibacterial agents |
| US8450355B2 (en) | 2008-09-24 | 2013-05-28 | Merck Sharp & Dohme Corp. | Compounds for the treatment of inflammatory diseases |
| AR073307A1 (es) | 2008-09-24 | 2010-10-28 | Schering Corp | Compuestos para el tratamiento de trastornos inflamatorios |
| JP5753785B2 (ja) * | 2008-11-07 | 2015-07-22 | ノバベイ・ファーマシューティカルズ・インコーポレイテッドＮｏｖａｂａｙ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | 抗菌オキサゾリジノン、ヒダントインおよびイミダゾリジノン組成物 |
| WO2010054278A2 (en) | 2008-11-10 | 2010-05-14 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
| US8541572B2 (en) | 2008-11-10 | 2013-09-24 | Merck Sharp & Dohme Corp. | Compounds for the treatment of inflammatory disorders |
| US8835472B2 (en) * | 2010-09-02 | 2014-09-16 | Boehringer Ingelheim International Gmbh | Compounds, pharmaceutical compositions and uses thereof |
| US9738604B2 (en) | 2010-09-03 | 2017-08-22 | Duke University | Ethynylbenzene derivatives |
| CA3006745C (en) * | 2010-11-05 | 2021-03-30 | Oat Agrio Co., Ltd. | Ethynylphenylamidine compound or salt thereof, method for producing same, and fungicide for agricultural and horticultural use |
| EP2847168A1 (de) | 2012-05-10 | 2015-03-18 | Achaogen, Inc. | Antibakterielle wirkstoffe |
| US9580407B2 (en) * | 2012-12-07 | 2017-02-28 | Merck Sharp & Dohme Corp. | Regioselective N-2 arylation of indazoles |
| WO2014165075A1 (en) | 2013-03-12 | 2014-10-09 | Achaogen, Inc. | Antibacterial agents |
| WO2015024010A2 (en) | 2013-08-16 | 2015-02-19 | Duke University | Substituted hydroxamic acid compounds |
| WO2015024011A2 (en) | 2013-08-16 | 2015-02-19 | Duke University | Antibacterial compounds |
| US9908851B2 (en) * | 2013-08-16 | 2018-03-06 | Duke University | 2-piperidinyl substituted N,3-dihydroxybutanamides |
| WO2016057931A1 (en) | 2014-10-10 | 2016-04-14 | The Research Foundation For The State University Of New York | Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration |
| LT3322701T (lt) | 2015-07-15 | 2019-07-10 | F. Hoffmann-La Roche Ag | Etinilo dariniai kaip metabotropinių glutamato receptorių moduliatoriai |
| EP3374355A4 (de) | 2015-11-09 | 2019-04-17 | Forge Therapeutics, Inc. | Verbindungen auf der basis von pyron und verfahren zur behandlung von bakteriellen infektionen |
| ES2909122T3 (es) | 2015-11-09 | 2022-05-05 | Forge Therapeutics Inc | Compuestos a base de hidroxipiridinona e hidroxipirimidinona para el tratamiento de infecciones bacterianas |
| WO2017223349A1 (en) | 2016-06-23 | 2017-12-28 | Achaogen, Inc. | Antibacterial agents |
| CR20190014A (es) | 2016-07-18 | 2019-03-04 | Hoffmann La Roche | Derivados etinilo |
| CN118271233A (zh) | 2017-04-24 | 2024-07-02 | 特沙诺有限公司 | 尼拉帕利的制造方法 |
| WO2018208985A2 (en) | 2017-05-10 | 2018-11-15 | Forge Therapeutics, Inc. | Antibacterial compounds |
| US20200095236A1 (en) * | 2017-05-10 | 2020-03-26 | Forge Therapeutics, Inc. | Antibacterial compounds |
| GB2562777A (en) * | 2017-05-25 | 2018-11-28 | Taisho Pharmaceutical Co Ltd | Novel alpha-amino amide derivatives |
| BR112020017453A2 (pt) * | 2018-03-15 | 2020-12-22 | Pfizer Inc | Fosfatos e boronatos de piridinona e pirimidinona úteis como agentes antibacterianos |
| IL281614B2 (en) | 2018-09-20 | 2024-12-01 | Blacksmith Medicines Inc | Antibacterial compounds |
| WO2021195260A1 (en) | 2020-03-25 | 2021-09-30 | Forge Therapeutics, Inc. | Lpxc inhibitor and methods of making |
| JP7783252B2 (ja) * | 2020-07-29 | 2025-12-09 | ヴィヴォゾン・インコーポレイテッド | ｍＧｌｕＲ５及び５－ＨＴ２Ａ受容体の二重調節剤及びその使用 |
| US20240166609A1 (en) * | 2021-02-11 | 2024-05-23 | Blacksmith Medicines, Inc. | Antibacterial compounds |
| WO2022173756A1 (en) * | 2021-02-11 | 2022-08-18 | Forge Therapeutics, Inc. | Antibacterial compounds |
| WO2023011573A1 (zh) * | 2021-08-05 | 2023-02-09 | 浙江海正药业股份有限公司 | 芳香乙炔类衍生物及其制备方法和用途 |
| JP2024536864A (ja) | 2021-09-28 | 2024-10-08 | ブラックスミス メディシンズ，インク． | Ｌｐｘｃ阻害剤およびその使用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE756848A (fr) | 1969-10-01 | 1971-03-30 | Henkel & Cie Gmbh | Agents d'ecurage a action blanchissante et desinfectante |
| US5346913A (en) | 1992-05-26 | 1994-09-13 | Rohm And Haas Company | N-iodopropargyl hydantoin compounds, compositions, preparation, and use as antimicrobial agents |
| US5925659A (en) | 1996-05-07 | 1999-07-20 | Merck & Co., Inc. | Antibacterial agents |
| US5859190A (en) | 1997-02-04 | 1999-01-12 | Trega Biosciences, Inc. | Combinatorial libraries of hydantoin and thiohydantoin derivatives, methods of making the libraries and compounds therein |
| JP4617449B2 (ja) | 2002-07-11 | 2011-01-26 | ヴィキュロン ファーマシューティカルズ インコーポレイテッド | 抗菌活性を有するｎ−ヒドロキシアミド誘導体 |
| SE0202539D0 (sv) | 2002-08-27 | 2002-08-27 | Astrazeneca Ab | Compounds |
| SG2012000667A (en) | 2003-01-08 | 2015-03-30 | Univ Washington | Antibacterial agents |
| JPWO2005068427A1 (ja) | 2004-01-14 | 2007-09-06 | 武田薬品工業株式会社 | カルボキサミド誘導体およびその用途 |
| BRPI0513433A (pt) | 2004-07-16 | 2008-05-06 | Schering Corp | derivados de hidantoìna para o tratamento de distúrbios inflamatórios |
| US7488745B2 (en) | 2004-07-16 | 2009-02-10 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
| US7504424B2 (en) | 2004-07-16 | 2009-03-17 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
| PE20071241A1 (es) | 2006-01-17 | 2008-01-14 | Schering Corp | Compuestos derivados de hidantoina para el tratamiento de trastornos inflamatorios |
| WO2008027466A1 (en) | 2006-08-31 | 2008-03-06 | Schering Corporation | Hydantoin derivatives useful as antibacterial agents |
-
2007
- 2007-08-29 WO PCT/US2007/019063 patent/WO2008027466A1/en not_active Ceased
- 2007-08-29 CN CNA2007800400356A patent/CN101528711A/zh active Pending
- 2007-08-29 JP JP2009526711A patent/JP2010502617A/ja not_active Withdrawn
- 2007-08-29 MX MX2009002347A patent/MX2009002347A/es unknown
- 2007-08-29 AT AT07811615T patent/ATE540932T1/de active
- 2007-08-29 EP EP07811615A patent/EP2057127B1/de active Active
- 2007-08-29 CA CA002661605A patent/CA2661605A1/en not_active Abandoned
- 2007-08-29 US US11/846,804 patent/US7998961B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010502617A (ja) | 2010-01-28 |
| EP2057127A1 (de) | 2009-05-13 |
| EP2057127B1 (de) | 2012-01-11 |
| US20080226618A1 (en) | 2008-09-18 |
| CA2661605A1 (en) | 2008-03-06 |
| US7998961B2 (en) | 2011-08-16 |
| MX2009002347A (es) | 2009-03-16 |
| CN101528711A (zh) | 2009-09-09 |
| WO2008027466A1 (en) | 2008-03-06 |
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