ATE542830T1 - Als gerüst verwendeter ob-fold zur entwicklung neuer spezifischer bindemittel - Google Patents

Als gerüst verwendeter ob-fold zur entwicklung neuer spezifischer bindemittel

Info

Publication number
ATE542830T1
ATE542830T1 AT06291869T AT06291869T ATE542830T1 AT E542830 T1 ATE542830 T1 AT E542830T1 AT 06291869 T AT06291869 T AT 06291869T AT 06291869 T AT06291869 T AT 06291869T AT E542830 T1 ATE542830 T1 AT E542830T1
Authority
AT
Austria
Prior art keywords
scaffold
development
new specific
specific binders
fold used
Prior art date
Application number
AT06291869T
Other languages
English (en)
Inventor
Frederic Pecorari
Pedro Alzari
Original Assignee
Pasteur Institut
Centre Nat Rech Scient
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pasteur Institut, Centre Nat Rech Scient filed Critical Pasteur Institut
Application granted granted Critical
Publication of ATE542830T1 publication Critical patent/ATE542830T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1041—Ribosome/Polysome display, e.g. SPERT, ARM
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Gram-negative bacteria
    • C07K16/1228—Enterobacterales (O), e.g. Citrobacter (G), Serratia (G), Proteus (G), Providencia (G), Morganella (G) or Yersinia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Gram-negative bacteria
    • C07K16/1228—Enterobacterales (O), e.g. Citrobacter (G), Serratia (G), Proteus (G), Providencia (G), Morganella (G) or Yersinia (G)
    • C07K16/1232—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4283—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polyurethanes Or Polyureas (AREA)
AT06291869T 2006-12-04 2006-12-04 Als gerüst verwendeter ob-fold zur entwicklung neuer spezifischer bindemittel ATE542830T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06291869A EP1930342B1 (de) 2006-12-04 2006-12-04 Als Gerüst verwendeter OB-Fold zur Entwicklung neuer spezifischer Bindemittel

Publications (1)

Publication Number Publication Date
ATE542830T1 true ATE542830T1 (de) 2012-02-15

Family

ID=37964126

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06291869T ATE542830T1 (de) 2006-12-04 2006-12-04 Als gerüst verwendeter ob-fold zur entwicklung neuer spezifischer bindemittel

Country Status (12)

Country Link
US (4) US20100145008A1 (de)
EP (3) EP1930342B1 (de)
JP (3) JP2010511691A (de)
CN (2) CN103145812A (de)
AT (1) ATE542830T1 (de)
AU (1) AU2007330409B2 (de)
CA (1) CA2671553C (de)
DK (1) DK2099817T3 (de)
ES (2) ES2602782T3 (de)
IL (1) IL199057A (de)
MX (1) MX2009005949A (de)
WO (1) WO2008068637A2 (de)

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US9897611B2 (en) 2012-12-27 2018-02-20 National Institute Of Advanced Industrial Science And Technology Molecule library constructed on the basis of backbone structure of microprotein
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IL268731B2 (en) 2017-02-17 2025-07-01 Ose Immunotherapeutics New uses of anti-SIRPG antibodies
EP3434692A1 (de) 2017-07-24 2019-01-30 Encefa Verbindungen mit spezifischer bindung an cd38 zur verwendung bei der behandlung von neurodegenerativen krankheiten
US11713356B2 (en) 2017-10-13 2023-08-01 Ose Immunotherapeutics Modified bifunctional anti-human signal regulatory protein alpha (SIRPa) antibody and method of use thereof for treating cancer
EP3483180A1 (de) * 2017-11-14 2019-05-15 Affilogic Multispezifische moleküle
BR112020011768A2 (pt) * 2017-12-15 2020-11-17 Syngenta Participations Ag ligantes diferentes de anticorpos para detecção de proteínas alvo
WO2019175218A1 (en) 2018-03-13 2019-09-19 Ose Immunotherapeutics Use of anti-human sirpa v1 antibodies and method for producing anti-sirpa v1 antibodies
BR112020020118A2 (pt) 2018-04-03 2021-02-23 Ose Immunotherapeutics composto anti-cmklr1, molécula de ácido nucleico, vetor, célula hospedeira, produto de combinação, combinação de composto, método para selecionar um composto anti-cmklr1, e, composto agonista de cmklr1.
US20230242640A1 (en) 2018-08-22 2023-08-03 Ose Immunotherapeutics ANTI-SIRPg Compounds
EP3632924A1 (de) * 2018-10-07 2020-04-08 Affilogic Bindemittel zur hemmung der bildung von multimeren proteinen
JP7797198B2 (ja) 2018-12-21 2026-01-13 オーエスイー・イミュノセラピューティクス ヒトｐｄ－１に対する二機能性分子
WO2020152290A1 (en) 2019-01-23 2020-07-30 Encefa Cd31 competitors and uses thereof
KR20220005568A (ko) 2019-05-09 2022-01-13 제넨테크, 인크. 항체의 제조 방법
WO2020231504A1 (en) 2019-05-16 2020-11-19 Massachusetts Institute Of Technology Glycan-binding proteins and related compositions and methods
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US20230040008A1 (en) * 2019-12-18 2023-02-09 Bracco Imaging S.P.A. Anti-her2 polypeptides derivatives as new diagnostic molecular probes
CA3157675A1 (en) * 2019-12-18 2021-06-24 Erika Reitano Anti-her2 polypeptides derivatives as new diagnostic molecular probes
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GB202019817D0 (en) * 2020-12-15 2021-01-27 Univ Oxford Innovation Ltd Ligand-binding polypeptides and uses thereof
US12428457B2 (en) * 2021-01-29 2025-09-30 University Of South Florida Cold-shock protein scaffold for engineering non-antibody binding proteins
EP4043481A1 (de) * 2021-02-15 2022-08-17 Affilogic Verbindungen und verfahren zur verlängerung der halbwertszeit von biomolekülen
CN117597353A (zh) * 2021-03-18 2024-02-23 艾菲洛之克公司 抗因子c3的sac7d变体及其治疗补体介导疾患的医疗用途
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WO2022198108A1 (en) * 2021-03-18 2022-09-22 Affilogic Polypeptides for complement inhibition
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Also Published As

Publication number Publication date
US20170166887A1 (en) 2017-06-15
JP2010511691A (ja) 2010-04-15
HK1141304A1 (en) 2010-11-05
US11434585B2 (en) 2022-09-06
CN101652386A (zh) 2010-02-17
US10584330B2 (en) 2020-03-10
WO2008068637A2 (en) 2008-06-12
AU2007330409A1 (en) 2008-06-12
US20160010083A1 (en) 2016-01-14
DK2099817T3 (en) 2015-05-18
EP2099817B1 (de) 2015-02-11
HK1117548A1 (en) 2009-01-16
EP1930342A1 (de) 2008-06-11
MX2009005949A (es) 2009-06-30
US20200181601A1 (en) 2020-06-11
US9422548B2 (en) 2016-08-23
CN101652386B (zh) 2013-03-20
AU2007330409B2 (en) 2013-04-18
CA2671553A1 (en) 2008-06-12
JP6253496B2 (ja) 2017-12-27
CA2671553C (en) 2017-09-05
JP2014169304A (ja) 2014-09-18
WO2008068637A3 (en) 2008-10-30
ES2602782T3 (es) 2017-02-22
CN103145812A (zh) 2013-06-12
IL199057A (en) 2016-02-29
EP2570424A1 (de) 2013-03-20
JP6684761B2 (ja) 2020-04-22
ES2536509T3 (es) 2015-05-26
EP1930342B1 (de) 2012-01-25
JP2018035139A (ja) 2018-03-08
EP2099817A2 (de) 2009-09-16
EP2570424B1 (de) 2016-09-28
US20100145008A1 (en) 2010-06-10

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