ATE543805T1 - Verfahren zur herstellung von oxazolidinonderivaten - Google Patents
Verfahren zur herstellung von oxazolidinonderivatenInfo
- Publication number
- ATE543805T1 ATE543805T1 AT08170827T AT08170827T ATE543805T1 AT E543805 T1 ATE543805 T1 AT E543805T1 AT 08170827 T AT08170827 T AT 08170827T AT 08170827 T AT08170827 T AT 08170827T AT E543805 T1 ATE543805 T1 AT E543805T1
- Authority
- AT
- Austria
- Prior art keywords
- oxazolidinone derivatives
- producing
- producing oxazolidinone
- derivatives
- linezolid
- Prior art date
Links
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical class O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- TYZROVQLWOKYKF-ZDUSSCGKSA-N linezolid Chemical compound O=C1O[C@@H](CNC(=O)C)CN1C(C=C1F)=CC=C1N1CCOCC1 TYZROVQLWOKYKF-ZDUSSCGKSA-N 0.000 abstract 1
- 229960003907 linezolid Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT002359A ITMI20072359A1 (it) | 2007-12-18 | 2007-12-18 | Procedimento per la preparazione di derivati ossazolidinonici |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE543805T1 true ATE543805T1 (de) | 2012-02-15 |
Family
ID=40315597
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08170827T ATE543805T1 (de) | 2007-12-18 | 2008-12-05 | Verfahren zur herstellung von oxazolidinonderivaten |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20090156806A1 (de) |
| EP (1) | EP2072505B1 (de) |
| AT (1) | ATE543805T1 (de) |
| IT (1) | ITMI20072359A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2033960A3 (de) | 2007-09-04 | 2009-04-29 | Dipharma Francis S.r.l. | Kristalline Linezolidhydratform und Linezolidsalze |
| US9586913B2 (en) | 2013-04-25 | 2017-03-07 | Symed Labs Limited | Processes for the preparation of linezolid using novel intermediates |
| CN103804315B (zh) * | 2014-02-20 | 2015-12-09 | 四川大学 | 一种5-氨甲基噁唑烷酮类化合物的制备方法 |
| CN105111160B (zh) * | 2015-09-11 | 2017-04-12 | 浙江新东港药业股份有限公司 | 一种利奈唑胺的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY115155A (en) * | 1993-09-09 | 2003-04-30 | Upjohn Co | Substituted oxazine and thiazine oxazolidinone antimicrobials. |
| US5839870A (en) * | 1996-03-13 | 1998-11-24 | Novus Corporation | Transfer system for use with a horizontal furnace |
| NZ504372A (en) * | 1997-11-07 | 2002-12-20 | Upjohn Co | Process to produce N-[3-fluoro-4(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinones |
| US6444813B2 (en) * | 2000-02-02 | 2002-09-03 | Pharmacia & Upjohn Company | Linezolid-crystal form II |
| ATE321024T1 (de) * | 2000-10-17 | 2006-04-15 | Pharmacia & Upjohn Co Llc | Verfahren zur herstellung von oxazolidinonverbindungen |
| ATE374463T1 (de) * | 2001-04-20 | 2007-10-15 | Pharmacia & Upjohn Co Llc | Verfahren zur herstellung von oxazolidinonen |
| EP1658275A1 (de) * | 2004-06-29 | 2006-05-24 | Teva Pharmaceutical Industries Ltd | Kristalline form iv von linezolid |
| EP1745028A2 (de) * | 2004-06-29 | 2007-01-24 | Teva Pharmaceutical Industries Ltd | Linezolid in fester form und herstellungsverfahren dafür |
-
2007
- 2007-12-18 IT IT002359A patent/ITMI20072359A1/it unknown
-
2008
- 2008-12-05 AT AT08170827T patent/ATE543805T1/de active
- 2008-12-05 EP EP08170827A patent/EP2072505B1/de not_active Not-in-force
- 2008-12-11 US US12/332,474 patent/US20090156806A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2072505A2 (de) | 2009-06-24 |
| ITMI20072359A1 (it) | 2009-06-19 |
| US20090156806A1 (en) | 2009-06-18 |
| EP2072505B1 (de) | 2012-02-01 |
| EP2072505A3 (de) | 2009-08-12 |
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