ATE372336T1 - Prozess zur herstellung von pioglitazon via verschiedene zwischenstufen - Google Patents
Prozess zur herstellung von pioglitazon via verschiedene zwischenstufenInfo
- Publication number
- ATE372336T1 ATE372336T1 AT03753913T AT03753913T ATE372336T1 AT E372336 T1 ATE372336 T1 AT E372336T1 AT 03753913 T AT03753913 T AT 03753913T AT 03753913 T AT03753913 T AT 03753913T AT E372336 T1 ATE372336 T1 AT E372336T1
- Authority
- AT
- Austria
- Prior art keywords
- via various
- intermediate stages
- various intermediate
- producing
- producing pioglitazone
- Prior art date
Links
- HYAFETHFCAUJAY-UHFFFAOYSA-N pioglitazone Chemical compound N1=CC(CC)=CC=C1CCOC(C=C1)=CC=C1CC1C(=O)NC(=O)S1 HYAFETHFCAUJAY-UHFFFAOYSA-N 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 229960005095 pioglitazone Drugs 0.000 title abstract 2
- 229940123464 Thiazolidinedione Drugs 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 150000001467 thiazolidinediones Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/32—Sulfur atoms
- C07D213/34—Sulfur atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN648MU2002 | 2002-07-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE372336T1 true ATE372336T1 (de) | 2007-09-15 |
Family
ID=30012270
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03753913T ATE372336T1 (de) | 2002-07-16 | 2003-07-15 | Prozess zur herstellung von pioglitazon via verschiedene zwischenstufen |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US7465801B2 (de) |
| EP (1) | EP1521753B1 (de) |
| AT (1) | ATE372336T1 (de) |
| AU (1) | AU2003272072A1 (de) |
| DE (1) | DE60316152D1 (de) |
| WO (1) | WO2004007490A2 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004007490A2 (en) | 2002-07-16 | 2004-01-22 | Cadila Healthcare Limited | A process to prepare pioglitazone via several intermediates. |
| US8993773B2 (en) | 2002-07-16 | 2015-03-31 | Cadila Healthcare Limited | Process to prepare pioglitazone via several novel intermediates |
| CZ297266B6 (cs) * | 2004-09-10 | 2006-10-11 | Zentiva, A. S. | Zpusob prípravy rosiglitazonu |
| WO2008075380A2 (en) * | 2006-12-21 | 2008-06-26 | Ind-Swift Laboratories Limited | Process for the preparation of thiazolidine derivatives |
| JOP20180077A1 (ar) | 2007-06-19 | 2019-01-30 | Kythera Biopharmaceuticals Inc | تركيبات وطرق لحمض صفراوي تخليقي |
| US8242294B2 (en) | 2007-06-19 | 2012-08-14 | Kythera Biopharmaceuticals, Inc. | Synthetic bile acid compositions and methods |
| US20080318870A1 (en) | 2007-06-19 | 2008-12-25 | Kythera Biopharmaceuticals, Inc. | Synthetic bile acid compositions and methods |
| CN101848901B (zh) | 2007-09-14 | 2012-11-21 | 新陈代谢解决方案开发公司 | 用于治疗高血压的噻唑烷二酮类似物 |
| US8304441B2 (en) | 2007-09-14 | 2012-11-06 | Metabolic Solutions Development Company, Llc | Thiazolidinedione analogues for the treatment of metabolic diseases |
| US8024889B2 (en) * | 2008-06-25 | 2011-09-27 | Brett Bunker | Pest control method and apparatus |
| WO2010105048A1 (en) * | 2009-03-12 | 2010-09-16 | Metabolic Solutions Development Company | Thiazolidinedione analogues |
| US8912335B2 (en) * | 2009-12-15 | 2014-12-16 | Metabolic Solutions Development Company, Llc | PPAR-sparing thiazolidinedione salts for the treatment of metabolic diseases |
| CN102917705A (zh) * | 2009-12-15 | 2013-02-06 | 新陈代谢解决方案开发公司 | 用于治疗肥胖症和其它代谢性疾病的ppar节制性噻唑烷二酮和组合 |
| KR101164429B1 (ko) | 2010-05-25 | 2012-07-12 | (주)부흥산업사 | 환상 아민 중간체를 이용한 피오글리타존 염산염의 제조 방법 |
| US8596663B2 (en) * | 2011-03-29 | 2013-12-03 | Shimano Inc. | Fluid flow control structure |
| WO2012153312A1 (en) | 2011-05-11 | 2012-11-15 | Ranbaxy Laboratories Limited | Process for the purification of pioglitazone |
| ES2831326T3 (es) | 2014-01-15 | 2021-06-08 | Poxel Sa | Métodos para tratar trastornos neurológicos, metabólicos y otros mediante el uso de pioglitazona enantiopura enriquecida con deuterio |
| CN109020790B (zh) * | 2018-08-16 | 2021-07-27 | 苏州大学 | 一种4-环烷基苯乙酮衍生物的制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5522636A (en) | 1978-08-04 | 1980-02-18 | Takeda Chem Ind Ltd | Thiazoliding derivative |
| US4444179A (en) * | 1981-03-02 | 1984-04-24 | Trippi Anthony C | Orthopedic tongs |
| NL8402765A (nl) * | 1984-09-11 | 1986-04-01 | Philips Nv | Manipulator met zes vrijheidsgraden. |
| AR240698A1 (es) * | 1985-01-19 | 1990-09-28 | Takeda Chemical Industries Ltd | Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales |
| US4812570A (en) | 1986-07-24 | 1989-03-14 | Takeda Chemical Industries, Ltd. | Method for producing thiazolidinedione derivatives |
| WO1993022445A1 (en) | 1992-05-05 | 1993-11-11 | The Upjohn Company | A process for producing pioglitazone metabolite |
| KR100366617B1 (ko) * | 2000-03-13 | 2003-01-09 | 삼성전자 주식회사 | 자기 정렬 콘택홀 제조 방법 |
| HUP0400091A2 (hu) * | 2001-04-26 | 2004-06-28 | Léciva, a.s. | Eljárás antidiabetikus hatású pioglitazon előállítására |
| WO2004007490A2 (en) | 2002-07-16 | 2004-01-22 | Cadila Healthcare Limited | A process to prepare pioglitazone via several intermediates. |
-
2003
- 2003-07-15 WO PCT/IN2003/000241 patent/WO2004007490A2/en not_active Ceased
- 2003-07-15 DE DE60316152T patent/DE60316152D1/de not_active Expired - Lifetime
- 2003-07-15 US US10/520,166 patent/US7465801B2/en not_active Expired - Fee Related
- 2003-07-15 AU AU2003272072A patent/AU2003272072A1/en not_active Abandoned
- 2003-07-15 EP EP03753913A patent/EP1521753B1/de not_active Expired - Lifetime
- 2003-07-15 AT AT03753913T patent/ATE372336T1/de not_active IP Right Cessation
-
2007
- 2007-09-06 US US11/896,911 patent/US7671207B2/en not_active Expired - Fee Related
-
2008
- 2008-01-25 US US12/010,473 patent/US7863300B2/en not_active Expired - Fee Related
-
2010
- 2010-10-02 US US12/896,844 patent/US8173816B2/en not_active Expired - Fee Related
-
2011
- 2011-11-28 US US13/305,295 patent/US8445685B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20080300282A1 (en) | 2008-12-04 |
| US20060167061A1 (en) | 2006-07-27 |
| US7465801B2 (en) | 2008-12-16 |
| EP1521753A2 (de) | 2005-04-13 |
| AU2003272072A1 (en) | 2004-02-02 |
| US8445685B2 (en) | 2013-05-21 |
| US8173816B2 (en) | 2012-05-08 |
| US20080004446A1 (en) | 2008-01-03 |
| EP1521753B1 (de) | 2007-09-05 |
| AU2003272072A8 (en) | 2004-02-02 |
| US7671207B2 (en) | 2010-03-02 |
| DE60316152D1 (de) | 2007-10-18 |
| WO2004007490A2 (en) | 2004-01-22 |
| US20120077848A1 (en) | 2012-03-29 |
| WO2004007490A3 (en) | 2004-03-25 |
| US20110021576A1 (en) | 2011-01-27 |
| US7863300B2 (en) | 2011-01-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |