ATE543806T1 - 5-aryl-4-(5-substituiertes 2,4-dihydroxyphenyl)-1,2,3-thiadiazole als inhibitoren von hsp90- chaperon und die zwischenprodukte für deren herstellung - Google Patents
5-aryl-4-(5-substituiertes 2,4-dihydroxyphenyl)-1,2,3-thiadiazole als inhibitoren von hsp90- chaperon und die zwischenprodukte für deren herstellungInfo
- Publication number
- ATE543806T1 ATE543806T1 AT08766671T AT08766671T ATE543806T1 AT E543806 T1 ATE543806 T1 AT E543806T1 AT 08766671 T AT08766671 T AT 08766671T AT 08766671 T AT08766671 T AT 08766671T AT E543806 T1 ATE543806 T1 AT E543806T1
- Authority
- AT
- Austria
- Prior art keywords
- thiadiazoles
- dihydroxyphenyl
- aryl
- substituted
- inhibitors
- Prior art date
Links
- 101710113864 Heat shock protein 90 Proteins 0.000 title 1
- 102100034051 Heat shock protein HSP 90-alpha Human genes 0.000 title 1
- 108010006519 Molecular Chaperones Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 239000013067 intermediate product Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 101001016865 Homo sapiens Heat shock protein HSP 90-alpha Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 150000004867 thiadiazoles Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LT2008035A LT5623B (lt) | 2008-04-30 | 2008-04-30 | 5-aril-4-(5-pakeistieji 2,4-dihidroksifenil)-1,2,3-tiadiazolai kaip hsp90 šaperono slopikliai ir tarpiniai junginiai jiems gauti |
| PCT/LT2008/000003 WO2009134110A1 (en) | 2008-04-30 | 2008-06-18 | 5-aryl-4-(5-substituted 2,4-dihydroxyphenyl)-1,2,3-thiadiazoles as inhibitors of hsp90 chaperone and the intermediates for production thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE543806T1 true ATE543806T1 (de) | 2012-02-15 |
Family
ID=39682765
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08766671T ATE543806T1 (de) | 2008-04-30 | 2008-06-18 | 5-aryl-4-(5-substituiertes 2,4-dihydroxyphenyl)-1,2,3-thiadiazole als inhibitoren von hsp90- chaperon und die zwischenprodukte für deren herstellung |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8314132B2 (de) |
| EP (1) | EP2268626B1 (de) |
| AT (1) | ATE543806T1 (de) |
| LT (1) | LT5623B (de) |
| WO (1) | WO2009134110A1 (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2655345T3 (en) | 2010-12-20 | 2015-05-04 | Sigma Tau Res Switzerland Sa | Aryltriazole Compounds with Anti-tumor Effect |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2559689B1 (fr) | 1984-02-22 | 1987-05-15 | Siderurgie Fse Inst Rech | Laminoir du type planetaire universel pour produits longs |
| KR19990076764A (ko) | 1996-10-25 | 1999-10-15 | 히라타 다다시 | 래디시콜 유도체 |
| US7439359B2 (en) | 2000-11-02 | 2008-10-21 | Sloan-Kettering Institute For Cancer Research | Small molecule compositions for binding to hsp90 |
| WO2003037860A2 (en) | 2001-10-30 | 2003-05-08 | Conforma Therapeutics Corporation | Purine analogs having hsp90-inhibiting activity |
| GB0228417D0 (en) | 2002-12-05 | 2003-01-08 | Cancer Rec Tech Ltd | Pyrazole compounds |
| SI1611112T1 (sl) * | 2003-02-11 | 2012-12-31 | Vernalis (R&D) Limited | Izoksazolne spojine kot inhibitorji vroäśinskih ĺ ok proteinov |
| GB0309637D0 (en) | 2003-04-28 | 2003-06-04 | Cancer Rec Tech Ltd | Pyrazole compounds |
| GB0315111D0 (en) | 2003-06-27 | 2003-07-30 | Cancer Rec Tech Ltd | Substituted 5-membered ring compounds and their use |
| MXPA06002997A (es) | 2003-09-18 | 2007-02-08 | Conforma Therapeutics Corp | Novedosos compuestos heterociclicos como inhibidores- hsp90. |
| JP2005225787A (ja) | 2004-02-12 | 2005-08-25 | Nippon Kayaku Co Ltd | Ｈｓｐ９０阻害剤 |
| DE102004039280A1 (de) * | 2004-08-13 | 2006-02-23 | Merck Patent Gmbh | 1,5-Diphenyl-pyrazole |
| FR2880540B1 (fr) | 2005-01-13 | 2008-07-11 | Aventis Pharma Sa | Utilisation de derives de la purine comme inhibiteurs de la proteine hsp90 |
| AU2006230447A1 (en) | 2005-03-30 | 2006-10-05 | Conforma Therapeutics Corporation | Alkynyl pyrrolopyrimidines and related analogs as HSP90-inhibitors |
| JP5154406B2 (ja) | 2005-04-13 | 2013-02-27 | アステックス、セラピューティックス、リミテッド | 医薬化合物 |
| BRPI0609309A2 (pt) | 2005-04-14 | 2010-03-09 | Novartis Vaccines & Diagnostic | 2-amino-quinazolin-5-onas como inibidores hsp90 com utilidade no tratamento de doenças proliferativas |
| JP2006306755A (ja) | 2005-04-27 | 2006-11-09 | Nippon Kayaku Co Ltd | 新規なピラゾール誘導体とそれを有効成分とするｈｓｐ９０阻害剤 |
| US7608635B2 (en) | 2005-08-12 | 2009-10-27 | Synta Pharmaceuticals Corp. | Pyrazole compounds that modulate HSP90 activity |
| JP5118039B2 (ja) | 2005-08-18 | 2013-01-16 | シンタ ファーマシューティカルズ コーポレーション | Ｈｓｐ９０活性を調節するトリアゾール化合物 |
| DE102006023337A1 (de) * | 2006-05-18 | 2007-11-22 | Merck Patent Gmbh | Triazolderivate II |
| WO2007139952A2 (en) | 2006-05-25 | 2007-12-06 | Synta Pharmaceuticals Corp. | Method for the preparation of triazole compounds with hsp90 modulating activity |
| WO2007139956A2 (en) | 2006-05-26 | 2007-12-06 | Laboratory Corporation Of America Holdings | Methods and systems for the quantitative analysis of biomarkers |
| CN1865252A (zh) * | 2006-06-19 | 2006-11-22 | 中国科学院上海药物研究所 | 4,5－二取代苯基－1,2,3－噻二唑类衍生物,及其制备方法和用途 |
| AU2007284537B2 (en) | 2006-08-17 | 2012-04-12 | Synta Pharmaceuticals Corp. | Triazole compounds that modulate HSP90 activity |
-
2008
- 2008-04-30 LT LT2008035A patent/LT5623B/lt not_active IP Right Cessation
- 2008-06-18 WO PCT/LT2008/000003 patent/WO2009134110A1/en not_active Ceased
- 2008-06-18 US US12/990,551 patent/US8314132B2/en not_active Expired - Fee Related
- 2008-06-18 AT AT08766671T patent/ATE543806T1/de active
- 2008-06-18 EP EP08766671A patent/EP2268626B1/de not_active Not-in-force
Also Published As
| Publication number | Publication date |
|---|---|
| EP2268626A1 (de) | 2011-01-05 |
| LT2008035A (en) | 2009-11-25 |
| WO2009134110A1 (en) | 2009-11-05 |
| LT5623B (lt) | 2010-01-25 |
| US20110046387A1 (en) | 2011-02-24 |
| US8314132B2 (en) | 2012-11-20 |
| EP2268626B1 (de) | 2012-02-01 |
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