ATE543814T1 - Prodrug für einen ice-inhibitor - Google Patents

Prodrug für einen ice-inhibitor

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Publication number
ATE543814T1
ATE543814T1 AT01939230T AT01939230T ATE543814T1 AT E543814 T1 ATE543814 T1 AT E543814T1 AT 01939230 T AT01939230 T AT 01939230T AT 01939230 T AT01939230 T AT 01939230T AT E543814 T1 ATE543814 T1 AT E543814T1
Authority
AT
Austria
Prior art keywords
ice inhibitor
inhibitor prodrug
prodrug
ice
inhibitor
Prior art date
Application number
AT01939230T
Other languages
English (en)
Inventor
Marion Wannamaker
Robert Davies
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Application granted granted Critical
Publication of ATE543814T1 publication Critical patent/ATE543814T1/de

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    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
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    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
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    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
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US9156880B2 (en) 2015-10-13
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US20200048306A1 (en) 2020-02-13
KR100863144B1 (ko) 2008-10-14
CA2379972A1 (en) 2001-11-29
WO2001090063A2 (en) 2001-11-29
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