ATE543822T1 - 2-alkyl-6-cycloamino-3-(pyridin-4-yl)imidazo ä1,2-ibü-pyridazinderivate, deren herstellung und deren therapeutische anwendung - Google Patents

2-alkyl-6-cycloamino-3-(pyridin-4-yl)imidazo ä1,2-ibü-pyridazinderivate, deren herstellung und deren therapeutische anwendung

Info

Publication number
ATE543822T1
ATE543822T1 AT09737011T AT09737011T ATE543822T1 AT E543822 T1 ATE543822 T1 AT E543822T1 AT 09737011 T AT09737011 T AT 09737011T AT 09737011 T AT09737011 T AT 09737011T AT E543822 T1 ATE543822 T1 AT E543822T1
Authority
AT
Austria
Prior art keywords
ibü
cycloamino
imidazo
pyridine
alkyl
Prior art date
Application number
AT09737011T
Other languages
English (en)
Inventor
Garcia Antonio Almario
Philippe Burnier
Combes Sylvain Cote-Des
Jean-Francois Gilbert
Christophe Pacaud
Frederic Puech
Yulin Chiang
Larry Davis
Zhongli Gao
Qiuxia Zhao
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Application granted granted Critical
Publication of ATE543822T1 publication Critical patent/ATE543822T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Oncology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT09737011T 2008-08-12 2009-08-12 2-alkyl-6-cycloamino-3-(pyridin-4-yl)imidazo ä1,2-ibü-pyridazinderivate, deren herstellung und deren therapeutische anwendung ATE543822T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8812608P 2008-08-12 2008-08-12
FR0804573A FR2934994B1 (fr) 2008-08-12 2008-08-12 Derives de 2-alkyl-6cycloamino-3-(pyridin-4-yl)imidaz°1,2-b! pyridazine, leur preparation et leur application en therapeutique
PCT/FR2009/001001 WO2010018327A1 (fr) 2008-08-12 2009-08-12 Derives de 2-alkyl-6-cycloamino-3-(pyridin-4-yl)imidazo[1,2-ib]-pyridazine, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
ATE543822T1 true ATE543822T1 (de) 2012-02-15

Family

ID=40512462

Family Applications (1)

Application Number Title Priority Date Filing Date
AT09737011T ATE543822T1 (de) 2008-08-12 2009-08-12 2-alkyl-6-cycloamino-3-(pyridin-4-yl)imidazo ä1,2-ibü-pyridazinderivate, deren herstellung und deren therapeutische anwendung

Country Status (17)

Country Link
US (1) US20110312934A1 (de)
EP (1) EP2331546B1 (de)
JP (1) JP2011530574A (de)
KR (1) KR20110052708A (de)
CN (1) CN102186852A (de)
AR (1) AR072932A1 (de)
AT (1) ATE543822T1 (de)
AU (1) AU2009281056A1 (de)
BR (1) BRPI0917939A2 (de)
CA (1) CA2734077A1 (de)
FR (1) FR2934994B1 (de)
IL (1) IL211141A0 (de)
MX (1) MX2011001667A (de)
RU (1) RU2011109223A (de)
TW (1) TW201011028A (de)
UY (1) UY32046A (de)
WO (1) WO2010018327A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2778949C (en) 2009-10-30 2018-02-27 Janssen Pharmaceutica Nv Imidazo[1,2-b]pyridazine derivatives and their use as pde10 inhibitors
AR080754A1 (es) 2010-03-09 2012-05-09 Janssen Pharmaceutica Nv Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10
US20140031547A1 (en) 2010-12-14 2014-01-30 Electrophoretics Limited CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODE-GENERATIVE DISEASES SUCH AS TAUOPATHIES
BR112013033375B1 (pt) 2011-06-27 2022-05-10 Janssen Pharmaceutica N.V Derivados de 1-aril-4-metil-[1,2,4]triazolo[4,3-a]quinoxa-lina, seu uso, composição farmacêutica que os compreende, processo de preparação dos mesmos, solução estéril e composto intermediário
NZ630719A (en) * 2012-03-09 2017-01-27 Lexicon Pharmaceuticals Inc Imidazo [1, 2 - b] pyridazine - based compounds, compositions comprising them, and uses thereof
RU2657540C2 (ru) 2012-06-26 2018-06-14 Янссен Фармацевтика Нв Комбинации, содержащие ингибиторы pde 2, такие как 1-арил-4-метил-[1,2,4]триазоло[4,3-а]хиноксалиновые соединения, и ингибиторы pde 10, для применения в лечении неврологических или метаболических расстройств
EP2869822B1 (de) 2012-07-09 2016-09-14 Janssen Pharmaceutica, N.V. Hemmer des phosphodiesterase-10-enzyms
RS64354B1 (sr) * 2017-03-14 2023-08-31 Daiichi Sankyo Co Ltd Postupak za proizvodnju derivata 3, 6-disupstituisanog imidazo[1, 2-b]piridazina
EP4063370A1 (de) 2021-03-23 2022-09-28 Fundación Centro Nacional de Investigaciones Oncológicas Carlos III Tricyclische verbindungen auf basis von imidazo[1,2-b]pyridazin als inhibitoren von haspin und therapeutische verwendungen davon
KR20240101561A (ko) 2021-10-14 2024-07-02 인사이트 코포레이션 Kras의 저해제로서의 퀴놀린 화합물

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009502734A (ja) * 2005-07-29 2009-01-29 アステラス製薬株式会社 Ｌｃｋ阻害剤としての縮合複素環
US7750000B2 (en) * 2005-09-02 2010-07-06 Bayer Schering Pharma Ag Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments
FR2918061B1 (fr) * 2007-06-28 2010-10-22 Sanofi Aventis Derives de 6-cycloamino-3-(pyridin-4-yl)imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique.

Also Published As

Publication number Publication date
EP2331546A1 (de) 2011-06-15
EP2331546B1 (de) 2012-02-01
FR2934994A1 (fr) 2010-02-19
BRPI0917939A2 (pt) 2015-11-17
AU2009281056A1 (en) 2010-02-18
AR072932A1 (es) 2010-09-29
MX2011001667A (es) 2011-03-24
WO2010018327A1 (fr) 2010-02-18
US20110312934A1 (en) 2011-12-22
CA2734077A1 (fr) 2010-02-18
CN102186852A (zh) 2011-09-14
TW201011028A (en) 2010-03-16
FR2934994B1 (fr) 2010-09-17
JP2011530574A (ja) 2011-12-22
KR20110052708A (ko) 2011-05-18
IL211141A0 (en) 2011-04-28
UY32046A (es) 2010-03-26
RU2011109223A (ru) 2012-09-20

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