ATE543822T1 - 2-alkyl-6-cycloamino-3-(pyridin-4-yl)imidazo ä1,2-ibü-pyridazinderivate, deren herstellung und deren therapeutische anwendung - Google Patents

2-alkyl-6-cycloamino-3-(pyridin-4-yl)imidazo ä1,2-ibü-pyridazinderivate, deren herstellung und deren therapeutische anwendung

Info

Publication number
ATE543822T1
ATE543822T1 AT09737011T AT09737011T ATE543822T1 AT E543822 T1 ATE543822 T1 AT E543822T1 AT 09737011 T AT09737011 T AT 09737011T AT 09737011 T AT09737011 T AT 09737011T AT E543822 T1 ATE543822 T1 AT E543822T1
Authority
AT
Austria
Prior art keywords
ibü
cycloamino
imidazo
pyridine
alkyl
Prior art date
Application number
AT09737011T
Other languages
English (en)
Inventor
Garcia Antonio Almario
Philippe Burnier
Combes Sylvain Cote-Des
Jean-Francois Gilbert
Christophe Pacaud
Frederic Puech
Yulin Chiang
Larry Davis
Zhongli Gao
Qiuxia Zhao
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Application granted granted Critical
Publication of ATE543822T1 publication Critical patent/ATE543822T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Oncology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT09737011T 2008-08-12 2009-08-12 2-alkyl-6-cycloamino-3-(pyridin-4-yl)imidazo ä1,2-ibü-pyridazinderivate, deren herstellung und deren therapeutische anwendung ATE543822T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8812608P 2008-08-12 2008-08-12
FR0804573A FR2934994B1 (fr) 2008-08-12 2008-08-12 Derives de 2-alkyl-6cycloamino-3-(pyridin-4-yl)imidaz°1,2-b! pyridazine, leur preparation et leur application en therapeutique
PCT/FR2009/001001 WO2010018327A1 (fr) 2008-08-12 2009-08-12 Derives de 2-alkyl-6-cycloamino-3-(pyridin-4-yl)imidazo[1,2-ib]-pyridazine, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
ATE543822T1 true ATE543822T1 (de) 2012-02-15

Family

ID=40512462

Family Applications (1)

Application Number Title Priority Date Filing Date
AT09737011T ATE543822T1 (de) 2008-08-12 2009-08-12 2-alkyl-6-cycloamino-3-(pyridin-4-yl)imidazo ä1,2-ibü-pyridazinderivate, deren herstellung und deren therapeutische anwendung

Country Status (17)

Country Link
US (1) US20110312934A1 (de)
EP (1) EP2331546B1 (de)
JP (1) JP2011530574A (de)
KR (1) KR20110052708A (de)
CN (1) CN102186852A (de)
AR (1) AR072932A1 (de)
AT (1) ATE543822T1 (de)
AU (1) AU2009281056A1 (de)
BR (1) BRPI0917939A2 (de)
CA (1) CA2734077A1 (de)
FR (1) FR2934994B1 (de)
IL (1) IL211141A0 (de)
MX (1) MX2011001667A (de)
RU (1) RU2011109223A (de)
TW (1) TW201011028A (de)
UY (1) UY32046A (de)
WO (1) WO2010018327A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH12012500778A1 (en) 2009-10-30 2012-11-26 Janssen Pharmaceutica Nv IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE10 INHIBITORS
AR080754A1 (es) 2010-03-09 2012-05-09 Janssen Pharmaceutica Nv Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10
EP2651405A2 (de) * 2010-12-14 2013-10-23 Electrophoretics Limited Casein-kinase-1 (ck1)-inhibitoren
JP6115962B2 (ja) 2011-06-27 2017-04-19 ヤンセン ファーマシューティカ エヌ．ベー． １−アリール−４−メチル−［１，２，４］トリアゾロ［４，３−ａ］キノキサリン誘導体
RU2014140739A (ru) * 2012-03-09 2016-04-27 Лексикон Фармасьютикалз, Инк. Соединения на основе имидазо[1, 2-b]пиридазина, композиции таких соединений и способы их применения
WO2014001314A1 (en) 2012-06-26 2014-01-03 Janssen Pharmaceutica Nv Combinations comprising pde 2 inhibitors such as 1-aryl-4-methyl- [1,2,4] triazolo [4,3-a] quinoxaline compounds and pde 10 inhibitors for use in the treatment of neurological or metabolic disorders
AU2013289284B2 (en) 2012-07-09 2017-03-30 Janssen Pharmaceutica Nv Inhibitors of phosphodiesterase 10 enzyme
SMT202300269T1 (it) * 2017-03-14 2023-09-06 Daiichi Sankyo Co Ltd Metodo per produrre un imidazo[1,2-b]piridazina-derivato 3,6-disostituito
EP4063370A1 (de) 2021-03-23 2022-09-28 Fundación Centro Nacional de Investigaciones Oncológicas Carlos III Tricyclische verbindungen auf basis von imidazo[1,2-b]pyridazin als inhibitoren von haspin und therapeutische verwendungen davon
KR20240101561A (ko) 2021-10-14 2024-07-02 인사이트 코포레이션 Kras의 저해제로서의 퀴놀린 화합물

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100216798A1 (en) * 2005-07-29 2010-08-26 Astellas Pharma Inc Fused heterocycles as lck inhibitors
US7750000B2 (en) * 2005-09-02 2010-07-06 Bayer Schering Pharma Ag Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments
FR2918061B1 (fr) * 2007-06-28 2010-10-22 Sanofi Aventis Derives de 6-cycloamino-3-(pyridin-4-yl)imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique.

Also Published As

Publication number Publication date
RU2011109223A (ru) 2012-09-20
WO2010018327A1 (fr) 2010-02-18
IL211141A0 (en) 2011-04-28
AU2009281056A1 (en) 2010-02-18
JP2011530574A (ja) 2011-12-22
AR072932A1 (es) 2010-09-29
UY32046A (es) 2010-03-26
US20110312934A1 (en) 2011-12-22
EP2331546B1 (de) 2012-02-01
CN102186852A (zh) 2011-09-14
MX2011001667A (es) 2011-03-24
FR2934994B1 (fr) 2010-09-17
KR20110052708A (ko) 2011-05-18
EP2331546A1 (de) 2011-06-15
FR2934994A1 (fr) 2010-02-19
BRPI0917939A2 (pt) 2015-11-17
TW201011028A (en) 2010-03-16
CA2734077A1 (fr) 2010-02-18

Similar Documents

Publication Publication Date Title
CY2022022I2 (el) Υποκατεστημενα 4-αρυλο-1,4-διυδρο-1,6-ναφθυριδιν αμιδια και η χρηση τους
PT3001903T (pt) 1h-pirazolo[3,4-b]piridinas e usos terapêuticos destas
ZA201006728B (en) Polysubstituted 2-aryl-6-phenyl-imidazo[1,2-a]pyridine derivatives,and preparation and therapeutic use thereof
DK2262803T3 (da) Polysubstituerede derivater af 2-aryl-6-phenyl-imidazo(1,2-A)pyridiner, fremstilling og terapeutisk anvendelse heraf
HUE046216T2 (hu) 1H-pirazolo [3,4-b]piridin-származékok és terápiás alkalmazásuk
FR2918061B1 (fr) Derives de 6-cycloamino-3-(pyridin-4-yl)imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique.
IL208247A0 (en) Polysubstituted derivatives of 6-heteroaryl-imidazo[1,2-a]pyridines, and preparation and therapeutic use thereof
BR112012000370A2 (pt) derivados de 1,2,4-tiazolidin-3-ona e seus usos no tratamento de câncer
BRPI0908433A2 (pt) pirrolo[2,3-d]piridinas e empregos destas como inibidores tirosina cinase
IL208245A0 (en) Polysubstituted derivatives of 2-heteroaryl-6-phenyl-imidazo[1,2-a]pyridines, and preparation and therapeutic use thereof
IL204663A0 (en) Nicotinamide derivatives, preparastion thereof and therapeutic use thereof
ATE475661T1 (de) Triazolopyridin-carboxamid-derivate sowie ihre herstellung und therapeutische verwendung
ATE372998T1 (de) 1-aminophthalazinderivate, deren herstellung und deren therapeutische verwendung
BR112012001344A2 (pt) derivados de 17hidróxi-17-pentafluoroetil-estra-4,9(10)-dieno-11-arila, método de produção destes e uso destes para o tratamento de doenças
SMT201400013B (it) Attivatori di ampk tieno[2,3-B] piridina dione e loro impieghi terapeutici
DK2158201T3 (da) Derivater af 7-alkynyl-1,8-naphthyridon, fremgangsmåde til fremstilling deraf og anvendelse deraf i terapi
FR2925902B1 (fr) DERIVES D'IMIDAZO°1,2-a!PYRIDINE-2-CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
ATE540023T1 (de) Neuartige 3-aminoalkyl-1,3-dihydro-2h-indol-2-on- derivate, ihre herstellung und therapeutische verwendung
ATE548349T1 (de) In stellung 3 disubstituierte indol-2-on- pyridinderivate, ihre herstellung sowie ihre therapeutische anwendung
ATE531715T1 (de) 1,3-dihydro-2h-pyrroloä3.2-büpyridin-2-onderiva e,deren herstellung und deren therapeutische verwendungen
IL206671A0 (en) N-HETEROCYCLIC-IMIDAZO[1,2-a]PYRIDINE-2-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
DE102008002364A8 (de) Ru-Sulfoxid-Komplexe, deren Herstellung und Verwendung
DK2310383T3 (da) 2-oxo-alkyl-1-piperazin-2-onderivater, fremstilling deraf og terapeutisk anvendelse deraf
ATE529426T1 (de) N-phenyl-imidazo(1,2-a)pyridincarboxamid- verbindungen, ihre herstellung sowie ihre therapeutische anwendung
ATE423119T1 (de) Pyridoä2,3-düpyrimidin-derivate sowie deren herstellung und therapeutische anwendung