ATE543823T1 - Verfahren zur reduzierung von unreinheiten in oxycodonbase - Google Patents

Verfahren zur reduzierung von unreinheiten in oxycodonbase

Info

Publication number: ATE543823T1
Authority: AT; Austria
Prior art keywords: oxycodone base; reducing impurities; impurities; oxycodone; base
Prior art date: 2006-12-04

Application number

AT07865161T

Other languages

English (en)

Inventor

D Phillip Cox

Yong Zhang

Original Assignee

Noramco Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-12-04

Filing date

2007-12-04

Publication date

2012-02-15

2007-12-04 Application filed by Noramco Inc filed Critical Noramco Inc

2012-02-15 Application granted granted Critical

2012-02-15 Publication of ATE543823T1 publication Critical patent/ATE543823T1/de

Links

BRUQQQPBMZOVGD-XFKAJCMBSA-N Oxycodone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C BRUQQQPBMZOVGD-XFKAJCMBSA-N 0.000 title abstract 2
239000012535 impurity Substances 0.000 title abstract 2
229960002085 oxycodone Drugs 0.000 title abstract 2
LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 abstract 2
YYCRAERBSFHMPL-XFKAJCMBSA-N (4r,4as,7ar,12bs)-4a-hydroxy-9-methoxy-3-methyl-2,4,7a,13-tetrahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one Chemical compound O=C([C@@H]1O2)C=C[C@@]3(O)[C@]4([H])N(C)CC[C@]13C1=C2C(OC)=CC=C1C4 YYCRAERBSFHMPL-XFKAJCMBSA-N 0.000 abstract 1
YYCRAERBSFHMPL-UHFFFAOYSA-N 14beta-Hydroxycodeinone Natural products O1C2C(=O)C=CC3(O)C4CC5=CC=C(OC)C1=C5C23CCN4C YYCRAERBSFHMPL-UHFFFAOYSA-N 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT07865161T 2006-12-04 2007-12-04 Verfahren zur reduzierung von unreinheiten in oxycodonbase ATE543823T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US87265506P	2006-12-04	2006-12-04
PCT/US2007/086372 WO2008070656A2 (en)	2006-12-04	2007-12-04	Process for reducing impurities in oxycodone base

Publications (1)

Publication Number	Publication Date
ATE543823T1 true ATE543823T1 (de)	2012-02-15

Family

ID=39264513

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07865161T ATE543823T1 (de)	2006-12-04	2007-12-04	Verfahren zur reduzierung von unreinheiten in oxycodonbase

Country Status (9)

Country	Link
US (1)	US7875719B2 (de)
EP (1)	EP2121698B1 (de)
JP (1)	JP2010511725A (de)
CN (2)	CN104761561A (de)
AT (1)	ATE543823T1 (de)
AU (1)	AU2007329451B2 (de)
CA (1)	CA2671551C (de)
ES (1)	ES2378710T3 (de)
WO (1)	WO2008070656A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI365880B (en) *	2004-03-30	2012-06-11	Euro Celtique Sa	Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone and oxycodone hydrochloride composition,pharmaceutical dosage form,sustained release oeal dosage form and pharmaceutically acceptable package having less than 25 pp
ES2378710T3 (es)	2006-12-04	2012-04-17	Noramco, Inc.	Procedimiento para reducir impurezas en la base de oxicodona
FR2923484B1 (fr) *	2007-11-09	2012-11-09	Sanofi Aventis	Procede de preparation de composes morphiniques
AU2010206724A1 (en) *	2009-01-22	2011-07-28	Nanotherapeutics, Inc.	Process for preparing particles of opioids and compositions produced thereby
CA2804101C (en)	2010-07-02	2021-01-19	Johnson Matthey Public Limited Company	Process for the synthesis and purification of oxycodone
EA028092B1 (ru) *	2012-07-16	2017-10-31	Родс Текнолоджис	Способ усовершенствованного синтеза опиоидов
NZ628695A (en)	2012-07-16	2016-02-26	Rhodes Technologies	Process for improved opioid synthesis
SI2880037T1 (sl)	2012-08-03	2019-04-30	Johnson Matthey Public Limited Company	Postopek za pripravo oksikodona
GB201313915D0 (en) *	2013-08-02	2013-09-18	Johnson Matthey Plc	Process
US9062062B1 (en)	2013-12-18	2015-06-23	Cody Laboratories, Inc.	Synthesis of oxycodone hydrochloride
US10227354B2 (en)	2013-12-18	2019-03-12	Cody Laboratories, Inc.	Conversion of oxycodone base to oxycodone hydrochloride
US8846923B1 (en)	2013-12-18	2014-09-30	Cody Laboratories, Inc.	Preparation of 14-hydroxycodeinone sulfate
AU2015207733A1 (en)	2014-01-15	2016-07-14	Rhodes Technologies	Process for improved oxycodone synthesis
MX379406B (es)	2014-01-15	2025-03-11	Rhodes Tech	Proceso para la síntesis mejorada de oximorfona.
US20160052932A1 (en)	2014-08-25	2016-02-25	Johnson Matthey Public Limited Company	Processes for Making Opioids Including 14-Hydroxycodeinone and 14-hydroxymorphinone
EP3252055B1 (de)	2016-05-31	2018-09-19	Alcaliber Investigacion Desarrollo e Innovacion SLU	Verfahren zur gewinnung von 3,14-diacetyloxymorphon aus oripavin
CA3067718A1 (en) *	2017-06-20	2018-12-27	Johnson Matthey Public Limited Company	Hydrogenation process for preparing oxycodone hydrochloride from 14-hydroxycodeinone
CN115326937B (zh) *	2021-05-11	2024-06-18	山东省食品药品检验研究院	一种基因毒杂质捕捉用固相探针及其使用方法与应用
CN114634514B (zh) *	2022-04-14	2024-04-09	甘肃农垦药物碱厂有限公司	一种去甲羟吗啡酮中杂质的去除方法

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US1485673A (en) *		1924-03-04		Ministrator
US4472253A (en) *	1981-08-17	1984-09-18	The Florida Board Of Regents On Behalf Of The Florida State University	Process for the preparation of an N-substituted 3-O-alkyl-14-hydroxynormorphinone derivative
US4795813A (en) *	1981-08-17	1989-01-03	The Florida Board Of Regents On Behalf Of The Florida State University	Synthesis of derivatives of codeine and other 3-O-alkylmorphines
US4613668A (en) *	1983-12-22	1986-09-23	The United States Of America As Represented By The Department Of Health And Human Services	Short total synthesis or morphinan compounds which uses cyclization of a cycloalkylcarbonyl compound selected from cyclopropylcarbonyl and cyclobutylcarbonyl
US6067749A (en) *	1996-07-11	2000-05-30	Tasmanian Alkaloids Pty. Ltd.	Papaver somniferum strain with high concentration of thebaine and oripavine
US5869669A (en) *	1996-07-26	1999-02-09	Penick Corporation	Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
GB9713703D0 (en)	1997-06-30	1997-09-03	Johnson Matthey Plc	Preparation of opiates
US6060943A (en) *	1998-04-14	2000-05-09	Nmb (Usa) Inc.	Circuit simulating a diode
US6177567B1 (en) *	1999-10-15	2001-01-23	Boehringer Ingelheim Chemicals, Inc.	Method for preparing oxycodone
US6864370B1 (en) *	2003-06-05	2005-03-08	Zhaiwei Lin	Process for manufacturing oxycodone
TWI365880B (en)	2004-03-30	2012-06-11	Euro Celtique Sa	Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone and oxycodone hydrochloride composition,pharmaceutical dosage form,sustained release oeal dosage form and pharmaceutically acceptable package having less than 25 pp
SK286087B6 (sk) *	2004-08-18	2008-03-05	Zentiva, A. S.	Spôsob prípravy oxykodonu
GB0421149D0 (en) *	2004-09-23	2004-10-27	Johnson Matthey Plc	Preparation of oxycodone
WO2006084389A1 (de) *	2005-02-11	2006-08-17	Cilag Ltd.	Verfahren zur reinigung von noroxymorphon-verbindungen
PT1861405E (pt) *	2005-03-04	2009-07-27	Euro Celtique Sa	Método de diminuír a quantidade de cetonas insaturadas em alfa-beta numa composição de opiáceos
EP2402346A1 (de)	2005-11-22	2012-01-04	Controlled Chemicals, Inc.	Verfahren zur Reduzierung kontaminierender Michael-Akzeptor-Werte in Oxycodon und anderen Zusammensetzungen
JP5695296B2 (ja)	2006-03-02	2015-04-01	マリンクロッドエルエルシー	低レベルのアルファ，ベータ−不飽和ケトン化合物を伴うモルフィナン−６−オン生成物の製造方法
ES2378710T3 (es)	2006-12-04	2012-04-17	Noramco, Inc.	Procedimiento para reducir impurezas en la base de oxicodona

2007
- 2007-12-04 ES ES07865161T patent/ES2378710T3/es active Active
- 2007-12-04 CA CA2671551A patent/CA2671551C/en active Active
- 2007-12-04 EP EP07865161A patent/EP2121698B1/de active Active
- 2007-12-04 AT AT07865161T patent/ATE543823T1/de active
- 2007-12-04 AU AU2007329451A patent/AU2007329451B2/en active Active
- 2007-12-04 JP JP2009540420A patent/JP2010511725A/ja active Pending
- 2007-12-04 CN CN201510063089.0A patent/CN104761561A/zh active Pending
- 2007-12-04 WO PCT/US2007/086372 patent/WO2008070656A2/en not_active Ceased
- 2007-12-04 US US11/949,824 patent/US7875719B2/en active Active
- 2007-12-04 CN CN200780050717A patent/CN101652369A/zh active Pending

Also Published As

Publication number	Publication date
ES2378710T3 (es)	2012-04-17
AU2007329451A1 (en)	2008-06-12
US7875719B2 (en)	2011-01-25
WO2008070656A2 (en)	2008-06-12
CA2671551A1 (en)	2008-06-12
EP2121698B1 (de)	2012-02-01
CN104761561A (zh)	2015-07-08
WO2008070656A3 (en)	2008-07-24
CN101652369A (zh)	2010-02-17
CA2671551C (en)	2015-02-10
JP2010511725A (ja)	2010-04-15
US20080132703A1 (en)	2008-06-05
AU2007329451B2 (en)	2012-08-30
EP2121698A2 (de)	2009-11-25

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