ATE544749T1 - Verfahren zur synthetisierung pharmazeutischer salze aus einem faktor-xa-hemmer - Google Patents

Verfahren zur synthetisierung pharmazeutischer salze aus einem faktor-xa-hemmer

Info

Publication number
ATE544749T1
ATE544749T1 AT07863800T AT07863800T ATE544749T1 AT E544749 T1 ATE544749 T1 AT E544749T1 AT 07863800 T AT07863800 T AT 07863800T AT 07863800 T AT07863800 T AT 07863800T AT E544749 T1 ATE544749 T1 AT E544749T1
Authority
AT
Austria
Prior art keywords
inhibitor
factor
pharmaceutical salts
synthesizing pharmaceutical
synthesizing
Prior art date
Application number
AT07863800T
Other languages
English (en)
Inventor
James P Kanter
Keiko Sujino
Sharique Sami Zuberi
Robert Scarborough
Original Assignee
Millennium Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc
Application granted granted Critical
Publication of ATE544749T1 publication Critical patent/ATE544749T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/90—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having more than three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
AT07863800T 2006-11-02 2007-11-01 Verfahren zur synthetisierung pharmazeutischer salze aus einem faktor-xa-hemmer ATE544749T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86414506P 2006-11-02 2006-11-02
PCT/US2007/083394 WO2008057972A1 (en) 2006-11-02 2007-11-01 Methods of synthesizing pharmaceutical salts of a factor xa inhibitor

Publications (1)

Publication Number Publication Date
ATE544749T1 true ATE544749T1 (de) 2012-02-15

Family

ID=39167635

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07863800T ATE544749T1 (de) 2006-11-02 2007-11-01 Verfahren zur synthetisierung pharmazeutischer salze aus einem faktor-xa-hemmer

Country Status (9)

Country Link
US (2) US8524907B2 (de)
EP (2) EP2404906B1 (de)
CN (1) CN101595092B (de)
AT (1) ATE544749T1 (de)
AU (1) AU2007317376B2 (de)
CA (1) CA2667488C (de)
ES (2) ES2382055T3 (de)
PT (2) PT2077995E (de)
WO (1) WO2008057972A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
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US7696352B2 (en) * 2004-06-18 2010-04-13 Millennium Pharmaceuticals, Inc. Factor Xa inhibitors
PE20070717A1 (es) 2005-11-08 2007-08-17 Millennium Pharm Inc Sal de maleato y polimorfo de [2-({4-[(dimetilamino)iminometil]fenil}carbonilamino)-5-metoxifenil]-n-(5-cloro-(2-piridil))carboxamida
NZ572418A (en) 2006-05-05 2011-08-26 Millennium Pharm Inc Factor xa inhibitors
CN101595092B (zh) * 2006-11-02 2012-02-01 米伦纽姆医药公司 合成因子xa抑制剂的医药盐的方法
EA020531B1 (ru) * 2007-04-13 2014-11-28 Милленниум Фармасьютикалз, Инк. КОМБИНИРОВАННАЯ ТЕРАПИЯ АНТИКОАГУЛИРУЮЩЕГО СРЕДСТВА С СОЕДИНЕНИЕМ, КОТОРОЕ ДЕЙСТВУЕТ КАК ИНГИБИТОР ФАКТОРА Ха
CN102762550B (zh) 2009-12-17 2015-04-01 米伦纽姆医药公司 Xa因子抑制剂的盐和结晶形式
AR079491A1 (es) 2009-12-17 2012-02-01 Millennium Pharm Inc Metodos de sintesis de inhibidores del factor xa tal como el betrixaban y composiciones farmaceuticas que contienen la base libre de betrixaban o su sal sustancialmente pura.
US8742120B2 (en) 2009-12-17 2014-06-03 Millennium Pharmaceuticals, Inc. Methods of preparing factor xa inhibitors and salts thereof
AR082804A1 (es) 2010-09-01 2013-01-09 Portola Pharm Inc Formas cristalinas de un inhibidor del factor xa
US9200268B2 (en) 2012-12-27 2015-12-01 Portola Pharmaceuticals, Inc. Compounds and methods for purification of serine proteases
US20140346397A1 (en) 2012-12-27 2014-11-27 Portola Pharmaceuticals, Inc. Compounds and methods for purification of serine proteases
CN104341343B (zh) * 2013-07-24 2018-09-28 四川海思科制药有限公司 贝曲西班的晶型及其制备方法和用途
CN104693114B (zh) * 2013-12-10 2019-08-16 四川海思科制药有限公司 一种贝曲西班的改进的制备方法
CN105085387A (zh) * 2014-05-20 2015-11-25 四川海思科制药有限公司 贝曲西班盐及其制备方法和用途
EP3078378B1 (de) 2015-04-08 2020-06-24 Vaiomer Verwendung von faktor-xa-inhibitoren zur regulierung von glykämie
WO2017091757A1 (en) 2015-11-24 2017-06-01 Portola Pharmaceuticals, Inc. Isotopically enriched betrixaban
CN105348187B (zh) * 2015-12-02 2017-12-08 安徽省逸欣铭医药科技有限公司 一种贝曲西班结构类似物及其制备方法和用途
CN105732490A (zh) * 2016-03-25 2016-07-06 重庆医科大学 一种贝曲西班的制备方法
EP3293174A1 (de) * 2016-09-09 2018-03-14 Sandoz Ag Kristalline formen von betrixaban
WO2018229796A2 (en) * 2017-06-14 2018-12-20 Mylan Laboratories Limited A process for betrixaban hydrochloride and betrixaban maleate salt
CN108570003A (zh) * 2018-06-01 2018-09-25 浙江宏元药业股份有限公司 一种贝曲西班马来酸盐的一水无定形及其制备方法

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AR079491A1 (es) * 2009-12-17 2012-02-01 Millennium Pharm Inc Metodos de sintesis de inhibidores del factor xa tal como el betrixaban y composiciones farmaceuticas que contienen la base libre de betrixaban o su sal sustancialmente pura.

Also Published As

Publication number Publication date
HK1165426A1 (en) 2012-10-05
CA2667488C (en) 2015-07-07
CN101595092B (zh) 2012-02-01
EP2077995B1 (de) 2012-02-08
EP2404906B1 (de) 2015-07-15
AU2007317376A1 (en) 2008-05-15
US20100197929A1 (en) 2010-08-05
PT2077995E (pt) 2012-05-10
US20140046071A1 (en) 2014-02-13
HK1133258A1 (en) 2010-03-19
US9221758B2 (en) 2015-12-29
ES2550057T3 (es) 2015-11-04
PT2404906E (pt) 2015-11-02
EP2404906A1 (de) 2012-01-11
ES2382055T3 (es) 2012-06-04
US8524907B2 (en) 2013-09-03
WO2008057972A1 (en) 2008-05-15
CN101595092A (zh) 2009-12-02
EP2077995A1 (de) 2009-07-15
AU2007317376B2 (en) 2013-01-17
CA2667488A1 (en) 2008-05-15

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