ATE497769T1 - Verfahren zur herstellung von ibandronat - Google Patents

Verfahren zur herstellung von ibandronat

Info

Publication number: ATE497769T1
Authority: AT; Austria
Prior art keywords: ibandronate; producing; producing ibandronate; hydroxypropane; monohydrate
Prior art date: 2004-10-29

Application number

AT05799731T

Other languages

English (en)

Inventor

Friedrich Baetz

Bernd Junghans

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-10-29

Filing date

2005-10-25

Publication date

2011-02-15

2005-10-25 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2011-02-15 Application granted granted Critical

2011-02-15 Publication of ATE497769T1 publication Critical patent/ATE497769T1/de

Links

MPBVHIBUJCELCL-UHFFFAOYSA-N Ibandronate Chemical compound CCCCCN(C)CCC(O)(P(O)(O)=O)P(O)(O)=O MPBVHIBUJCELCL-UHFFFAOYSA-N 0.000 title 1
229940015872 ibandronate Drugs 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
DRPKUPBGKFMTRM-UHFFFAOYSA-N (2-amino-1-hydroxy-1-phosphonopropyl)phosphonic acid Chemical compound CC(N)C(O)(P(O)(O)=O)P(O)(O)=O DRPKUPBGKFMTRM-UHFFFAOYSA-N 0.000 abstract 1
KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical class [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 abstract 1
150000004682 monohydrates Chemical class 0.000 abstract 1
238000007040 multi-step synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Physical Education & Sports Medicine (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)

AT05799731T 2004-10-29 2005-10-25 Verfahren zur herstellung von ibandronat ATE497769T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP04105407		2004-10-29
PCT/EP2005/011404 WO2006045578A2 (en)	2004-10-29	2005-10-25	Process for the preparation of ibandronate

Publications (1)

Publication Number	Publication Date
ATE497769T1 true ATE497769T1 (de)	2011-02-15

Family

ID=36097233

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05799731T ATE497769T1 (de)	2004-10-29	2005-10-25	Verfahren zur herstellung von ibandronat

Country Status (13)

Country	Link
US (1)	US7214818B2 (de)
EP (1)	EP1807090B9 (de)
JP (1)	JP4560548B2 (de)
KR (1)	KR100880061B1 (de)
CN (1)	CN101048165B (de)
AT (1)	ATE497769T1 (de)
CA (1)	CA2585027C (de)
DE (1)	DE602005026310D1 (de)
ES (1)	ES2359415T3 (de)
IL (1)	IL182690A (de)
MX (1)	MX2007005114A (de)
TW (1)	TWI293304B (de)
WO (1)	WO2006045578A2 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2006002348A2 (en) *	2004-06-23	2006-01-05	Teva Pharmaceutical Industies Ltd.	Solid and crystalline ibandronic acid
WO2007074475A2 (en) *	2005-12-27	2007-07-05	Natco Pharma Limited	Novel polymorphic forms of ibandronate
US8178712B2 (en)	2006-06-23	2012-05-15	Cipla Ltd.	Process for the synthesis of Ibandronate sodium
CA2656053A1 (en) *	2006-07-03	2008-01-10	Generics [Uk] Limited	Novel process for the preparation of bisphosphonic acids
WO2008014510A2 (en) *	2006-07-28	2008-01-31	Dr. Reddy's Laboratories Limited	Crystalline form a of ibandronic acid and process for the preparation
US20090012047A1 (en) *	2006-11-16	2009-01-08	Eran Turgeman	Crystalline forms of ibandronate sodium
CA2570949A1 (en) *	2006-12-12	2008-06-12	Apotex Pharmachem Inc.	Ibandronate sodium propylene glycol solvate and processes for the preparation thereof
CN101679465B (zh) *	2007-04-11	2013-08-21	霍夫曼-拉罗奇有限公司	伊班膦酸盐的制备方法
KR20100014728A (ko) *	2007-04-19	2010-02-10	닥터 레디스 레보러터리즈 리미티드	이반드로네이트 나트륨 다형태
US20090042839A1 (en) *	2007-08-09	2009-02-12	Sharon Avhar-Maydan	Crystalline forms of ibandronate sodium
US20090075944A1 (en) *	2007-09-15	2009-03-19	Protia, Llc	Deuterium-enriched ibandronate
WO2009093258A2 (en) *	2008-01-24	2009-07-30	Fleming Laboratories Limited	A new and improved process for the preparation of ibandronate sodium monohydrate
EP2180003A1 (de)	2008-10-21	2010-04-28	Zentiva, k.s.	Herstellung von Trinatriumbandronat
EP2192126B1 (de)	2008-11-26	2013-03-27	Synthon B.V.	Verfahren zur Herstellung von Zoledronsäure
US20100130746A1 (en) *	2008-11-26	2010-05-27	Martin Kas	Process for Making Zoledronic Acid
CN101863919B (zh) *	2010-07-05	2011-11-23	武汉同源药业有限公司	一种化合物伊班膦酸钠的制备方法
CN102093416B (zh) *	2011-03-17	2013-07-24	南京恒生制药有限公司	一种合成伊班膦酸钠的方法
CN103012155A (zh) *	2012-11-29	2013-04-03	张家港市大伟助剂有限公司	一种n-甲基戊胺的制备方法
CN103396332A (zh) *	2013-08-19	2013-11-20	四川协力制药有限公司	3—[（n—甲基—n—戊基）氨基]丙酸盐酸盐的制备方法
CN104628768A (zh) *	2015-03-06	2015-05-20	江苏正大清江制药有限公司	一种伊班膦酸钠的制备方法
CN114524925B (zh) *	2020-11-23	2023-11-14	华润化学材料科技股份有限公司	钛系催化剂及其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3919321A (en) *	1966-11-08	1975-11-11	Hoffmann La Roche	Halo-substituted-5H-dibenzo{8 a,d{9 cyclohepten-5-ones
US4220611A (en)	1978-06-29	1980-09-02	Sandoz, Inc.	Polyoxyalkylene bridged phosphate esters
DE3623397A1 (de)	1986-07-11	1988-01-14	Boehringer Mannheim Gmbh	Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE3808074A1 (de)	1988-03-11	1989-09-21	Henkel Kgaa	Verfahren zur herstellung von azacycloalkan-2,2-diphosphonsaeuren
DE3822650A1 (de)	1988-07-05	1990-02-01	Boehringer Mannheim Gmbh	Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US4922007A (en)	1989-06-09	1990-05-01	Merck & Co., Inc.	Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US6562974B2 (en)	2000-02-01	2003-05-13	The Procter & Gamble Company	Process for making geminal bisphosphonates
AU2003233569A1 (en)	2002-05-17	2003-12-02	Teva Pharmaceutical Industries Ltd.	Use of certain diluents for making bisphosphonic acids

2005
- 2005-10-18 US US11/252,668 patent/US7214818B2/en not_active Expired - Lifetime
- 2005-10-25 CN CN2005800371320A patent/CN101048165B/zh not_active Expired - Fee Related
- 2005-10-25 CA CA2585027A patent/CA2585027C/en not_active Expired - Fee Related
- 2005-10-25 DE DE602005026310T patent/DE602005026310D1/de not_active Expired - Lifetime
- 2005-10-25 WO PCT/EP2005/011404 patent/WO2006045578A2/en not_active Ceased
- 2005-10-25 EP EP05799731A patent/EP1807090B9/de not_active Expired - Lifetime
- 2005-10-25 KR KR1020077011938A patent/KR100880061B1/ko not_active Expired - Fee Related
- 2005-10-25 AT AT05799731T patent/ATE497769T1/de active
- 2005-10-25 ES ES05799731T patent/ES2359415T3/es not_active Expired - Lifetime
- 2005-10-25 JP JP2007538322A patent/JP4560548B2/ja not_active Expired - Lifetime
- 2005-10-25 MX MX2007005114A patent/MX2007005114A/es active IP Right Grant
- 2005-10-27 TW TW094137688A patent/TWI293304B/zh not_active IP Right Cessation
2007
- 2007-04-19 IL IL182690A patent/IL182690A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
JP4560548B2 (ja)	2010-10-13
JP2008517964A (ja)	2008-05-29
KR100880061B1 (ko)	2009-01-22
US7214818B2 (en)	2007-05-08
CN101048165A (zh)	2007-10-03
EP1807090B9 (de)	2011-11-09
TW200621792A (en)	2006-07-01
IL182690A0 (en)	2007-09-20
CA2585027C (en)	2010-05-18
KR20070070246A (ko)	2007-07-03
MX2007005114A (es)	2007-06-26
TWI293304B (en)	2008-02-11
CN101048165B (zh)	2010-12-01
EP1807090A2 (de)	2007-07-18
WO2006045578A3 (en)	2006-08-17
CA2585027A1 (en)	2006-05-04
WO2006045578A2 (en)	2006-05-04
US20060094898A1 (en)	2006-05-04
IL182690A (en)	2011-07-31
ES2359415T3 (es)	2011-05-23
EP1807090B1 (de)	2011-02-09
DE602005026310D1 (de)	2011-03-24

Legal Events

Date

Code

Title

Description

2011-10-15

UEP

Publication of translation of european patent specification

Ref document number: 1807090

Country of ref document: EP

Publication	Publication Date	Title
DE602005026310D1 (de)	2011-03-24	Verfahren zur herstellung von ibandronat
ATE451380T1 (de)	2009-12-15	Verfahren zur herstellung von bisphosphonsäureverbindungen
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