ATE545638T1 - Optisch aktive carbamate, verfahren zu deren herstellung und deren anwendung als pharmazeutische zwischenprodukte - Google Patents
Optisch aktive carbamate, verfahren zu deren herstellung und deren anwendung als pharmazeutische zwischenprodukteInfo
- Publication number
- ATE545638T1 ATE545638T1 AT06831510T AT06831510T ATE545638T1 AT E545638 T1 ATE545638 T1 AT E545638T1 AT 06831510 T AT06831510 T AT 06831510T AT 06831510 T AT06831510 T AT 06831510T AT E545638 T1 ATE545638 T1 AT E545638T1
- Authority
- AT
- Austria
- Prior art keywords
- production
- optically active
- intermediate products
- pharmaceutical intermediate
- phenylmethyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 title 1
- 239000012450 pharmaceutical intermediate Substances 0.000 title 1
- 239000000047 product Substances 0.000 title 1
- HIKIBGRLBOCOAZ-UHFFFAOYSA-N 1-[[1-(4-chlorophenyl)cyclohexa-2,4-dien-1-yl]methyl]piperazine Chemical compound C1=CC(Cl)=CC=C1C1(CN2CCNCC2)C=CC=CC1 HIKIBGRLBOCOAZ-UHFFFAOYSA-N 0.000 abstract 2
- 230000003287 optical effect Effects 0.000 abstract 2
- JMQVUSCMFQCHMY-UHFFFAOYSA-N 2,2,2-trichloroethyl 4-[(4-chlorophenyl)-phenylmethyl]piperazine-1-carboxylate Chemical compound C1=CC(Cl)=CC=C1C(C=1C=CC=CC=1)N1CCN(C(=O)OCC(Cl)(Cl)Cl)CC1 JMQVUSCMFQCHMY-UHFFFAOYSA-N 0.000 abstract 1
- 239000008186 active pharmaceutical agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0501139A HU227074B1 (en) | 2005-12-08 | 2005-12-08 | An optically active carbamic acid derivative, method for producing the same and use as a pharmaceutical intermediate |
| PCT/HU2006/000109 WO2007066163A2 (en) | 2005-12-08 | 2006-12-08 | Optically active carbamates, process for preparation thereof and use thereof as pharmaceutical intermediates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE545638T1 true ATE545638T1 (de) | 2012-03-15 |
Family
ID=89986439
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06831510T ATE545638T1 (de) | 2005-12-08 | 2006-12-08 | Optisch aktive carbamate, verfahren zu deren herstellung und deren anwendung als pharmazeutische zwischenprodukte |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7851627B2 (de) |
| EP (1) | EP1963296B1 (de) |
| JP (1) | JP2009518379A (de) |
| CN (1) | CN101356162A (de) |
| AT (1) | ATE545638T1 (de) |
| EA (1) | EA015801B1 (de) |
| HU (1) | HU227074B1 (de) |
| NO (1) | NO20083068L (de) |
| UA (1) | UA92195C2 (de) |
| WO (1) | WO2007066163A2 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100928776B1 (ko) * | 2007-09-07 | 2009-11-25 | 한미약품 주식회사 | (ｒ)-1-[(4-클로로페닐)페닐메틸]피페라진 또는 이의 염의제조방법 |
| KR101427100B1 (ko) | 2007-10-23 | 2014-08-08 | 주식회사 씨트리 | 광학활성을 갖는 1-[(4-클로로페닐)페닐메틸]-피페라진의제조방법 |
| US7989623B2 (en) * | 2007-11-21 | 2011-08-02 | Synthon Bv | Process for making n-(diphenylmethyl)piperazines |
| ES2361343T3 (es) * | 2007-11-21 | 2011-06-16 | Synthon B.V. | Procedimiento para obtener n-(difenilmetil)piperazinas. |
| WO2009147389A2 (en) * | 2008-06-02 | 2009-12-10 | Cipla Limited | Processes for the synthesis of levocetirizine and intermediates for use therein |
| US20100145049A1 (en) * | 2008-11-21 | 2010-06-10 | Jie Zhu | Process for making n-(diphenylmethyl)piperazines |
| WO2010057515A1 (en) * | 2008-11-21 | 2010-05-27 | Synthon B.V. | Levocetirizine by menthyl intermediate |
| WO2012101475A1 (en) | 2011-01-27 | 2012-08-02 | Jubilant Life Sciences Limited | An improved process for the preparation of antihistaminic drugs via a novel carbamate intermediate |
| US8580886B2 (en) | 2011-09-20 | 2013-11-12 | Dow Corning Corporation | Method for the preparation and use of bis (alkoxysilylorgano)-dicarboxylates |
| US9518072B2 (en) | 2011-12-02 | 2016-12-13 | Dow Corning Corporation | Ester-functional silanes and the preparation and use thereof; and use of iminium compounds as phase transfer catalysts |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2709169A (en) * | 1955-05-24 | X c chs | ||
| BE508650A (de) * | ||||
| BE501277A (fr) * | 1951-02-15 | 1952-05-09 | H Morren | Procede de preparation de 1,4-aralcoyl-piperazines. |
| IT1140978B (it) * | 1980-05-23 | 1986-10-10 | Selvi & C Spa | 1-(4-clorobenzidril)-4-(2,3-diidros sipropil)-piperazina, metodi per la sua preparazione e relative composizione farmaceutiche |
| GB9305282D0 (en) * | 1993-03-15 | 1993-05-05 | Ucb Sa | Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine |
| JP2002249487A (ja) * | 2001-02-22 | 2002-09-06 | Sumitomo Chem Co Ltd | ４−（ｔｅｒｔ−ブトキシカルボニル）ピペラジン誘導体、その光学活性な酸付加塩、それらの製造法、およびそれらを用いる光学活性な１−［（置換フェニル）フェニルメチル］ピペラジンの製造法。 |
-
2005
- 2005-12-08 HU HU0501139A patent/HU227074B1/hu not_active IP Right Cessation
-
2006
- 2006-08-12 UA UAA200808116A patent/UA92195C2/ru unknown
- 2006-12-08 US US12/096,636 patent/US7851627B2/en not_active Expired - Fee Related
- 2006-12-08 EP EP06831510A patent/EP1963296B1/de active Active
- 2006-12-08 EA EA200801507A patent/EA015801B1/ru not_active IP Right Cessation
- 2006-12-08 WO PCT/HU2006/000109 patent/WO2007066163A2/en not_active Ceased
- 2006-12-08 JP JP2008543923A patent/JP2009518379A/ja active Pending
- 2006-12-08 CN CNA2006800462042A patent/CN101356162A/zh active Pending
- 2006-12-08 AT AT06831510T patent/ATE545638T1/de active
-
2008
- 2008-07-08 NO NO20083068A patent/NO20083068L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EA200801507A1 (ru) | 2008-10-30 |
| HU0501139D0 (en) | 2006-02-28 |
| CN101356162A (zh) | 2009-01-28 |
| EA015801B1 (ru) | 2011-12-30 |
| HU227074B1 (en) | 2010-06-28 |
| EP1963296A2 (de) | 2008-09-03 |
| EP1963296B1 (de) | 2012-02-15 |
| NO20083068L (no) | 2008-07-08 |
| WO2007066163A3 (en) | 2007-08-02 |
| WO2007066163A2 (en) | 2007-06-14 |
| US20090221823A1 (en) | 2009-09-03 |
| UA92195C2 (ru) | 2010-10-11 |
| HUP0501139A2 (en) | 2007-08-28 |
| US7851627B2 (en) | 2010-12-14 |
| JP2009518379A (ja) | 2009-05-07 |
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