NO20092715L - 5,6,7,8-tetrahydro-imidazo[1,5-A]pyrazinderivater - Google Patents

5,6,7,8-tetrahydro-imidazo[1,5-A]pyrazinderivater

Info

Publication number: NO20092715L
Authority: NO; Norway
Prior art keywords: alkyl; imidazo; tetrahydro; alkoxy; halogen
Prior art date: 2006-12-22

Application number

NO20092715A

Other languages

English (en)

Norwegian (no)

Inventor

Hamed Aissaoui

Christoph Boss

Markus Gude

Ralf Koberstein

Thierry Sifferlen

Original Assignee

Actelion Pharmaceuticals Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-12-22

Filing date

2009-07-20

Publication date

2009-07-20

2009-07-20 Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd

2009-07-20 Publication of NO20092715L publication Critical patent/NO20092715L/no

Links

WROMFHICINADER-UHFFFAOYSA-N 5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine Chemical class C1NCCN2C=NC=C21 WROMFHICINADER-UHFFFAOYSA-N 0.000 title abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 6
229910052736 halogen Inorganic materials 0.000 abstract 3
150000002367 halogens Chemical class 0.000 abstract 3
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 1
229940123730 Orexin receptor antagonist Drugs 0.000 abstract 1
125000004849 alkoxymethyl group Chemical group 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
-1 cyano, hydroxymethyl Chemical group 0.000 abstract 1
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
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Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Physical Education & Sports Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Addiction (AREA)
Orthopedic Medicine & Surgery (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Hospice & Palliative Care (AREA)
Dermatology (AREA)
Psychology (AREA)
Hematology (AREA)
Anesthesiology (AREA)
Gynecology & Obstetrics (AREA)
Reproductive Health (AREA)
Vascular Medicine (AREA)
Ophthalmology & Optometry (AREA)
Obesity (AREA)

NO20092715A 2006-12-22 2009-07-20 5,6,7,8-tetrahydro-imidazo[1,5-A]pyrazinderivater NO20092715L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IB2006055019		2006-12-22
PCT/IB2007/055245 WO2008078291A1 (en)	2006-12-22	2007-12-20	5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine derivatives

Publications (1)

Publication Number	Publication Date
NO20092715L true NO20092715L (no)	2009-07-20

Family

ID=39273168

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20092715A NO20092715L (no)	2006-12-22	2009-07-20	5,6,7,8-tetrahydro-imidazo[1,5-A]pyrazinderivater

Country Status (15)

Country	Link
US (1)	US8188082B2 (de)
EP (1)	EP2125823B1 (de)
JP (1)	JP2010513466A (de)
KR (1)	KR20090106538A (de)
CN (1)	CN101568542B (de)
AT (1)	ATE545647T1 (de)
AU (1)	AU2007337659A1 (de)
BR (1)	BRPI0720522A2 (de)
CA (1)	CA2669561A1 (de)
ES (1)	ES2380391T3 (de)
MA (1)	MA31002B1 (de)
MX (1)	MX2009006553A (de)
NO (1)	NO20092715L (de)
RU (1)	RU2009127842A (de)
WO (1)	WO2008078291A1 (de)

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US7775298B2 (en)	2007-10-29	2010-08-17	Abergeldie Holdings Pty Ltd/Abergeldie Plant Pty Ltd	Drilling assemblies and methods of drilling
CN101468988A (zh) *	2007-12-26	2009-07-01	上海恒瑞医药有限公司	哌嗪类衍生物,其制备方法及其在医药上的应用
US20110105514A1 (en) *	2008-06-25	2011-05-05	Hamed Aissaoui	5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine compounds
ES2585806T3 (es)	2009-10-23	2016-10-10	Janssen Pharmaceutica N.V.	Octahidropirrolo [3,4-c] pirroles disustituidos como moduladores de receptores de orexina
CN102258508A (zh) *	2011-04-14	2011-11-30	威海迪素制药有限公司	芳基丙烯酸衍生物抗癫痫的用途
US9440982B2 (en)	2012-02-07	2016-09-13	Eolas Therapeutics, Inc.	Substituted prolines/piperidines as orexin receptor antagonists
WO2013119639A1 (en)	2012-02-07	2013-08-15	Eolas Therapeutics, Inc.	Substituted prolines / piperidines as orexin receptor antagonists
CN103980281B (zh) *	2014-05-27	2016-06-08	天津市斯芬克司药物研发有限公司	一种咪唑吡嗪化合物及其制备方法
TW201613902A (en)	2014-08-13	2016-04-16	Eolas Therapeutics Inc	Difluoropyrrolidines as orexin receptor modulators
LT3414241T (lt)	2016-02-12	2022-08-25	Astrazeneca Ab	Halogenu pakeisti piperidinai kaip oreksino receptoriaus moduliatoriai
HRP20220642T1 (hr)	2016-03-10	2022-06-24	Janssen Pharmaceutica Nv	Postupci za liječenje depresije uporabom antagonista receptora oreksina 2
CN105753788A (zh) *	2016-04-08	2016-07-13	西南科技大学	一种1-取代-2-苯基-4-碘咪唑的制备方法
WO2017194548A1 (en)	2016-05-10	2017-11-16	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory diseases
DK3682881T3 (da)	2017-09-14	2026-05-11	Daiichi Sankyo Co Limited	Forbindelse med cyklisk struktur
CN108101930B (zh) *	2017-12-22	2020-10-30	武汉大学	一类含有苯并噻二唑并噻吩单元的小分子受体材料及其制备方法与应用
AU2019245403B2 (en) *	2018-03-29	2025-02-06	Board Of Regents, The University Of Texas System	Imidazopiperazine inhibitors of transcription activating proteins
WO2019195846A1 (en)	2018-04-06	2019-10-10	Board Of Regents, The University Of Texas System	Imidazopiperazinone inhibitors of transcription activating proteins
GB201908511D0 (en)	2019-06-13	2019-07-31	Adorx Therapeutics Ltd	Hydroxamate compounds
CN116348112A (zh) *	2020-10-02	2023-06-27	德州大学系统董事会	转录激活蛋白的咪唑并哌嗪抑制剂
JP2023544173A (ja)	2020-10-02	2023-10-20	ボードオブレジェンツ，ザユニバーシティオブテキサスシステム	転写活性化タンパク質のイミダゾピペラジン阻害剤
KR102910851B1 (ko) *	2021-04-21	2026-01-09	장춘 진사이언스 파마슈티컬 씨오., 엘티디.	이미다졸 함유 축합고리계 유도체, 이의 제조방법 및 이의 의약적 용도
EP4574826A4 (de) *	2022-10-19	2025-12-10	Changchun Genescience Pharmaceutical Co Ltd	Kristallform eines nk3r-antagonisten und herstellungsverfahren dafür und verwendung davon
WO2025224168A1 (en)	2024-04-24	2025-10-30	Idorsia Pharmaceuticals Ltd	Aryl sulfone and sulfanone derivatives as orexin receptor modulators

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2007
- 2007-12-20 ES ES07859469T patent/ES2380391T3/es active Active
- 2007-12-20 AT AT07859469T patent/ATE545647T1/de active
- 2007-12-20 MX MX2009006553A patent/MX2009006553A/es not_active Application Discontinuation
- 2007-12-20 AU AU2007337659A patent/AU2007337659A1/en not_active Abandoned
- 2007-12-20 JP JP2009542373A patent/JP2010513466A/ja active Pending
- 2007-12-20 WO PCT/IB2007/055245 patent/WO2008078291A1/en not_active Ceased
- 2007-12-20 CA CA002669561A patent/CA2669561A1/en not_active Abandoned
- 2007-12-20 BR BRPI0720522-8A patent/BRPI0720522A2/pt not_active IP Right Cessation
- 2007-12-20 KR KR1020097015261A patent/KR20090106538A/ko not_active Ceased
- 2007-12-20 RU RU2009127842/04A patent/RU2009127842A/ru not_active Application Discontinuation
- 2007-12-20 US US12/520,693 patent/US8188082B2/en not_active Expired - Fee Related
- 2007-12-20 CN CN2007800478100A patent/CN101568542B/zh not_active Expired - Fee Related
- 2007-12-20 EP EP07859469A patent/EP2125823B1/de active Active
2009
- 2009-06-17 MA MA32006A patent/MA31002B1/fr unknown
- 2009-07-20 NO NO20092715A patent/NO20092715L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
ATE545647T1 (de)	2012-03-15
MA31002B1 (fr)	2009-12-01
AU2007337659A1 (en)	2008-07-03
WO2008078291A1 (en)	2008-07-03
KR20090106538A (ko)	2009-10-09
CN101568542A (zh)	2009-10-28
BRPI0720522A2 (pt)	2014-01-07
EP2125823A1 (de)	2009-12-02
CA2669561A1 (en)	2008-07-03
MX2009006553A (es)	2009-06-26
JP2010513466A (ja)	2010-04-30
CN101568542B (zh)	2013-03-27
RU2009127842A (ru)	2011-01-27
ES2380391T3 (es)	2012-05-11
US20100093740A1 (en)	2010-04-15
EP2125823B1 (de)	2012-02-15
US8188082B2 (en)	2012-05-29

Legal Events

Date	Code	Title	Description
2012-07-23	FC2A	Withdrawal, rejection or dismissal of laid open patent application

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