ATE546142T1 - Salze und polymorphe einer wirkungsvollen antidiabetischen verbindung - Google Patents
Salze und polymorphe einer wirkungsvollen antidiabetischen verbindungInfo
- Publication number
- ATE546142T1 ATE546142T1 AT04794053T AT04794053T ATE546142T1 AT E546142 T1 ATE546142 T1 AT E546142T1 AT 04794053 T AT04794053 T AT 04794053T AT 04794053 T AT04794053 T AT 04794053T AT E546142 T1 ATE546142 T1 AT E546142T1
- Authority
- AT
- Austria
- Prior art keywords
- salts
- polymorphos
- polymorphs
- compound
- antidiabetic compound
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 230000003178 anti-diabetic effect Effects 0.000 title 1
- 239000003472 antidiabetic agent Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 abstract 1
- 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 abstract 1
- 210000001789 adipocyte Anatomy 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000019439 energy homeostasis Effects 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000037356 lipid metabolism Effects 0.000 abstract 1
- 230000002503 metabolic effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Quinoline Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50847003P | 2003-10-03 | 2003-10-03 | |
| PCT/US2004/032552 WO2005033074A2 (en) | 2003-10-03 | 2004-10-04 | Salts and polymorphs of a potent antidiabetic compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE546142T1 true ATE546142T1 (de) | 2012-03-15 |
Family
ID=34421741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04794053T ATE546142T1 (de) | 2003-10-03 | 2004-10-04 | Salze und polymorphe einer wirkungsvollen antidiabetischen verbindung |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7223761B2 (de) |
| EP (1) | EP1677797B1 (de) |
| JP (2) | JP5426813B2 (de) |
| KR (1) | KR101156277B1 (de) |
| CN (1) | CN1886134A (de) |
| AT (1) | ATE546142T1 (de) |
| AU (1) | AU2004278416B2 (de) |
| BR (1) | BRPI0414957A (de) |
| CA (1) | CA2540536C (de) |
| DK (1) | DK1677797T3 (de) |
| EA (1) | EA013367B1 (de) |
| ES (1) | ES2386670T3 (de) |
| IL (1) | IL174728A (de) |
| IS (1) | IS8378A (de) |
| MX (1) | MXPA06003313A (de) |
| NO (1) | NO333002B1 (de) |
| NZ (1) | NZ546783A (de) |
| WO (1) | WO2005033074A2 (de) |
| ZA (1) | ZA200602669B (de) |
Families Citing this family (35)
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| US7041691B1 (en) | 1999-06-30 | 2006-05-09 | Amgen Inc. | Compounds for the modulation of PPARγ activity |
| AU6118001A (en) | 2000-05-03 | 2001-11-12 | Tularik Inc | Combination therapeutic compositions and methods of use |
| US20030171399A1 (en) * | 2000-06-28 | 2003-09-11 | Tularik Inc. | Quinolinyl and benzothiazolyl modulators |
| US7223761B2 (en) * | 2003-10-03 | 2007-05-29 | Amgen Inc. | Salts and polymorphs of a potent antidiabetic compound |
| BRPI0620268B8 (pt) * | 2005-12-22 | 2021-05-25 | Oakwood Laboratories LLC | composição eficaz como sistema de fornecimento para liberação controlada, seu uso, seu método de fabricação, e método para proteger um agente biologicamente ativo |
| BRPI0717106A2 (pt) * | 2006-09-21 | 2013-10-08 | Piramal Life Sciences Ltd | Compostos para o tratamento de distúrbios metabólicos |
| US20130245024A1 (en) * | 2008-03-06 | 2013-09-19 | Dennis Lanfear | Combination of PPARy Agonist and a Dipeptidyl Peptidase-Inhibitor for the Treatment of Diabetes and Obesity |
| WO2010040055A2 (en) * | 2008-10-03 | 2010-04-08 | Intekrin Therapeutics, Inc. | Oral pharmaceutical formulations for antidiabetic compounds |
| WO2011017488A2 (en) * | 2009-08-05 | 2011-02-10 | Intekrin Therapeutics, Inc. | Combination of a selective ppar-gamma modulator and an incretin for the treatment of diabetes and obesity |
| CA2811634C (en) * | 2010-09-21 | 2019-01-15 | Intekrin Therapeutics, Inc. | Antidiabetic solid pharmaceutical compositions |
| US20130158077A1 (en) | 2011-12-19 | 2013-06-20 | Ares Trading S.A. | Pharmaceutical compositions |
| KR102056756B1 (ko) * | 2013-01-30 | 2019-12-17 | 인테크린 테라퓨틱스, 아이엔씨. | 다발성 경화증의 치료를 위한 PPARγ 작용제 |
| EA201791982A1 (ru) | 2015-03-09 | 2020-02-17 | Интекрин Терапьютикс, Инк. | Способы лечения неалкогольной жировой болезни печени и/или липодистрофии |
| WO2017178408A1 (en) | 2016-04-15 | 2017-10-19 | Syngenta Participations Ag | Microbiocidal silicon containing aryl derivatives |
| WO2018035446A1 (en) * | 2016-08-18 | 2018-02-22 | Intekrin Therapeutics, Inc. | PPARγ AGONIST FOR TREATMENT OF BLOOD CANCERS |
| WO2018035449A1 (en) * | 2016-08-18 | 2018-02-22 | Intekrin Therapeutics, Inc. | Pparϒ agonist for treatment of bone disorders |
| CN110461318A (zh) * | 2016-09-13 | 2019-11-15 | 因特克林治疗股份有限公司 | 用chs-131治疗多发性硬化 |
| SG11201906644YA (en) * | 2017-01-18 | 2019-08-27 | Coherus Biosciences Inc | Pparϒ agonist for the treatment of huntington's disease |
| JP2020515639A (ja) | 2017-04-03 | 2020-05-28 | コヒラス・バイオサイエンシズ・インコーポレイテッド | 進行性核上性麻痺の処置のためのＰＰＡＲγアゴニスト |
| CN109651208B (zh) * | 2017-10-10 | 2022-01-04 | 中国科学院上海药物研究所 | N-芳基磺酰胺类化合物，其药物组合物及其用途 |
| MX2021008010A (es) | 2018-12-31 | 2021-10-13 | Coherus Biosciences Inc | Composiciones y métodos para tratar las enfermedades del hígado graso no alcohólico (nafld). |
| EP3946336A1 (de) | 2019-04-02 | 2022-02-09 | Coherus Biosciences, Inc. | Zusammensetzungen und verfahren zur behandlung von nichtalkoholischen fettleberkrankheiten (nafld) |
| WO2020205026A1 (en) | 2019-04-04 | 2020-10-08 | Christos Mantzoros | Compositions and methods to treat non-alcoholic fatty liver diseases (nafld) |
| EP3946334A1 (de) | 2019-04-04 | 2022-02-09 | Coherus Biosciences, Inc. | Zusammensetzungen und verfahren zur behandlung von nichtalkoholischen fettleberkrankheiten (nafld) |
| US20220288054A1 (en) | 2019-04-04 | 2022-09-15 | Coherus Biosciences, Inc. | Compositions and methods to treat non-alcoholic fatty liver diseases (nafld) |
| US20220288053A1 (en) | 2019-04-04 | 2022-09-15 | Coherus Biosciences, Inc. | Compositions and methods to treat non-alcoholic fatty liver diseases (nafld) |
| WO2020243058A1 (en) | 2019-05-30 | 2020-12-03 | Coherus Biosciences, Inc. | Compositions and methods to treat cancer |
| WO2021076616A1 (en) | 2019-10-15 | 2021-04-22 | Coherus Biosciences, Inc. | Compositions and methods to treat non-alcoholic fatty liver diseases (nafld) |
| WO2022051318A1 (en) | 2020-09-03 | 2022-03-10 | Coherus Biosciences, Inc. | Fixed dose combinations of chs-131 and a thyroid receptor beta agonist |
| WO2022051321A1 (en) | 2020-09-03 | 2022-03-10 | Coherus Biosciences, Inc. | Fixed dose combinations of chs-131 and a fxr agonist |
| WO2022051319A1 (en) | 2020-09-03 | 2022-03-10 | Coherus Biosciences, Inc. | Fixed dose combinations of chs-131 and a dpp-4 inhibitor |
| WO2022051323A1 (en) | 2020-09-03 | 2022-03-10 | Coherus Biosciences, Inc. | Fixed dose combinations of chs-131 and a ppar agonist |
| WO2022051316A1 (en) | 2020-09-03 | 2022-03-10 | Coherus Biosciences, Inc. | Fixed dose combinations of chs-131 and a sglt-2 inhibitor |
| JP2022104747A (ja) * | 2020-12-29 | 2022-07-11 | 国立研究開発法人国立がん研究センター | 抗ウイルス剤 |
| CN116715637A (zh) * | 2023-02-23 | 2023-09-08 | 甘肃康巴斯生物科技有限公司 | 精喹禾灵中间体的制备方法 |
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-
2004
- 2004-10-01 US US10/956,251 patent/US7223761B2/en not_active Expired - Lifetime
- 2004-10-04 BR BRPI0414957-2A patent/BRPI0414957A/pt not_active IP Right Cessation
- 2004-10-04 AU AU2004278416A patent/AU2004278416B2/en not_active Ceased
- 2004-10-04 ES ES04794053T patent/ES2386670T3/es not_active Expired - Lifetime
- 2004-10-04 CN CNA2004800346697A patent/CN1886134A/zh active Pending
- 2004-10-04 NZ NZ546783A patent/NZ546783A/en not_active IP Right Cessation
- 2004-10-04 AT AT04794053T patent/ATE546142T1/de active
- 2004-10-04 ZA ZA200602669A patent/ZA200602669B/en unknown
- 2004-10-04 CA CA2540536A patent/CA2540536C/en not_active Expired - Lifetime
- 2004-10-04 MX MXPA06003313A patent/MXPA06003313A/es active IP Right Grant
- 2004-10-04 EP EP04794053A patent/EP1677797B1/de not_active Expired - Lifetime
- 2004-10-04 DK DK04794053.1T patent/DK1677797T3/da active
- 2004-10-04 KR KR1020067008440A patent/KR101156277B1/ko not_active Expired - Fee Related
- 2004-10-04 EA EA200600701A patent/EA013367B1/ru not_active IP Right Cessation
- 2004-10-04 JP JP2006534205A patent/JP5426813B2/ja not_active Expired - Fee Related
- 2004-10-04 WO PCT/US2004/032552 patent/WO2005033074A2/en not_active Ceased
-
2006
- 2006-03-27 IS IS8378A patent/IS8378A/is unknown
- 2006-04-02 IL IL174728A patent/IL174728A/en active IP Right Review Request
- 2006-05-03 NO NO20061974A patent/NO333002B1/no not_active IP Right Cessation
-
2007
- 2007-05-24 US US11/807,208 patent/US8003665B2/en active Active
-
2011
- 2011-12-02 JP JP2011264219A patent/JP2012097090A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| NO20061974L (no) | 2006-07-03 |
| WO2005033074A2 (en) | 2005-04-14 |
| ZA200602669B (en) | 2007-07-25 |
| US7223761B2 (en) | 2007-05-29 |
| EA013367B1 (ru) | 2010-04-30 |
| IS8378A (is) | 2006-03-27 |
| BRPI0414957A (pt) | 2006-11-07 |
| JP2007507537A (ja) | 2007-03-29 |
| DK1677797T3 (da) | 2012-06-04 |
| IL174728A0 (en) | 2006-08-20 |
| NO333002B1 (no) | 2013-02-11 |
| AU2004278416B2 (en) | 2010-04-15 |
| US20050143416A1 (en) | 2005-06-30 |
| KR101156277B1 (ko) | 2012-07-05 |
| MXPA06003313A (es) | 2006-06-08 |
| EP1677797B1 (de) | 2012-02-22 |
| JP5426813B2 (ja) | 2014-02-26 |
| JP2012097090A (ja) | 2012-05-24 |
| EP1677797A2 (de) | 2006-07-12 |
| US20070293536A1 (en) | 2007-12-20 |
| AU2004278416A1 (en) | 2005-04-14 |
| IL174728A (en) | 2011-06-30 |
| ES2386670T3 (es) | 2012-08-24 |
| US8003665B2 (en) | 2011-08-23 |
| NZ546783A (en) | 2008-11-28 |
| WO2005033074A3 (en) | 2005-06-16 |
| EP1677797A4 (de) | 2009-03-25 |
| KR20060097121A (ko) | 2006-09-13 |
| CN1886134A (zh) | 2006-12-27 |
| CA2540536C (en) | 2013-07-02 |
| CA2540536A1 (en) | 2005-04-14 |
| EA200600701A1 (ru) | 2006-10-27 |
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