ATE546543T1 - Screening-verfahren mit verwendung des neuen substrats epha4 für gamma-sekretase - Google Patents
Screening-verfahren mit verwendung des neuen substrats epha4 für gamma-sekretaseInfo
- Publication number
- ATE546543T1 ATE546543T1 AT08765357T AT08765357T ATE546543T1 AT E546543 T1 ATE546543 T1 AT E546543T1 AT 08765357 T AT08765357 T AT 08765357T AT 08765357 T AT08765357 T AT 08765357T AT E546543 T1 ATE546543 T1 AT E546543T1
- Authority
- AT
- Austria
- Prior art keywords
- epha4
- secretase
- screening method
- new substrate
- gamma secretase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94268707P | 2007-06-08 | 2007-06-08 | |
| PCT/JP2008/060567 WO2008150010A1 (ja) | 2007-06-08 | 2008-06-09 | γ-セクレターゼの新規基質EphA4を利用したスクリーニング方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE546543T1 true ATE546543T1 (de) | 2012-03-15 |
Family
ID=40093812
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08765357T ATE546543T1 (de) | 2007-06-08 | 2008-06-09 | Screening-verfahren mit verwendung des neuen substrats epha4 für gamma-sekretase |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US7910324B2 (de) |
| EP (1) | EP2166110B1 (de) |
| JP (1) | JP5511377B2 (de) |
| AT (1) | ATE546543T1 (de) |
| WO (1) | WO2008150010A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7910324B2 (en) | 2007-06-08 | 2011-03-22 | Eisai R&D Management Co., Ltd. | Method of screening for compounds which affect the processing of EphA4 by γ-secretase |
| US20090191580A1 (en) * | 2007-07-19 | 2009-07-30 | Eisai R & D Management Co., Ltd. | METHOD OF SCREENING USING c-MET, A NOVEL SUBSTRATE FOR GAMMA-SECRETASE |
| JPWO2009017234A1 (ja) * | 2007-08-01 | 2010-10-28 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | γ−セクレターゼの新規基質ｃ−Ｒｅｔを利用したスクリーニング方法 |
| JP5580598B2 (ja) | 2007-11-15 | 2014-08-27 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | γ−セクレターゼの新規基質ＥｐｈＡ７を利用したスクリーニング方法 |
| US7892769B2 (en) | 2007-11-30 | 2011-02-22 | Eisai R&D Management Co., Ltd. | Processing of EphA4 polypeptide by γ-secretase activity |
| WO2010141974A1 (en) * | 2009-06-10 | 2010-12-16 | The University Of Melbourne | Therapeutic applications |
| JP6059017B2 (ja) * | 2010-12-17 | 2017-01-11 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ゼラチナーゼによるＥｐｈＡ４の切断反応を指標としたスクリーニング方法 |
| JP5961608B2 (ja) | 2011-04-25 | 2016-08-02 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ＥｐｈＡ４細胞外ドメインの測定による認知機能障害を伴う神経系疾患の検出方法 |
| WO2017043466A1 (ja) | 2015-09-08 | 2017-03-16 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 抗ＥｐｈＡ４抗体 |
| JP6877419B2 (ja) * | 2015-10-27 | 2021-05-26 | ザ ユニバーシティー オブ クイーンズランド | 治療の方法およびそのために有用な剤 |
| AR119303A1 (es) | 2019-07-01 | 2021-12-09 | Eisai R&D Man Co Ltd | Anticuerpo anti-epha4 humano |
| CA3195085A1 (en) * | 2020-12-24 | 2022-06-30 | Eisai R&D Management Co., Ltd. | Therapeutic pharmaceutical composition for amyotrophic lateral sclerosis |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6887698A (en) | 1997-04-08 | 1998-10-30 | Sugen, Inc. | Study and treatment of diseases related to specific cellular functions of receptor protein tyrosine kinases |
| US20020068361A1 (en) * | 1997-04-08 | 2002-06-06 | Douglas Clary | Methods of evaluating specific cellular functions of receptor protein tyrosine kinases in a ligand independent manner |
| US20060241074A1 (en) * | 2001-08-14 | 2006-10-26 | The General Hospital Corporation | Methods for treatment of pain |
| US20070026409A1 (en) * | 2001-08-14 | 2007-02-01 | The General Hospital Corporation | Nucleic acid and amino acid sequences involved in pain |
| AU2002324700A1 (en) | 2001-08-14 | 2003-03-03 | Bayer Ag | Nucleic acid and amino acid sequences involved in pain |
| JP2003169699A (ja) | 2001-12-10 | 2003-06-17 | Japan Science & Technology Corp | 特異的γプロテアーゼ阻害剤のスクリーニング方法 |
| JP2004000060A (ja) | 2002-05-31 | 2004-01-08 | Otsuka Pharmaceut Co Ltd | アミロイドβ産生に影響を与える化合物のスクリーニング方法 |
| HRP20050461A2 (en) | 2002-11-26 | 2005-08-31 | Pharmacia & Upjohn Company Llc | Soluble notch-based substrates for gamma secretase and methods and compositions for using same |
| WO2005045028A1 (ja) | 2003-11-10 | 2005-05-19 | Osaka Industrial Promotion Organization | セル・フリー・Ｎｏｔｃｈ切断分析方法及び薬剤スクリーニング方法 |
| TW200538739A (en) | 2004-02-27 | 2005-12-01 | Oncotherapy Science Inc | EphA4 as therapeutic target of PRC and PDACa |
| EP1662259A1 (de) * | 2004-11-25 | 2006-05-31 | Cellzome Ag | Verwendung von Eph Rezeptor-Inhibitoren zur Behandlung von neurodegenerativen Erkrankungen |
| GB0427023D0 (en) | 2004-12-09 | 2005-01-12 | Merck Sharp & Dohme | Assay method |
| US20070051145A1 (en) * | 2005-09-02 | 2007-03-08 | Ez Trend Technology Co.,Ltd | Electric lock |
| EP1947193A1 (de) * | 2007-01-17 | 2008-07-23 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Screening-Verfahren für antidiabetische Zusammensetzungen |
| US7910324B2 (en) * | 2007-06-08 | 2011-03-22 | Eisai R&D Management Co., Ltd. | Method of screening for compounds which affect the processing of EphA4 by γ-secretase |
| CA2692604A1 (en) * | 2007-07-13 | 2009-01-22 | Elan Pharmaceuticals, Inc. | Compositions and methods for identifying substrate specificity of inhibitors of gamma secretase |
| US20090191580A1 (en) * | 2007-07-19 | 2009-07-30 | Eisai R & D Management Co., Ltd. | METHOD OF SCREENING USING c-MET, A NOVEL SUBSTRATE FOR GAMMA-SECRETASE |
| US20090163594A1 (en) * | 2007-10-31 | 2009-06-25 | Elan Pharmaceuticals, Inc. | Triple Assay System for Identifying Substrate Selectivity of Gamma Secretase Inhibitors |
| US7892769B2 (en) * | 2007-11-30 | 2011-02-22 | Eisai R&D Management Co., Ltd. | Processing of EphA4 polypeptide by γ-secretase activity |
| US20100113415A1 (en) * | 2008-05-29 | 2010-05-06 | Rajapakse Hemaka A | Epha4 rtk inhibitors for treatment of neurological and neurodegenerative disorders and cancer |
-
2008
- 2008-06-09 US US12/135,307 patent/US7910324B2/en active Active
- 2008-06-09 AT AT08765357T patent/ATE546543T1/de active
- 2008-06-09 EP EP08765357A patent/EP2166110B1/de active Active
- 2008-06-09 JP JP2009517923A patent/JP5511377B2/ja active Active
- 2008-06-09 WO PCT/JP2008/060567 patent/WO2008150010A1/ja not_active Ceased
-
2011
- 2011-01-19 US US13/009,127 patent/US8137926B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2166110B1 (de) | 2012-02-22 |
| WO2008150010A1 (ja) | 2008-12-11 |
| JPWO2008150010A1 (ja) | 2010-08-26 |
| US8137926B2 (en) | 2012-03-20 |
| US7910324B2 (en) | 2011-03-22 |
| EP2166110A1 (de) | 2010-03-24 |
| EP2166110A4 (de) | 2010-07-28 |
| US20110111444A1 (en) | 2011-05-12 |
| JP5511377B2 (ja) | 2014-06-04 |
| US20090142788A1 (en) | 2009-06-04 |
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