ATE535612T1 - Toxizitätsscreeningverfahren - Google Patents
ToxizitätsscreeningverfahrenInfo
- Publication number
- ATE535612T1 ATE535612T1 AT07752400T AT07752400T ATE535612T1 AT E535612 T1 ATE535612 T1 AT E535612T1 AT 07752400 T AT07752400 T AT 07752400T AT 07752400 T AT07752400 T AT 07752400T AT E535612 T1 ATE535612 T1 AT E535612T1
- Authority
- AT
- Austria
- Prior art keywords
- toxicity
- concentration
- determining
- cell type
- present
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 231100000041 toxicology testing Toxicity 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 230000001988 toxicity Effects 0.000 abstract 3
- 231100000419 toxicity Toxicity 0.000 abstract 3
- 238000000099 in vitro assay Methods 0.000 abstract 2
- 238000004458 analytical method Methods 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 231100000816 toxic dose Toxicity 0.000 abstract 1
- 230000007675 toxicity by organ Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5061—Muscle cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5067—Liver cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77966006P | 2006-03-06 | 2006-03-06 | |
| US74359906P | 2006-03-21 | 2006-03-21 | |
| PCT/US2007/005696 WO2007103374A2 (en) | 2006-03-06 | 2007-03-06 | Toxicity screening methods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE535612T1 true ATE535612T1 (de) | 2011-12-15 |
Family
ID=38475502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07752400T ATE535612T1 (de) | 2006-03-06 | 2007-03-06 | Toxizitätsscreeningverfahren |
Country Status (4)
| Country | Link |
|---|---|
| US (3) | US7615361B2 (de) |
| EP (2) | EP1996718B1 (de) |
| AT (1) | ATE535612T1 (de) |
| WO (1) | WO2007103374A2 (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8114615B2 (en) | 2006-05-17 | 2012-02-14 | Cernostics, Inc. | Method for automated tissue analysis |
| TW200927060A (en) * | 2007-11-05 | 2009-07-01 | Kci Licensing Inc | Identification of tissue for debridement |
| CA2724512A1 (en) * | 2008-05-28 | 2009-12-23 | Bennard Van Ravenzwaay | Means and methods for assessing liver enzyme induction |
| EP2294412A1 (de) * | 2008-06-04 | 2011-03-16 | Ceetox Inc. | Verfahren zur vorhersage der hautsensibilisierungswirkung von verbindungen |
| WO2010094694A1 (en) * | 2009-02-23 | 2010-08-26 | F. Hoffmann-La Roche Ag | Assays to predict cardiotoxicity |
| US20110004414A1 (en) * | 2009-06-06 | 2011-01-06 | Ceetox, Inc. | Method for Predicting Respiratory Toxicity of Compounds |
| CA2776383C (en) * | 2009-10-06 | 2019-04-30 | Wisconsin Alumni Research Foundation | Metabolic biomarkers of drug-induced cardiotoxicity |
| US20110212461A1 (en) * | 2010-02-26 | 2011-09-01 | Hans Marcus Ludwig Bitter | Prediction of cardiotoxicity |
| US20110212480A1 (en) * | 2010-02-26 | 2011-09-01 | Kyle Louis Kolaja | Use of primary human cardiomyocytes |
| US20120179381A1 (en) * | 2010-06-17 | 2012-07-12 | Mckim James M | Toxicity screening methods |
| WO2012016150A2 (en) * | 2010-07-29 | 2012-02-02 | The Board Of Trustees Of The University Of Illinois | Methods for predicting risk of stroke |
| ES2739623T3 (es) | 2011-03-17 | 2020-02-03 | Cernostics Inc | Sistemas y composiciones para diagnosticar el esófago de Barrett y métodos para usarlos |
| EP2574924A1 (de) | 2011-09-28 | 2013-04-03 | Merck Patent GmbH | Verfahren zur Bestimmung des Status von Zellen |
| US10852296B2 (en) * | 2011-12-27 | 2020-12-01 | BiOMICom Incorporated | Micro-sampling for cell, tissue, and micro-organism monitoring |
| WO2013116307A1 (en) | 2012-01-30 | 2013-08-08 | Mount Sinai School Of Medicine | Method for programming differentiated cells into hematopoietic stem cells |
| MX2014013875A (es) | 2012-05-22 | 2015-06-04 | Berg Llc | Ensayo basado en celulas interrogadoras para identificar marcadores de toxicidad inducida por medicamentos. |
| US10352947B2 (en) | 2012-09-12 | 2019-07-16 | Berg Llc | Use of markers in the identification of cardiotoxic agents and in the diagnosis and monitoring of cardiomyopathy and cardiovascular disease |
| CA2995767A1 (en) * | 2015-08-18 | 2017-02-23 | Coyne Scientific, Llc | Method of estimating the incidence of in vivo reactions to chemical or biological agents using in vitro experiments |
| CN106770693A (zh) * | 2015-11-19 | 2017-05-31 | 中国药科大学 | 新型药物体外温孵、代谢物寻找、药物-药物相互作用预测快速筛选与分析整合策略 |
| GB201700138D0 (en) | 2017-01-05 | 2017-02-22 | Senzagen Ab | Analytical methods and arrays for use in the same |
| CA3186840A1 (en) * | 2020-07-24 | 2022-01-27 | Angus A. Lamar | Synthesis and use of n-benzyl sulfonamides |
| CN115616134A (zh) * | 2022-10-24 | 2023-01-17 | 南京理工大学 | 一种新污染物转化效应的评估系统 |
| CN117169091B (zh) * | 2023-07-28 | 2024-09-13 | 恩大细胞基因工程有限公司 | 一种细胞活性检测系统 |
| US20250316343A1 (en) * | 2024-03-08 | 2025-10-09 | AxiomBio, Inc. | Optimizing molecule toxicity by replacing target fragments with bioisosteres |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL62879A (en) | 1981-05-15 | 1985-09-29 | Chaya Moroz | Monoclonal antibodies,clones producing them,preparation of such antibodies and clones and cytotoxic and immunoassay using such antibodies |
| US4532751B1 (en) | 1984-04-16 | 1998-02-03 | Mayer Oskar Foods | Automatic sheet product line |
| GB9221664D0 (en) | 1992-10-15 | 1992-11-25 | Shiny Chemical Ind Co Limited | Propylene glycol monomethyl ether propionate and the process for the preparation thereof |
| CA2189634A1 (en) | 1994-05-06 | 1995-11-16 | John J. Baldwin | Combinatorial dihydrobenzopyran library |
| WO1995032184A1 (en) | 1994-05-23 | 1995-11-30 | Arqule, Inc. | Systematic modular production of aminimide- and oxazolone- based molecules having at least two structural diversity elements |
| US5525735A (en) | 1994-06-22 | 1996-06-11 | Affymax Technologies Nv | Methods for synthesizing diverse collections of pyrrolidine compounds |
| AU3577997A (en) | 1996-06-24 | 1998-01-14 | Irori | Solid phase tyrphostin library linked to matrices with memories |
| US6558916B2 (en) * | 1996-08-02 | 2003-05-06 | Axiom Biotechnologies, Inc. | Cell flow apparatus and method for real-time measurements of patient cellular responses |
| US5985268A (en) * | 1997-09-15 | 1999-11-16 | Lockheed Martin Energy Research Corp. | Gamma-irradiated bacterial preparation having anti-tumor activity |
| US6998249B1 (en) * | 1999-09-27 | 2006-02-14 | Pharmacia & Upjohn Company | Toxicity screening method |
-
2007
- 2007-03-06 US US11/714,526 patent/US7615361B2/en not_active Expired - Fee Related
- 2007-03-06 EP EP07752400A patent/EP1996718B1/de not_active Not-in-force
- 2007-03-06 WO PCT/US2007/005696 patent/WO2007103374A2/en not_active Ceased
- 2007-03-06 AT AT07752400T patent/ATE535612T1/de active
- 2007-03-06 EP EP10171513.4A patent/EP2287327B1/de active Active
-
2009
- 2009-09-30 US US12/570,992 patent/US20110008823A1/en not_active Abandoned
-
2013
- 2013-01-03 US US13/733,706 patent/US20130252270A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20070218457A1 (en) | 2007-09-20 |
| EP1996718A4 (de) | 2009-11-25 |
| EP2287327A1 (de) | 2011-02-23 |
| WO2007103374A2 (en) | 2007-09-13 |
| US20110008823A1 (en) | 2011-01-13 |
| EP1996718A2 (de) | 2008-12-03 |
| US20130252270A1 (en) | 2013-09-26 |
| EP2287327B1 (de) | 2013-06-05 |
| US7615361B2 (en) | 2009-11-10 |
| EP1996718B1 (de) | 2011-11-30 |
| WO2007103374A3 (en) | 2008-11-27 |
| WO2007103374A9 (en) | 2009-01-15 |
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