ATE547396T1 - Dicycloalkylcarbamoyl-harnstoffe als glucokinase- aktivatoren - Google Patents

Dicycloalkylcarbamoyl-harnstoffe als glucokinase- aktivatoren

Info

Publication number
ATE547396T1
ATE547396T1 AT06777658T AT06777658T ATE547396T1 AT E547396 T1 ATE547396 T1 AT E547396T1 AT 06777658 T AT06777658 T AT 06777658T AT 06777658 T AT06777658 T AT 06777658T AT E547396 T1 ATE547396 T1 AT E547396T1
Authority
AT
Austria
Prior art keywords
dicycloalkylcarbamoyl
ureas
glucokinase activators
glucokinase
activators
Prior art date
Application number
AT06777658T
Other languages
English (en)
Inventor
Anthony Murray
Jesper Lau
Per Vedsy
Lone Jeppesen
Marit Kristiansen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Application granted granted Critical
Publication of ATE547396T1 publication Critical patent/ATE547396T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/46—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylureas
    • C07C275/58—Y being a hetero atom
    • C07C275/62—Y being a nitrogen atom, e.g. biuret
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT06777658T 2005-07-08 2006-07-07 Dicycloalkylcarbamoyl-harnstoffe als glucokinase- aktivatoren ATE547396T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05106283 2005-07-08
PCT/EP2006/064028 WO2007006761A1 (en) 2005-07-08 2006-07-07 Dicycloalkylcarbamoyl ureas as glucokinase activators

Publications (1)

Publication Number Publication Date
ATE547396T1 true ATE547396T1 (de) 2012-03-15

Family

ID=37067087

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06777658T ATE547396T1 (de) 2005-07-08 2006-07-07 Dicycloalkylcarbamoyl-harnstoffe als glucokinase- aktivatoren

Country Status (6)

Country Link
US (1) US7999114B2 (de)
EP (1) EP1904438B1 (de)
JP (1) JP2009500378A (de)
AT (1) ATE547396T1 (de)
ES (1) ES2382815T3 (de)
WO (1) WO2007006761A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
EP2553086B1 (de) 2010-03-31 2017-04-19 The Scripps Research Institute Umprogrammierung von zellen
NZ603614A (en) * 2010-05-26 2014-10-31 Transtech Pharma Llc Use of metformin in combination with a glucokinase activator and compositions comprising metformin and a glucokinase activator
US8933024B2 (en) 2010-06-18 2015-01-13 Sanofi Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
CN118453592A (zh) 2012-05-17 2024-08-09 Vtv治疗有限责任公司 用于治疗糖尿病的葡萄糖激酶活化剂组合物
CN102731351B (zh) * 2012-06-27 2014-01-01 浙江国邦药业有限公司 一种1-甲基-5-[3-甲基-4-(4-三氟甲硫基-苯氧基)-苯基]-缩二脲的制备方法及其应用
AU2019287437A1 (en) 2018-06-12 2020-09-10 Vtv Therapeutics Llc Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs
WO2021167840A1 (en) 2020-02-18 2021-08-26 Vtv Therapeutics Llc Sulfoxide and sulfone glucokinase activators and methods of use thereof
CN116194442A (zh) 2020-06-08 2023-05-30 维特卫治疗有限责任公司 {2-[3-环己基-3-(反式-4-丙氧基-环己基)-脲基]-噻唑-5-基硫烷基}-乙酸的盐或共晶体及其用途

Family Cites Families (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB771147A (en) 1954-06-04 1957-03-27 Merck & Co Inc Derivatives of urea
NL92947C (de) * 1954-10-08
US3152136A (en) * 1958-10-30 1964-10-06 Dow Chemical Co Dinitroaroyl-nu-pyridyl amides
US3067250A (en) * 1959-01-26 1962-12-04 Dow Chemical Co 4-aryl, 1, 1-di propynyl-semicarbazides
US3317534A (en) * 1963-10-30 1967-05-02 Chugai Pharmaceutical Co Ltd Benzamidopyrimidines
US3551442A (en) * 1965-04-06 1970-12-29 Pechiney Saint Gobain Thiazole derivatives
ZA6706928B (de) * 1967-03-23
CH493195A (de) 1968-01-23 1970-07-15 Ciba Geigy Schädlingsbekämpfungsmittel
GB1195672A (en) 1968-02-01 1970-06-17 Mobil Oil Corp Novel Urea Derivatives and Herbicides containing the same
US4175081A (en) * 1968-02-01 1979-11-20 Mobil Oil Corporation 5-Substituted thiadiazole ureas
FR7428M (de) 1968-05-06 1969-11-12
CH498859A (de) 1968-07-17 1970-11-15 Agripat Sa Verfahren zur Herstellung von Thiadiazolyl-harnstoffen
GB1266769A (de) * 1969-08-15 1972-03-15
BE754783A (fr) 1969-08-15 1971-02-12 May & Baker Ltd Derives thiazolyl a usage herbicide leur preparation et les compositions qui les contiennent
GB1318291A (en) 1970-04-15 1973-05-23 Shell Int Research Carboxamide derivatives and fungicidal compositions containing them
NL7106557A (de) 1970-06-15 1971-12-17
IT960595B (it) 1971-06-16 1973-11-30 Hispaco Ag Navetta per tessitura
US3887709A (en) * 1971-09-16 1975-06-03 Zdzislaw Brzozowski 2-Pyrazoline-1-carboxamide sulfonamide derivatives useful as hypoglycemic agents
DE2151766C3 (de) 1971-10-14 1981-03-19 Schering Ag, 1000 Berlin Und 4619 Bergkamen N-Thiazolinyl-phenoxycarbonsäureamide
US3862163A (en) * 1971-10-14 1975-01-21 Schering Ag Phenoxycarboxylic acid amides
US3874873A (en) * 1972-03-27 1975-04-01 Fmc Corp Herbicidal compositions based on 1,2,3-thiadiazol-5-yl ureas
IE38778B1 (en) 1973-02-02 1978-05-24 Ciba Geigy New 1,2,4-benzotriazine derivatives
JPS5614643B2 (de) * 1973-07-02 1981-04-06
PL106114B1 (pl) * 1976-12-31 1979-11-30 Akad Medyczna Sposob wytwarzania nowych n-(4-/2-/pirazolo-1-karbonamido/-etylo/-benzenosulfonylo)-mocznikow
DE2712630A1 (de) * 1977-03-23 1978-09-28 Bayer Ag 1,3,4-thiadiazol-2-yl-harnstoffe, verfahren zu ihrer herstellung sowie ihre verwendung als fungizide
DE2716324A1 (de) * 1977-04-07 1978-10-12 Schering Ag 1,2,3-thiadiazol-3-in-5-yliden- harnstoffe, verfahren zur herstellung dieser verbindungen sowie diese enthaltende mittel mit wachstumsregulatorischer wirkung fuer pflanzen
JPS6033109B2 (ja) * 1977-04-28 1985-08-01 塩野義製薬株式会社 尿素誘導体の合成法
US4241072A (en) * 1979-01-18 1980-12-23 Merck & Co., Inc. Substituted ureas and processes for their preparation
DE2928485A1 (de) * 1979-07-14 1981-01-29 Bayer Ag Verwendung von harnstoffderivaten als arzneimittel bei der behandlung von fettstoffwechselstoerungen
IL72093A0 (en) 1983-06-20 1984-10-31 Lilly Co Eli N'-substituted(3-alkyl-5-isothiazolyl)urea derivatives
US4694004A (en) * 1984-07-09 1987-09-15 Fujisawa Pharmaceutical Co., Ltd. Semicarbazide derivatives, processes for preparation thereof and pharmaceutical composition comprising the same
US4808722A (en) * 1985-10-31 1989-02-28 Fmc Corporation Pyridinylurea N-oxide compounds and agricultural uses
JPS6456660A (en) 1987-05-11 1989-03-03 Sumitomo Chemical Co Urea derivative or its salt, production thereof and germicide for agriculture and horticulture containing said derivative or salt thereof as active ingredient
WO1991004027A1 (en) 1989-09-15 1991-04-04 Pfizer Inc. New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat)
IE68593B1 (en) 1989-12-06 1996-06-26 Sanofi Sa Heterocyclic substituted acylaminothiazoles their preparation and pharmaceutical compositions containing them
RU2021258C1 (ru) 1991-02-28 1994-10-15 Агролинц Агрархемикалиен ГмбХ Способ получения несимметрично дизамещенных мочевин
JPH05294935A (ja) * 1991-03-15 1993-11-09 Green Cross Corp:The アミノピリジン系化合物
US5371086A (en) * 1991-03-15 1994-12-06 The Green Cross Corporation Aminopyridine compounds
JPH04334374A (ja) 1991-05-07 1992-11-20 Mitsui Toatsu Chem Inc Ｎ−（２−チアゾリル）尿素誘導体、その製造方法および該化合物を含有する殺虫剤
EP0642498A1 (de) * 1992-05-28 1995-03-15 Pfizer Inc. N-aryl und n-heteroaryl derivate als acat-hemmstoffe
JP3176137B2 (ja) 1992-07-02 2001-06-11 大正製薬株式会社 ビウレット誘導体
JPH06102611A (ja) 1992-09-22 1994-04-15 Konica Corp ハロゲン化銀写真感光材料
WO1994014801A1 (en) 1992-12-29 1994-07-07 Smithkline Beecham Plc Heterocyclic urea derivatives as 5ht2c and 5ht2b antagonists
JPH0748360A (ja) * 1993-05-31 1995-02-21 Yoshitomi Pharmaceut Ind Ltd ビフェニルテトラゾール誘導体
US5849769A (en) * 1994-08-24 1998-12-15 Medivir Ab N-arylalkyl-N-heteroarylurea and guandine compounds and methods of treating HIV infection
US5556969A (en) * 1994-12-07 1996-09-17 Merck Sharp & Dohme Ltd. Benzodiazepine derivatives
US6579314B1 (en) 1995-03-10 2003-06-17 C.R. Bard, Inc. Covered stent with encapsulated ends
WO1996040629A1 (en) * 1995-06-07 1996-12-19 Sugen, Inc. Tyrphostin-like compounds for the treatment of cell proliferative disorders or cell differentiation disorders
US5846990A (en) * 1995-07-24 1998-12-08 Bristol-Myers Squibb Co. Substituted biphenyl isoxazole sulfonamides
JPH09124620A (ja) * 1995-10-11 1997-05-13 Bristol Myers Squibb Co 置換ビフェニルスルホンアミドエンドセリン拮抗剤
GB9526560D0 (en) 1995-12-27 1996-02-28 Bayer Ag Use of 2-Amino-Heterocycles
CA2197364A1 (en) * 1996-02-15 1997-08-16 Toshikazu Suzuki Phenol compound and process for preparing the same
CA2247286A1 (en) 1996-02-26 1997-08-28 Hirohiko Hasegawa Sulfonylureidopyrazole derivatives
TW523506B (en) * 1996-12-18 2003-03-11 Ono Pharmaceutical Co Sulfonamide or carbamide derivatives and drugs containing the same as active ingredients
US5846985A (en) * 1997-03-05 1998-12-08 Bristol-Myers Squibb Co. Substituted biphenyl isoxazole sulfonamides
SE9702001D0 (sv) * 1997-05-28 1997-05-28 Astra Pharma Prod Novel compounds
US6268384B1 (en) * 1997-08-29 2001-07-31 Vertex Pharmaceuticals Incorporated Compounds possessing neuronal activity
US6225346B1 (en) * 1997-10-24 2001-05-01 Sugen, Inc. Tyrphostin like compounds
CA2309319A1 (en) 1997-11-10 1999-05-20 Bristol-Myers Squibb Company Benzothiazole protein tyrosine kinase inhibitors
US6040321A (en) 1997-11-12 2000-03-21 Bristol-Myers Squibb Company Aminothiazole inhibitors of cyclin dependent kinases
EP0979823B1 (de) 1997-11-14 2006-03-29 Kowa Company Ltd. Neue amidverbindungen und medikamente die diese enthalten
US6407124B1 (en) * 1998-06-18 2002-06-18 Bristol-Myers Squibb Company Carbon substituted aminothiazole inhibitors of cyclin dependent kinases
GT199900147A (es) * 1998-09-17 1999-09-06 1, 2, 3, 4- tetrahidroquinolinas 2-sustituidas 4-amino sustituidas.
GB9823873D0 (en) * 1998-10-30 1998-12-30 Pharmacia & Upjohn Spa 2-ureido-thiazole derivatives,process for their preparation,and their use as antitumour agents
JP2002539119A (ja) * 1999-03-08 2002-11-19 バイエル アクチェンゲゼルシャフト チアゾリルウレア誘導体および抗ウイルス剤としてのそれらの使用
CZ301366B6 (cs) 1999-03-29 2010-02-03 F. Hoffmann-La Roche Ag 2-Fenyl-3-cykloalkylpropionamidová sloucenina, zpusob její prípravy a farmaceutický prostredek s jejím obsahem
US6610846B1 (en) * 1999-03-29 2003-08-26 Hoffman-La Roche Inc. Heteroaromatic glucokinase activators
US6503949B1 (en) * 1999-05-17 2003-01-07 Noro Nordisk A/S Glucagon antagonists/inverse agonists
US6114365A (en) * 1999-08-12 2000-09-05 Pharmacia & Upjohn S.P.A. Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents
US6806230B1 (en) 1999-09-09 2004-10-19 Kumiai Chemical Industry Co., Ltd. Pyrimidine derivatives and herbicides containing them
EP1282611B1 (de) 2000-05-08 2004-10-20 F. Hoffmann-La Roche Ag Substituierte phenylacetamide und ihre verwendung als glukokinase aktivatoren
IL153688A0 (en) * 2000-06-28 2003-07-06 Teva Pharma Carvedilol
PT1305301E (pt) * 2000-07-20 2005-09-30 Hoffmann La Roche Benzeno-acetamidas alfa-acilo e alfa-heteroatomo-substituidas activadoras da glucocinase
US6645990B2 (en) * 2000-08-15 2003-11-11 Amgen Inc. Thiazolyl urea compounds and methods of uses
OA12542A (en) * 2001-01-31 2006-06-05 Pfizer Prod Inc Thiazolyl-, oxazolyl-, pyrrolyl-, and imidazolyl-acid amide derivatives useful as inhibitors of PDE4isozymes.
DE60208630T2 (de) * 2001-05-11 2006-08-17 Pfizer Products Inc., Groton Thiazolderivate und ihre Verwendung als cdk-Inhibitoren
EP1408950B1 (de) * 2001-07-11 2007-04-25 Boehringer Ingelheim Pharmaceuticals Inc. Methode zur behandlung von zytokinvermittelten erkrankungen
US6881746B2 (en) * 2001-12-03 2005-04-19 Novo Nordick A/S Glucagon antagonists/inverse agonists
US6936629B2 (en) * 2001-12-21 2005-08-30 Virochem Pharma Inc. Compounds and methods for the treatment or prevention of flavivirus infections
WO2003055482A1 (en) 2001-12-21 2003-07-10 Novo Nordisk A/S Amide derivatives as gk activators
AU2003243921B2 (en) * 2002-06-27 2009-05-07 Novo Nordisk A/S Aryl carbonyl derivatives as therapeutic agents
TW200505894A (en) * 2003-08-08 2005-02-16 Yamanouchi Pharma Co Ltd Tetrahydro-2H-thiopyran-4-carboxamide derivative
PT1723128E (pt) * 2004-01-06 2013-02-27 Novo Nordisk As Heteroaril-ureias e o seu uso como activadores da glicoquinase
JP4334374B2 (ja) 2004-03-05 2009-09-30 株式会社東芝 被ばく線量評価方法、被ばく線量評価システムおよび被ばく線量評価プログラム
KR20080024211A (ko) * 2005-07-08 2008-03-17 노보 노르디스크 에이/에스 디시클로알킬 우레아 글루코키나제 활성제

Also Published As

Publication number Publication date
ES2382815T3 (es) 2012-06-13
JP2009500378A (ja) 2009-01-08
WO2007006761A1 (en) 2007-01-18
EP1904438B1 (de) 2012-02-29
EP1904438A1 (de) 2008-04-02
US20080319028A1 (en) 2008-12-25
US7999114B2 (en) 2011-08-16

Similar Documents

Publication Publication Date Title
BRPI0506662B8 (pt) compostos ativadores de glucoquinase
ATE406351T1 (de) Kondensierte heteroyralderivate zur verwendung als p38-kinase-inhibitoren
MX2009006267A (es) Derivados de dihidropiridina de utilidad como inhibidores de la proteina quinasa.
EA201190158A1 (ru) Производные бензофуранила для применения в качестве ингибиторов глюкокиназы
ATE517896T1 (de) P38-kinase-inhibitoren
NO20062950L (no) 5,7-diaminopyrazolo `43-Dlpyrimidiner med PDE-5 inhiberende aktivitet
GEP20156309B (en) Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
TW200745037A (en) Organic compounds
ATE539748T1 (de) Glucokinaseaktivatoren
ATE521608T1 (de) Glucokinaseaktivatoren
EA200802213A1 (ru) Способы лечения заболеваний крови
DE60315146D1 (de) Heteroarylsubstituierte biphenylderivate als inhibitoren von p38-kinase
NO20071843L (no) Substituerte anilinderivater
DE602005026508D1 (de) Monozyklische heterozyklen als kinase-hemmer
MX2008000294A (es) Activadores de dicicloalquil urea glucocinasa.
TW200510333A (en) Benzimidazole compounds
EA201070169A1 (ru) 2,3-дигидробензо[1,4]диоксин-2-илметиловые производные в качестве альфа2с антагонистов для применения в лечении заболеваний перифирической центральной нервной системы
DE602009000550D1 (de) Neuartige P2X7R-Antagonisten und ihre Verwendung
UA83311C2 (en) 3-aminocyclopentanecarboxamides as modulators of chemokine receptors
TW200700422A (en) Compounds for inhibiting ksp kinesin activity
ATE478863T1 (de) Heterotetracyclische verbindungen als tpo- mimetica
CY1109569T1 (el) Υποκατεστημενα παραγωγα κυκλοεξανο-1,4-διαμινης
UA83917C2 (en) 3-(4-heteroarylcyclohexylamino) cyclopentanecarboxamides as modulators of chemokine receptors
ATE413392T1 (de) Kondensierte heteroyralderivate und deren verwendung als p38-kinase-inhibitoren
MEP1008A (xx) 3-aminociklopentankarboksamidi kao modulatori receptora hemokina