ATE549035T1 - Neue formen von cddo-methylester - Google Patents

Neue formen von cddo-methylester

Info

Publication number: ATE549035T1
Authority: AT; Austria
Prior art keywords: methyl ester; new forms; cddo methyl; cddo; new
Prior art date: 2007-08-15

Application number

AT08795303T

Other languages

English (en)

Inventor

John Walling

Stephan Parent

David Jonaitis

Robert Kral

Original Assignee

Reata Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-08-15

Filing date

2008-08-14

Publication date

2012-03-15

2008-08-14 Application filed by Reata Pharmaceuticals Inc filed Critical Reata Pharmaceuticals Inc

2012-03-15 Application granted granted Critical

2012-03-15 Publication of ATE549035T1 publication Critical patent/ATE549035T1/de

Links

WPTTVJLTNAWYAO-KPOXMGGZSA-N Bardoxolone methyl Chemical compound C([C@@]12C)=C(C#N)C(=O)C(C)(C)[C@@H]1CC[C@]1(C)C2=CC(=O)[C@@H]2[C@@H]3CC(C)(C)CC[C@]3(C(=O)OC)CC[C@]21C WPTTVJLTNAWYAO-KPOXMGGZSA-N 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Steroid Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Glass Compositions (AREA)

AT08795303T 2007-08-15 2008-08-14 Neue formen von cddo-methylester ATE549035T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US95593907P	2007-08-15	2007-08-15
PCT/US2008/009703 WO2009023232A1 (en)	2007-08-15	2008-08-14	Novel forms of cddo methyl ester

Publications (1)

Publication Number	Publication Date
ATE549035T1 true ATE549035T1 (de)	2012-03-15

Family

ID=40351005

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT08795303T ATE549035T1 (de)	2007-08-15	2008-08-14	Neue formen von cddo-methylester

Country Status (28)

Country	Link
US (3)	US8088824B2 (de)
EP (2)	EP2187741B1 (de)
JP (4)	JP5005812B2 (de)
KR (2)	KR101544766B1 (de)
CN (2)	CN101820758B (de)
AR (2)	AR073155A1 (de)
AT (1)	ATE549035T1 (de)
AU (1)	AU2008287388B2 (de)
BR (1)	BRPI0815540A8 (de)
CA (2)	CA2696330C (de)
CL (1)	CL2008002417A1 (de)
CY (2)	CY1112864T1 (de)
DK (2)	DK2187741T3 (de)
EA (2)	EA018704B1 (de)
ES (2)	ES2382571T3 (de)
HR (2)	HRP20120350T1 (de)
HU (1)	HUE031866T2 (de)
IL (2)	IL203824A (de)
LT (1)	LT2450057T (de)
MX (1)	MX2010001628A (de)
NZ (1)	NZ583269A (de)
PL (2)	PL2450057T3 (de)
PT (2)	PT2187741E (de)
SG (2)	SG10201504650VA (de)
SI (2)	SI2450057T1 (de)
TW (2)	TWI486357B (de)
WO (1)	WO2009023232A1 (de)
ZA (1)	ZA201001066B (de)

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US8921340B2 (en)	2006-11-17	2014-12-30	Trustees Of Dartmouth College	Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions
WO2008064132A2 (en)	2006-11-17	2008-05-29	Trustees Of Dartmouth College	Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
EP2094651A1 (de)	2006-11-17	2009-09-02	Trustees Of Dartmouth College	Synthese und biologische wirkungen neuer tricyclischer bis-enone (tbes)
US8088824B2 (en) *	2007-08-15	2012-01-03	Reata Pharmaceuticals Inc.	Forms of CDDO methyl ester
ME03529B (de)	2008-01-11	2020-04-20	Reata Pharmaceuticals Inc	Synthetische triterpenoide und anwendungsverfahren bei der behandlung von erkrankungen
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ES2449396T3 (es)	2008-07-22	2014-03-19	Trustees Of Dartmouth College	Cianoenonas monocíclicas y métodos de uso de las mismas
SG173601A1 (en) *	2009-02-13	2011-09-29	Reata Pharmaceuticals Inc	Delayed release, oral dosage compositions that contain amorphous cddo-me
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US8921419B2 (en)	2012-05-08	2014-12-30	Trustees Of Dartmouth College	Triterpenoids and compositions containing the same
US8981144B2 (en)	2012-05-08	2015-03-17	Trustees Of Dartmouth College	Method for synthesizing 2-cyano-3,12-dioxoolean-1, 9(11)-dien-28-oic acid methyl ester and derivatives thereof
US9556222B2 (en)	2012-06-15	2017-01-31	Reata Pharmaceuticals, Inc.	A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof
TWI630212B (zh)	2012-09-10	2018-07-21	瑞塔醫藥有限責任公司	丁香油素（ｏｌｅａｎｏｌｉｃａｃｉｄ）之ｃ１７－烷二基與烯二基衍生物及其使用方法
US9278912B2 (en)	2012-09-10	2016-03-08	Reata Pharmaceuticals, Inc.	C13-hydroxy derivatives of oleanolic acid and methods of use thereof
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EP2977381B1 (de)	2013-03-19	2018-09-26	Daiichi Sankyo Company, Limited	Terpenoidderivat
TWI649330B (zh)	2013-04-24	2019-02-01	艾伯維有限公司	甲基巴多索龍之２，２－二氟丙醯胺衍生物、其多晶形及其使用方法
IL285832B2 (en) *	2013-08-23	2024-01-01	Reata Pharmaceuticals Inc	Methods of treating and preventing endothelial dysfunction using bardoxolone methyl or analogs thereof
US9896475B2 (en)	2014-08-26	2018-02-20	Trustees Of Dartmouth College	Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)dien-28-oyl) imidazole
US10189791B2 (en)	2014-08-26	2019-01-29	Trustees Of Dartmouth College	Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)dien-28-oyl) imidazole
EP3192875B1 (de)	2014-09-10	2019-12-18	Daiichi Sankyo Company, Limited	Pharmazeutische retard-zusammensetzung zur behandlung und vorbeugung von augenerkrankungen
WO2016089648A1 (en)	2014-12-01	2016-06-09	Vtv Therapeutics Llc	Bach 1 inhibitors in combination with nrf2 activators and pharmaceutical compositions thereof
SMT202200091T1 (it)	2014-12-19	2022-03-21	Geistlich Pharma Ag	Processi per preparare composti simili a ossatiazina
US11591302B2 (en)	2014-12-19	2023-02-28	Geistlich Pharm A Ag	Processes for preparing oxathiazin-like compounds
AU2016219109B2 (en)	2015-02-12	2020-05-14	Reata Pharmaceuticals, Inc.	Imidazolyl tricyclic enones as antioxidant iflammation modulators
IL293821A (en)	2015-07-02	2022-08-01	Acerta Pharma Bv	Solid forms and formulations of (S)-4-(8-amino-3-(1-(but-2-aminoyl)pyrrolidine-2-yl)imidazo[5,1-yl]pyrazin-1-yl)-en- (pyridine-2-yl)benzamide
BR112018005861B1 (pt)	2015-09-23	2022-11-22	Reata Pharmaceuticals, Inc	Compostos derivados de ácido oleanólico modificado com c4 para a inibição de il-17, composição farmacêutica e usos terapêuticos dos ditos compostos
BR112019009256A2 (pt)	2016-11-08	2019-07-16	Reata Pharmaceuticals, Inc.	métodos para tratar síndrome de alport usando bardoxolona metil ou análogos do mesmo
TWI831738B (zh)	2016-12-16	2024-02-11	美商瑞塔醫藥有限責任公司	用於抑制ＲＯＲγ及其他用途的嘧啶三環烯酮衍生物
WO2019014412A1 (en)	2017-07-13	2019-01-17	Pliva Hrvatska D.O.O.	NOVEL CRYSTALLINE POLYMORPHIC FORMS OF METHYL BARDOXOLONE
EP3773509B1 (de)	2018-04-06	2023-11-01	Capsugel Belgium NV	Sprühtrocknungsverfahren für teilchen mit niedrigem aspektverhältnis mit poly[(methyl-methacrylat)-co-(methacrylsäure)]
US11993574B2 (en)	2018-06-15	2024-05-28	Reata Pharmaceuticals, Inc	Pyrazole and imidazole compounds for inhibition of IL-17 and RORgamma
US12060340B2 (en)	2018-06-20	2024-08-13	Reata Pharmaceuticals, Inc	Cysteine-dependent inverse agonists of nuclear receptors ROR-gamma/ROR-gamma-t and methods of treating diseases or disorders therewith
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2008
- 2008-08-13 US US12/191,176 patent/US8088824B2/en active Active
- 2008-08-14 NZ NZ583269A patent/NZ583269A/en unknown
- 2008-08-14 HR HRP20120350AT patent/HRP20120350T1/hr unknown
- 2008-08-14 BR BRPI0815540A patent/BRPI0815540A8/pt not_active Application Discontinuation
- 2008-08-14 SI SI200831728A patent/SI2450057T1/sl unknown
- 2008-08-14 AT AT08795303T patent/ATE549035T1/de active
- 2008-08-14 PL PL12153605T patent/PL2450057T3/pl unknown
- 2008-08-14 EP EP08795303A patent/EP2187741B1/de active Active
- 2008-08-14 KR KR1020147002848A patent/KR101544766B1/ko active Active
- 2008-08-14 HU HUE12153605A patent/HUE031866T2/en unknown
- 2008-08-14 PL PL08795303T patent/PL2187741T3/pl unknown
- 2008-08-14 KR KR1020107005094A patent/KR101481764B1/ko active Active
- 2008-08-14 CL CL2008002417A patent/CL2008002417A1/es unknown
- 2008-08-14 CN CN2008801112346A patent/CN101820758B/zh active Active
- 2008-08-14 JP JP2010521031A patent/JP5005812B2/ja active Active
- 2008-08-14 PT PT08795303T patent/PT2187741E/pt unknown
- 2008-08-14 EP EP12153605.6A patent/EP2450057B1/de active Active
- 2008-08-14 EA EA201070149A patent/EA018704B1/ru unknown
- 2008-08-14 ES ES08795303T patent/ES2382571T3/es active Active
- 2008-08-14 CN CN201310016448.8A patent/CN103254267B/zh active Active
- 2008-08-14 SG SG10201504650VA patent/SG10201504650VA/en unknown
- 2008-08-14 AR ARP080103557A patent/AR073155A1/es unknown
- 2008-08-14 ES ES12153605.6T patent/ES2602978T3/es active Active
- 2008-08-14 MX MX2010001628A patent/MX2010001628A/es active IP Right Grant
- 2008-08-14 DK DK08795303.0T patent/DK2187741T3/da active
- 2008-08-14 TW TW102134576A patent/TWI486357B/zh active
- 2008-08-14 PT PT121536056T patent/PT2450057T/pt unknown
- 2008-08-14 CA CA2696330A patent/CA2696330C/en active Active
- 2008-08-14 SG SG2011094158A patent/SG177905A1/en unknown
- 2008-08-14 WO PCT/US2008/009703 patent/WO2009023232A1/en not_active Ceased
- 2008-08-14 CA CA2871864A patent/CA2871864C/en active Active
- 2008-08-14 AU AU2008287388A patent/AU2008287388B2/en active Active
- 2008-08-14 TW TW097130947A patent/TWI419899B/zh active
- 2008-08-14 SI SI200830650T patent/SI2187741T1/sl unknown
- 2008-08-14 LT LTEP12153605.6T patent/LT2450057T/lt unknown
- 2008-08-14 EA EA201370109A patent/EA023550B1/ru unknown
- 2008-08-14 DK DK12153605.6T patent/DK2450057T3/en active
2010
- 2010-02-09 IL IL203824A patent/IL203824A/en active IP Right Grant
- 2010-02-12 ZA ZA201001066A patent/ZA201001066B/xx unknown
2011
- 2011-11-29 US US13/306,043 patent/US8309601B2/en active Active
2012
- 2012-05-23 JP JP2012117773A patent/JP2012188438A/ja active Pending
- 2012-06-13 CY CY20121100542T patent/CY1112864T1/el unknown
- 2012-06-29 US US13/537,583 patent/US8633243B2/en active Active
2015
- 2015-05-07 JP JP2015094538A patent/JP2015164939A/ja active Pending
2016
- 2016-11-15 HR HRP20161503TT patent/HRP20161503T1/hr unknown
- 2016-11-23 CY CY20161101205T patent/CY1118329T1/el unknown
2017
- 2017-03-27 IL IL251419A patent/IL251419A0/en unknown
- 2017-08-10 JP JP2017154939A patent/JP2018009001A/ja active Pending
2020
- 2020-03-25 AR ARP200100825A patent/AR119704A2/es unknown

Also Published As

Publication number	Publication date
NZ583269A (en)	2012-03-30
EP2187741A4 (de)	2010-08-25
HK1143537A1 (en)	2011-01-07
KR101481764B1 (ko)	2015-01-13
AR073155A1 (es)	2010-10-20
EP2187741A1 (de)	2010-05-26
KR101544766B1 (ko)	2015-08-17
KR20100056488A (ko)	2010-05-27
EA201370109A1 (ru)	2014-01-30
US20120330050A1 (en)	2012-12-27
HRP20161503T1 (hr)	2017-01-13
SI2187741T1 (sl)	2012-07-31
SG177905A1 (en)	2012-02-28
EA201070149A1 (ru)	2010-08-30
JP2015164939A (ja)	2015-09-17
JP2012188438A (ja)	2012-10-04
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ZA201001066B (en)	2010-10-27
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DK2187741T3 (da)	2012-04-16
CY1112864T1 (el)	2016-04-13
BRPI0815540A2 (pt)	2014-09-30
JP2018009001A (ja)	2018-01-18
CA2696330A1 (en)	2009-02-19
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US8633243B2 (en)	2014-01-21
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CA2696330C (en)	2015-03-24
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US8088824B2 (en)	2012-01-03
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BRPI0815540A8 (pt)	2023-04-11
TW200916476A (en)	2009-04-16
SG10201504650VA (en)	2015-07-30
US8309601B2 (en)	2012-11-13
ES2602978T3 (es)	2017-02-23
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CN101820758B (zh)	2013-03-06
KR20140024063A (ko)	2014-02-27
EP2450057B1 (de)	2016-09-28
CL2008002417A1 (es)	2009-03-27
SI2450057T1 (sl)	2017-01-31
AU2008287388A1 (en)	2009-02-19
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AR119704A2 (es)	2022-01-05
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