ATE549035T1 - Neue formen von cddo-methylester - Google Patents

Neue formen von cddo-methylester

Info

Publication number: ATE549035T1
Authority: AT; Austria
Prior art keywords: methyl ester; new forms; cddo methyl; cddo; new
Prior art date: 2007-08-15

Application number

AT08795303T

Other languages

English (en)

Inventor

John Walling

Stephan Parent

David Jonaitis

Robert Kral

Original Assignee

Reata Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-08-15

Filing date

2008-08-14

Publication date

2012-03-15

2008-08-14 Application filed by Reata Pharmaceuticals Inc filed Critical Reata Pharmaceuticals Inc

2012-03-15 Application granted granted Critical

2012-03-15 Publication of ATE549035T1 publication Critical patent/ATE549035T1/de

Links

WPTTVJLTNAWYAO-KPOXMGGZSA-N Bardoxolone methyl Chemical compound C([C@@]12C)=C(C#N)C(=O)C(C)(C)[C@@H]1CC[C@]1(C)C2=CC(=O)[C@@H]2[C@@H]3CC(C)(C)CC[C@]3(C(=O)OC)CC[C@]21C WPTTVJLTNAWYAO-KPOXMGGZSA-N 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Molecular Biology (AREA)
Epidemiology (AREA)
Immunology (AREA)
Rheumatology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Steroid Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Glass Compositions (AREA)

AT08795303T 2007-08-15 2008-08-14 Neue formen von cddo-methylester ATE549035T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US95593907P	2007-08-15	2007-08-15
PCT/US2008/009703 WO2009023232A1 (en)	2007-08-15	2008-08-14	Novel forms of cddo methyl ester

Publications (1)

Publication Number	Publication Date
ATE549035T1 true ATE549035T1 (de)	2012-03-15

Family

ID=40351005

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT08795303T ATE549035T1 (de)	2007-08-15	2008-08-14	Neue formen von cddo-methylester

Country Status (28)

Country	Link
US (3)	US8088824B2 (de)
EP (2)	EP2450057B1 (de)
JP (4)	JP5005812B2 (de)
KR (2)	KR101481764B1 (de)
CN (2)	CN101820758B (de)
AR (2)	AR073155A1 (de)
AT (1)	ATE549035T1 (de)
AU (1)	AU2008287388B2 (de)
BR (1)	BRPI0815540A8 (de)
CA (2)	CA2871864C (de)
CL (1)	CL2008002417A1 (de)
CY (2)	CY1112864T1 (de)
DK (2)	DK2450057T3 (de)
EA (2)	EA018704B1 (de)
ES (2)	ES2382571T3 (de)
HR (2)	HRP20120350T1 (de)
HU (1)	HUE031866T2 (de)
IL (2)	IL203824A (de)
LT (1)	LT2450057T (de)
MX (1)	MX2010001628A (de)
NZ (1)	NZ583269A (de)
PL (2)	PL2187741T3 (de)
PT (2)	PT2187741E (de)
SG (2)	SG10201504650VA (de)
SI (2)	SI2187741T1 (de)
TW (2)	TWI486357B (de)
WO (1)	WO2009023232A1 (de)
ZA (1)	ZA201001066B (de)

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US6326507B1 (en)	1998-06-19	2001-12-04	Trustees Of Dartmouth College	Therapeutic compounds and methods of use
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EP2094651A1 (de)	2006-11-17	2009-09-02	Trustees Of Dartmouth College	Synthese und biologische wirkungen neuer tricyclischer bis-enone (tbes)
US8299046B2 (en)	2006-11-17	2012-10-30	Trustees Of Dartmouth College	Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
US8921340B2 (en)	2006-11-17	2014-12-30	Trustees Of Dartmouth College	Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions
US8088824B2 (en) *	2007-08-15	2012-01-03	Reata Pharmaceuticals Inc.	Forms of CDDO methyl ester
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JP5529851B2 (ja)	2008-04-18	2014-06-25	リアタファーマシューティカルズインコーポレイテッド	抗酸化炎症モジュレーター：ｃ−１７においてアミノ改変およびその他の改変を加えたオレアノール酸誘導体
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EP2309860B1 (de)	2008-07-22	2014-01-08	Trustees of Dartmouth College	Monocyclische cyanoenone und anwendungsverfahren
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DK2536285T3 (en)	2010-02-18	2018-07-16	Vtv Therapeutics Llc	Substituted fused imidazole derivatives, pharmaceutical compositions and methods for their use
US8759535B2 (en)	2010-02-18	2014-06-24	High Point Pharmaceuticals, Llc	Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof
DK2558105T3 (da)	2010-04-12	2020-01-27	Reata Pharmaceuticals Inc	Bardoxolonmethyl til behandling af fedme
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CN102887936A (zh) *	2012-10-24	2013-01-23	苏州晶云药物科技有限公司	2-氰基-3,12-二氧代齐墩果-1,9(11)-二烯-28-酸甲酯晶型
CN102875634B (zh) *	2012-10-24	2014-08-20	苏州晶云药物科技有限公司	2-氰基-3,12-二氧代齐墩果-1,9(11)-二烯-28-酸甲酯的几种晶型
WO2014148455A1 (ja)	2013-03-19	2014-09-25	第一三共株式会社	テルペノイド誘導体
AR096046A1 (es)	2013-04-24	2015-12-02	Abbvie Inc	Derivados de 2,2-difluoropropanamida de metil bardoxolona, formas polimórficas y métodos de uso
EP4736949A2 (de)	2013-08-23	2026-05-06	Reata Pharmaceuticals Holdings, LLC	Verfahren zur behandlung und vorbeugung einer endothelfehlfunktion unter verwendung von bardoxolonmethyl oder analogen davon
US10189791B2 (en)	2014-08-26	2019-01-29	Trustees Of Dartmouth College	Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)dien-28-oyl) imidazole
WO2016033132A1 (en)	2014-08-26	2016-03-03	Trustees Of Dartmouth College	Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)dien-28-oyl) imidazole
KR20170055482A (ko)	2014-09-10	2017-05-19	다이이찌 산쿄 가부시키가이샤	안질환 치료용 및 예방용 서방성 의약 조성물
WO2016089648A1 (en)	2014-12-01	2016-06-09	Vtv Therapeutics Llc	Bach 1 inhibitors in combination with nrf2 activators and pharmaceutical compositions thereof
KR102594322B1 (ko)	2014-12-19	2023-10-26	가이스틀리히 파마 아게	옥사티아진-유사 화합물의 제조방법
US11591302B2 (en)	2014-12-19	2023-02-28	Geistlich Pharm A Ag	Processes for preparing oxathiazin-like compounds
EP3256451B1 (de)	2015-02-12	2021-10-20	Reata Pharmaceuticals, Inc.	Zur verwendung als antioxidative entzündungsmodulatoren geeignete tricyclische imidazolylenone
HUE062258T2 (hu) *	2015-07-02	2023-10-28	Acerta Pharma Bv	(S)-4-(8-amino-3-(1-(but-2-inoil)pirrolidin-2-il)imidazo[1,5-a]pirazin-1-il)-N-(piridin-2-il)benzamid szilárd alakjai és készítményei
JP7074674B2 (ja)	2015-09-23	2022-05-24	リアタファーマシューティカルズインコーポレイテッド	Ｉｌ－１７の阻害及び他の使用のためのｃ４修飾オレアノール酸誘導体
CN110198718B (zh)	2016-11-08	2023-01-10	里亚塔医药控股有限责任公司	使用甲基巴多索隆或其类似物治疗阿尔波特综合征的方法
TWI831738B (zh)	2016-12-16	2024-02-11	美商瑞塔醫藥有限責任公司	用於抑制ＲＯＲγ及其他用途的嘧啶三環烯酮衍生物
US11427533B2 (en)	2017-07-13	2022-08-30	Pliva Hrvatska D.O.O.	Crystalline polymorphs of bardoxolone methyl
ES2967689T3 (es)	2018-04-06	2024-05-03	Capsugel Belgium Nv	Proceso de secado por aspersión para partículas de baja relación de aspecto que comprenden poli[(metacrilato de metilo)-co-(ácido metacrílico)]
US11993574B2 (en)	2018-06-15	2024-05-28	Reata Pharmaceuticals, Inc	Pyrazole and imidazole compounds for inhibition of IL-17 and RORgamma
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2008
- 2008-08-13 US US12/191,176 patent/US8088824B2/en active Active
- 2008-08-14 CA CA2871864A patent/CA2871864C/en active Active
- 2008-08-14 PL PL08795303T patent/PL2187741T3/pl unknown
- 2008-08-14 EP EP12153605.6A patent/EP2450057B1/de active Active
- 2008-08-14 CN CN2008801112346A patent/CN101820758B/zh active Active
- 2008-08-14 TW TW102134576A patent/TWI486357B/zh active
- 2008-08-14 HU HUE12153605A patent/HUE031866T2/en unknown
- 2008-08-14 EA EA201070149A patent/EA018704B1/ru unknown
- 2008-08-14 CA CA2696330A patent/CA2696330C/en active Active
- 2008-08-14 JP JP2010521031A patent/JP5005812B2/ja active Active
- 2008-08-14 CL CL2008002417A patent/CL2008002417A1/es unknown
- 2008-08-14 MX MX2010001628A patent/MX2010001628A/es active IP Right Grant
- 2008-08-14 AT AT08795303T patent/ATE549035T1/de active
- 2008-08-14 ES ES08795303T patent/ES2382571T3/es active Active
- 2008-08-14 PT PT08795303T patent/PT2187741E/pt unknown
- 2008-08-14 KR KR1020107005094A patent/KR101481764B1/ko active Active
- 2008-08-14 SG SG10201504650VA patent/SG10201504650VA/en unknown
- 2008-08-14 EA EA201370109A patent/EA023550B1/ru unknown
- 2008-08-14 SI SI200830650T patent/SI2187741T1/sl unknown
- 2008-08-14 TW TW097130947A patent/TWI419899B/zh active
- 2008-08-14 AU AU2008287388A patent/AU2008287388B2/en active Active
- 2008-08-14 DK DK12153605.6T patent/DK2450057T3/en active
- 2008-08-14 CN CN201310016448.8A patent/CN103254267B/zh active Active
- 2008-08-14 LT LTEP12153605.6T patent/LT2450057T/lt unknown
- 2008-08-14 ES ES12153605.6T patent/ES2602978T3/es active Active
- 2008-08-14 HR HRP20120350AT patent/HRP20120350T1/hr unknown
- 2008-08-14 BR BRPI0815540A patent/BRPI0815540A8/pt not_active Application Discontinuation
- 2008-08-14 NZ NZ583269A patent/NZ583269A/en unknown
- 2008-08-14 PL PL12153605T patent/PL2450057T3/pl unknown
- 2008-08-14 WO PCT/US2008/009703 patent/WO2009023232A1/en not_active Ceased
- 2008-08-14 KR KR1020147002848A patent/KR101544766B1/ko active Active
- 2008-08-14 SI SI200831728A patent/SI2450057T1/sl unknown
- 2008-08-14 AR ARP080103557A patent/AR073155A1/es unknown
- 2008-08-14 DK DK08795303.0T patent/DK2187741T3/da active
- 2008-08-14 SG SG2011094158A patent/SG177905A1/en unknown
- 2008-08-14 PT PT121536056T patent/PT2450057T/pt unknown
- 2008-08-14 EP EP08795303A patent/EP2187741B1/de active Active
2010
- 2010-02-09 IL IL203824A patent/IL203824A/en active IP Right Grant
- 2010-02-12 ZA ZA201001066A patent/ZA201001066B/xx unknown
2011
- 2011-11-29 US US13/306,043 patent/US8309601B2/en active Active
2012
- 2012-05-23 JP JP2012117773A patent/JP2012188438A/ja active Pending
- 2012-06-13 CY CY20121100542T patent/CY1112864T1/el unknown
- 2012-06-29 US US13/537,583 patent/US8633243B2/en active Active
2015
- 2015-05-07 JP JP2015094538A patent/JP2015164939A/ja active Pending
2016
- 2016-11-15 HR HRP20161503TT patent/HRP20161503T1/hr unknown
- 2016-11-23 CY CY20161101205T patent/CY1118329T1/el unknown
2017
- 2017-03-27 IL IL251419A patent/IL251419A0/en unknown
- 2017-08-10 JP JP2017154939A patent/JP2018009001A/ja active Pending
2020
- 2020-03-25 AR ARP200100825A patent/AR119704A2/es unknown

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Publication number	Publication date
JP2012188438A (ja)	2012-10-04
HUE031866T2 (en)	2017-08-28
BRPI0815540A8 (pt)	2023-04-11
AR073155A1 (es)	2010-10-20
DK2187741T3 (da)	2012-04-16
EA201070149A1 (ru)	2010-08-30
TW200916476A (en)	2009-04-16
CN103254267B (zh)	2016-03-16
US8633243B2 (en)	2014-01-21
US20120330050A1 (en)	2012-12-27
EP2450057A1 (de)	2012-05-09
CA2696330C (en)	2015-03-24
TWI419899B (zh)	2013-12-21
JP5005812B2 (ja)	2012-08-22
DK2450057T3 (en)	2016-12-19
HK1143537A1 (en)	2011-01-07
SG177905A1 (en)	2012-02-28
CN103254267A (zh)	2013-08-21
KR20100056488A (ko)	2010-05-27
EP2187741A1 (de)	2010-05-26
IL203824A (en)	2017-04-30
HRP20120350T1 (hr)	2012-05-31
ZA201001066B (en)	2010-10-27
CN101820758B (zh)	2013-03-06
US8309601B2 (en)	2012-11-13
JP2018009001A (ja)	2018-01-18
SI2450057T1 (sl)	2017-01-31
JP2015164939A (ja)	2015-09-17
CY1112864T1 (el)	2016-04-13
LT2450057T (lt)	2016-12-27
CL2008002417A1 (es)	2009-03-27
EP2450057B1 (de)	2016-09-28
KR101481764B1 (ko)	2015-01-13
CA2871864A1 (en)	2009-02-19
IL251419A0 (en)	2017-05-29
CA2871864C (en)	2016-05-17
AR119704A2 (es)	2022-01-05
BRPI0815540A2 (pt)	2014-09-30
AU2008287388B2 (en)	2014-11-06
MX2010001628A (es)	2010-06-02
KR101544766B1 (ko)	2015-08-17
EA018704B1 (ru)	2013-10-30
EA201370109A1 (ru)	2014-01-30
KR20140024063A (ko)	2014-02-27
TW201402597A (zh)	2014-01-16
PL2450057T3 (pl)	2017-02-28
EP2187741B1 (de)	2012-03-14
ES2602978T3 (es)	2017-02-23
EA023550B1 (ru)	2016-06-30
CN101820758A (zh)	2010-09-01
HRP20161503T1 (hr)	2017-01-13
CY1118329T1 (el)	2017-06-28
JP2010536754A (ja)	2010-12-02
US8088824B2 (en)	2012-01-03
US20090048204A1 (en)	2009-02-19
TWI486357B (zh)	2015-06-01
CA2696330A1 (en)	2009-02-19
ES2382571T3 (es)	2012-06-11
PT2450057T (pt)	2016-12-15
US20120071684A1 (en)	2012-03-22
EP2187741A4 (de)	2010-08-25
WO2009023232A1 (en)	2009-02-19
NZ583269A (en)	2012-03-30
SG10201504650VA (en)	2015-07-30
SI2187741T1 (sl)	2012-07-31
PT2187741E (pt)	2012-06-21
AU2008287388A1 (en)	2009-02-19
PL2187741T3 (pl)	2012-08-31

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