BRPI0815540A8 - Novas formas de éster metílico de cddo - Google Patents

Novas formas de éster metílico de cddo

Info

Publication number
BRPI0815540A8
BRPI0815540A8 BRPI0815540A BRPI0815540A BRPI0815540A8 BR PI0815540 A8 BRPI0815540 A8 BR PI0815540A8 BR PI0815540 A BRPI0815540 A BR PI0815540A BR PI0815540 A BRPI0815540 A BR PI0815540A BR PI0815540 A8 BRPI0815540 A8 BR PI0815540A8
Authority
BR
Brazil
Prior art keywords
methyl ester
cddo methyl
new forms
cddo
usually
Prior art date
Application number
BRPI0815540A
Other languages
English (en)
Inventor
Walling John
D Parent Stephan
t jonaitis David
M Kral Robert
Original Assignee
Reata Pharmaceuticals Inc
Reata Pharmaceuticals Holdings Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reata Pharmaceuticals Inc, Reata Pharmaceuticals Holdings Llc filed Critical Reata Pharmaceuticals Inc
Publication of BRPI0815540A2 publication Critical patent/BRPI0815540A2/pt
Publication of BRPI0815540A8 publication Critical patent/BRPI0815540A8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Glass Compositions (AREA)

Abstract

NOVAS FORMAS DO ÉSTER METÍLICO DE CDDO. Composto triterpenoide, metil 2-ciano-3,12-dioxoleano-1,9 (11) -dien-28-oato (éster metílico de CDDO), com uma forma vítrea não cristalina e uma forma cristalina não hidratada que podem ser preparadas, por exemplo, a partir de uma solução saturada em metanol. A forma vítrea tem biodisponibilidade superior à da forma cristalina não hidratada. Cada forma do éster metílico de CDDO é um candidato de nível superior para uso, geralmente em dose sólida, no tratamento de uma série de estados patológicos, normalmente associados a processos inflamatórios.
BRPI0815540A 2007-08-15 2008-08-14 Novas formas de éster metílico de cddo BRPI0815540A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95593907P 2007-08-15 2007-08-15
PCT/US2008/009703 WO2009023232A1 (en) 2007-08-15 2008-08-14 Novel forms of cddo methyl ester

Publications (2)

Publication Number Publication Date
BRPI0815540A2 BRPI0815540A2 (pt) 2014-09-30
BRPI0815540A8 true BRPI0815540A8 (pt) 2023-04-11

Family

ID=40351005

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0815540A BRPI0815540A8 (pt) 2007-08-15 2008-08-14 Novas formas de éster metílico de cddo

Country Status (28)

Country Link
US (3) US8088824B2 (pt)
EP (2) EP2187741B1 (pt)
JP (4) JP5005812B2 (pt)
KR (2) KR101544766B1 (pt)
CN (2) CN101820758B (pt)
AR (2) AR073155A1 (pt)
AT (1) ATE549035T1 (pt)
AU (1) AU2008287388B2 (pt)
BR (1) BRPI0815540A8 (pt)
CA (2) CA2696330C (pt)
CL (1) CL2008002417A1 (pt)
CY (2) CY1112864T1 (pt)
DK (2) DK2187741T3 (pt)
EA (2) EA018704B1 (pt)
ES (2) ES2382571T3 (pt)
HR (2) HRP20120350T1 (pt)
HU (1) HUE031866T2 (pt)
IL (2) IL203824A (pt)
LT (1) LT2450057T (pt)
MX (1) MX2010001628A (pt)
NZ (1) NZ583269A (pt)
PL (2) PL2450057T3 (pt)
PT (2) PT2187741E (pt)
SG (2) SG10201504650VA (pt)
SI (2) SI2450057T1 (pt)
TW (2) TWI486357B (pt)
WO (1) WO2009023232A1 (pt)
ZA (1) ZA201001066B (pt)

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Also Published As

Publication number Publication date
NZ583269A (en) 2012-03-30
EP2187741A4 (en) 2010-08-25
HK1143537A1 (en) 2011-01-07
KR101481764B1 (ko) 2015-01-13
AR073155A1 (es) 2010-10-20
EP2187741A1 (en) 2010-05-26
KR101544766B1 (ko) 2015-08-17
KR20100056488A (ko) 2010-05-27
EA201370109A1 (ru) 2014-01-30
US20120330050A1 (en) 2012-12-27
HRP20161503T1 (hr) 2017-01-13
SI2187741T1 (sl) 2012-07-31
SG177905A1 (en) 2012-02-28
EA201070149A1 (ru) 2010-08-30
JP2015164939A (ja) 2015-09-17
JP2012188438A (ja) 2012-10-04
TWI486357B (zh) 2015-06-01
ZA201001066B (en) 2010-10-27
EA023550B1 (ru) 2016-06-30
DK2187741T3 (da) 2012-04-16
CY1112864T1 (el) 2016-04-13
BRPI0815540A2 (pt) 2014-09-30
JP2018009001A (ja) 2018-01-18
CA2696330A1 (en) 2009-02-19
WO2009023232A1 (en) 2009-02-19
US8633243B2 (en) 2014-01-21
PT2187741E (pt) 2012-06-21
CA2696330C (en) 2015-03-24
CA2871864C (en) 2016-05-17
DK2450057T3 (en) 2016-12-19
US8088824B2 (en) 2012-01-03
PL2450057T3 (pl) 2017-02-28
CN103254267B (zh) 2016-03-16
JP5005812B2 (ja) 2012-08-22
TW201402597A (zh) 2014-01-16
TW200916476A (en) 2009-04-16
SG10201504650VA (en) 2015-07-30
US8309601B2 (en) 2012-11-13
ES2602978T3 (es) 2017-02-23
IL251419A0 (en) 2017-05-29
ATE549035T1 (de) 2012-03-15
EP2450057A1 (en) 2012-05-09
PL2187741T3 (pl) 2012-08-31
PT2450057T (pt) 2016-12-15
HUE031866T2 (en) 2017-08-28
CY1118329T1 (el) 2017-06-28
MX2010001628A (es) 2010-06-02
CN101820758B (zh) 2013-03-06
KR20140024063A (ko) 2014-02-27
EP2450057B1 (en) 2016-09-28
CL2008002417A1 (es) 2009-03-27
SI2450057T1 (sl) 2017-01-31
AU2008287388A1 (en) 2009-02-19
LT2450057T (lt) 2016-12-27
HRP20120350T1 (hr) 2012-05-31
IL203824A (en) 2017-04-30
AR119704A2 (es) 2022-01-05
CN101820758A (zh) 2010-09-01
CA2871864A1 (en) 2009-02-19
TWI419899B (zh) 2013-12-21
US20120071684A1 (en) 2012-03-22
EP2187741B1 (en) 2012-03-14
CN103254267A (zh) 2013-08-21
EA018704B1 (ru) 2013-10-30
ES2382571T3 (es) 2012-06-11
US20090048204A1 (en) 2009-02-19
AU2008287388B2 (en) 2014-11-06
JP2010536754A (ja) 2010-12-02

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