ATE549637T1 - Verfahren zur untersuchung des verhaltens einer testsubstanz mittels nmr-spektroskopie - Google Patents

Verfahren zur untersuchung des verhaltens einer testsubstanz mittels nmr-spektroskopie

Info

Publication number
ATE549637T1
ATE549637T1 AT01938393T AT01938393T ATE549637T1 AT E549637 T1 ATE549637 T1 AT E549637T1 AT 01938393 T AT01938393 T AT 01938393T AT 01938393 T AT01938393 T AT 01938393T AT E549637 T1 ATE549637 T1 AT E549637T1
Authority
AT
Austria
Prior art keywords
nmr
methods
spectroscopy
magnetic resonance
studying
Prior art date
Application number
AT01938393T
Other languages
English (en)
Inventor
Neil Cook
Albie Santos
Nigel Bosworth
Jan Wolber
Mike Looker
Peter Knox
Jan H Ardenkjaer-Larsen
Klaes Golman
Original Assignee
Ge Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Ltd filed Critical Ge Healthcare Ltd
Application granted granted Critical
Publication of ATE549637T1 publication Critical patent/ATE549637T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/465—NMR spectroscopy applied to biological material, e.g. in vitro testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/62—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using double resonance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Food Science & Technology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
AT01938393T 2000-06-14 2001-06-12 Verfahren zur untersuchung des verhaltens einer testsubstanz mittels nmr-spektroskopie ATE549637T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0014463.4A GB0014463D0 (en) 2000-06-14 2000-06-14 NMR Method
PCT/GB2001/002559 WO2001096895A1 (en) 2000-06-14 2001-06-12 Method for investigating the fate of a test compound or the stateof a biological system by means of nmr of hyperpolarised nmr active nuclei

Publications (1)

Publication Number Publication Date
ATE549637T1 true ATE549637T1 (de) 2012-03-15

Family

ID=9893582

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01938393T ATE549637T1 (de) 2000-06-14 2001-06-12 Verfahren zur untersuchung des verhaltens einer testsubstanz mittels nmr-spektroskopie

Country Status (8)

Country Link
US (1) US8372654B2 (de)
EP (1) EP1290461B1 (de)
JP (1) JP4993424B2 (de)
AT (1) ATE549637T1 (de)
AU (1) AU2001264072A1 (de)
ES (1) ES2381335T3 (de)
GB (1) GB0014463D0 (de)
WO (1) WO2001096895A1 (de)

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IL155476A0 (en) 2000-11-03 2003-11-23 Amersham Health As Methods and devices for dissolving hyperpolarised material for nmr analyses
US7126332B2 (en) * 2001-07-20 2006-10-24 Baker Hughes Incorporated Downhole high resolution NMR spectroscopy with polarization enhancement
US7179450B2 (en) * 2001-09-20 2007-02-20 Medi-Physics, Inc. Methods for in vivo evaluation of pulmonary physiology and/or function using NMR signals of polarized Xe
CA2424112C (en) * 2002-04-02 2010-06-15 Baker Hughes Incorporated A method and apparatus for combined nmr and formation testing for assessing relative permeability with formation testing and nuclear magnetic resonance testing
NO20023358D0 (no) * 2002-04-19 2002-07-11 Amersham Health As Metode
NO20023357D0 (no) 2002-04-19 2002-07-11 Amersham Health As Blanding
DE10393475B4 (de) * 2002-10-09 2014-09-25 Waters Technologies Corp. (N.D.Ges.D. Staates Delaware) Verfahren und Vorrichtung zur Identifizierung von Verbindungen in einer Probe
NO20025738D0 (no) * 2002-11-29 2002-11-29 Amersham Health As Metode
GB0308586D0 (en) 2003-04-14 2003-05-21 Amersham Health R & D Ab Method and arrangements in NMR spectroscopy
US7351402B2 (en) * 2003-08-21 2008-04-01 Massachusetts Institute Of Technology Polarizing agents for dynamic nuclear polarization
NO20035626D0 (no) * 2003-12-17 2003-12-17 Amersham Health As Metode
EP1555538A1 (de) * 2004-01-15 2005-07-20 Bruker BioSpin MRI GmbH Verfahren der schnellen multidimensionalen NMR-Spektroskopie
NZ552898A (en) 2004-07-30 2011-02-25 Ge Healthcare As Method of producing a composition, composition and its use
EP1948248A2 (de) * 2005-11-06 2008-07-30 Katz-Brull, Rachel Magnetresonanztomographie- und spektroskopie-mittel und verfahren dafür
CA2628539C (en) 2005-12-01 2014-04-29 Ge Healthcare As Method of dynamic nuclear polarisation (dnp) using a trityl radical and a paramagnetic metal ion
JP5269791B2 (ja) 2006-08-30 2013-08-21 ジーイー・ヘルスケア・アクスイェ・セルスカプ 動的核分極（ｄｎｐ）方法並びに該方法で使用するための化合物及び組成物
US8812076B2 (en) 2006-11-21 2014-08-19 General Electric Company Proton decoupled hyperpolarized magnetic resonance imaging
EP2072061A1 (de) 2007-12-19 2009-06-24 GE Healthcare Limited Zusammensetzung und Verfahren zur Erzeugung eines metabolischen Profils bei Verwendung von 13C-MR
JP2011519554A (ja) 2008-05-02 2011-07-14 ゼネラル・エレクトリック・カンパニイ 過分極１３ｃ−ピルビン酸塩を用いた１３ｃ−ｍｒ検出によるアラニントランスアミナーゼ（ａｌｔ）活性の測定方法
EP2374016B1 (de) 2008-12-10 2017-05-10 University of York Impulssequenzierung mit hyperpolarisierbaren kernen
CN102388317B (zh) 2009-04-02 2015-11-25 通用电气健康护理有限公司 包含超极化13c丙酮酸盐的磁共振成像介质用于检测炎症或感染的用途
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WO2011124672A1 (en) 2010-04-08 2011-10-13 Bracco Imaging Spa Process for preparing hyperpolarized substrates and method for mri
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WO2011138269A1 (en) 2010-05-03 2011-11-10 Ge Healthcare Limited Hyperpolarized lactate contrast agent for determination of ldh activity
US9511154B2 (en) 2011-10-12 2016-12-06 Bracco Imaging S.P.A. Process for the preparation of hyperpolarized derivatives for use in MRI analysis
US9693828B2 (en) 2011-12-05 2017-07-04 Bracco Imaging S.P.A. Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation in MRI analysis
US8715621B2 (en) 2012-03-15 2014-05-06 Massachusetts Institute Of Technology Radical polarizing agents for dynamic nuclear polarization
WO2013167587A1 (en) 2012-05-07 2013-11-14 Albeda Innovation Aps Intra-operative cancer diagnosis based on a hyperpolarized marker
CN104198517B (zh) * 2014-09-23 2017-02-08 中国科学院昆明植物研究所 联合使用不同核的一维核磁共振混合物定量方法
JP6923837B2 (ja) 2015-06-29 2021-08-25 国立研究開発法人理化学研究所 可溶性ペンタセンを用いた動的核偏極による核スピン高偏極化方法
EP3316912B1 (de) * 2015-06-30 2022-11-30 Technion Research & Development Foundation Ltd. Verfahren zur herstellung von proben mit hochpolarisierten kernspins
CN105092628B (zh) * 2015-07-21 2017-05-31 中国农业科学院农业质量标准与检测技术研究所 一种鉴别奶品品质的方法
GB2552452A (en) * 2016-05-23 2018-01-31 Creo Medical Ltd Electrosurgical apparatus and method for promoting haemostasis in biological tissue
CN106404818B (zh) * 2016-08-31 2018-01-23 安徽省农业科学院畜牧兽医研究所 一种生鲜乳新鲜度检测的方法
US11016044B2 (en) * 2017-08-23 2021-05-25 Osaka University Nuclear spin hyperpolarization method and apparatus
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KR20240026126A (ko) * 2021-04-26 2024-02-27 푼다시오 인스티튜트 데 바이오엔지네리아 데 카탈루냐 피분석물에서의 생리학적 컨디션의 nmr 분석을 위한 시스템 및 방법

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Also Published As

Publication number Publication date
EP1290461B1 (de) 2012-03-14
JP2004503786A (ja) 2004-02-05
EP1290461A1 (de) 2003-03-12
JP4993424B2 (ja) 2012-08-08
ES2381335T3 (es) 2012-05-25
AU2001264072A1 (en) 2001-12-24
WO2001096895A1 (en) 2001-12-20
US20040039281A1 (en) 2004-02-26
GB0014463D0 (en) 2000-08-09
US8372654B2 (en) 2013-02-12

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