ATE550335T1 - 3,4-dihydro-3-amino-2h-1-benzopyran und - benzothiopyran derivate als dopamine-beta- hydroxylase inhibitoren und verfahren zu ihrer herstellung - Google Patents
3,4-dihydro-3-amino-2h-1-benzopyran und - benzothiopyran derivate als dopamine-beta- hydroxylase inhibitoren und verfahren zu ihrer herstellungInfo
- Publication number
- ATE550335T1 ATE550335T1 AT07076123T AT07076123T ATE550335T1 AT E550335 T1 ATE550335 T1 AT E550335T1 AT 07076123 T AT07076123 T AT 07076123T AT 07076123 T AT07076123 T AT 07076123T AT E550335 T1 ATE550335 T1 AT E550335T1
- Authority
- AT
- Austria
- Prior art keywords
- benzopyran
- dihydro
- amino
- production
- hydroxylase inhibitors
- Prior art date
Links
- ONJRTQUWKRDCTA-UHFFFAOYSA-N 2h-thiochromene Chemical class C1=CC=C2C=CCSC2=C1 ONJRTQUWKRDCTA-UHFFFAOYSA-N 0.000 title 1
- SVWDNDQOXZHBRM-UHFFFAOYSA-N 3,4-dihydro-2h-chromen-3-amine Chemical compound C1=CC=C2CC(N)COC2=C1 SVWDNDQOXZHBRM-UHFFFAOYSA-N 0.000 title 1
- 108010015720 Dopamine beta-Hydroxylase Proteins 0.000 title 1
- 102100033156 Dopamine beta-hydroxylase Human genes 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0223719A GB2393958A (en) | 2002-10-11 | 2002-10-11 | Peripherally-selective imidazole inhibitors of dopamine-beta-hydroxylase |
| GB0224306A GB2394223B (en) | 2002-10-11 | 2002-10-18 | Peripherally-selective inhibitors of dopamine-beta-hydroxylase and method of their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE550335T1 true ATE550335T1 (de) | 2012-04-15 |
Family
ID=9945777
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07076123T ATE550335T1 (de) | 2002-10-11 | 2003-10-10 | 3,4-dihydro-3-amino-2h-1-benzopyran und - benzothiopyran derivate als dopamine-beta- hydroxylase inhibitoren und verfahren zu ihrer herstellung |
| AT07076125T ATE505465T1 (de) | 2002-10-11 | 2003-10-10 | Chroman- und thiochroman-3-yl-1,3- dihydroimidazole als hemmer der dopamin-beta- hydroxylase und verfahren zu ihrer herstellung |
| AT07076122T ATE500248T1 (de) | 2002-10-11 | 2003-10-10 | Silyl-geschützte hydroxymethyl-carbamoylalkyl- ketone als intermediate in der herstellung von dopamine-beta-hydroxylase inhibitoren |
| AT03256420T ATE403652T1 (de) | 2002-10-11 | 2003-10-10 | Imidazolderivate und deren verwendung als peripheral-selektive inhibitoren von dopamin-beta-hydroxylasen |
| AT07076124T ATE500247T1 (de) | 2002-10-11 | 2003-10-10 | Verfahren zur herstellung von 3-(1,3- dihydroimidazol-2-thion-1-yl)-chromanen und thiochromanen als dopamin-beta-hydroxylase inhibitor |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07076125T ATE505465T1 (de) | 2002-10-11 | 2003-10-10 | Chroman- und thiochroman-3-yl-1,3- dihydroimidazole als hemmer der dopamin-beta- hydroxylase und verfahren zu ihrer herstellung |
| AT07076122T ATE500248T1 (de) | 2002-10-11 | 2003-10-10 | Silyl-geschützte hydroxymethyl-carbamoylalkyl- ketone als intermediate in der herstellung von dopamine-beta-hydroxylase inhibitoren |
| AT03256420T ATE403652T1 (de) | 2002-10-11 | 2003-10-10 | Imidazolderivate und deren verwendung als peripheral-selektive inhibitoren von dopamin-beta-hydroxylasen |
| AT07076124T ATE500247T1 (de) | 2002-10-11 | 2003-10-10 | Verfahren zur herstellung von 3-(1,3- dihydroimidazol-2-thion-1-yl)-chromanen und thiochromanen als dopamin-beta-hydroxylase inhibitor |
Country Status (10)
| Country | Link |
|---|---|
| KR (1) | KR101350741B1 (da) |
| CN (1) | CN100393715C (da) |
| AR (2) | AR041589A1 (da) |
| AT (5) | ATE550335T1 (da) |
| CY (2) | CY1108452T1 (da) |
| DE (4) | DE60336275D1 (da) |
| DK (2) | DK1408038T3 (da) |
| ES (5) | ES2384118T3 (da) |
| GB (2) | GB2393958A (da) |
| SI (2) | SI1408038T1 (da) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0708818D0 (en) * | 2007-05-08 | 2007-06-13 | Portela & Ca Sa | Compounds |
| KR101941467B1 (ko) * | 2010-12-22 | 2019-01-23 | 바이알 - 포르텔라 앤드 씨에이 에스에이 | 결정형 및 이들의 제조방법 |
| GB201316410D0 (en) | 2013-09-13 | 2013-10-30 | Bial Portela & Ca Sa | Processes for preparing peripherally-selective inhibitors of dopamine-?-hydroxylase and intermediates for use therein |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL82401A0 (en) * | 1986-05-06 | 1987-11-30 | Merrell Dow Pharma | Dopamine beta hydroxy-lase inhibiting imidazole derivatives and pharmaceutical compositions containing them |
| US4868210A (en) | 1988-03-30 | 1989-09-19 | Warner-Lambert Company | Antihyperlipidemic and antiatherosclerotic compounds and compositions |
| FI20040310A7 (fi) * | 1994-04-26 | 2004-02-27 | Syntex Inc | Menetelmä bentsosykloalkyyliatsolitionijohdannaisten valmistamiseksi |
-
2002
- 2002-10-11 GB GB0223719A patent/GB2393958A/en not_active Withdrawn
- 2002-10-18 GB GB0224306A patent/GB2394223B/en not_active Expired - Lifetime
-
2003
- 2003-10-10 AT AT07076123T patent/ATE550335T1/de active
- 2003-10-10 ES ES07076123T patent/ES2384118T3/es not_active Expired - Lifetime
- 2003-10-10 DK DK03256420T patent/DK1408038T3/da active
- 2003-10-10 DE DE60336275T patent/DE60336275D1/de not_active Expired - Lifetime
- 2003-10-10 AT AT07076125T patent/ATE505465T1/de active
- 2003-10-10 AT AT07076122T patent/ATE500248T1/de not_active IP Right Cessation
- 2003-10-10 DE DE60322642T patent/DE60322642D1/de not_active Expired - Lifetime
- 2003-10-10 CN CNB2003801059426A patent/CN100393715C/zh not_active Expired - Fee Related
- 2003-10-10 SI SI200331309T patent/SI1408038T1/sl unknown
- 2003-10-10 SI SI200331986T patent/SI1908760T1/sl unknown
- 2003-10-10 AT AT03256420T patent/ATE403652T1/de active
- 2003-10-10 DK DK07076125.9T patent/DK1908760T3/da active
- 2003-10-10 ES ES07076125T patent/ES2364919T3/es not_active Expired - Lifetime
- 2003-10-10 ES ES03256420T patent/ES2309279T3/es not_active Expired - Lifetime
- 2003-10-10 ES ES07076124T patent/ES2361939T3/es not_active Expired - Lifetime
- 2003-10-10 AT AT07076124T patent/ATE500247T1/de not_active IP Right Cessation
- 2003-10-10 ES ES07076122T patent/ES2361938T3/es not_active Expired - Lifetime
- 2003-10-10 AR ARP030103711A patent/AR041589A1/es active IP Right Grant
- 2003-10-10 DE DE60336276T patent/DE60336276D1/de not_active Expired - Lifetime
- 2003-10-10 DE DE60336772T patent/DE60336772D1/de not_active Expired - Lifetime
- 2003-10-10 KR KR1020127005102A patent/KR101350741B1/ko not_active Expired - Fee Related
-
2008
- 2008-10-24 CY CY20081101204T patent/CY1108452T1/el unknown
-
2011
- 2011-07-01 CY CY20111100639T patent/CY1112457T1/el unknown
-
2014
- 2014-03-18 AR ARP140101283A patent/AR095674A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1116188A1 (en) | 2008-12-19 |
| ATE500248T1 (de) | 2011-03-15 |
| ATE403652T1 (de) | 2008-08-15 |
| SI1408038T1 (sl) | 2008-10-31 |
| GB2394223A (en) | 2004-04-21 |
| CY1112457T1 (el) | 2015-12-09 |
| ATE500247T1 (de) | 2011-03-15 |
| ES2309279T3 (es) | 2008-12-16 |
| DK1408038T3 (da) | 2008-11-24 |
| ATE505465T1 (de) | 2011-04-15 |
| CN1726211A (zh) | 2006-01-25 |
| GB0224306D0 (en) | 2002-11-27 |
| AR041589A1 (es) | 2005-05-26 |
| DE60336276D1 (de) | 2011-04-14 |
| CY1108452T1 (el) | 2014-04-09 |
| CN100393715C (zh) | 2008-06-11 |
| DE60322642D1 (de) | 2008-09-18 |
| ES2361939T3 (es) | 2011-06-24 |
| ES2361938T3 (es) | 2011-06-24 |
| GB2394223B (en) | 2007-05-16 |
| ES2364919T3 (es) | 2011-09-16 |
| ES2384118T3 (es) | 2012-06-29 |
| GB2393958A (en) | 2004-04-14 |
| GB0223719D0 (en) | 2002-11-20 |
| DK1908760T3 (da) | 2011-07-25 |
| DE60336275D1 (de) | 2011-04-14 |
| AR095674A2 (es) | 2015-11-04 |
| DE60336772D1 (de) | 2011-05-26 |
| SI1908760T1 (sl) | 2011-05-31 |
| KR20120038014A (ko) | 2012-04-20 |
| KR101350741B1 (ko) | 2014-01-10 |
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