ATE552250T1 - Verfahren zur herstellung von duloxetin und verwandten verbindungen - Google Patents

Verfahren zur herstellung von duloxetin und verwandten verbindungen

Info

Publication number
ATE552250T1
ATE552250T1 AT07857175T AT07857175T ATE552250T1 AT E552250 T1 ATE552250 T1 AT E552250T1 AT 07857175 T AT07857175 T AT 07857175T AT 07857175 T AT07857175 T AT 07857175T AT E552250 T1 ATE552250 T1 AT E552250T1
Authority
AT
Austria
Prior art keywords
related compounds
duloxetine
producing
producing duloxetine
compounds
Prior art date
Application number
AT07857175T
Other languages
English (en)
Inventor
Karel Pospisilik
Bohumil Dymacek
Original Assignee
Synthon Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthon Bv filed Critical Synthon Bv
Application granted granted Critical
Publication of ATE552250T1 publication Critical patent/ATE552250T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT07857175T 2006-12-22 2007-12-19 Verfahren zur herstellung von duloxetin und verwandten verbindungen ATE552250T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87162606P 2006-12-22 2006-12-22
PCT/EP2007/011485 WO2008077645A1 (en) 2006-12-22 2007-12-19 Process for making duloxetine and related compounds

Publications (1)

Publication Number Publication Date
ATE552250T1 true ATE552250T1 (de) 2012-04-15

Family

ID=39183198

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07857175T ATE552250T1 (de) 2006-12-22 2007-12-19 Verfahren zur herstellung von duloxetin und verwandten verbindungen

Country Status (6)

Country Link
US (1) US7928250B2 (de)
EP (1) EP2114912B1 (de)
CN (1) CN101657438A (de)
AR (1) AR064658A1 (de)
AT (1) ATE552250T1 (de)
WO (1) WO2008077645A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009019719A2 (en) * 2007-08-09 2009-02-12 Ind-Swift Laboratories Limited Process for the preparation of 3-aryloxy-3-arylpropanamines
US8168805B2 (en) 2007-10-29 2012-05-01 Sci Pharmtech, Inc Optically active methylhydroxylaminopropanol compound and its use as intermediate for preparation of (S)-(−)-3-methylamino-1-(2-thienyl)propan-1-ol
US7829731B2 (en) 2007-10-29 2010-11-09 Sci Pharmtech, Inc. Methylhydroxylaminopropanol derivative and its use as intermediate for preparation of 3-methylamino-1-(2-thienyl)propan-1-OL
CA2758736A1 (en) * 2009-01-06 2010-07-15 Alembic Pharmaceuticals Limited An improved process for the reparation of duloxetine and salts thereof
US8148549B2 (en) * 2009-03-12 2012-04-03 Sci Pharmtech, Inc. Preparation of (S)-(+)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl) propylamine using optically active methylhydroxylaminopropanol compound as an intermediate
CN103214452B (zh) * 2013-05-07 2014-08-06 浙江丽晶化学有限公司 N-甲基-3-羟基-3-（2-噻吩基）-丙胺的制备方法
CN108341797B (zh) * 2017-01-25 2021-04-27 重庆常捷医药有限公司 一种度洛西汀中间体的合成方法
WO2020035040A1 (zh) * 2018-08-17 2020-02-20 上海璃道医药科技有限公司 3-芳氧基-3-五元杂芳基-丙胺类化合物及其用途
EP3971181A4 (de) * 2019-05-16 2023-11-08 Shanghai Leado Pharmatech Co. Ltd. 3-aryloxyl-3-fünfgliedrige heteroarylpropylaminverbindung sowie kristallform und deren verwendung

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR880007433A (ko) 1986-12-22 1988-08-27 메리 앤 터커 3-아릴옥시-3-치환된 프로판아민
CA2042346A1 (en) 1990-05-17 1991-11-18 Michael Alexander Staszak Chiral synthesis of 1-aryl-3-aminopropan-1-ols
US5362886A (en) * 1993-10-12 1994-11-08 Eli Lilly And Company Asymmetric synthesis
US5508276A (en) 1994-07-18 1996-04-16 Eli Lilly And Company Duloxetine enteric pellets
ATE309196T1 (de) 1999-04-09 2005-11-15 Lilly Co Eli Verfahren zur herstellung von 3-aryloxy-3- arylpropylamine und deren zwischenprodukte
WO2003062219A1 (en) 2002-01-24 2003-07-31 Eli Lilly And Company Process for preparing an intermediate useful for the asymmetric synthesis of duloxetine
DE10207586A1 (de) * 2002-02-22 2003-09-11 Degussa Herstellung von N-Methyl-3-hydroxy-3-(2-thienyl)propanamin über neue carbamatgruppenhaltige Thiophenderivate als Zwischenprodukte
DE10212301A1 (de) 2002-03-20 2003-10-02 Bayer Ag Verfahren zur Herstellung von Aryl-aminopropanolen
WO2003097632A1 (en) 2002-05-20 2003-11-27 Mitsubishi Rayon Co., Ltd. Propanolamine derivatives, process for preparation of 3-n-methylamino-1-(2-thienyl)-1-propanols and process for preparation of propanolamine derivatives
WO2004005307A1 (en) 2002-07-09 2004-01-15 Lonza Ag Process for the preparation of optically active 3-n-methylamino-1-(2-thienyl)-1-propanol
DK1539673T3 (da) 2002-07-09 2008-01-21 Lonza Ag Fremgangsmåde til fremstilling af N-monosubstituerede beta-aminoalkoholer
DE10235206A1 (de) 2002-08-01 2004-02-19 Basf Ag Verfahren zur Herstellung von (S)-3-Methylmino-1-(thien-2-yl)propan-1-ol
GB0221438D0 (en) 2002-09-16 2002-10-23 Avecia Ltd Processes and compounds
JP4483165B2 (ja) 2002-10-01 2010-06-16 山川薬品工業株式会社 光学活性な３−（メチルアミノ）−１−（２−チエニル）プロパン−１−オールの製造方法および製造の中間体
WO2004031168A2 (en) * 2002-10-07 2004-04-15 Lonza Ag Processes and intermediates for the preparation of optically active 3-amino-1-(2-thienyl)-1-propanol derivatives
GB0229583D0 (en) 2002-12-19 2003-01-22 Cipla Ltd A process for preparing duloxetine and intermediates for use therein
DE10302595A1 (de) 2003-01-22 2004-07-29 Basf Ag 3-Methylamino-1-(2-thienyl)-1-proganon, seine Herstellung und Verwendung
CZ297560B6 (cs) 2004-10-26 2007-02-07 Zentiva, A. S. Zpusob výroby hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu (duloxetinu)

Also Published As

Publication number Publication date
WO2008077645A1 (en) 2008-07-03
EP2114912B1 (de) 2012-04-04
CN101657438A (zh) 2010-02-24
US20080171887A1 (en) 2008-07-17
AR064658A1 (es) 2009-04-15
EP2114912A1 (de) 2009-11-11
US7928250B2 (en) 2011-04-19

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