ATE553108T1 - Thiazoloä4,5-cüpyridinderivative als antagonisten des mglu5-rezeptors - Google Patents

Thiazoloä4,5-cüpyridinderivative als antagonisten des mglu5-rezeptors

Info

Publication number: ATE553108T1
Authority: AT; Austria
Prior art keywords: thiazoloa4; cupyridine; antagonists; derivative; mglu5 receptor
Prior art date: 2005-11-08

Application number

AT06807563T

Other languages

English (en)

Inventor

Georg Jaeschke

Sabine Kolczewski

Richard H P Porter

Patrick Schnider

Eric Vieira

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-11-08

Filing date

2006-10-26

Publication date

2012-04-15

2006-10-26 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2012-04-15 Application granted granted Critical

2012-04-15 Publication of ATE553108T1 publication Critical patent/ATE553108T1/de

Links

101001032845 Homo sapiens Metabotropic glutamate receptor 5 Proteins 0.000 title 1
102100038357 Metabotropic glutamate receptor 5 Human genes 0.000 title 1
239000005557 antagonist Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Addiction (AREA)
Hematology (AREA)
Diabetes (AREA)
Child & Adolescent Psychology (AREA)
Obesity (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT06807563T 2005-11-08 2006-10-26 Thiazoloä4,5-cüpyridinderivative als antagonisten des mglu5-rezeptors ATE553108T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP05110461		2005-11-08
PCT/EP2006/067794 WO2007054436A2 (en)	2005-11-08	2006-10-26	Thiazolo [4 , 5-c] pyridine derivatives as mglu5 receptor antagonists

Publications (1)

Publication Number	Publication Date
ATE553108T1 true ATE553108T1 (de)	2012-04-15

Family

ID=37897285

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06807563T ATE553108T1 (de)	2005-11-08	2006-10-26	Thiazoloä4,5-cüpyridinderivative als antagonisten des mglu5-rezeptors

Country Status (16)

Country	Link
US (1)	US7659401B2 (de)
EP (1)	EP1948667B1 (de)
JP (1)	JP5015166B2 (de)
KR (1)	KR101020431B1 (de)
CN (1)	CN101291939B (de)
AR (1)	AR058179A1 (de)
AT (1)	ATE553108T1 (de)
AU (1)	AU2006311084A1 (de)
BR (1)	BRPI0618636A2 (de)
CA (1)	CA2628936A1 (de)
ES (1)	ES2382162T3 (de)
IL (1)	IL190989A0 (de)
RU (1)	RU2425834C2 (de)
TW (1)	TWI323261B (de)
WO (1)	WO2007054436A2 (de)
ZA (1)	ZA200803821B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2010533147A (ja)	2007-07-13	2010-10-21	アデックスファルマエス．エイ．	代謝調節型グルタミン酸レセプターのモジュレーターとしてのピラゾール誘導体
GB0800411D0 (en) *	2008-01-10	2008-02-20	Glaxo Group Ltd	Novel compounds
WO2011073339A1 (en) *	2009-12-18	2011-06-23	Janssen Pharmaceutica Nv	Bicyclic thiazoles as allosteric modulators of mglur5 receptors
CN102666551B (zh)	2009-12-18	2014-12-10	詹森药业有限公司	作为mglur5受体的变构调节剂的双环噻唑
AU2017223706A1 (en)	2016-02-23	2018-09-20	Indiana University Research & Technology Corporation	Combination therapies for treatment of spinal muscular atrophy
KR102224677B1 (ko)	2018-08-23	2021-03-08	가천대학교 산학협력단	티아졸로 피페라진 유도체 및 이를 유효성분으로 함유하는 자가면역질환 예방 또는 치료용 조성물

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0321115B1 (de)	1987-12-14	1991-08-14	Sawai Pharmaceutical Co., Ltd.	Carboxamide mit Tetrazol- und Thiazol-Ringen und ihre Anwendung
JP2695037B2 (ja) *	1990-11-07	1997-12-24	富士通株式会社	エラーパルス延伸回路
US6107300A (en) *	1996-03-27	2000-08-22	Dupont Pharmaceuticals	Arylamino fused pyrimidines
AU3571997A (en)	1996-08-01	1998-02-25	Warner-Lambert Company	Novel glutamate receptor antagonists: fused cycloalkyl quinoxalinediones
EP1025501B1 (de) *	1997-10-29	2002-04-03	Continental Teves AG & Co. oHG	Verfahren und vorrichtung zur überprüfung einer fehlerüberwachung einer schaltung
US6110929A (en) *	1998-07-28	2000-08-29	3M Innovative Properties Company	Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and analogs thereof
US6660753B2 (en) *	1999-08-19	2003-12-09	Nps Pharmaceuticals, Inc.	Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
KR100875222B1 (ko)	1999-08-19	2008-12-19	아스트라제네카 아베	헤테로폴리사이클릭 화합물 및 간접 글루타메이트 수용체길항제로서의 그들의 용도
EP1889891B1 (de)	2000-11-30	2017-11-22	Canon Kabushiki Kaisha	Lumineszenzvorrichtung und Anzeigeapparat
NZ526883A (en) *	2001-02-20	2005-11-25	Chugai Pharmaceutical Co Ltd	Azoles as malonyl-coa decarboxylase inhibitors useful as metabolic modulators
MXPA03007513A (es)	2001-02-21	2004-07-30	Nps Pharma Inc	Compuestos heteropoliciclicos y su uso como antagonistas del receptor metabotropico de glutamato.
DE60214846T2 (de)	2001-04-02	2007-05-16	Brown University Research Foundation	Verwendung von mGLuR5 antagonists zur Herstellung von Medikamenten zur Behandlung von empfindlichen X Syndrome, Autismus und geistiger Zurückgebliebenheit
US6529046B1 (en) *	2001-12-12	2003-03-04	Etron Technology, Inc.	Minimum pulse width detection and regeneration circuit
WO2004041285A1 (en) *	2002-10-31	2004-05-21	Amgen Inc.	Antiinflammation agents
ITMI20030151A1 (it) *	2003-01-30	2004-07-31	Recordati Ind Chimica E Farma Ceutica S P A	Uso di antagonisti selettivi del recettore mglu5 per il trattamento di disfunzioni neuromuscolari del tratto urinario inferiore.
EP1781647A2 (de)	2004-07-22	2007-05-09	Astex Therapeutics Limited	Thiazol- und isothiazolderivate als proteinkinaseinhibitoren
EP1869052A1 (de) *	2005-04-06	2007-12-26	AstraZeneca AB	Substituierte heterocyclen und ihre verwendung als chk1-, pdk1- und pak-inhibitoren

2006
- 2006-10-26 RU RU2008115034/04A patent/RU2425834C2/ru not_active IP Right Cessation
- 2006-10-26 WO PCT/EP2006/067794 patent/WO2007054436A2/en not_active Ceased
- 2006-10-26 CN CN2006800386693A patent/CN101291939B/zh not_active Expired - Fee Related
- 2006-10-26 ES ES06807563T patent/ES2382162T3/es active Active
- 2006-10-26 AT AT06807563T patent/ATE553108T1/de active
- 2006-10-26 JP JP2008539390A patent/JP5015166B2/ja not_active Expired - Fee Related
- 2006-10-26 CA CA002628936A patent/CA2628936A1/en not_active Abandoned
- 2006-10-26 KR KR1020087013474A patent/KR101020431B1/ko not_active Expired - Fee Related
- 2006-10-26 AU AU2006311084A patent/AU2006311084A1/en not_active Abandoned
- 2006-10-26 BR BRPI0618636-0A patent/BRPI0618636A2/pt not_active IP Right Cessation
- 2006-10-26 EP EP06807563A patent/EP1948667B1/de not_active Not-in-force
- 2006-10-31 US US11/590,087 patent/US7659401B2/en not_active Expired - Fee Related
- 2006-11-06 AR ARP060104855A patent/AR058179A1/es not_active Application Discontinuation
- 2006-11-06 TW TW095140997A patent/TWI323261B/zh not_active IP Right Cessation
2008
- 2008-04-17 IL IL190989A patent/IL190989A0/en unknown
- 2008-05-05 ZA ZA200803821A patent/ZA200803821B/xx unknown

Also Published As

Publication number	Publication date
ZA200803821B (en)	2009-03-25
KR20080069229A (ko)	2008-07-25
ES2382162T3 (es)	2012-06-05
BRPI0618636A2 (pt)	2011-09-06
KR101020431B1 (ko)	2011-03-08
AR058179A1 (es)	2008-01-23
AU2006311084A1 (en)	2007-05-18
IL190989A0 (en)	2008-12-29
CA2628936A1 (en)	2007-05-18
EP1948667A2 (de)	2008-07-30
TWI323261B (en)	2010-04-11
CN101291939B (zh)	2013-02-13
JP5015166B2 (ja)	2012-08-29
US7659401B2 (en)	2010-02-09
WO2007054436A2 (en)	2007-05-18
EP1948667B1 (de)	2012-04-11
WO2007054436A3 (en)	2007-06-28
JP2009514923A (ja)	2009-04-09
CN101291939A (zh)	2008-10-22
TW200736264A (en)	2007-10-01
RU2008115034A (ru)	2009-12-20
RU2425834C2 (ru)	2011-08-10
US20070105891A1 (en)	2007-05-10

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ATE553108T1 (de)	2012-04-15	Thiazoloä4,5-cüpyridinderivative als antagonisten des mglu5-rezeptors