ATE554097T1 - Verfahren zur herstellung von antithrombin-iii- zusammensetzungen - Google Patents

Verfahren zur herstellung von antithrombin-iii- zusammensetzungen

Info

Publication number: ATE554097T1
Authority: AT; Austria
Prior art keywords: antithrombin iii; producing; iii compositions; sugar chains; producing antithrombin
Prior art date: 2003-10-09

Application number

AT04773775T

Other languages

English (en)

Inventor

Tsuyoshi Yamada

Mitsuo Satoh

Yutaka Kanda

Kazuya Yamano

Original Assignee

Kyowa Hakko Kirin Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-10-09

Filing date

2004-10-08

Publication date

2012-05-15

2004-10-08 Application filed by Kyowa Hakko Kirin Co Ltd filed Critical Kyowa Hakko Kirin Co Ltd

2012-05-15 Application granted granted Critical

2012-05-15 Publication of ATE554097T1 publication Critical patent/ATE554097T1/de

Links

102000004411 Antithrombin III Human genes 0.000 title abstract 3
108090000935 Antithrombin III Proteins 0.000 title abstract 3
229960005348 antithrombin iii Drugs 0.000 title abstract 3
239000000203 mixture Substances 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
229930182474 N-glycoside Natural products 0.000 abstract 2
SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 abstract 1
PNNNRSAQSRJVSB-SLPGGIOYSA-N Fucose Natural products C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-SLPGGIOYSA-N 0.000 abstract 1
SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 abstract 1
OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 abstract 1
OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical group CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 abstract 1
MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 abstract 1
229950006780 n-acetylglucosamine Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C07K14/8128—Antithrombin III
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/01—Hexosyltransferases (2.4.1)
- C12Y204/01068—Glycoprotein 6-alpha-L-fucosyltransferase (2.4.1.68), i.e. FUT8
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/01—Hydro-lyases (4.2.1)
- C12Y402/01047—GDP-mannose 4,6-dehydratase (4.2.1.47), i.e. GMD
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y501/00—Racemaces and epimerases (5.1)
- C12Y501/03—Racemaces and epimerases (5.1) acting on carbohydrates and derivatives (5.1.3)
- C12Y501/03018—GDP-mannose 3,5-epimerase (5.1.3.18)

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
General Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Biotechnology (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Veterinary Medicine (AREA)
Microbiology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Hematology (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Toxicology (AREA)
Peptides Or Proteins (AREA)
Enzymes And Modification Thereof (AREA)

AT04773775T 2003-10-09 2004-10-08 Verfahren zur herstellung von antithrombin-iii- zusammensetzungen ATE554097T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2003350164		2003-10-09
PCT/JP2004/015324 WO2005035563A1 (ja)	2003-10-09	2004-10-08	アンチトロンビンⅲ組成物の製造方法

Publications (1)

Publication Number	Publication Date
ATE554097T1 true ATE554097T1 (de)	2012-05-15

Family

ID=34431032

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04773775T ATE554097T1 (de)	2003-10-09	2004-10-08	Verfahren zur herstellung von antithrombin-iii- zusammensetzungen

Country Status (9)

Country	Link
EP (1)	EP1676860B1 (de)
JP (1)	JP4263191B2 (de)
KR (1)	KR101017336B1 (de)
CN (2)	CN103993056A (de)
AT (1)	ATE554097T1 (de)
AU (1)	AU2004279741B2 (de)
CA (1)	CA2542035C (de)
ES (1)	ES2383371T3 (de)
WO (1)	WO2005035563A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2007099988A1 (ja) *	2006-02-28	2007-09-07	Kyowa Hakko Kogyo Co., Ltd.	α-1,6-フコシルトランスフェラーゼ変異体とその用途
CN107630011A (zh) *	2006-07-05	2018-01-26	催化剂生物科学公司	蛋白酶筛选方法及由此鉴别的蛋白酶
ATE530644T1 (de)	2006-07-05	2011-11-15	Catalyst Biosciences Inc	Protease-screening-verfahren und dadurch identifizierte proteasen
CN101883850B (zh)	2007-07-12	2014-11-12	桑格摩生物科学股份有限公司	用于失活α-1,6岩藻糖基转移酶(FUT8)基因表达的方法和组合物
WO2010018847A1 (ja)	2008-08-13	2010-02-18	協和発酵キリン株式会社	遺伝子組換えプロテインs組成物
US9487566B2 (en) *	2011-06-29	2016-11-08	Kyowa Hakko Kirin Co., Ltd	Method for purifying protein
US9127274B2 (en) *	2012-04-26	2015-09-08	Alnylam Pharmaceuticals, Inc.	Serpinc1 iRNA compositions and methods of use thereof
JP6432083B2 (ja)	2012-12-28	2018-12-05	生化学工業株式会社	リムルス試験に付されるアンチトロンビンｉｉｉ用の前処理剤及び前処理方法
JP7090421B2 (ja) *	2014-11-15	2022-06-24	ズムトールバイオロジクス、インコーポレイテッド	Ｄｎａ結合ドメイン、非フコシル化及び部分的フコシル化タンパク質、並びにその方法
US20180104318A1 (en) *	2015-03-31	2018-04-19	Kyowa Hakko Kirin Co., Ltd.	Therapeutic composition containing antithrombin gamma
AU2020222120A1 (en)	2019-02-11	2021-09-02	Kyowa Kirin Co., Ltd.	Method for treating pregancy-induced hypertension nephrosis
CN111109248A (zh) *	2019-12-24	2020-05-08	武汉博士德生物工程有限公司	一种杂交瘤细胞冻存液及96孔板冻存复苏方法
CN115247160B (zh) *	2022-07-28	2024-03-15	格进(杭州)生物技术有限责任公司	蛋白核心岩藻糖基化修饰的检测方法
CN117567597B (zh) *	2024-01-17	2024-03-22	成都艾科斯伦医疗科技有限公司	一种抗凝血酶Ⅲ及抗Xa活性检测试剂盒

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5843705A (en)	1995-02-21	1998-12-01	Genzyme Transgenic Corporation	Transgenically produced antithrombin III
WO1997027303A1 (en) *	1996-01-24	1997-07-31	Toyo Boseki Kabushiki Kaisha	Alpha-1-6 fucosyltransferases
WO2002002793A1 (fr)	2000-07-05	2002-01-10	Japan As Represented By Secretary Of Osaka University	Processus de production de glycoproteine
HU231090B1 (hu) *	2000-10-06	2020-07-28	Kyowa Kirin Co., Ltd.	Antitest-kompozíciót termelő sejt
AU2003236015A1 (en) *	2002-04-09	2003-10-20	Kyowa Hakko Kirin Co., Ltd.	Process for producing antibody composition
WO2003085107A1 (en) *	2002-04-09	2003-10-16	Kyowa Hakko Kogyo Co., Ltd.	Cells with modified genome
JP2005058111A (ja) *	2003-08-14	2005-03-10	Univ Osaka	糖鎖修飾制御方法

2004
- 2004-10-08 AT AT04773775T patent/ATE554097T1/de active
- 2004-10-08 JP JP2005514674A patent/JP4263191B2/ja not_active Expired - Lifetime
- 2004-10-08 ES ES04773775T patent/ES2383371T3/es not_active Expired - Lifetime
- 2004-10-08 CA CA2542035A patent/CA2542035C/en not_active Expired - Lifetime
- 2004-10-08 CN CN201410016193.XA patent/CN103993056A/zh active Pending
- 2004-10-08 EP EP04773775A patent/EP1676860B1/de not_active Expired - Lifetime
- 2004-10-08 CN CN200480035813.9A patent/CN1890262B/zh not_active Expired - Lifetime
- 2004-10-08 WO PCT/JP2004/015324 patent/WO2005035563A1/ja not_active Ceased
- 2004-10-08 AU AU2004279741A patent/AU2004279741B2/en not_active Expired
- 2004-10-08 KR KR1020067008648A patent/KR101017336B1/ko not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA2542035A1 (en)	2005-04-21
ES2383371T9 (es)	2012-12-14
CN1890262A (zh)	2007-01-03
EP1676860B1 (de)	2012-04-18
CN1890262B (zh)	2015-01-28
JPWO2005035563A1 (ja)	2007-11-22
HK1091500A1 (en)	2007-01-19
KR20060125732A (ko)	2006-12-06
EP1676860A1 (de)	2006-07-05
WO2005035563A1 (ja)	2005-04-21
EP1676860A4 (de)	2008-12-31
AU2004279741A1 (en)	2005-04-21
ES2383371T3 (es)	2012-06-20
JP4263191B2 (ja)	2009-05-13
AU2004279741B2 (en)	2010-03-11
KR101017336B1 (ko)	2011-02-28
CA2542035C (en)	2013-02-26
CN103993056A (zh)	2014-08-20

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