ATE554751T1 - Nanopartikel mit einem nicht ionisierbaren polymer und einem anionischen zellulosepolymer - Google Patents

Nanopartikel mit einem nicht ionisierbaren polymer und einem anionischen zellulosepolymer

Info

Publication number
ATE554751T1
ATE554751T1 AT08762998T AT08762998T ATE554751T1 AT E554751 T1 ATE554751 T1 AT E554751T1 AT 08762998 T AT08762998 T AT 08762998T AT 08762998 T AT08762998 T AT 08762998T AT E554751 T1 ATE554751 T1 AT E554751T1
Authority
AT
Austria
Prior art keywords
polymer
nanoparticles
ionizable
anionic cellulose
cellulose polymer
Prior art date
Application number
AT08762998T
Other languages
English (en)
Inventor
Corey Bloom
Marshall Crew
Warren Miller
Daniel Smithey
Original Assignee
Bend Res Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bend Res Inc filed Critical Bend Res Inc
Application granted granted Critical
Publication of ATE554751T1 publication Critical patent/ATE554751T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
AT08762998T 2007-07-13 2008-06-30 Nanopartikel mit einem nicht ionisierbaren polymer und einem anionischen zellulosepolymer ATE554751T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94952207P 2007-07-13 2007-07-13
PCT/IB2008/001776 WO2009010837A2 (en) 2007-07-13 2008-06-30 Nanoparticles comprising a non-ionizable polymer and an anionic cellulosic polymer

Publications (1)

Publication Number Publication Date
ATE554751T1 true ATE554751T1 (de) 2012-05-15

Family

ID=39731304

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08762998T ATE554751T1 (de) 2007-07-13 2008-06-30 Nanopartikel mit einem nicht ionisierbaren polymer und einem anionischen zellulosepolymer

Country Status (4)

Country Link
US (1) US20100266692A1 (de)
EP (1) EP2178519B1 (de)
AT (1) ATE554751T1 (de)
WO (1) WO2009010837A2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU227970B1 (en) * 2007-07-10 2012-07-30 Egis Gyogyszergyar Nyrt Pharmaceutical compositions containing silicones of high volatility
US9724362B2 (en) * 2007-12-06 2017-08-08 Bend Research, Inc. Pharmaceutical compositions comprising nanoparticles and a resuspending material
US9233078B2 (en) 2007-12-06 2016-01-12 Bend Research, Inc. Nanoparticles comprising a non-ionizable polymer and an Amine-functionalized methacrylate copolymer
HRP20130621T1 (en) 2008-02-28 2013-09-30 University Of Virginia Patent Foundation Serotonin transporter gene and treatment of alcoholism
JP5470032B2 (ja) 2009-08-12 2014-04-16 富士フイルム株式会社 セルロース誘導体、熱成形材料、成形体及びその製造方法並びに電気電子機器用筐体
WO2011059931A2 (en) * 2009-11-10 2011-05-19 Celgene Corporation Nanosuspension of a poorly soluble drug via microfluidization process
ES2664083T3 (es) 2010-07-02 2018-04-18 University Of Virginia Patent Foundation Enfoque genético molecular para el tratamiento y diagnóstico de la dependencia de alcohol y drogas
CA2848211A1 (en) 2011-09-09 2013-03-14 University Of Virginia Patent Foundation Molecular genetic approach to treatment and diagnosis of alcohol and drug dependence
US11154535B2 (en) 2012-07-31 2021-10-26 Egis Pharmaceuticals Plc Transdermal formulation containing COX inhibitors
US10045935B2 (en) 2012-07-31 2018-08-14 Egis Pharmaceuticals Plc Transdermal formulation containing COX inhibitors
US10045965B2 (en) 2012-07-31 2018-08-14 Egis Pharmaceuticals Plc Transdermal formulation containing COX inhibitors
WO2017062920A1 (en) * 2015-10-07 2017-04-13 Chopra Sunandini Nanoparticles with ph triggered drug release
IL294928A (en) 2020-01-24 2022-09-01 Nanocopoeia Llc Amorphous solid dispersions of dasatinib and uses thereof
IL295007A (en) 2020-01-31 2022-09-01 Nanocopoeia Llc Amorphous nilotinib microparticles and uses thereof
CA3181361A1 (en) 2020-04-30 2021-11-04 Nanocopoeia, Llc Orally disintegrating tablet comprising amorphous solid dispersion of nilotinib
US11980619B2 (en) 2021-07-28 2024-05-14 Nanocopoeia, Llc Pharmaceutical compositions and crushable tablets including amorphous solid dispersions of dasatinib and uses

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2608988B1 (fr) 1986-12-31 1991-01-11 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanoparticules
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
US20040018236A1 (en) 1995-05-08 2004-01-29 Robert Gurny Nanoparticles for oral administration of pharmaceutical agents of low solubility
AU5860798A (en) * 1997-12-29 1999-07-19 Universite De Geneve Method for producing an aqueous colloidal dispersion of nanoparticles
WO1999052863A1 (fr) * 1998-04-10 1999-10-21 Chugai Seiyaku Kabushiki Kaisha DERIVES DE LA VITAMINE D SUBSTITUES A LA POSITION 2$g(b)
PT1175220E (pt) * 1999-12-08 2005-07-29 Pharmacia Corp Composicoes de eplerenona em nanoparticulas
EA006402B1 (ru) * 1999-12-23 2005-12-29 Пфайзер Продактс Инк. Комбинация лекарства и целлюлозного полимера, повышающего концентрацию; способ введения лекарства и водный раствор (варианты)

Also Published As

Publication number Publication date
WO2009010837A2 (en) 2009-01-22
EP2178519B1 (de) 2012-04-25
EP2178519A2 (de) 2010-04-28
US20100266692A1 (en) 2010-10-21
WO2009010837A3 (en) 2009-03-12

Similar Documents

Publication Publication Date Title
ATE554751T1 (de) Nanopartikel mit einem nicht ionisierbaren polymer und einem anionischen zellulosepolymer
WO2008149192A3 (en) Nanoparticles comprising a non-ionizable cellulosic polymer and an amphiphilic non-ionizable block copolymer
ECSP10010622A (es) Composición farmacéutica que comprende una sal de estroncio, vitamina d y una ciclodextrina
BRPI1014139A2 (pt) sistema de liberação de fármacos compreendendo polioxazolina e um agente biotivo.
WO2009010842A3 (en) Nanoparticles comprising ionizable, poorly water soluble cellulosic polymers
EP2983659A4 (de) Wirkstofffreisetzendes polymer und verwendungen davon
JP2012205928A5 (de)
MX2013000956A (es) Pildora de alta viscosidad que reacciona a estimulos.
BRPI0811985A2 (pt) Complexos de ferro-derivado de carboidrato solúveis em água, produção dos mesmos e medicamentos que contêm os mesmos
CL2008000219A1 (es) Composicion farmaceutica de liberacion modificada que comprende a uno o mas ingredientes farmaceuticamente activos, con solubilidad dependiente del ph, un polimero controlador de la liberacion, agentes facilitadores de la gelificacion; procedimiento
EA201001402A1 (ru) Фармацевтические растворы, способ получения и терапевтическое применение
AR072761A1 (es) Mezcla de fibras pediatrica
EA201690051A1 (ru) Поликонъюгаты для доставки триггеров рнк интерференции в клетки опухоли in vivo
NZ608239A (en) Aqueous drug delivery system comprising off - flavor masking agent
BRPI0910403A2 (pt) Uso de um agente traçador de mpi, e, método para o monitoramento visual de um produto biocompatível.
BRPI0920112A2 (pt) derivados de anilinopirimidina substituídos com sulfoximina como inibidores cdk, sua produção e uso como medicamento.
CL2014003148A1 (es) Composición farmacéutica acuosa que contiene un agente terapéutico biológico y guanidina o un derivado de la guanidina y una inyección que incluye la composición.
WO2012131378A3 (en) Pharmaceutical preparation comprising alpha emitting radionuclide
TR200904159A1 (tr) Değiştirilmiş salım sağlayan emoksipin formülasyonları.
UY31452A1 (es) Recubrimiento mejorado de tableta
WO2008149230A3 (en) Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glycol succinate
WO2011056702A3 (en) Fast dissolving/disintegrating coating compositions
DE602008000367D1 (de) Valsartanformulierungen
EP2241582A4 (de) Wässrige dispersion mit einem polyolefin-pfropf-copolymer
EP2670780A4 (de) Zellulosebasierte nanopartikel zur wirkstofffreisetzung