ATE554776T1 - Antivirale phosphinatverbindungen - Google Patents
Antivirale phosphinatverbindungenInfo
- Publication number
- ATE554776T1 ATE554776T1 AT07796752T AT07796752T ATE554776T1 AT E554776 T1 ATE554776 T1 AT E554776T1 AT 07796752 T AT07796752 T AT 07796752T AT 07796752 T AT07796752 T AT 07796752T AT E554776 T1 ATE554776 T1 AT E554776T1
- Authority
- AT
- Austria
- Prior art keywords
- phosphinate compounds
- antiviral
- antiviral phosphinate
- compounds
- phosphinate
- Prior art date
Links
- 230000000840 anti-viral effect Effects 0.000 title 1
- ACVYVLVWPXVTIT-UHFFFAOYSA-M phosphinate Chemical class [O-][PH2]=O ACVYVLVWPXVTIT-UHFFFAOYSA-M 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81948806P | 2006-07-07 | 2006-07-07 | |
| US83290806P | 2006-07-24 | 2006-07-24 | |
| PCT/US2007/015664 WO2008005565A2 (en) | 2006-07-07 | 2007-07-06 | Antiviral phosphinate compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE554776T1 true ATE554776T1 (de) | 2012-05-15 |
Family
ID=38626760
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07796752T ATE554776T1 (de) | 2006-07-07 | 2007-07-06 | Antivirale phosphinatverbindungen |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US20090227491A1 (de) |
| EP (2) | EP2422791B1 (de) |
| JP (3) | JP2009542698A (de) |
| KR (1) | KR20090026216A (de) |
| CN (1) | CN102532198A (de) |
| AR (1) | AR061840A1 (de) |
| AT (1) | ATE554776T1 (de) |
| AU (1) | AU2007269567B2 (de) |
| BR (1) | BRPI0713961A2 (de) |
| CA (1) | CA2656356C (de) |
| EA (1) | EA018098B1 (de) |
| ES (2) | ES2531315T3 (de) |
| HR (1) | HRP20090076A2 (de) |
| IL (1) | IL195489A0 (de) |
| MX (1) | MX2009000236A (de) |
| NO (1) | NO20090596L (de) |
| TW (1) | TW200819460A (de) |
| WO (1) | WO2008005565A2 (de) |
| ZA (1) | ZA200810400B (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20090024834A (ko) * | 2006-07-05 | 2009-03-09 | 인터뮨, 인크. | Ｃ형 간염 바이러스 복제의 신규 억제제 |
| US20090227491A1 (en) * | 2006-07-07 | 2009-09-10 | Gilead Sciences, Inc. | Antiviral phosphinate compounds |
| KR20110005869A (ko) * | 2008-04-15 | 2011-01-19 | 인터뮨, 인크. | Ｃ형 간염 바이러스 복제의 신규한 마크로사이클릭 억제제 |
| JP5690286B2 (ja) * | 2009-03-04 | 2015-03-25 | イデニク プハルマセウティカルス，インコーポレイテッド | ホスホチオフェン及びホスホチアゾールｈｃｖポリメラーゼ阻害剤 |
| UY32715A (es) * | 2009-06-23 | 2011-01-31 | Gilead Sciences Inc | Combinaciones farmacéuticas útiles para el tratamiento del virus de la hepatitis c (vhc), usos y métodos relacionados |
| US8476225B2 (en) | 2009-12-04 | 2013-07-02 | Gilead Sciences, Inc. | Antiviral compounds |
| UY33445A (es) * | 2010-06-10 | 2012-01-31 | Gilead Sciences Inc | Un régimen de dosificación, métodos para tratar el virus de la hepatitis c, composición farmacéutica, compuesta, compuestos anti-hcv y kit |
| AU2011349844B2 (en) * | 2010-12-20 | 2017-06-01 | Gilead Sciences, Inc. | Combinations for treating HCV |
| US8957203B2 (en) | 2011-05-05 | 2015-02-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8691757B2 (en) | 2011-06-15 | 2014-04-08 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| SI2709613T2 (sl) | 2011-09-16 | 2020-12-31 | Gilead Pharmasset LLC c/o Gilead Sciences, Inc. | Postopki za zdravljenje HCV |
| US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
| CN104023726A (zh) | 2011-10-21 | 2014-09-03 | 艾伯维公司 | 用于治疗hcv的一种或多种daa的联合治疗(例如，与abt-072或abt-333) |
| CA2811203C (en) | 2011-10-21 | 2015-05-05 | Abbvie Inc. | Methods for treating hcv |
| US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
| SI2909205T1 (sl) | 2012-10-19 | 2017-02-28 | Bristol-Myers Squibb Company | 9-metil substituiran heksadekahidrociklopropa(e)pirolo(1,2-A)(1,4)diazaciklopentadecinil karbamat derivati kot nestrukturalni 3 (NS3) proteazni inhibitorji za zdravljenje hepatitis C virusnih infekcij |
| EP2914598B1 (de) | 2012-11-02 | 2017-10-18 | Bristol-Myers Squibb Company | Inhibitoren des hepatitis-c-virus |
| EP2914613B1 (de) | 2012-11-02 | 2017-11-22 | Bristol-Myers Squibb Company | Inhibitoren des hepatitis-c-virus |
| US9643999B2 (en) | 2012-11-02 | 2017-05-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US9409943B2 (en) | 2012-11-05 | 2016-08-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| NZ729172A (en) | 2013-01-31 | 2018-06-29 | Gilead Pharmasset Llc | Combination formulation of two antiviral compounds |
| US9580463B2 (en) | 2013-03-07 | 2017-02-28 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| CN103539833B (zh) * | 2013-09-29 | 2016-02-03 | 北京林业大学 | 高活性α-葡萄糖苷酶抑制肽及其制备方法和用途 |
| CN103539831B (zh) * | 2013-09-29 | 2016-02-03 | 北京林业大学 | 山杏α-葡萄糖苷酶抑制肽及其制备方法和用途 |
| JP7129703B2 (ja) | 2016-04-28 | 2022-09-02 | エモリー ユニバーシティー | アルキン含有ヌクレオチド及びヌクレオシド治療組成物並びにそれらに関連した使用 |
| MX2018014377A (es) | 2016-05-27 | 2019-03-14 | Gilead Sciences Inc | Metodos para tratar infecciones por virus de hepatitis b usando inhibidores de proteina no estructural 5a (ns5a), proteina no estructural 5b (ns5b) o proteina no estructural 3 (ns3). |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816570A (en) | 1982-11-30 | 1989-03-28 | The Board Of Regents Of The University Of Texas System | Biologically reversible phosphate and phosphonate protective groups |
| US4968788A (en) | 1986-04-04 | 1990-11-06 | Board Of Regents, The University Of Texas System | Biologically reversible phosphate and phosphonate protective gruops |
| AU651835B2 (en) | 1990-06-13 | 1994-08-04 | Arnold Glazier | Phosphorous prodrugs |
| EP0481214B1 (de) * | 1990-09-14 | 1998-06-24 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | Wirkstoffvorläufer von Phosphonaten |
| DE4308096A1 (de) | 1993-03-13 | 1994-09-15 | Hoechst Ag | Prodrug-Derivate von Enzyminhibitoren mit Hydroxylgruppen, Verfahren zu deren Herstellung und ihre Verwendung |
| ATE199906T1 (de) | 1993-06-29 | 2001-04-15 | Mitsubishi Chem Corp | Phosphonat-nukleotid ester-derivate |
| EP0719273B1 (de) | 1993-09-17 | 2010-11-03 | Gilead Sciences, Inc. | Nukleotidanaloge |
| JPH07183249A (ja) * | 1993-12-22 | 1995-07-21 | Nec Yamagata Ltd | イオン注入工程管理方法 |
| US5543523A (en) | 1994-11-15 | 1996-08-06 | Regents Of The University Of Minnesota | Method and intermediates for the synthesis of korupensamines |
| US5968788A (en) * | 1995-08-28 | 1999-10-19 | Toray Industries, Inc. | Method for producing folic acid |
| US6004977A (en) * | 1996-12-27 | 1999-12-21 | Hoechst Marion Roussel, Inc. | N-(pyridinylamino) isoindolines and related compounds |
| DE19843360A1 (de) * | 1998-09-22 | 2000-03-30 | Hassan Jomaa | Phosphororganische Verbindungen und ihre Verwendung |
| US6828301B2 (en) * | 2002-02-07 | 2004-12-07 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for hepatitis C viral protease inhibitors |
| EP1629000B1 (de) * | 2003-04-16 | 2009-02-18 | Bristol-Myers Squibb Company | Makrocyclische isochinolinpeptidinhibitoren des hepatitis-c-virus |
| DK1778702T3 (da) | 2004-07-16 | 2011-10-17 | Gilead Sciences Inc | Antivirale forbindelser |
| WO2007001406A2 (en) | 2004-10-05 | 2007-01-04 | Chiron Corporation | Aryl-containing macrocyclic compounds |
| US20080306054A1 (en) | 2005-04-13 | 2008-12-11 | Astex Therapeutics Limited | Pharmaceutical Compounds |
| JP5249028B2 (ja) * | 2005-07-25 | 2013-07-31 | インターミューン・インコーポレーテッド | Ｃ型肝炎ウイルス複製の新規大環状阻害剤 |
| PE20070211A1 (es) * | 2005-07-29 | 2007-05-12 | Medivir Ab | Compuestos macrociclicos como inhibidores del virus de hepatitis c |
| PL1919898T3 (pl) * | 2005-07-29 | 2011-06-30 | Tibotec Pharm Ltd | Makrocykliczne inhibitory wirusa zapalenia wątroby typu C |
| US7772183B2 (en) * | 2005-10-12 | 2010-08-10 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US20090227491A1 (en) | 2006-07-07 | 2009-09-10 | Gilead Sciences, Inc. | Antiviral phosphinate compounds |
| US8293705B2 (en) * | 2007-12-21 | 2012-10-23 | Avila Therapeutics, Inc. | HCV protease inhibitors and uses thereof |
| UY32715A (es) | 2009-06-23 | 2011-01-31 | Gilead Sciences Inc | Combinaciones farmacéuticas útiles para el tratamiento del virus de la hepatitis c (vhc), usos y métodos relacionados |
| US8691757B2 (en) | 2011-06-15 | 2014-04-08 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
-
2007
- 2007-07-06 US US12/303,219 patent/US20090227491A1/en not_active Abandoned
- 2007-07-06 CA CA2656356A patent/CA2656356C/en not_active Expired - Fee Related
- 2007-07-06 CN CN2011104294087A patent/CN102532198A/zh active Pending
- 2007-07-06 AT AT07796752T patent/ATE554776T1/de active
- 2007-07-06 EP EP11190674.9A patent/EP2422791B1/de active Active
- 2007-07-06 BR BRPI0713961-6A patent/BRPI0713961A2/pt not_active IP Right Cessation
- 2007-07-06 AR ARP070103031A patent/AR061840A1/es not_active Application Discontinuation
- 2007-07-06 HR HR20090076A patent/HRP20090076A2/xx not_active Application Discontinuation
- 2007-07-06 JP JP2009518397A patent/JP2009542698A/ja not_active Withdrawn
- 2007-07-06 EP EP07796752A patent/EP2043658B1/de active Active
- 2007-07-06 ES ES11190674T patent/ES2531315T3/es active Active
- 2007-07-06 WO PCT/US2007/015664 patent/WO2008005565A2/en not_active Ceased
- 2007-07-06 TW TW096124722A patent/TW200819460A/zh unknown
- 2007-07-06 AU AU2007269567A patent/AU2007269567B2/en not_active Ceased
- 2007-07-06 US US11/825,606 patent/US7893264B2/en active Active
- 2007-07-06 MX MX2009000236A patent/MX2009000236A/es active IP Right Grant
- 2007-07-06 EA EA200900154A patent/EA018098B1/ru not_active IP Right Cessation
- 2007-07-06 KR KR1020097002642A patent/KR20090026216A/ko not_active Ceased
- 2007-07-06 ES ES07796752T patent/ES2388969T3/es active Active
-
2008
- 2008-11-25 IL IL195489A patent/IL195489A0/en unknown
- 2008-12-09 ZA ZA2008/10400A patent/ZA200810400B/en unknown
-
2009
- 2009-02-06 NO NO20090596A patent/NO20090596L/no not_active Application Discontinuation
-
2010
- 2010-10-27 US US12/913,704 patent/US8586744B2/en active Active
- 2010-10-27 US US12/913,692 patent/US8674088B2/en active Active
-
2012
- 2012-02-28 JP JP2012041605A patent/JP2012107061A/ja not_active Withdrawn
-
2015
- 2015-01-22 JP JP2015010367A patent/JP6010640B2/ja not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| LTPA2020501I1 (lt) | Pakeistieji enaminokarbonilo junginiai | |
| IL195489A0 (en) | Antiviral phosphinate compounds | |
| ATE524477T1 (de) | Aziridinylepothilonverbindungen | |
| BRPI0815042A2 (pt) | Compostos de pirazol | |
| BRPI0813500A2 (pt) | Compostos antivirais | |
| BRPI0821086A2 (pt) | Compostos inseticidas | |
| DE602007008423D1 (de) | Flüssigkeitshärtung | |
| DE602007009267D1 (de) | Reifenaufblasverfahren | |
| BRPI0720097A2 (pt) | Compostos de fosfonato | |
| BRPI0811264A2 (pt) | Compostos | |
| ATE546437T1 (de) | Aminomethyl-4-imidazole | |
| DE502007000218D1 (de) | nsetzungen | |
| BRPI0809996A2 (pt) | Compostos | |
| BRPI0814424A2 (pt) | Compostos heterociclila | |
| CR10675A (es) | Analogos de 2-fenoxipirimidinona | |
| DK1994062T3 (da) | Aryl/alkyl-vinylsulfonhyaluronsyrederivater | |
| BRPI0815181A2 (pt) | Compostos | |
| FI20061014A0 (fi) | Diffuusiopinnoitusmenetelmä | |
| DE112007003147A5 (de) | Rohr-Biegevorrichtung | |
| DE602007012951D1 (de) | Verbundschraubenausräumtür | |
| BRPI0814725A2 (pt) | Composição antiviral | |
| DE502007005975D1 (de) | Wischblatt | |
| PT2792662T (pt) | Compostos de morfinano | |
| BRPI0814613A2 (pt) | Compostos | |
| FI20060691A0 (fi) | Laitekotelointi |