ATE555119T1 - Expression von proteaseinhibitoren und varianten davon in filamentösen pilzen - Google Patents

Expression von proteaseinhibitoren und varianten davon in filamentösen pilzen

Info

Publication number
ATE555119T1
ATE555119T1 AT04796291T AT04796291T ATE555119T1 AT E555119 T1 ATE555119 T1 AT E555119T1 AT 04796291 T AT04796291 T AT 04796291T AT 04796291 T AT04796291 T AT 04796291T AT E555119 T1 ATE555119 T1 AT E555119T1
Authority
AT
Austria
Prior art keywords
variants
expression
protease inhibitors
filamentous fungi
filamentous
Prior art date
Application number
AT04796291T
Other languages
English (en)
Inventor
Nobel Hans De
David A Estell
Wei Liu
Scott D Power
Brian Schmidt
Huaming Wang
Original Assignee
Danisco Us Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Danisco Us Inc filed Critical Danisco Us Inc
Application granted granted Critical
Publication of ATE555119T1 publication Critical patent/ATE555119T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT04796291T 2003-11-06 2004-10-22 Expression von proteaseinhibitoren und varianten davon in filamentösen pilzen ATE555119T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51815403P 2003-11-06 2003-11-06
PCT/US2004/035278 WO2005047302A1 (en) 2003-11-06 2004-10-22 Expression in filamentous fungi of protease inhibitors and variants thereof

Publications (1)

Publication Number Publication Date
ATE555119T1 true ATE555119T1 (de) 2012-05-15

Family

ID=34590229

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04796291T ATE555119T1 (de) 2003-11-06 2004-10-22 Expression von proteaseinhibitoren und varianten davon in filamentösen pilzen

Country Status (9)

Country Link
US (3) US7279564B2 (de)
EP (2) EP1689766B1 (de)
JP (1) JP4834554B2 (de)
KR (3) KR20120099303A (de)
CN (2) CN1875029B (de)
AT (1) ATE555119T1 (de)
CA (1) CA2545053C (de)
DK (1) DK1689766T3 (de)
WO (1) WO2005047302A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006246425B2 (en) * 2003-11-06 2012-03-22 Genencor International, Inc. Personal care compositions and methods for their use
CA2544820C (en) * 2003-11-06 2014-02-18 Genencor International, Inc. Bacterial expression of protease inhibitors and variants thereof
DK2333045T3 (en) * 2005-04-12 2017-02-20 Danisco Us Inc GEN-INACTIVATED MUTANTS WITH CHANGED PROTEIN PRODUCTION
JP5284789B2 (ja) * 2005-11-15 2013-09-11 グライコフィ， インコーポレイテッド Ｏ−グリコシル化を減少している糖タンパク質の生成
US8198046B2 (en) * 2006-07-11 2012-06-12 Danisco Us Inc. KEX2 cleavage regions of recombinant fusion proteins
US20080026376A1 (en) 2006-07-11 2008-01-31 Huaming Wang KEX2 cleavage regions of recombinant fusion proteins
ES2386991T3 (es) 2006-12-18 2012-09-10 Danisco Us Inc. Nuevas composiciones de laccasas y sus procedimientos de utilización
US20090221030A1 (en) * 2007-11-01 2009-09-03 Kai Bao Signal sequences and co-expressed chaperones for improving protein production in a host cell
US7803902B2 (en) 2008-10-15 2010-09-28 Danisco Us Inc. Modified variant bowman birk protease inhibitors
US7772181B2 (en) 2008-10-15 2010-08-10 Danisco Us Inc. Personal care compositions comprising modified variant Bowman Birk Protease Inhibitors
RU2509776C2 (ru) * 2008-10-15 2014-03-20 ДАНИСКО ЮЭс ИНК. МОДИФИЦИРОВАННЫЕ ВАРИАНТЫ ИНГИБИТОРОВ ПРОТЕАЗ Bowman Birk
GB0921001D0 (en) 2009-11-30 2010-01-13 Aqua Bio Technology Asa Products and uses
EP2519251A4 (de) * 2009-12-30 2013-08-28 Solae Llc Aus einem sojaverarbeitungsstrom isolierte gereinigte bowman-birk-protease-hemmerproteine
AU2011293263B2 (en) * 2010-08-25 2014-10-23 Danisco Us Inc. Filamentous fungi having an altered viscosity phenotype
DK2643468T3 (en) * 2010-11-22 2018-09-24 Amicus Therapeutics Inc Hitherto UNKNOWN SIGNAL SEQUENCES TO IMPROVE EXPRESSION AND SECRETARY OF RECOMBINANT ENZYMES AND OTHER PROTEINS
EP2673290B1 (de) * 2011-04-22 2016-07-20 Danisco US Inc. Fadenpilze mit einem veränderten viskositäts-phänotyp
DK3027746T3 (en) * 2013-07-29 2019-02-04 Academia Sinica HEAT STABLE KERATINASE AND USE THEREOF
JP6544503B2 (ja) * 2014-01-30 2019-07-17 福岡県 コラゲナーゼ阻害剤、並びにコラゲナーゼ阻害剤を配合した化粧料組成物及び機能性食品
EA202190999A1 (ru) 2018-10-10 2021-10-15 Амикус Терапьютикс, Инк. Композиции на основе полипептидов, стабилизированных с помощью дисульфидной связи, и способы применения
AU2020307369B2 (en) * 2019-06-26 2026-01-08 Eg Crop Science, Inc. Identification of resistance genes from wild relatives of banana and their uses in controlling Panama disease
CN112553274B (zh) * 2020-12-02 2023-06-13 江南大学 大豆提取物Bowman-Birk inhibitor切割DNA的方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US214237A (en) 1879-04-15 Improvement in grain-driers
DE3009104C2 (de) 1980-03-10 1990-10-04 Odenwald-Chemie GmbH, 6901 Schönau Verwendung eines Epoxydharzes zur Herstellung von feuerhemmenden Schichten oder Überzügen und Verfahren zur Herstellung derselben
CA1338400C (en) 1983-08-31 1996-06-18 David H. Gelfand Recombinant fungal cellulases
US5411873A (en) 1984-05-29 1995-05-02 Genencor, Inc. Process for producing heterologous polypeptides
EP0625577A1 (de) 1985-08-29 1994-11-23 Genencor International, Inc. Expression von heterologer Polypeptiden in filamentlözen Pilzen, Verfahren zu deren Herstellung und Vektoren zu deren Herstellung
US5364770A (en) * 1985-08-29 1994-11-15 Genencor International Inc. Heterologous polypeptides expressed in aspergillus
US5679543A (en) 1985-08-29 1997-10-21 Genencor International, Inc. DNA sequences, vectors and fusion polypeptides to increase secretion of desired polypeptides from filamentous fungi
US4935349A (en) * 1986-01-17 1990-06-19 Zymogenetics, Inc. Expression of higher eucaryotic genes in aspergillus
US5780292A (en) * 1987-04-29 1998-07-14 Alko Group Ltd. Production of phytate degrading enzymes in trichoderma
GB2200118A (en) 1987-01-23 1988-07-27 Allelix Inc Synthetic chymosin-and prochymosin-encoding DNA segments
CA1333777C (en) 1988-07-01 1995-01-03 Randy M. Berka Aspartic proteinase deficient filamentous fungi
US5766934A (en) 1989-03-13 1998-06-16 Guiseppi-Elie; Anthony Chemical and biological sensors having electroactive polymer thin films attached to microfabricated devices and possessing immobilized indicator moieties
AU664223B2 (en) * 1991-12-09 1995-11-09 Unilever Plc Process for producing/secreting a protein by a transformed mould using expression/secretion regulating regions derived from an (aspergillus) endoxylanase II gene
US5429950A (en) 1992-03-30 1995-07-04 Genencor International, Inc. Heterologous gene expression in bacillus subtilis: fusion approach
ATE219143T1 (de) 1992-12-10 2002-06-15 Dsm Nv Herstellung von heterologen proteinen in filamentösen fungi
US5365770A (en) * 1993-04-05 1994-11-22 Ford Motor Company Ultrasonic wave interferometers
DK52293D0 (de) * 1993-05-05 1993-05-05 Novo Nordisk As
US6268196B1 (en) 1993-12-17 2001-07-31 Genencor International, Inc. Method and compositions for treating cellulose containing fabrics using truncated cellulase enzyme compositions
KR0163197B1 (ko) 1995-01-28 1999-03-20 유성식 자동 판매기
US5646025A (en) * 1995-05-05 1997-07-08 Novo Nordisk A/S Scytalidium catalase gene
US6265204B1 (en) 1997-01-17 2001-07-24 Genencor International, Inc. DNA sequences, vectors, and fusion polypeptides for secretion of polypeptides in filamentous fungi
ATE223971T1 (de) * 1998-07-20 2002-09-15 Inoxell As Neue methoden zum auffinden von liganden- und ziel-biomolekülen
US6391848B1 (en) 1999-04-30 2002-05-21 The Regents Of The University Of California Soybean protein nutraceuticals
US6537968B1 (en) 2000-07-24 2003-03-25 Alphamed Pharmaceuticals Corp Treatment of lupus erythematosus
JP2005531307A (ja) 2002-06-26 2005-10-20 ノボザイムス アクティーゼルスカブ 変化した免疫原性を有するスブチラーゼ及びスブチラーゼ変異体
CA2544820C (en) * 2003-11-06 2014-02-18 Genencor International, Inc. Bacterial expression of protease inhibitors and variants thereof

Also Published As

Publication number Publication date
US20050153399A1 (en) 2005-07-14
WO2005047302A1 (en) 2005-05-26
US7592157B2 (en) 2009-09-22
KR101211444B1 (ko) 2012-12-13
JP2007528212A (ja) 2007-10-11
KR101348530B1 (ko) 2014-02-14
EP1689766B1 (de) 2012-04-25
HK1100181A1 (en) 2007-09-07
CA2545053C (en) 2016-04-19
CN101857867A (zh) 2010-10-13
EP2292641B1 (de) 2017-12-06
US7279564B2 (en) 2007-10-09
KR20110119844A (ko) 2011-11-02
US20080234465A1 (en) 2008-09-25
EP1689766A4 (de) 2008-07-23
CN1875029A (zh) 2006-12-06
EP2292641A2 (de) 2011-03-09
CN1875029B (zh) 2010-06-16
CA2545053A1 (en) 2005-05-26
KR20120099303A (ko) 2012-09-07
US7592420B2 (en) 2009-09-22
JP4834554B2 (ja) 2011-12-14
EP2292641A3 (de) 2011-06-22
EP1689766A1 (de) 2006-08-16
KR20060111451A (ko) 2006-10-27
DK1689766T3 (da) 2012-07-16
US20080131932A1 (en) 2008-06-05

Similar Documents

Publication Publication Date Title
DK1689766T3 (da) Ekspression af proteaseinhibitorer og varianter deraf i filamentøse svampe
ATE513917T1 (de) Bakterielle expression von proteaseinhibitoren und varianten davon
ATE454938T1 (de) Düsen und komponenten davon sowie herstellungsverfahren dafür
EP1704180A4 (de) Nukleierungsmittel
ATE429320T1 (de) Medizinische vorrichtung und herstellungsverfahren dafür
NO20044906L (no) Parasittkontroll hos dyr
ATE439863T1 (de) Ophthalmische zusammensetzungen von parasympathischen stimulantia und entzündungshemmer zur verwendung bei der behandlung von presbyopie
BR0214309A (pt) Derivados aril-1,4-pirazina substituìdos
DE60131537D1 (de) Nitrosierte und nitrosylierte taxane, zubereitungen und methoden der verwendung
DE602004021802D1 (de) Heisspressgeformtes produkt und herstellungsverfahren dafür
DE602004013006D1 (de) Wiedergabegerät, programm und wiedergabeverfahren
ATE537155T1 (de) Zur behandlung von diabetes, obesitas und dyslipidämie geeignete inhibitoren von 11-beta- hydroxysteroid-dehydrogenase-1
DE60209944D1 (de) Inhibitoren von faktor xa und anderen serinproteasen, die an der koagulationskaskade beteiligt sind
DE60306904D1 (de) Selektive dipeptidische inhibitoren von kallikrein
BRPI0409367A (pt) derivados de piperidina inibidores de renina
ATE526399T1 (de) Neue biologische einheiten und deren verwendung
UY27143A1 (es) Inhibidores de sulfonamida lactama de fxa y método
DE60218633D1 (de) Inhibitoren von cruzipain und anderen cysteinproteasen
DE60310014D1 (de) Musiksuchverfahren, Musiksuchgerät und Musiksuchprogramm
ATE498134T1 (de) Nachweis von staphylococcus
ATE319439T1 (de) Mittel zur behandlung von erkrankungen des tracheo-bronchialtraktes, insbesondere der copd
ATE428417T1 (de) Derivate von piperidinylalkylcarbamaten, herstellungsverfahren davon und verwendung derselben als faah-enzym-inhibitoren
DE602004009824D1 (de) Analyse von massenspektraldaten in den ruhigen gebieten
DE60300563D1 (de) Optischer Verstärker und zugehöriges Ansteuerungsverfahren
ATE549024T1 (de) Chinazolin-kaliumkanalhemmer