BRPI0409367A - derivados de piperidina inibidores de renina - Google Patents

derivados de piperidina inibidores de renina

Info

Publication number
BRPI0409367A
BRPI0409367A BRPI0409367-4A BRPI0409367A BRPI0409367A BR PI0409367 A BRPI0409367 A BR PI0409367A BR PI0409367 A BRPI0409367 A BR PI0409367A BR PI0409367 A BRPI0409367 A BR PI0409367A
Authority
BR
Brazil
Prior art keywords
renin inhibitors
piperidine derivatives
piperidine
inhibitors
derivatives
Prior art date
Application number
BRPI0409367-4A
Other languages
English (en)
Inventor
Wayne Livingston Cody
Jeremy John Edmunds
Daniel Dale Holsworth
Noel Aaron Powell
Xue-Min Cheng
Noe Erasga
Chitase Lee
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of BRPI0409367A publication Critical patent/BRPI0409367A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"DERIVADOS DE PIPERIDINA INIBIDORES DE RENINA". São revelados derivados de piperidina, seu fabrico e utilização como inibidores de renina.
BRPI0409367-4A 2003-04-10 2004-04-01 derivados de piperidina inibidores de renina BRPI0409367A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46196203P 2003-04-10 2003-04-10
US54227904P 2004-02-09 2004-02-09
PCT/IB2004/001162 WO2004089903A1 (en) 2003-04-10 2004-04-01 Piperidine derivatives as renin inhibitors for the treatment of hypertension

Publications (1)

Publication Number Publication Date
BRPI0409367A true BRPI0409367A (pt) 2006-04-25

Family

ID=33162258

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0409367-4A BRPI0409367A (pt) 2003-04-10 2004-04-01 derivados de piperidina inibidores de renina

Country Status (7)

Country Link
US (1) US20040204455A1 (pt)
EP (1) EP1615890A1 (pt)
JP (1) JP2006522793A (pt)
BR (1) BRPI0409367A (pt)
CA (1) CA2521433A1 (pt)
MX (1) MXPA05010944A (pt)
WO (1) WO2004089903A1 (pt)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200900399A (en) 2003-10-01 2009-01-01 Speedel Experimenta Ag Organic compounds
CN1906163A (zh) * 2003-11-26 2007-01-31 诺瓦提斯公司 作为肾素抑制剂的4－苯基哌啶衍生物
AR053406A1 (es) * 2004-07-09 2007-05-09 Speedel Experimenta Ag Derivados de piperidina como inhibidores de renina. composiciones farmaceuticas
JP2008510755A (ja) 2004-08-25 2008-04-10 アクテリオン ファーマシューティカルズ リミテッド ビシクロノネン誘導体
GB0428526D0 (en) * 2004-12-30 2005-02-09 Novartis Ag Organic compounds
GB0504850D0 (en) * 2005-03-09 2005-04-13 Novartis Ag Organic compounds
WO2006103275A1 (en) * 2005-03-31 2006-10-05 Speedel Experimenta Ag 3,4,5-substituted piperidines as renin inhibitors
EP1897879A3 (en) * 2005-03-31 2008-06-11 Speedel Experimenta AG 2,4,5-substituted piperidines as renin inhibitors
EP1707202A1 (de) * 2005-03-31 2006-10-04 Speedel Experimenta AG Organische Verbindungen
TW200722424A (en) 2005-03-31 2007-06-16 Speedel Experimenta Ag Substituted piperidines
AR055756A1 (es) * 2005-03-31 2007-09-05 Speedel Experimenta Ag Piperidinas sustituidas; procesos de preparacion y su uso como medicamentos
ES2352564T3 (es) * 2005-03-31 2011-02-21 Novartis Ag Piperidinas sustituidas.
GB0508992D0 (en) * 2005-05-03 2005-06-08 Novartis Ag Organic compounds
JP4297972B2 (ja) 2005-05-27 2009-07-15 アクテリオン ファーマシューティカルズ リミテッド 新規なピペリジンカルボン酸アミド誘導体
EP1741709A1 (en) 2005-06-28 2007-01-10 Sanofi-Aventis Deutschland GmbH Heteroaryl-substituted amides comprising a saturated linker group, and their use as pharmaceuticals
GB0514203D0 (en) * 2005-07-11 2005-08-17 Novartis Ag Organic compounds
EP1968940B1 (en) * 2005-12-30 2014-04-02 Novartis AG 3 , 5-substitued piperidine compounds as renin inhibitors
TW200804359A (en) * 2006-01-19 2008-01-16 Speedel Experimenta Ag Substituted 4-phenylpiperidines
EP2044059A1 (en) * 2006-06-08 2009-04-08 Speedel Experimenta AG 2,5-disubstituted piperidines
TW200821303A (en) * 2006-08-08 2008-05-16 Speedel Experimenta Ag Organic compounds
EP1908761A1 (en) * 2006-10-04 2008-04-09 Speedel Experimenta AG Organic compounds
EP1911758A1 (en) * 2006-10-04 2008-04-16 Speedel Experimenta AG Phenyl piperidine derivatives for use as renin inhibitors
DE602007007664D1 (de) * 2006-11-17 2010-08-19 Merck Frosst Canada Inc Renininhibitoren
US20100056497A1 (en) * 2007-01-31 2010-03-04 Dainippon Sumitomo Pharma Co., Ltd Amide derivative
JP2010163361A (ja) * 2007-04-27 2010-07-29 Dainippon Sumitomo Pharma Co Ltd キノリン誘導体
JP2010189275A (ja) * 2007-06-14 2010-09-02 Dainippon Sumitomo Pharma Co Ltd ナフタレン誘導体
NZ582098A (en) * 2007-06-25 2012-03-30 Novartis Ag N5-(2-ethoxyethyl)-n3-(2-pyridinyl)-3,5-piperidinedicarboxamide derivatives for use as renin inhibitors
JP2010208947A (ja) * 2007-06-29 2010-09-24 Dainippon Sumitomo Pharma Co Ltd キノロン誘導体
JP2011037712A (ja) * 2007-12-08 2011-02-24 Dainippon Sumitomo Pharma Co Ltd ４−アリールフェニル誘導体
EP2243779A4 (en) * 2007-12-19 2011-04-20 Dainippon Sumitomo Pharma Co HETEROCYCLIC BICYCLIC DERIVATIVE
SG192543A1 (en) 2008-05-05 2013-08-30 Merck Canada Inc 3, 4 - substituted piperidine derivatives as renin inhibitors
EA019755B1 (ru) 2008-06-19 2014-06-30 Такеда Фармасьютикал Компани Лимитед Гетероциклическое соединение и его применение
US20100321199A1 (en) * 2009-06-17 2010-12-23 Chi-Hsing Hsu Light-emitting module and image-capturing module for arbitrarily changing light-emitting position
CA2765527A1 (en) 2009-06-24 2010-12-29 Satoshi Suetsugu N-substituted-cyclic amino derivative
EP2601950A1 (en) * 2011-12-06 2013-06-12 Sanofi Cycloalkane carboxylic acid derivatives as CXCR3 receptor antagonists
BR112015026513A2 (pt) * 2013-04-17 2017-07-25 Pfizer derivados de n-piperidin-3-ilbenzamida para tratar as doenças cardiovasculares

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4656269A (en) * 1986-04-15 1987-04-07 Kissei Pharmaceutical Co., Ltd. Histidine derivatives
BR9206161A (pt) * 1991-06-20 1995-10-31 Pfizer Derivados fluoroalcoxibenzilamino de heterociclos contendo nitrogénio
US5576317A (en) * 1994-12-09 1996-11-19 Pfizer Inc. NK-1 receptor antagonists and 5HT3 receptor antagonists for the treatment of emesis
TR199800409T1 (xx) * 1995-09-07 1998-05-21 F.Hoffmann-La Roche Ag Kalp ve b�brek yetersizli�inin tedavii�in yeni 4-(oksialkoksifenil)-3-oksi-piperidinler
WO2002088101A2 (en) * 2001-04-27 2002-11-07 Vertex Pharmaceuticals Incorporated Inhibitors of bace

Also Published As

Publication number Publication date
CA2521433A1 (en) 2004-10-21
EP1615890A1 (en) 2006-01-18
WO2004089903A1 (en) 2004-10-21
MXPA05010944A (es) 2005-11-25
US20040204455A1 (en) 2004-10-14
JP2006522793A (ja) 2006-10-05
WO2004089903A9 (en) 2005-10-27

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]