BRPI0409367A - derivados de piperidina inibidores de renina - Google Patents

derivados de piperidina inibidores de renina

Info

Publication number
BRPI0409367A
BRPI0409367A BRPI0409367-4A BRPI0409367A BRPI0409367A BR PI0409367 A BRPI0409367 A BR PI0409367A BR PI0409367 A BRPI0409367 A BR PI0409367A BR PI0409367 A BRPI0409367 A BR PI0409367A
Authority
BR
Brazil
Prior art keywords
renin inhibitors
piperidine derivatives
piperidine
inhibitors
derivatives
Prior art date
Application number
BRPI0409367-4A
Other languages
English (en)
Inventor
Wayne Livingston Cody
Jeremy John Edmunds
Daniel Dale Holsworth
Noel Aaron Powell
Xue-Min Cheng
Noe Erasga
Chitase Lee
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of BRPI0409367A publication Critical patent/BRPI0409367A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"DERIVADOS DE PIPERIDINA INIBIDORES DE RENINA". São revelados derivados de piperidina, seu fabrico e utilização como inibidores de renina.
BRPI0409367-4A 2003-04-10 2004-04-01 derivados de piperidina inibidores de renina BRPI0409367A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46196203P 2003-04-10 2003-04-10
US54227904P 2004-02-09 2004-02-09
PCT/IB2004/001162 WO2004089903A1 (en) 2003-04-10 2004-04-01 Piperidine derivatives as renin inhibitors for the treatment of hypertension

Publications (1)

Publication Number Publication Date
BRPI0409367A true BRPI0409367A (pt) 2006-04-25

Family

ID=33162258

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0409367-4A BRPI0409367A (pt) 2003-04-10 2004-04-01 derivados de piperidina inibidores de renina

Country Status (7)

Country Link
US (1) US20040204455A1 (pt)
EP (1) EP1615890A1 (pt)
JP (1) JP2006522793A (pt)
BR (1) BRPI0409367A (pt)
CA (1) CA2521433A1 (pt)
MX (1) MXPA05010944A (pt)
WO (1) WO2004089903A1 (pt)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200900399A (en) 2003-10-01 2009-01-01 Speedel Experimenta Ag Organic compounds
CN1906163A (zh) 2003-11-26 2007-01-31 诺瓦提斯公司 作为肾素抑制剂的4－苯基哌啶衍生物
AR053406A1 (es) * 2004-07-09 2007-05-09 Speedel Experimenta Ag Derivados de piperidina como inhibidores de renina. composiciones farmaceuticas
ATE462703T1 (de) 2004-08-25 2010-04-15 Actelion Pharmaceuticals Ltd Bicyclononen-derivate als renin-inhibitoren
GB0428526D0 (en) * 2004-12-30 2005-02-09 Novartis Ag Organic compounds
GB0504850D0 (en) * 2005-03-09 2005-04-13 Novartis Ag Organic compounds
EP1897879A3 (en) * 2005-03-31 2008-06-11 Speedel Experimenta AG 2,4,5-substituted piperidines as renin inhibitors
EP1707202A1 (de) * 2005-03-31 2006-10-04 Speedel Experimenta AG Organische Verbindungen
ES2352564T3 (es) * 2005-03-31 2011-02-21 Novartis Ag Piperidinas sustituidas.
TW200716622A (en) * 2005-03-31 2007-05-01 Speedel Experimenta Ag Substituted piperidines
BRPI0609534A2 (pt) * 2005-03-31 2010-04-13 Speedel Experimenta Ag piperidinas 3,4,5-substituìdas
TW200722424A (en) 2005-03-31 2007-06-16 Speedel Experimenta Ag Substituted piperidines
GB0508992D0 (en) * 2005-05-03 2005-06-08 Novartis Ag Organic compounds
GEP20115206B (en) 2005-05-27 2011-04-26 Actelion Pharmaceuticals Ltd Novel piperidine carboxylic acid amide derivatives
EP1741709A1 (en) 2005-06-28 2007-01-10 Sanofi-Aventis Deutschland GmbH Heteroaryl-substituted amides comprising a saturated linker group, and their use as pharmaceuticals
GB0514203D0 (en) * 2005-07-11 2005-08-17 Novartis Ag Organic compounds
BRPI0620736A2 (pt) * 2005-12-30 2011-12-20 Novartis Ag compostos orgánicos
TW200804359A (en) * 2006-01-19 2008-01-16 Speedel Experimenta Ag Substituted 4-phenylpiperidines
TW200815425A (en) * 2006-06-08 2008-04-01 Speedel Experimenta Ag 2,5-disubstituted piperidines
TW200821303A (en) * 2006-08-08 2008-05-16 Speedel Experimenta Ag Organic compounds
EP1911758A1 (en) * 2006-10-04 2008-04-16 Speedel Experimenta AG Phenyl piperidine derivatives for use as renin inhibitors
EP1908761A1 (en) * 2006-10-04 2008-04-09 Speedel Experimenta AG Organic compounds
CA2668742A1 (en) 2006-11-17 2008-05-22 Merck Frosst Canada Ltd. Renin inhibitors
EP2119702A4 (en) * 2007-01-31 2010-12-08 Dainippon Sumitomo Pharma Co amide derivative
JP2010163361A (ja) * 2007-04-27 2010-07-29 Dainippon Sumitomo Pharma Co Ltd キノリン誘導体
JP2010189275A (ja) * 2007-06-14 2010-09-02 Dainippon Sumitomo Pharma Co Ltd ナフタレン誘導体
SG182223A1 (en) 2007-06-25 2012-07-30 Novartis Ag N5-(2-ethoxyethyl)-n3-(2-pyridinyl)-3,5-piperidinedicarboxamide derivatives for use as renin inhibitors
JP2010208947A (ja) * 2007-06-29 2010-09-24 Dainippon Sumitomo Pharma Co Ltd キノロン誘導体
JP2011037712A (ja) * 2007-12-08 2011-02-24 Dainippon Sumitomo Pharma Co Ltd ４−アリールフェニル誘導体
JP5484069B2 (ja) * 2007-12-19 2014-05-07 大日本住友製薬株式会社 二環性へテロ環誘導体
KR101403311B1 (ko) 2008-05-05 2014-06-05 액테리온 파마슈티칼 리미티드 레닌 억제제로서의 3,4-치환된 피페리딘 유도체
NZ600238A (en) 2008-06-19 2014-04-30 Takeda Pharmaceutical Heterocyclic compound and use thereof
US20100321199A1 (en) * 2009-06-17 2010-12-23 Chi-Hsing Hsu Light-emitting module and image-capturing module for arbitrarily changing light-emitting position
KR20120109292A (ko) 2009-06-24 2012-10-08 다이닛본 스미토모 세이야꾸 가부시끼가이샤 Ｎ-치환-시클릭 아미노 유도체
EP2601950A1 (en) * 2011-12-06 2013-06-12 Sanofi Cycloalkane carboxylic acid derivatives as CXCR3 receptor antagonists
EP2986599A1 (en) * 2013-04-17 2016-02-24 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4656269A (en) * 1986-04-15 1987-04-07 Kissei Pharmaceutical Co., Ltd. Histidine derivatives
FI990419A7 (fi) * 1991-06-20 1999-02-26 Pfizer Typpeä sisältävien hetrosyklisten yhdisteiden fluorialkoksibentsyyliaminojohdannaiset
US5576317A (en) * 1994-12-09 1996-11-19 Pfizer Inc. NK-1 receptor antagonists and 5HT3 receptor antagonists for the treatment of emesis
TR199800409T1 (xx) * 1995-09-07 1998-05-21 F.Hoffmann-La Roche Ag Kalp ve b�brek yetersizli�inin tedavii�in yeni 4-(oksialkoksifenil)-3-oksi-piperidinler
EP1389194A2 (en) * 2001-04-27 2004-02-18 Vertex Pharmaceuticals Incorporated Inhibitors of bace

Also Published As

Publication number Publication date
JP2006522793A (ja) 2006-10-05
US20040204455A1 (en) 2004-10-14
WO2004089903A1 (en) 2004-10-21
WO2004089903A9 (en) 2005-10-27
EP1615890A1 (en) 2006-01-18
CA2521433A1 (en) 2004-10-21
MXPA05010944A (es) 2005-11-25

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]