ATE556055T1 - Verfahren zur herstellung von 3-(4-(2,4- difluorbenzyloxy)-3-brom-6-methyl- 2-oxopyridin- 1(2h)-yl)-n,4-dimethylbenzamid - Google Patents

Verfahren zur herstellung von 3-(4-(2,4- difluorbenzyloxy)-3-brom-6-methyl- 2-oxopyridin- 1(2h)-yl)-n,4-dimethylbenzamid

Info

Publication number: ATE556055T1
Authority: AT; Austria
Prior art keywords: difluorbenzyloxy; oxopyridine; dimethylbenzamide; bromine; methyl
Prior art date: 2006-12-13

Application number

AT07859110T

Other languages

English (en)

Inventor

Daniel Dukeshereer

Michael Mao

Embse Richard Vonder

Gopichand Yalamanchili

Rajappa Vaidyanathan

Brian Chekal

George Klemm

Ronald Vanderroest

Randy Geurink

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-12-13

Filing date

2007-12-05

Publication date

2012-05-15

2007-12-05 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2012-05-15 Application granted granted Critical

2012-05-15 Publication of ATE556055T1 publication Critical patent/ATE556055T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/00—Drugs for skeletal disorders
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Ophthalmology & Optometry (AREA)
Physical Education & Sports Medicine (AREA)
Oncology (AREA)
Rheumatology (AREA)
Diabetes (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Epidemiology (AREA)
Communicable Diseases (AREA)
Orthopedic Medicine & Surgery (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Gastroenterology & Hepatology (AREA)
Psychiatry (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Reproductive Health (AREA)
Vascular Medicine (AREA)

AT07859110T 2006-12-13 2007-12-05 Verfahren zur herstellung von 3-(4-(2,4- difluorbenzyloxy)-3-brom-6-methyl- 2-oxopyridin- 1(2h)-yl)-n,4-dimethylbenzamid ATE556055T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US86974806P	2006-12-13	2006-12-13
PCT/IB2007/003993 WO2008072079A2 (en)	2006-12-13	2007-12-05	Processes for the preparation of 3-(4-(2,4-difluorobenzyloxy)-3-bromo-6-methyl-2-oxopyridin-1(2h)-yl)-n,4-dimethylbenzamide

Publications (1)

Publication Number	Publication Date
ATE556055T1 true ATE556055T1 (de)	2012-05-15

Family

ID=39365911

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07859110T ATE556055T1 (de)	2006-12-13	2007-12-05	Verfahren zur herstellung von 3-(4-(2,4- difluorbenzyloxy)-3-brom-6-methyl- 2-oxopyridin- 1(2h)-yl)-n,4-dimethylbenzamid

Country Status (17)

Country	Link
US (1)	US7906536B2 (de)
EP (1)	EP2102161B1 (de)
JP (1)	JP2008231090A (de)
KR (1)	KR20090090379A (de)
CN (1)	CN101611006A (de)
AR (1)	AR064312A1 (de)
AT (1)	ATE556055T1 (de)
AU (1)	AU2007331199A1 (de)
BR (1)	BRPI0720757A2 (de)
CA (1)	CA2672256C (de)
IL (1)	IL199239A0 (de)
MX (1)	MX2009006266A (de)
NZ (1)	NZ577639A (de)
RU (1)	RU2411236C1 (de)
TW (1)	TW200837057A (de)
WO (1)	WO2008072079A2 (de)
ZA (1)	ZA200903981B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP5679159B2 (ja)	2010-07-05	2015-03-04	信越化学工業株式会社	希土類金属抽出剤の合成方法、及び希土類金属の溶媒抽出用有機相
WO2014181213A1 (en)	2013-05-10	2014-11-13	Pfizer Inc.	Crystalline form of (sa)-(-)-3-(3-bromo-4-((2,4-difluorobenzyl)oxy)-6-methyl-2-oxopyridin-1 (2h)-yl)-n,4-dimethylbenzamide
ES2927715T3 (es)	2017-10-05	2022-11-10	Fulcrum Therapeutics Inc	Inhibidores de la quinasa p38 reducen la expresión de dux4 y de los genes que le siguen para el tratamiento de la FSHD
EP4253380A3 (de) *	2019-10-18	2023-11-15	FMC Corporation	Verfahren zur herstellung von 5-brom-2-( 3-chlor-pyridin-2-yl) -2h-pyrazol-3-carbonsäure

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3286645B2 (ja) *	1993-03-26	2002-05-27	メルシャン株式会社	光学活性１，４−ジヒドロピリジン誘導体およびその製造方法
AP1822A (en)	2002-02-14	2008-01-30	Pharmacia Corp	Substituted pyridinones as modulators of P38 MAP kinase.
CL2004002050A1 (es) *	2003-08-13	2005-06-03	Pharmacia Corp Sa Organizada B	Compuestos derivados de piridinonas sustituidas; su uso en el tratamiento de afecciones causadas o exacerbadas por actividad p38 map kinasa y/o tnf no regulada, tales como inflamaciones, tumores, sida y otros.
KR20080072105A (ko) *	2004-08-26	2008-08-05	화이자 인코포레이티드	단백질 티로신 키나제 저해제 중간체의 제조를 위한거울상이성질선택적 생물학적 전환
EP1987022A1 (de) *	2006-02-10	2008-11-05	Pfizer Products Inc.	Pyridinonpyrazolharnstoff und pyrimidinonpyrazolharnstoffderivate

2007
- 2007-12-05 KR KR1020097014467A patent/KR20090090379A/ko not_active Ceased
- 2007-12-05 CN CNA2007800513123A patent/CN101611006A/zh active Pending
- 2007-12-05 AU AU2007331199A patent/AU2007331199A1/en not_active Abandoned
- 2007-12-05 NZ NZ577639A patent/NZ577639A/en not_active IP Right Cessation
- 2007-12-05 AT AT07859110T patent/ATE556055T1/de active
- 2007-12-05 RU RU2009122369/04A patent/RU2411236C1/ru not_active IP Right Cessation
- 2007-12-05 MX MX2009006266A patent/MX2009006266A/es active IP Right Grant
- 2007-12-05 CA CA2672256A patent/CA2672256C/en not_active Expired - Fee Related
- 2007-12-05 EP EP07859110A patent/EP2102161B1/de not_active Not-in-force
- 2007-12-05 BR BRPI0720757-3A patent/BRPI0720757A2/pt not_active IP Right Cessation
- 2007-12-05 WO PCT/IB2007/003993 patent/WO2008072079A2/en not_active Ceased
- 2007-12-11 JP JP2007319333A patent/JP2008231090A/ja not_active Ceased
- 2007-12-12 AR ARP070105576A patent/AR064312A1/es unknown
- 2007-12-12 TW TW096147368A patent/TW200837057A/zh unknown
- 2007-12-12 US US11/954,883 patent/US7906536B2/en not_active Expired - Fee Related
2009
- 2009-06-08 ZA ZA200903981A patent/ZA200903981B/xx unknown
- 2009-06-08 IL IL199239A patent/IL199239A0/en unknown

Also Published As

Publication number	Publication date
AU2007331199A1 (en)	2008-06-19
ZA200903981B (en)	2010-08-25
US20080177077A1 (en)	2008-07-24
NZ577639A (en)	2012-01-12
US7906536B2 (en)	2011-03-15
BRPI0720757A2 (pt)	2014-01-14
JP2008231090A (ja)	2008-10-02
MX2009006266A (es)	2009-06-22
EP2102161B1 (de)	2012-05-02
WO2008072079A2 (en)	2008-06-19
IL199239A0 (en)	2010-03-28
EP2102161A2 (de)	2009-09-23
KR20090090379A (ko)	2009-08-25
CN101611006A (zh)	2009-12-23
TW200837057A (en)	2008-09-16
AR064312A1 (es)	2009-03-25
WO2008072079A3 (en)	2008-08-07
RU2411236C1 (ru)	2011-02-10
CA2672256A1 (en)	2008-06-19
CA2672256C (en)	2011-08-30

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