ATE557032T1 - Verfahren zur erzeugung von zwischenprodukten zur herstellung neuer makrocyclen als inhibitoren der proteasomischen degradation von p27 wie argyrin und derivate davon sowie verwendung dieser makrocyclen - Google Patents
Verfahren zur erzeugung von zwischenprodukten zur herstellung neuer makrocyclen als inhibitoren der proteasomischen degradation von p27 wie argyrin und derivate davon sowie verwendung dieser makrocyclenInfo
- Publication number
- ATE557032T1 ATE557032T1 AT09797415T AT09797415T ATE557032T1 AT E557032 T1 ATE557032 T1 AT E557032T1 AT 09797415 T AT09797415 T AT 09797415T AT 09797415 T AT09797415 T AT 09797415T AT E557032 T1 ATE557032 T1 AT E557032T1
- Authority
- AT
- Austria
- Prior art keywords
- macrocycles
- inhibitors
- derivatives
- argyrine
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08011346A EP2138507A1 (de) | 2008-06-23 | 2008-06-23 | Verfahren zur Erzeugung von Zwischenprodukten zur Herstellung von neuartigen Makrozyklen als Inhibitoren der proteasomischen Degradation von p27 wie Argyrin und Derivate davon, und Verwendungen besagter Makrozyklen |
| PCT/EP2009/004526 WO2010006682A1 (en) | 2008-06-23 | 2009-06-23 | Method for producing intermediates for the production of novel macrocycles that are inhibitors of the proteasomic degradation of p27, such as argyrin and derivatives thereof, and uses of said macrocycles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE557032T1 true ATE557032T1 (de) | 2012-05-15 |
Family
ID=39957997
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT09797415T ATE557032T1 (de) | 2008-06-23 | 2009-06-23 | Verfahren zur erzeugung von zwischenprodukten zur herstellung neuer makrocyclen als inhibitoren der proteasomischen degradation von p27 wie argyrin und derivate davon sowie verwendung dieser makrocyclen |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9458200B2 (de) |
| EP (2) | EP2138507A1 (de) |
| JP (1) | JP5634397B2 (de) |
| AT (1) | ATE557032T1 (de) |
| AU (1) | AU2009270571B2 (de) |
| CA (1) | CA2729188C (de) |
| ES (1) | ES2391220T3 (de) |
| WO (1) | WO2010006682A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2010332988B2 (en) * | 2009-12-14 | 2015-03-19 | Gottfried Wilhelm Leibniz Universitat | Improved method for producing intermediates for the production of macrocycles that are inhibitors of the proteasomic degradation of p27, such as argyrin and derivatives thereof |
| US9029501B2 (en) | 2010-11-02 | 2015-05-12 | Rigel Pharmaceuticals, Inc. | Method for making macrocycles |
| EP3072899B1 (de) | 2015-03-23 | 2018-05-02 | Eberhard Karls Universität Tübingen | Neuartige antiinfektiöse verbindung |
| AU2019396560B2 (en) | 2018-12-11 | 2024-10-03 | Heidelberg Pharma Research Gmbh | Synthesis of (S)-6-hydroxytryptophan and derivatives thereof |
| EP4731739A1 (de) | 2023-06-21 | 2026-04-29 | Givaudan SA | Neue verbindungen |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6355774B1 (en) | 1994-01-07 | 2002-03-12 | Fred Hutchinson Cancer Research Center | Isolated p27 protein |
| GB2367553A (en) | 2000-09-04 | 2002-04-10 | Novartis Ag | Pharmaceutically Active Macrocycles |
| AU2002243477B2 (en) | 2001-01-05 | 2007-12-20 | New York University | Methods to identify compounds useful for the treatment of proliferative and differentiative disorders |
| EP1964560A1 (de) | 2007-02-28 | 2008-09-03 | Helmholtz-Zentrum für Infektionsforschung GmbH | Verwendung von Inhibitoren des p27-Abbaus zur Behandlung von Krebs |
-
2008
- 2008-06-23 EP EP08011346A patent/EP2138507A1/de not_active Withdrawn
-
2009
- 2009-06-23 AT AT09797415T patent/ATE557032T1/de active
- 2009-06-23 AU AU2009270571A patent/AU2009270571B2/en not_active Ceased
- 2009-06-23 CA CA2729188A patent/CA2729188C/en active Active
- 2009-06-23 EP EP09797415A patent/EP2303916B1/de active Active
- 2009-06-23 US US13/000,516 patent/US9458200B2/en not_active Expired - Fee Related
- 2009-06-23 ES ES09797415T patent/ES2391220T3/es active Active
- 2009-06-23 WO PCT/EP2009/004526 patent/WO2010006682A1/en not_active Ceased
- 2009-06-23 JP JP2011515193A patent/JP5634397B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US9458200B2 (en) | 2016-10-04 |
| EP2303916A1 (de) | 2011-04-06 |
| JP2011525512A (ja) | 2011-09-22 |
| WO2010006682A1 (en) | 2010-01-21 |
| JP5634397B2 (ja) | 2014-12-03 |
| EP2138507A1 (de) | 2009-12-30 |
| AU2009270571A1 (en) | 2010-01-21 |
| EP2303916B1 (de) | 2012-05-09 |
| ES2391220T3 (es) | 2012-11-22 |
| CA2729188C (en) | 2017-10-24 |
| AU2009270571B2 (en) | 2014-05-15 |
| US20110311564A1 (en) | 2011-12-22 |
| CA2729188A1 (en) | 2010-01-21 |
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