ATE557038T1 - Herstellung von rekombinantem il-18 bindendem protein - Google Patents

Herstellung von rekombinantem il-18 bindendem protein

Info

Publication number
ATE557038T1
ATE557038T1 AT10184728T AT10184728T ATE557038T1 AT E557038 T1 ATE557038 T1 AT E557038T1 AT 10184728 T AT10184728 T AT 10184728T AT 10184728 T AT10184728 T AT 10184728T AT E557038 T1 ATE557038 T1 AT E557038T1
Authority
AT
Austria
Prior art keywords
binding protein
recombinant
preparation
composition
production
Prior art date
Application number
AT10184728T
Other languages
English (en)
Inventor
Urs Wieber
Thierry Ziegler
Original Assignee
Ares Trading Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ares Trading Sa filed Critical Ares Trading Sa
Application granted granted Critical
Publication of ATE557038T1 publication Critical patent/ATE557038T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
AT10184728T 2005-06-03 2006-06-01 Herstellung von rekombinantem il-18 bindendem protein ATE557038T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US68763105P 2005-06-03 2005-06-03
EP05104878 2005-06-03
EP05106429 2005-07-13

Publications (1)

Publication Number Publication Date
ATE557038T1 true ATE557038T1 (de) 2012-05-15

Family

ID=44352415

Family Applications (2)

Application Number Title Priority Date Filing Date
AT06763472T ATE517917T1 (de) 2005-06-03 2006-06-01 Herstellung eines rekombinanten il-18-bindenden proteins
AT10184728T ATE557038T1 (de) 2005-06-03 2006-06-01 Herstellung von rekombinantem il-18 bindendem protein

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT06763472T ATE517917T1 (de) 2005-06-03 2006-06-01 Herstellung eines rekombinanten il-18-bindenden proteins

Country Status (15)

Country Link
US (2) US7691611B2 (de)
EP (2) EP1885753B1 (de)
JP (2) JP5199073B2 (de)
AT (2) ATE517917T1 (de)
AU (1) AU2006254103B2 (de)
CA (1) CA2609060C (de)
CY (2) CY1111969T1 (de)
DK (2) DK2267024T3 (de)
ES (2) ES2385639T3 (de)
IL (1) IL187838A (de)
NO (1) NO342802B1 (de)
PL (2) PL1885753T3 (de)
PT (2) PT1885753E (de)
SI (2) SI2267024T1 (de)
WO (1) WO2006128908A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2399148A1 (en) * 2000-02-10 2001-08-16 Abbott Laboratories Antibodies that bind human interleukin-18 and methods of making and using
US7824907B2 (en) 2003-03-11 2010-11-02 Merck Serono Sa Expression vectors comprising the mCMV IE2 promoter
US20080076708A1 (en) * 2003-05-13 2008-03-27 Valter Altarocca Active Variants of the Il-18 Binding Protein and Medical Uses Thereof
PT1675956E (pt) 2003-10-21 2010-11-04 Merck Serono Sa Sequência mínima de adn que actua como um isolador de cromatina e sua utilização na expressão de proteína
DK1689777T3 (da) * 2003-11-05 2007-06-11 Ares Trading Sa Fremgangsmåde til oprensning af il18-bindende protein
US7968684B2 (en) 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
ES2292127T3 (es) 2004-03-01 2008-03-01 Ares Trading S.A. Uso de un medio de cultivo celular exento de suero para la produccion de il-18bp en celulas de mamiferos.
JP5043654B2 (ja) * 2004-06-29 2012-10-10 アレス トレーディング ソシエテ アノニム Ｉｌ−１８結合タンパク質の精製のための方法
AU2006256763B2 (en) 2005-06-10 2012-08-02 Ares Trading S.A. Process for the purification of IL-18 binding protein
US20160145589A1 (en) 2011-06-24 2016-05-26 Green Cross Corporation Composition and formulation comprising recombinant human iduronate-2-sulfatase and preparation method thereof
PT2837680T (pt) * 2011-07-01 2020-04-17 Amgen Inc Cultura celular de mamífero
US20140004097A1 (en) * 2012-06-29 2014-01-02 Shire Human Genetic Therapies, Inc. Method of producing recombinant iduronate-2-sulfatase
KR101380740B1 (ko) 2012-06-29 2014-04-11 쉐어 휴먼 제네텍 세러피스, 인코포레이티드 이듀로네이트-2-설파타제의 정제
US9150841B2 (en) 2012-06-29 2015-10-06 Shire Human Genetic Therapies, Inc. Cells for producing recombinant iduronate-2-sulfatase
US9677105B2 (en) 2013-03-14 2017-06-13 Momenta Pharmaceuticals, Inc. Methods of cell culture
US9217168B2 (en) 2013-03-14 2015-12-22 Momenta Pharmaceuticals, Inc. Methods of cell culture
US8956830B2 (en) 2013-03-14 2015-02-17 Momenta Pharmaceuticals, Inc. Methods of cell culture
SG10201802023RA (en) * 2013-03-26 2018-05-30 Coherus Biosciences Inc Protein production method
UA125204C2 (uk) 2013-09-05 2022-02-02 Аб2 Біо Са Застосування il-18-зв'язувального білка (il-18bp) при запальних захворюваннях
USD759075S1 (en) * 2014-04-11 2016-06-14 Nutonian, Inc. Display screen with graphical user interface
USD759076S1 (en) * 2014-04-18 2016-06-14 Nutonian, Inc. Display screen with graphical user interface
US10882905B2 (en) 2015-03-05 2021-01-05 Ab2 Bio Sa IL-18 binding protein (IL-18BP) and antibodies in inflammatory diseases
KR101789509B1 (ko) * 2015-11-05 2017-10-26 주식회사 프로젠 재조합 인간 갑상선 자극 호르몬을 포함하는 조성물 및 상기 재조합 인간 갑상선 자극 호르몬의 생산 방법
EP4039786A1 (de) 2017-10-16 2022-08-10 Regeneron Pharmaceuticals, Inc. Perfusionsbioreaktor und zugehörige verwendungsverfahren
IL307155B2 (en) 2018-05-01 2025-11-01 Amgen Inc Antibodies with modulated glycan profiles

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4737462A (en) 1982-10-19 1988-04-12 Cetus Corporation Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-β
US4588585A (en) 1982-10-19 1986-05-13 Cetus Corporation Human recombinant cysteine depleted interferon-β muteins
US4959314A (en) 1984-11-09 1990-09-25 Cetus Corporation Cysteine-depleted muteins of biologically active proteins
US5116943A (en) 1985-01-18 1992-05-26 Cetus Corporation Oxidation-resistant muteins of Il-2 and other protein
US5266476A (en) 1985-06-18 1993-11-30 Yeda Research & Development Co., Ltd. Fibrous matrix for in vitro cell cultivation
US5017691A (en) 1986-07-03 1991-05-21 Schering Corporation Mammalian interleukin-4
US4879111A (en) 1986-04-17 1989-11-07 Cetus Corporation Treatment of infections with lymphokines
US4965195A (en) 1987-10-26 1990-10-23 Immunex Corp. Interleukin-7
US4904584A (en) 1987-12-23 1990-02-27 Genetics Institute, Inc. Site-specific homogeneous modification of polypeptides
ES2145744T5 (es) 1991-01-18 2008-02-01 Amgen Inc. Procedimientos para tratar las enfermedades inducidas por el factor de necrosis tumoral.
JP4306813B2 (ja) * 1995-09-19 2009-08-05 アスビオファーマ株式会社 動物細胞の新規培養方法
BR9707589A (pt) 1996-02-20 2000-01-04 Applied Research Systems Proteìna hìbrida, molécula de dna, vetor de expressão, célula hospedeira, composição farmacêutica e processos para produzir proteìna hìbrida e para induzir maturação folicular.
CA2258721C (en) 1996-07-12 2014-09-09 Genentech, Inc. Chimeric heteromultimer adhesins
IL121860A0 (en) 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use
CA2377513A1 (en) 1999-06-25 2001-01-04 Universitat Zurich Hetero-associating coiled-coil peptides
US7754855B1 (en) 1999-07-13 2010-07-13 Bolder Biotechnology, Inc. Immunoglobulin fusion proteins
IL131047A0 (en) 1999-07-22 2001-01-28 Yeda Res & Dev Use of il-18 inhibitors
UA74557C2 (en) 1999-09-03 2006-01-16 Applied Research Systems A method for producing a heterologous secreted protein from chinese hamster ovaries cells grown on microcarriers
ME00546B (me) 2000-02-21 2011-10-10 Serono Lab Korišćenje inhibitora il-18
CZ300792B6 (cs) 2000-05-05 2009-08-12 Applied Research Systems Ars Holding N. V. Farmaceutický prostredek
IL140110A0 (en) * 2000-12-05 2002-02-10 Applied Research Systems Improvement of homogeneity and secretion of recombinant proteins in mammalian systems
CN1326562C (zh) 2001-01-29 2007-07-18 应用研究系统Ars股份公司 Il－18抑制剂制造治疗和/或预防心脏病的药物的应用
WO2002101049A2 (en) 2001-03-08 2002-12-19 Ares Trading S.A. Interleukin-18 mutants, their production and use
EP1425028B1 (de) 2001-05-16 2009-12-16 Yeda Research And Development Co. Ltd. Verwendung von il-18-hemmern zur behandlung oder prävention von sepsis
HRP20030842B1 (hr) 2001-05-25 2017-06-02 Ares Trading S.A. UPOTREBA IL-18 INHIBITORA ZA LIJEČENJE I PREVENCIJU OZLJEDA CNS-a
UA78516C2 (en) 2001-08-10 2007-04-10 Applied Research Systems Use of inhibitors of il-18 for treatment and/or prevention of hypersensitivity disorders, and in particular of delayed-type hypersensitivity
BRPI0308663B8 (pt) 2002-03-22 2021-05-25 Applied Res Systems Ars Holding N V uso de inibidores de il-18 para o tratamento e/ou prevenção de doenças vasculares periféricas
WO2004020639A2 (en) 2002-08-14 2004-03-11 Avidis Sa Production of multimeric fusion proteins using a c4bp scaffold
EP1558278B1 (de) 2002-10-11 2009-09-02 ZymoGenetics, Inc. Herstellung von homotrimeren fusionsproteinen
MXPA05006523A (es) * 2002-12-23 2005-08-26 Squibb Bristol Myers Co Procesos de cultivo de celulas de mamiferos para la produccion de proteinas.
US7824907B2 (en) * 2003-03-11 2010-11-02 Merck Serono Sa Expression vectors comprising the mCMV IE2 promoter
US20080076708A1 (en) 2003-05-13 2008-03-27 Valter Altarocca Active Variants of the Il-18 Binding Protein and Medical Uses Thereof
PT1675956E (pt) * 2003-10-21 2010-11-04 Merck Serono Sa Sequência mínima de adn que actua como um isolador de cromatina e sua utilização na expressão de proteína
DK1689777T3 (da) * 2003-11-05 2007-06-11 Ares Trading Sa Fremgangsmåde til oprensning af il18-bindende protein
ES2292127T3 (es) 2004-03-01 2008-03-01 Ares Trading S.A. Uso de un medio de cultivo celular exento de suero para la produccion de il-18bp en celulas de mamiferos.
JP5043654B2 (ja) * 2004-06-29 2012-10-10 アレス トレーディング ソシエテ アノニム Ｉｌ−１８結合タンパク質の精製のための方法
AU2006256763B2 (en) * 2005-06-10 2012-08-02 Ares Trading S.A. Process for the purification of IL-18 binding protein

Also Published As

Publication number Publication date
CA2609060A1 (en) 2006-12-07
ES2370417T3 (es) 2011-12-15
CY1111969T1 (el) 2015-11-04
US20100137195A1 (en) 2010-06-03
IL187838A0 (en) 2008-03-20
DK2267024T3 (da) 2012-06-25
PL1885753T3 (pl) 2011-12-30
NO342802B1 (no) 2018-08-06
US20080199913A1 (en) 2008-08-21
JP2008541748A (ja) 2008-11-27
EP2267024A1 (de) 2010-12-29
DK1885753T3 (da) 2011-10-03
IL187838A (en) 2011-07-31
JP5199073B2 (ja) 2013-05-15
PT1885753E (pt) 2011-10-06
SI1885753T1 (sl) 2011-12-30
ATE517917T1 (de) 2011-08-15
WO2006128908A1 (en) 2006-12-07
EP1885753B1 (de) 2011-07-27
PT2267024E (pt) 2012-06-01
CY1113056T1 (el) 2016-04-13
JP5837476B2 (ja) 2015-12-24
EP2267024B1 (de) 2012-05-09
CA2609060C (en) 2014-07-15
PL2267024T3 (pl) 2012-10-31
EP1885753A1 (de) 2008-02-13
SI2267024T1 (sl) 2012-09-28
JP2013048633A (ja) 2013-03-14
US7691611B2 (en) 2010-04-06
ES2385639T3 (es) 2012-07-27
NO20076672L (no) 2008-02-22
AU2006254103A1 (en) 2006-12-07
AU2006254103B2 (en) 2012-09-06

Similar Documents

Publication Publication Date Title
CY1113056T1 (el) Παρασκευη ανασυνδυασμενης συνδετικης πρωτεϊνης il-18
SG155183A1 (en) Process for the preparation of glycosylated interferon beta
DE602007011171D1 (de) Zusammensetzung und Verfahren zur Herstellung von Steviolglykosiden
SE0301010D0 (sv) Novel compounds
EA200700255A1 (ru) Новый карбамилированный еро и способ его получения
WO2006029094A3 (en) Erythropoietin derivatives with altered immunogenicity
SE0301009D0 (sv) Novel compounds
CR10852A (es) Compuestos biciclicos y su uso como anti-diabeticos
DE602006010132D1 (de) Zwischenprodukte für die Herstellung von Trans-5-Chlor-2-Methyl-2,3,3a,12b-Tetrahydro-1h-DibenzÄ2,3:6,7ÜOxepinoÄ4,5-cÜPyrrol
TW200745003A (en) Novel compounds
DE60223511D1 (de) Neurotrophe faktoren
WO2007052023A3 (en) Novel compounds
PT1969127E (pt) Processo de produção de proteínas dependentes da vitamina k biologicamente activos por métodos recombinantes
NO20082989L (no) Fremstiling av gamma-aminosyrer som har affinitet for alfa-2-deltaproteinet
TW200745159A (en) IL-6 binding proteins
WO2004039834A3 (en) Recombinant protein variants
ATE461934T1 (de) Verfahren zur herstellung von 17-hydroxy-6 beta, 7 beta, 15 beta,16 beta-bismethylen-17alpha-pregn-4-en-3-on-21-car onsäure -lacton und schlüsselzwischenprodukte für dieses verfahren
DE60216135D1 (de) Prozess zur herstellung von organischen hydroperoxiden
WO2007045019A3 (en) Polyoleosins
PL1627881T3 (pl) Sposób otrzymywania topiramatu
ATE511644T1 (de) Neues screening-verfahren
DK1988086T3 (da) Fremgangsmåde til opløsning af citalopram via dets (S)-berigede citalopramtartratforbindelse
DK1935981T3 (da) Fremgangsmåde til fremstilling af rekombinant protein
ATE500211T1 (de) Neue 1-methoxy-2-phenylethene zur herstellung von 5-carboxaldehyd-2,3-dihydrobenzoxepinen
ATE502047T1 (de) T-helper antigenic determinant (thd) peptide