ATE56096T1 - Test zur sofortigen feststellung von liganden, testsatz und seine herstellung. - Google Patents
Test zur sofortigen feststellung von liganden, testsatz und seine herstellung.Info
- Publication number
- ATE56096T1 ATE56096T1 AT84301769T AT84301769T ATE56096T1 AT E56096 T1 ATE56096 T1 AT E56096T1 AT 84301769 T AT84301769 T AT 84301769T AT 84301769 T AT84301769 T AT 84301769T AT E56096 T1 ATE56096 T1 AT E56096T1
- Authority
- AT
- Austria
- Prior art keywords
- reactant
- beads
- fluorescer
- test
- ligand
- Prior art date
Links
- 239000003446 ligand Substances 0.000 title abstract 4
- 238000001514 detection method Methods 0.000 title 1
- 239000000376 reactant Substances 0.000 abstract 6
- 239000011324 bead Substances 0.000 abstract 5
- 238000003556 assay Methods 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 230000002285 radioactive effect Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/534—Production of labelled immunochemicals with radioactive label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP84301769A EP0154734B1 (de) | 1984-03-15 | 1984-03-15 | Test zur sofortigen Feststellung von Liganden, Testsatz und seine Herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE56096T1 true ATE56096T1 (de) | 1990-09-15 |
Family
ID=8192592
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT84301769T ATE56096T1 (de) | 1984-03-15 | 1984-03-15 | Test zur sofortigen feststellung von liganden, testsatz und seine herstellung. |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0154734B1 (de) |
| JP (1) | JPH0654313B2 (de) |
| AT (1) | ATE56096T1 (de) |
| DE (1) | DE3483099D1 (de) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4868103A (en) * | 1986-02-19 | 1989-09-19 | Enzo Biochem, Inc. | Analyte detection by means of energy transfer |
| GB8610426D0 (en) * | 1986-04-29 | 1986-06-04 | Leaback D H | Bound assay components |
| US4943525A (en) * | 1987-11-02 | 1990-07-24 | Bioventures, Inc. | Simultaneous immunoassay for the determination of antigens and antibodies |
| SE8804657D0 (sv) * | 1988-12-27 | 1988-12-27 | Gerald Potter Colin | Support structure for use in a proximity assey |
| US6017496A (en) | 1995-06-07 | 2000-01-25 | Irori | Matrices with memories and uses thereof |
| JP2000501171A (ja) * | 1995-09-15 | 2000-02-02 | メルク エンド カンパニー インコーポレーテッド | 融合タンパク質を用いるハイスループットアッセイ |
| US6977141B2 (en) | 1998-02-10 | 2005-12-20 | Vicuron Pharmaceuticals Inc. | Direct adsorption scintillation assay for measuring enzyme activity and assaying biochemical processes |
| EP1195604A1 (de) | 2000-09-29 | 2002-04-10 | Warner-Lambert Company | Verfahren und Zusammensetzungen zum Screenen von Modulatoren von Lipidkinasen |
| SK142004A3 (en) | 2001-06-11 | 2004-06-08 | Applied Research Systems | Scintillation proximity assays for aminoglycoside binding molecules |
| SE0104101D0 (sv) | 2001-12-05 | 2001-12-05 | Astrazeneca Ab | New assay |
| SE0104102D0 (sv) | 2001-12-05 | 2001-12-05 | Astrazeneca Ab | New assay |
| JP4845730B2 (ja) | 2003-07-17 | 2011-12-28 | プレキシコン，インコーポレーテッド | Ｐｐａｒ活性化合物 |
| US7348338B2 (en) | 2003-07-17 | 2008-03-25 | Plexxikon, Inc. | PPAR active compounds |
| CN1925855B (zh) | 2003-12-19 | 2010-06-16 | 普莱希科公司 | 开发Ret调节剂的化合物和方法 |
| US7794713B2 (en) | 2004-04-07 | 2010-09-14 | Lpath, Inc. | Compositions and methods for the treatment and prevention of hyperproliferative diseases |
| CA2565965A1 (en) | 2004-05-06 | 2006-07-27 | Plexxikon, Inc. | Pde4b inhibitors and uses therefor |
| US7498342B2 (en) | 2004-06-17 | 2009-03-03 | Plexxikon, Inc. | Compounds modulating c-kit activity |
| US7927820B2 (en) | 2004-07-20 | 2011-04-19 | Janssen Pharmaceutica Nv | Assay systems and methods for detecting molecules that interact with membrane channels |
| EP1786813A2 (de) | 2004-09-03 | 2007-05-23 | Plexxikon, Inc. | Bizyklische heteroaryl-pde4b-inhibitoren |
| AU2005311925A1 (en) | 2004-11-30 | 2006-06-08 | Plexxikon, Inc. | Indole derivatives for use as PPAR PPAR active compounds |
| MX2007014377A (es) | 2005-05-17 | 2008-02-06 | Plexxikon Inc | Inhibidores de proteina cinasa de derivados de pirrol (2,3-b) piridina. |
| PL2395004T3 (pl) | 2005-06-22 | 2016-08-31 | Plexxikon Inc | Pochodne pirolo[2,3-b]pirydyny jako inhibitory kinazy białkowej |
| JP4652902B2 (ja) | 2005-06-23 | 2011-03-16 | 株式会社日立ソリューションズ | 安定保存された担体微小粒子 |
| US7862812B2 (en) | 2006-05-31 | 2011-01-04 | Lpath, Inc. | Methods for decreasing immune response and treating immune conditions |
| WO2008063888A2 (en) | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
| WO2008079909A1 (en) | 2006-12-21 | 2008-07-03 | Plexxikon, Inc. | Pyrrolo [2,3-b] pyridines as kinase modulators |
| US7872018B2 (en) | 2006-12-21 | 2011-01-18 | Plexxikon, Inc. | Compounds and methods for kinase modulation, and indications therefor |
| PE20081581A1 (es) | 2006-12-21 | 2008-11-12 | Plexxikon Inc | COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA |
| PE20090159A1 (es) | 2007-03-08 | 2009-02-21 | Plexxikon Inc | COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs |
| MX2010000617A (es) | 2007-07-17 | 2010-05-17 | Plexxikon Inc | Compuestos y metodos para modulacion de cinasa, e indicaciones de estos. |
| EA031116B1 (ru) | 2009-04-03 | 2018-11-30 | Ф. Хоффманн-Ля Рош Аг | КРИСТАЛЛИЧЕСКИЕ ПОЛИМОРФНЫЕ ФОРМЫ {3-[5-(4-ХЛОРФЕНИЛ)-1H-ПИРРОЛО[2,3-b]ПИРИДИН-3-КАРБОНИЛ]-2,4-ДИФТОРФЕНИЛ}АМИДА ПРОПАН-1-СУЛЬФОНОВОЙ КИСЛОТЫ |
| US8329724B2 (en) | 2009-08-03 | 2012-12-11 | Hoffmann-La Roche Inc. | Process for the manufacture of pharmaceutically active compounds |
| UA105813C2 (uk) | 2009-11-06 | 2014-06-25 | Плексікон, Інк. | Сполуки-інгібітори кіназ та фармацевтична композиція (варіанти) |
| PL2672967T3 (pl) | 2011-02-07 | 2019-04-30 | Plexxikon Inc | Związki i sposoby modulacji kinaz i wskazania ku temu |
| TWI558702B (zh) | 2011-02-21 | 2016-11-21 | 普雷辛肯公司 | 醫藥活性物質的固態形式 |
| SG194847A1 (en) | 2011-05-17 | 2013-12-30 | Plexxikon Inc | Kinase modulation and indications therefor |
| US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
| WO2016164641A1 (en) | 2015-04-08 | 2016-10-13 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| US10829484B2 (en) | 2015-07-28 | 2020-11-10 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| MX2018006856A (es) | 2015-12-07 | 2018-08-01 | Plexxikon Inc | Compuestos y metodos para modulacion de la quinasa, e indicaciones de los mismos. |
| TW201815766A (zh) | 2016-09-22 | 2018-05-01 | 美商普雷辛肯公司 | 用於ｉｄｏ及ｔｄｏ調節之化合物及方法以及其適應症 |
| WO2018136202A2 (en) | 2016-12-23 | 2018-07-26 | Plexxikon Inc. | Compounds and methods for cdk8 modulation and indications therefor |
| US10428067B2 (en) | 2017-06-07 | 2019-10-01 | Plexxikon Inc. | Compounds and methods for kinase modulation |
| CN113710668B (zh) | 2019-04-09 | 2025-01-07 | Opna生物公司 | 用于ep300或cbp调节及其适应症的缩合吖嗪 |
| US12509444B2 (en) | 2019-12-06 | 2025-12-30 | Plexxikon Inc. | Compounds and methods for CD73 modulation and indications therefor |
| US20210315869A1 (en) | 2020-04-02 | 2021-10-14 | Plexxikon Inc. | Compounds and methods for csk modulation and indications therefor |
| AU2021261383A1 (en) | 2020-04-23 | 2022-11-17 | Opna Bio SA | Compounds and methods for CD73 modulation and indications therefor |
| WO2022061251A1 (en) | 2020-09-18 | 2022-03-24 | Plexxikon Inc. | Compounds and methods for kras modulation and indications therefor |
| WO2022240966A1 (en) | 2021-05-11 | 2022-11-17 | Opna Immuno-Oncology Sa | Compounds and methods for yap/tead modulation and indications therefor |
| WO2024044570A1 (en) | 2022-08-22 | 2024-02-29 | Iambic Therapeutics, Inc. | Compounds and methods for modulating her2 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4000252A (en) * | 1974-01-04 | 1976-12-28 | Kenneth Kosak | Immunoscintillation cell |
| SE7811630L (sv) * | 1977-11-17 | 1979-05-18 | Welsh Nat School Med | Metod for uppteckt eller mengdbestemning av substanser med anvendning av merkningsteknik |
| US4271139A (en) * | 1978-03-27 | 1981-06-02 | Hiram Hart | Scintillation proximity assay |
| US4382074A (en) * | 1978-03-27 | 1983-05-03 | Hiram Hart | Scintillation proximity assay |
| US4259313A (en) * | 1978-10-18 | 1981-03-31 | Eastman Kodak Company | Fluorescent labels |
| CA1185177A (en) * | 1981-07-17 | 1985-04-09 | Larry E. Morrison | Non-radiative energy transfer immunochemical technique |
-
1984
- 1984-03-15 EP EP84301769A patent/EP0154734B1/de not_active Expired
- 1984-03-15 DE DE8484301769T patent/DE3483099D1/de not_active Expired - Lifetime
- 1984-03-15 AT AT84301769T patent/ATE56096T1/de not_active IP Right Cessation
- 1984-03-21 JP JP59052452A patent/JPH0654313B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE3483099D1 (de) | 1990-10-04 |
| EP0154734B1 (de) | 1990-08-29 |
| JPH0654313B2 (ja) | 1994-07-20 |
| JPS60196668A (ja) | 1985-10-05 |
| EP0154734A1 (de) | 1985-09-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EELA | Cancelled due to lapse of time |