ATE56436T1 - Diselenobisbenzoesaeureamide primaerer heterocyclischer amine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen. - Google Patents

Diselenobisbenzoesaeureamide primaerer heterocyclischer amine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.

Info

Publication number: ATE56436T1
Authority: AT; Austria
Prior art keywords: processes; pharmaceutical compositions; heterocyclic amines; nitro; alkoxy
Prior art date: 1986-08-06

Application number

AT87110648T

Other languages

English (en)

Inventor

Andre Dr Welter

Axel Dr Roemer

Sigurd Dr Leyck

Michael John Dr Parnham

Original Assignee

Nattermann A & Cie

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-08-06

Filing date

1987-07-23

Publication date

1990-09-15

1987-07-23 Application filed by Nattermann A & Cie filed Critical Nattermann A & Cie

1990-09-15 Application granted granted Critical

1990-09-15 Publication of ATE56436T1 publication Critical patent/ATE56436T1/de

Links

239000008194 pharmaceutical composition Substances 0.000 title abstract 2
150000001412 amines Chemical class 0.000 title 1
-1 heterocyclic amines Chemical class 0.000 abstract 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical class NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 abstract 1
206010061216 Infarction Diseases 0.000 abstract 1
206010067125 Liver injury Diseases 0.000 abstract 1
201000004681 Psoriasis Diseases 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000005864 Sulphur Substances 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
230000005779 cell damage Effects 0.000 abstract 1
208000037887 cell injury Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
230000006378 damage Effects 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
231100000234 hepatic damage Toxicity 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
230000007574 infarction Effects 0.000 abstract 1
208000015181 infectious disease Diseases 0.000 abstract 1
230000008818 liver damage Effects 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
150000002926 oxygen Chemical class 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
230000005855 radiation Effects 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Toxicology (AREA)
Hematology (AREA)
Obesity (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyrrole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Thiazole And Isothizaole Compounds (AREA)
Furan Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

AT87110648T 1986-08-06 1987-07-23 Diselenobisbenzoesaeureamide primaerer heterocyclischer amine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen. ATE56436T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19863626554 DE3626554A1 (de)	1986-08-06	1986-08-06	Diselenobis-benzoesaeureamide primaerer heterocyclischer amine, verfahren zur ihrer herstellung und diese enthaltende pharmazeutische praeparate
EP87110648A EP0257306B1 (de)	1986-08-06	1987-07-23	Diselenobisbenzoesäureamide primärer heterocyclischer Amine, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen

Publications (1)

Publication Number	Publication Date
ATE56436T1 true ATE56436T1 (de)	1990-09-15

Family

ID=6306768

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT87110648T ATE56436T1 (de)	1986-08-06	1987-07-23	Diselenobisbenzoesaeureamide primaerer heterocyclischer amine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.

Country Status (19)

Country	Link
US (1)	US4910313A (de)
EP (1)	EP0257306B1 (de)
JP (1)	JPH0830060B2 (de)
KR (1)	KR960001202B1 (de)
AT (1)	ATE56436T1 (de)
AU (1)	AU598285B2 (de)
CA (1)	CA1303038C (de)
DD (1)	DD261597A5 (de)
DE (2)	DE3626554A1 (de)
DK (1)	DK169407B1 (de)
ES (1)	ES2017483B3 (de)
FI (1)	FI85018C (de)
GR (1)	GR3001180T3 (de)
HU (1)	HU197753B (de)
IE (1)	IE60366B1 (de)
NO (1)	NO171215C (de)
PT (1)	PT85501B (de)
SU (1)	SU1597097A3 (de)
ZA (1)	ZA875821B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5128365A (en) *	1989-07-19	1992-07-07	The Trustees Of Columbia University In The City Of New York	Compounds having glutathione peroxidase activity and use thereof
DE3937171A1 (de) *	1989-11-08	1991-05-16	Nattermann A & Cie	Picolylselenobenzamide von aminopyridinen, anilinen und picolylaminen
DE3937170A1 (de) *	1989-11-08	1991-05-16	Nattermann A & Cie	Benzylselenobenzamide von aminopyridinen und picolylaminen
DK0622076T3 (da) *	1992-01-17	1997-06-02	Daiichi Seiyaku Co	Inhibitor for restenose efter perkutan coronar arterioplasti
FR2757857B1 (fr) *	1996-12-27	1999-04-23	Oxis International Sa	Diselenures et selenosulfures aromatiques, leur preparation et leurs utilisations, notamment therapeutiques
AU3457300A (en)	1999-03-31	2000-10-16	Daiichi Pharmaceutical Co., Ltd.	Substrates for thioredoxin reductase
US7776925B2 (en) *	2002-03-06	2010-08-17	Duke University	Reversing, postponing or preventing the occurrence of GTN tolerance and/or generation of reactive oxygen species from mitochondria
US10058542B1 (en)	2014-09-12	2018-08-28	Thioredoxin Systems Ab	Composition comprising selenazol or thiazolone derivatives and silver and method of treatment therewith

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3027075A1 (de) *	1980-07-17	1982-02-18	A. Nattermann & Cie GmbH, 5000 Köln	Benzisoselenazolone, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DE3027074A1 (de) *	1980-07-17	1982-02-18	A. Nattermann & Cie GmbH, 5000 Köln	Benzisoselenazolon enthaltende pharmazeutische praeparate und ihre verwendung
DE3027073C2 (de) *	1980-07-17	1985-03-07	A. Nattermann & Cie GmbH, 5000 Köln	Pharmazeutische Präparate, enthaltend 2-Phenyl-1,2-benzisoselenazol-3(2H)-on
DE3226284A1 (de) *	1982-07-14	1984-01-19	A. Nattermann & Cie GmbH, 5000 Köln	Neue benzisoselenazolone, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DE3568775D1 (en) *	1984-06-22	1989-04-20	Nattermann A & Cie	S-(carbamoyl-phenylselenyl) derivatives of glutathion and of amino mercaptocarboxylic acids, process for their preparation and pharmaceutical preparations containing them
DE3443467A1 (de) *	1984-11-29	1986-05-28	A. Nattermann & Cie GmbH, 5000 Köln	Mercaptanderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
EP0198277B1 (de) *	1985-04-12	1989-05-03	A. Nattermann & Cie. GmbH	Diselenobis-benzoesäureamide primärer und sekundärer Amine, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
DE3515272C2 (de) *	1985-04-27	1993-10-14	Nattermann A & Cie	Benzisoselenazolone, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate

1986
- 1986-08-06 DE DE19863626554 patent/DE3626554A1/de not_active Withdrawn
1987
- 1987-07-23 DE DE8787110648T patent/DE3764910D1/de not_active Expired - Lifetime
- 1987-07-23 AT AT87110648T patent/ATE56436T1/de not_active IP Right Cessation
- 1987-07-23 ES ES87110648T patent/ES2017483B3/es not_active Expired - Lifetime
- 1987-07-23 EP EP87110648A patent/EP0257306B1/de not_active Expired - Lifetime
- 1987-07-27 IE IE203387A patent/IE60366B1/en not_active IP Right Cessation
- 1987-07-30 CA CA000543452A patent/CA1303038C/en not_active Expired - Fee Related
- 1987-08-03 NO NO873231A patent/NO171215C/no unknown
- 1987-08-04 FI FI873383A patent/FI85018C/fi not_active IP Right Cessation
- 1987-08-05 DK DK409087A patent/DK169407B1/da not_active IP Right Cessation
- 1987-08-05 HU HU873576A patent/HU197753B/hu not_active IP Right Cessation
- 1987-08-06 JP JP62195406A patent/JPH0830060B2/ja not_active Expired - Lifetime
- 1987-08-06 US US07/082,438 patent/US4910313A/en not_active Expired - Fee Related
- 1987-08-06 PT PT85501A patent/PT85501B/pt active IP Right Revival
- 1987-08-06 ZA ZA875821A patent/ZA875821B/xx unknown
- 1987-08-06 DD DD87305765A patent/DD261597A5/de not_active IP Right Cessation
- 1987-08-06 AU AU76651/87A patent/AU598285B2/en not_active Ceased
- 1987-08-06 SU SU874203234A patent/SU1597097A3/ru active
- 1987-08-06 KR KR1019870008679A patent/KR960001202B1/ko not_active Expired - Fee Related
1990
- 1990-12-11 GR GR90401048T patent/GR3001180T3/el unknown

Also Published As

Publication number	Publication date
CA1303038C (en)	1992-06-09
FI85018C (fi)	1992-02-25
HU197753B (en)	1989-05-29
IE872033L (en)	1988-02-06
US4910313A (en)	1990-03-20
NO873231D0 (no)	1987-08-03
DK409087D0 (da)	1987-08-05
AU7665187A (en)	1988-02-11
PT85501B (pt)	1990-06-29
FI85018B (fi)	1991-11-15
IE60366B1 (en)	1994-07-13
NO171215C (no)	1993-02-10
EP0257306A1 (de)	1988-03-02
FI873383L (fi)	1988-02-07
JPS6379875A (ja)	1988-04-09
KR960001202B1 (ko)	1996-01-24
EP0257306B1 (de)	1990-09-12
GR3001180T3 (en)	1992-06-30
DK169407B1 (da)	1994-10-24
NO873231L (no)	1988-02-08
NO171215B (no)	1992-11-02
ZA875821B (en)	1988-02-10
ES2017483B3 (es)	1991-02-16
SU1597097A3 (ru)	1990-09-30
JPH0830060B2 (ja)	1996-03-27
HUT44572A (en)	1988-03-28
DD261597A5 (de)	1988-11-02
PT85501A (en)	1987-09-01
DE3764910D1 (de)	1990-10-18
AU598285B2 (en)	1990-06-21
DK409087A (da)	1988-02-07
FI873383A0 (fi)	1987-08-04
KR880002889A (ko)	1988-05-12
DE3626554A1 (de)	1988-02-18

Legal Events

Date	Code	Title	Description
1991-04-15	UEP	Publication of translation of european patent specification
2001-04-15	REN	Ceased due to non-payment of the annual fee

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ATE18196T1 (de)	1986-03-15	1,4-acyloxynaphthalenderivate, diese enthaltende kompositionen, verfahren fuer ihre herstellung und zwischenprodukte dafuer.
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ATE108440T1 (de)	1994-07-15	Arylaralkylether, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzung.
ATE32221T1 (de)	1988-02-15	3 n-substituierte 3,4-dihydropyrimidinderivate, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen.
ATE48276T1 (de)	1989-12-15	1,6-naphthyridin-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel.
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