ATE80608T1 - N-alkyl-derivate von 2-amino-6,7dimethoxytetralin, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen mit antihypertensiver wirkung. - Google Patents

N-alkyl-derivate von 2-amino-6,7dimethoxytetralin, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen mit antihypertensiver wirkung.

Info

Publication number: ATE80608T1
Authority: AT; Austria
Prior art keywords: amino; alkyl derivatives; preparation; pharmaceutical compositions; compositions containing
Prior art date: 1986-12-23

Application number

AT87830449T

Other languages

English (en)

Inventor

Mauro Marzi

Maria Ornella Tinti

Fabio Romano Di

Domenico Misiti

Original Assignee

Sigma Tau Ind Farmaceuti

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-12-23

Filing date

1987-12-21

Publication date

1992-10-15

1987-12-21 Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti

1992-10-15 Application granted granted Critical

1992-10-15 Publication of ATE80608T1 publication Critical patent/ATE80608T1/de

Links

230000003276 anti-hypertensive effect Effects 0.000 title abstract 2
OVSNYLXMTWOUKT-UHFFFAOYSA-N 6,7-dimethoxy-1,2,3,4-tetrahydronaphthalen-2-amine Chemical class C1CC(N)CC2=C1C=C(OC)C(OC)=C2 OVSNYLXMTWOUKT-UHFFFAOYSA-N 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 2
125000001153 fluoro group Chemical group F* 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
CXWXQJXEFPUFDZ-UHFFFAOYSA-N tetraline Natural products C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT87830449T 1986-12-23 1987-12-21 N-alkyl-derivate von 2-amino-6,7dimethoxytetralin, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen mit antihypertensiver wirkung. ATE80608T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT48779/86A IT1199339B (it)	1986-12-23	1986-12-23	N-alchil derivati della 2-ammino-6,7-dimetossi tetralina,procedimenti per la loro preparazione e composizioni farmaceutiche ad attivita'an tiipertensiva che li contengono
EP87830449A EP0273017B1 (de)	1986-12-23	1987-12-21	N-Alkyl-Derivate von 2-Amino-6,7-dimethoxytetralin, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen mit antihypertensiver Wirkung

Publications (1)

Publication Number	Publication Date
ATE80608T1 true ATE80608T1 (de)	1992-10-15

Family

ID=11268513

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT87830449T ATE80608T1 (de)	1986-12-23	1987-12-21	N-alkyl-derivate von 2-amino-6,7dimethoxytetralin, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen mit antihypertensiver wirkung.

Country Status (8)

Country	Link
US (1)	US5047433A (de)
EP (1)	EP0273017B1 (de)
JP (1)	JP2545105B2 (de)
AT (1)	ATE80608T1 (de)
DE (1)	DE3781783T2 (de)
ES (1)	ES2035105T3 (de)
GR (1)	GR3006342T3 (de)
IT (1)	IT1199339B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1230931B (it) *	1989-06-27	1991-11-08	Chiesi Farma Spa	Derivati di 2 ammino 1,2,3,4 tetraidronaftalene ad attivita' cardiovascolare, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
IT1241988B (it) *	1990-06-15	1994-02-02	Sigma Tau Ind Farmaceuti	2- amminotetraline-6, 7-sostituite attive come immunomodulanti e composizioni farmaceutiche che le contengono
IL104567A (en) *	1992-02-03	1997-03-18	Fujisawa Pharmaceutical Co	Ethanolamine derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
IT1278045B1 (it) *	1995-03-09	1997-11-17	Sigma Tau Ind Farmaceuti	Uso di 2-amminotetraline-6,7-sostituite per la preparazione di composizioni farmaceutiche atte al trattamento dello shock, e di

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3709996A (en) *	1963-08-02	1973-01-09	Aspro Nicholas Ltd	Pharmaceutical compositions containing n-cyclopropyl-1-aminoindane compounds and adapted for administration to obtain inhibition of monoamine oxidase enzyme and process
GB1187017A (en) *	1966-07-16	1970-04-08	Aspro Nicholas Ltd	Substituted 1-Amino Indanes and Tetrahydronaphthalens
US3629463A (en) *	1969-04-15	1971-12-21	Aspro Nicholas Ltd	Pharmaceutical compositions containing n-cyclopropyl-1-amino-1 2 3 4-tetrahydronaphthalenes and use of such n-cyclopropyl compounds as hypotensives
US3930022A (en) *	1972-07-03	1975-12-30	Squibb & Sons Inc	Certain tetrahydronaphthalenes used in the treatment of cardiac arrhythmia
US4181738A (en) *	1976-11-30	1980-01-01	Cornell Research Foundation, Inc.	Catecholamine derivatives, a process for their preparation and pharmaceutical compositions thereof
US4314082A (en) *	1978-07-14	1982-02-02	American Hospital Supply Corporation	Derivatives of 2-amino-6,7-dihydroxytetrahydro naphthalene (ADTN)
EP0033789B1 (de) *	1980-01-30	1984-03-07	American Hospital Supply Corporation	2-alpha-Methyl-dopaminimino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalin, seine Salze, und Verfahren zu dessen Herstellung
DE3479314D1 (en) *	1984-05-22	1989-09-14	Nelson Res & Dev	Substituted 2-aminotetralins and processes for synthesis
IL79323A (en) *	1985-07-10	1990-03-19	Sanofi Sa	Phenylethanolaminotetralines,their preparation and pharmaceutical compositions containing them

1986
- 1986-12-23 IT IT48779/86A patent/IT1199339B/it active
1987
- 1987-12-21 US US07/135,335 patent/US5047433A/en not_active Expired - Fee Related
- 1987-12-21 DE DE8787830449T patent/DE3781783T2/de not_active Expired - Fee Related
- 1987-12-21 AT AT87830449T patent/ATE80608T1/de not_active IP Right Cessation
- 1987-12-21 EP EP87830449A patent/EP0273017B1/de not_active Expired - Lifetime
- 1987-12-21 ES ES198787830449T patent/ES2035105T3/es not_active Expired - Lifetime
- 1987-12-23 JP JP62326631A patent/JP2545105B2/ja not_active Expired - Lifetime
1992
- 1992-11-26 GR GR920402697T patent/GR3006342T3/el unknown

Also Published As

Publication number	Publication date
EP0273017B1 (de)	1992-09-16
EP0273017A2 (de)	1988-06-29
JP2545105B2 (ja)	1996-10-16
JPS63190858A (ja)	1988-08-08
EP0273017A3 (en)	1989-03-01
DE3781783T2 (de)	1993-02-25
DE3781783D1 (de)	1992-10-22
IT1199339B (it)	1988-12-30
US5047433A (en)	1991-09-10
GR3006342T3 (de)	1993-06-21
ES2035105T3 (es)	1993-04-16
IT8648779A0 (it)	1986-12-23

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Legal Events

Date	Code	Title	Description
1993-04-15	UEP	Publication of translation of european patent specification
2002-09-15	REN	Ceased due to non-payment of the annual fee