ATE60605T1 - 7-substituierte bicyclische pyrazolidinone. - Google Patents

7-substituierte bicyclische pyrazolidinone.

Info

Publication number
ATE60605T1
ATE60605T1 AT86303174T AT86303174T ATE60605T1 AT E60605 T1 ATE60605 T1 AT E60605T1 AT 86303174 T AT86303174 T AT 86303174T AT 86303174 T AT86303174 T AT 86303174T AT E60605 T1 ATE60605 T1 AT E60605T1
Authority
AT
Austria
Prior art keywords
substituted
group
alkyl
arylalkyl
phenyl
Prior art date
Application number
AT86303174T
Other languages
English (en)
Inventor
Louis Nickolaus Jungheim
Sandra Kay Sigmund
Richard Elmer Holmes
Charles Jackson Barnett
Robert John Ternansky
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE60605T1 publication Critical patent/ATE60605T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D231/08—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen or sulfur atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/65031—Five-membered rings having the nitrogen atoms in the positions 1 and 2
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT86303174T 1985-04-30 1986-04-28 7-substituierte bicyclische pyrazolidinone. ATE60605T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72902185A 1985-04-30 1985-04-30

Publications (1)

Publication Number Publication Date
ATE60605T1 true ATE60605T1 (de) 1991-02-15

Family

ID=24929253

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86303174T ATE60605T1 (de) 1985-04-30 1986-04-28 7-substituierte bicyclische pyrazolidinone.

Country Status (16)

Country Link
US (4) US4734505A (de)
EP (1) EP0202046B1 (de)
JP (2) JPH0759582B2 (de)
KR (1) KR880001092B1 (de)
CN (1) CN86103619A (de)
AT (1) ATE60605T1 (de)
AU (1) AU5675586A (de)
CA (1) CA1274832A (de)
DE (1) DE3677253D1 (de)
DK (1) DK193086A (de)
ES (1) ES8801833A1 (de)
GR (1) GR861118B (de)
HU (1) HUT40660A (de)
IL (1) IL78634A0 (de)
PT (1) PT82468B (de)
ZA (2) ZA863170B (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8801833A1 (es) * 1985-04-30 1988-02-16 Lilly Co Eli Un procedimiento para la preparacion de un compuesto.
US4940718A (en) * 1985-04-30 1990-07-10 Eli Lilly And Company 7-substituted bicyclic pyrazolidinones, pharmaceutical compositions and use
US4935536A (en) * 1987-05-21 1990-06-19 Millipore Corporation Protecting groups for asparagine and glutamine in peptide synthesis
IL86095A0 (de) * 1987-09-30 1988-09-30 Lilly Co Eli
US5011938A (en) * 1989-10-02 1991-04-30 Eli Lilly And Company 7-substituted bicyclic pyrazolidinones
US5430145A (en) * 1990-10-18 1995-07-04 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5308841A (en) * 1990-12-21 1994-05-03 Merrell Dow Pharmaceuticals Inc. Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
US5457196A (en) * 1991-09-27 1995-10-10 Merrell Dow Pharmaceuticals Inc. 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
US5455242A (en) * 1991-09-27 1995-10-03 Merrell Dow Pharmaceuticals Inc. Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
EP0534363B1 (de) * 1991-09-27 1997-07-09 Merrell Pharmaceuticals Inc. 2-Substituierte Indan-2-Mercaptoacetylamid-Verbindungen mit Enkephalinase und ACE-Hemmwirkung
NZ246811A (en) * 1992-02-14 1996-02-27 Merrell Dow Pharma N-[pyrido (and oxazino and thiazino) benzazepine] 1-benzyl-1-(heterocyclyl(alkyl)carbonylthio) acetamide derivatives and pharmaceutical compositions
ES2138622T3 (es) * 1992-05-15 2000-01-16 Merrell Pharma Inc Derivados de mercaptoacetilamido piridazo(1,2-a)(1,2)diazepina utilizados como inhibidores de encefalinasa y eca.
US5420271A (en) * 1992-08-24 1995-05-30 Merrell Dow Pharmaceuticals, Inc. 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
CA2107644A1 (en) * 1992-10-28 1994-04-29 David R. Magnin .alpha.-phosphonosulfonae squalene synthetase inhibitors and methd
US5712396A (en) * 1992-10-28 1998-01-27 Magnin; David R. α-phosphonosulfonate squalene synthetase inhibitors
ATE197714T1 (de) * 1992-10-30 2000-12-15 Merrell Pharma Inc Mercaptoacetylamid substituiertes bizyclisches laktam zur verwendung als enkephalinase und ace- hemmer
FI963167A0 (fi) * 1994-02-14 1996-08-13 Merrell Pharma Inc Enkefalinaasin ja ACE:n ihibiittoreina käyttökelpoisia uusia 2-substituoituja indaani-2-merkaptoasetyyliamididisulfidijohdannaisia
AU687984B2 (en) * 1994-02-14 1998-03-05 Merrell Pharmaceuticals Inc. Novel indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase
CN1100785C (zh) * 1994-02-14 2003-02-05 默里尔药物公司 1,3,4,5－四氢苯并[c]氮杂䓬－3－酮二硫化物衍生物及方法
US5530013A (en) * 1994-02-14 1996-06-25 American Home Products Corporation Venlafaxine in the inducement of cognition enhancement
JP3596778B2 (ja) * 1994-02-14 2004-12-02 メレル ファーマスーティカルズ インコーポレーテッド エンケファリナーゼ及びａｃｅの阻害剤として有用な、新規なメルカプトアセチルアミドジスルフィド誘導体類
US5484783A (en) * 1994-03-24 1996-01-16 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
NZ282568A (en) * 1994-03-24 1997-07-27 Merrell Pharma Inc Use of condensed aminoacetylmercaptobenzazepines in treating elevated cholesterol levels, atherosclerosis, and hypotriglyceridemia
US6013645A (en) * 1994-03-24 2000-01-11 Hoechst Marion Roussel, Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide disulfide derivatives
US5447922A (en) * 1994-08-24 1995-09-05 Bristol-Myers Squibb Company α-phosphonosulfinic squalene synthetase inhibitors
US5786448A (en) * 1996-11-07 1998-07-28 Trega Biosciences, Inc. Combinatorial libraries of cyclic urea and cyclic thiourea derivatives and compounds therein
GB0119305D0 (en) 2001-04-12 2001-10-03 Aventis Pharma Gmbh Mercaptoacetylamide derivatives,a process for their preparation and their use
US20110034469A1 (en) 2009-08-04 2011-02-10 Takeda Pharmaceutical Company Limited Heterocyclic Compound
CN106883236B (zh) * 2017-03-17 2018-12-04 浙江大学 一种制备含硫的n，n-双环吡唑烷酮类衍生物的方法
CN115286635B (zh) * 2022-08-22 2023-10-24 河南师范大学 一种手性并环吡唑啉酮类化合物的合成方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3065224A (en) 1955-06-24 1962-11-20 Bayer Ag Process for the production of addition products of organic isocyanates and organic carbodiimides
US2938892A (en) 1958-10-10 1960-05-31 Little Inc A Amides and process of preparing same with a monocarbodhmide
AR206201A1 (es) 1972-06-29 1976-07-07 Ciba Geigy Ag Procedimiento para la obtencion de compuestos de acido 7beta-amino-3-cefem-3-01-4-carboxilico0-substituidos
GB1415910A (en) * 1973-03-21 1975-12-03 Kyowa Hakko Kogyo Kk Benzothiazoles
DD110868A1 (de) * 1974-04-03 1975-01-12
GB1472052A (en) * 1975-02-14 1977-04-27 Pliva Pharm & Chem Works Preparation of d-penicillamine and substituted 3-pyrazoline- 5-ones
GB1591439A (en) 1976-10-01 1981-06-24 Glaxo Operations Ltd 7-syn (oxyimino -acylamido) cephalosporins
DE2714880A1 (de) 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
US4128425A (en) * 1977-05-06 1978-12-05 Polaroid Corporation Photographic developers
DD143617A1 (de) 1979-05-14 1980-09-03 Helmut Dorn Verfahren zur herstellung von 2-nitro-und 2-amino-5-oxo-perhydro-pyrazolo eckige klammer auf 1,2-a eckige klammer zu pyrazolen
DE2931673A1 (de) * 1979-08-04 1981-02-26 Basf Ag Pyrazolin-5-on-yl-methyl-(di)thiophosphorsaeureester, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung von schaedlingen
GB2073740A (en) * 1980-03-03 1981-10-21 Wellcome Found Pyrazolidinones
US4396619A (en) 1981-09-08 1983-08-02 Eli Lilly And Company Cephalosporin betaines
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
US4465679A (en) * 1983-01-31 1984-08-14 Usv Pharmaceutical Corporation 1,2-Diaza-3-one compounds, their use in treating hypertension and pharmaceutical compositions thereof
AU575854B2 (en) 1983-10-04 1988-08-11 Shionogi & Co., Ltd. 7beta-(carboxyalkenamido) cephalosporins
IL78630A0 (en) 1985-04-30 1986-08-31 Lilly Co Eli Pyrazolidinium ylides
ES8801833A1 (es) * 1985-04-30 1988-02-16 Lilly Co Eli Un procedimiento para la preparacion de un compuesto.
KR890001150B1 (ko) 1985-04-30 1989-04-25 일라이 릴리 앤드 캄파니 디아졸리디논 유도체 및 그의 제조방법

Also Published As

Publication number Publication date
US4716232A (en) 1987-12-29
KR860008181A (ko) 1986-11-12
PT82468A (en) 1986-05-01
ZA863170B (en) 1987-12-30
AU5675586A (en) 1986-11-13
GR861118B (en) 1986-08-18
DK193086D0 (da) 1986-04-28
EP0202046A1 (de) 1986-11-20
HUT40660A (en) 1987-01-28
PT82468B (en) 1988-03-23
ES554463A0 (es) 1988-02-16
ES8801833A1 (es) 1988-02-16
JPH0759582B2 (ja) 1995-06-28
IL78634A0 (en) 1986-08-31
ZA882604B (en) 1989-12-27
CN86103619A (zh) 1986-10-29
EP0202046B1 (de) 1991-01-30
KR880001092B1 (ko) 1988-06-23
US4734504A (en) 1988-03-29
JPS63112583A (ja) 1988-05-17
DK193086A (da) 1987-01-20
CA1274832A (en) 1990-10-02
JPS61254589A (ja) 1986-11-12
US4795815A (en) 1989-01-03
DE3677253D1 (de) 1991-03-07
US4734505A (en) 1988-03-29

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee