ES554463A0 - Un procedimiento para la preparacion de un compuesto. - Google Patents

Un procedimiento para la preparacion de un compuesto.

Info

Publication number
ES554463A0
ES554463A0 ES554463A ES554463A ES554463A0 ES 554463 A0 ES554463 A0 ES 554463A0 ES 554463 A ES554463 A ES 554463A ES 554463 A ES554463 A ES 554463A ES 554463 A0 ES554463 A0 ES 554463A0
Authority
ES
Spain
Prior art keywords
substituted
group
alkyl
arylalkyl
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES554463A
Other languages
English (en)
Other versions
ES8801833A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES8801833A1 publication Critical patent/ES8801833A1/es
Publication of ES554463A0 publication Critical patent/ES554463A0/es
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D231/08Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen or sulfur atoms directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503Five-membered rings
    • C07F9/65031Five-membered rings having the nitrogen atoms in the positions 1 and 2
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
ES554463A 1985-04-30 1986-04-28 Un procedimiento para la preparacion de un compuesto. Expired ES8801833A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72902185A 1985-04-30 1985-04-30

Publications (2)

Publication Number Publication Date
ES8801833A1 ES8801833A1 (es) 1988-02-16
ES554463A0 true ES554463A0 (es) 1988-02-16

Family

ID=24929253

Family Applications (1)

Application Number Title Priority Date Filing Date
ES554463A Expired ES8801833A1 (es) 1985-04-30 1986-04-28 Un procedimiento para la preparacion de un compuesto.

Country Status (16)

Country Link
US (4) US4716232A (es)
EP (1) EP0202046B1 (es)
JP (2) JPH0759582B2 (es)
KR (1) KR880001092B1 (es)
CN (1) CN86103619A (es)
AT (1) ATE60605T1 (es)
AU (1) AU5675586A (es)
CA (1) CA1274832A (es)
DE (1) DE3677253D1 (es)
DK (1) DK193086A (es)
ES (1) ES8801833A1 (es)
GR (1) GR861118B (es)
HU (1) HUT40660A (es)
IL (1) IL78634A0 (es)
PT (1) PT82468B (es)
ZA (2) ZA863170B (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3677253D1 (de) * 1985-04-30 1991-03-07 Lilly Co Eli 7-substituierte bicyclische pyrazolidinone.
US4940718A (en) * 1985-04-30 1990-07-10 Eli Lilly And Company 7-substituted bicyclic pyrazolidinones, pharmaceutical compositions and use
US4935536A (en) * 1987-05-21 1990-06-19 Millipore Corporation Protecting groups for asparagine and glutamine in peptide synthesis
IL86095A0 (es) * 1987-09-30 1988-09-30 Lilly Co Eli
US5011938A (en) * 1989-10-02 1991-04-30 Eli Lilly And Company 7-substituted bicyclic pyrazolidinones
US5430145A (en) * 1990-10-18 1995-07-04 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5308841A (en) * 1990-12-21 1994-05-03 Merrell Dow Pharmaceuticals Inc. Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
US5457196A (en) * 1991-09-27 1995-10-10 Merrell Dow Pharmaceuticals Inc. 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
EP0534363B1 (en) * 1991-09-27 1997-07-09 Merrell Pharmaceuticals Inc. Novel 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5455242A (en) * 1991-09-27 1995-10-03 Merrell Dow Pharmaceuticals Inc. Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
DE69317764T2 (de) * 1992-02-14 1998-07-30 Merrell Pharmaceuticals Inc., Cincinnati, Ohio Aminoacetylmercaptoacetylamid derivate mit enkephalinase- und ace-hemmwirkung
WO1993023403A1 (en) * 1992-05-15 1993-11-25 Merrell Dow Pharmaceuticals Inc. NOVEL MERCAPTOACETYLAMIDO PYRIDAZO[1,2]PYRIDAZINE, PYRAZOLO[1,2]PYRIDAZINE, PYRIDAZO[1,2-a][1,2]DIAZEPINE AND PYRAZOLO[1,2-a][1,2]DIAZEPINE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE
US5420271A (en) * 1992-08-24 1995-05-30 Merrell Dow Pharmaceuticals, Inc. 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
CA2107644A1 (en) * 1992-10-28 1994-04-29 David R. Magnin .alpha.-phosphonosulfonae squalene synthetase inhibitors and methd
US5470845A (en) * 1992-10-28 1995-11-28 Bristol-Myers Squibb Company Methods of using α-phosphonosulfonate squalene synthetase inhibitors including the treatment of atherosclerosis and hypercholesterolemia
AU673857B2 (en) * 1992-10-30 1996-11-28 Aventisub Ii Inc. Mercaptoacetylamide bicyclic lactam derivatives
EP0746566A1 (en) * 1994-02-14 1996-12-11 Merrell Pharmaceuticals Inc. Novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
JPH09508906A (ja) * 1994-02-14 1997-09-09 メレル ファーマスーティカルズ インコーポレーテッド エンケファリナーゼ及びaceの阻害剤として有用な新規なメルカプトアセチルアミド1,3,4,5−テトラヒドロベンゾ[c]アゼピン−3−オンジスルフィド誘導体類
HUT74584A (en) * 1994-02-14 1997-01-28 Merrell Pharma Inc Novel heterocycle fused benzazepine-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase, process for producing them and pharmaceutical compositions containing them
CA2183320C (en) * 1994-02-14 1999-10-26 Gary A. Flynn Novel mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
US5530013A (en) * 1994-02-14 1996-06-25 American Home Products Corporation Venlafaxine in the inducement of cognition enhancement
US5484783A (en) * 1994-03-24 1996-01-16 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
WO1995025532A1 (en) * 1994-03-24 1995-09-28 Merrell Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic aminoacetylmercapto derivatives
AU688012B2 (en) * 1994-03-24 1998-03-05 Merrell Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide disulfide derivatives
US5447922A (en) * 1994-08-24 1995-09-05 Bristol-Myers Squibb Company α-phosphonosulfinic squalene synthetase inhibitors
US5786448A (en) * 1996-11-07 1998-07-28 Trega Biosciences, Inc. Combinatorial libraries of cyclic urea and cyclic thiourea derivatives and compounds therein
GB0119305D0 (en) 2001-04-12 2001-10-03 Aventis Pharma Gmbh Mercaptoacetylamide derivatives,a process for their preparation and their use
UY32826A (es) 2009-08-04 2011-02-28 Takeda Pharmaceutical Compuestos heterocíclicos
CN106883236B (zh) * 2017-03-17 2018-12-04 浙江大学 一种制备含硫的n,n-双环吡唑烷酮类衍生物的方法
CN115286635B (zh) * 2022-08-22 2023-10-24 河南师范大学 一种手性并环吡唑啉酮类化合物的合成方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3065224A (en) 1955-06-24 1962-11-20 Bayer Ag Process for the production of addition products of organic isocyanates and organic carbodiimides
US2938892A (en) 1958-10-10 1960-05-31 Little Inc A Amides and process of preparing same with a monocarbodhmide
AR206201A1 (es) 1972-06-29 1976-07-07 Ciba Geigy Ag Procedimiento para la obtencion de compuestos de acido 7beta-amino-3-cefem-3-01-4-carboxilico0-substituidos
GB1415910A (en) * 1973-03-21 1975-12-03 Kyowa Hakko Kogyo Kk Benzothiazoles
DD110868A1 (es) * 1974-04-03 1975-01-12
GB1472052A (en) * 1975-02-14 1977-04-27 Pliva Pharm & Chem Works Preparation of d-penicillamine and substituted 3-pyrazoline- 5-ones
GB1591439A (en) 1976-10-01 1981-06-24 Glaxo Operations Ltd 7-syn (oxyimino -acylamido) cephalosporins
DE2714880A1 (de) 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
US4128425A (en) * 1977-05-06 1978-12-05 Polaroid Corporation Photographic developers
DD143617A1 (de) 1979-05-14 1980-09-03 Helmut Dorn Verfahren zur herstellung von 2-nitro-und 2-amino-5-oxo-perhydro-pyrazolo eckige klammer auf 1,2-a eckige klammer zu pyrazolen
DE2931673A1 (de) * 1979-08-04 1981-02-26 Basf Ag Pyrazolin-5-on-yl-methyl-(di)thiophosphorsaeureester, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung von schaedlingen
GB2073740A (en) * 1980-03-03 1981-10-21 Wellcome Found Pyrazolidinones
US4396619A (en) 1981-09-08 1983-08-02 Eli Lilly And Company Cephalosporin betaines
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
US4465679A (en) * 1983-01-31 1984-08-14 Usv Pharmaceutical Corporation 1,2-Diaza-3-one compounds, their use in treating hypertension and pharmaceutical compositions thereof
AU575854B2 (en) 1983-10-04 1988-08-11 Shionogi & Co., Ltd. 7beta-(carboxyalkenamido) cephalosporins
KR890001150B1 (ko) 1985-04-30 1989-04-25 일라이 릴리 앤드 캄파니 디아졸리디논 유도체 및 그의 제조방법
IL78630A0 (en) 1985-04-30 1986-08-31 Lilly Co Eli Pyrazolidinium ylides
DE3677253D1 (de) * 1985-04-30 1991-03-07 Lilly Co Eli 7-substituierte bicyclische pyrazolidinone.

Also Published As

Publication number Publication date
CN86103619A (zh) 1986-10-29
DK193086D0 (da) 1986-04-28
PT82468A (en) 1986-05-01
US4734505A (en) 1988-03-29
GR861118B (en) 1986-08-18
ES8801833A1 (es) 1988-02-16
HUT40660A (en) 1987-01-28
ZA882604B (en) 1989-12-27
KR860008181A (ko) 1986-11-12
DK193086A (da) 1987-01-20
EP0202046B1 (en) 1991-01-30
PT82468B (en) 1988-03-23
IL78634A0 (en) 1986-08-31
EP0202046A1 (en) 1986-11-20
CA1274832A (en) 1990-10-02
US4734504A (en) 1988-03-29
AU5675586A (en) 1986-11-13
US4716232A (en) 1987-12-29
ZA863170B (en) 1987-12-30
JPS63112583A (ja) 1988-05-17
ATE60605T1 (de) 1991-02-15
KR880001092B1 (ko) 1988-06-23
US4795815A (en) 1989-01-03
JPS61254589A (ja) 1986-11-12
DE3677253D1 (de) 1991-03-07
JPH0759582B2 (ja) 1995-06-28

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