ATE60607T1 - Verfahren zur herstellung von kristallinischem ceftazidime-pentahydrat. - Google Patents

Verfahren zur herstellung von kristallinischem ceftazidime-pentahydrat.

Info

Publication number: ATE60607T1
Authority: AT; Austria
Prior art keywords: ceftazidime; pentahydrate; crystalline pentahydrate; optimum; crystalline
Prior art date: 1984-11-08

Application number

AT85308016T

Other languages

English (en)

Inventor

Ronald Clay Browning

Melvin Gale Pleiss Jr

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-11-08

Filing date

1985-11-05

Publication date

1991-02-15

1985-11-05 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1991-02-15 Application granted granted Critical

1991-02-15 Publication of ATE60607T1 publication Critical patent/ATE60607T1/de

Links

229960000484 ceftazidime Drugs 0.000 title abstract 2
NMVPEQXCMGEDNH-TZVUEUGBSA-N ceftazidime pentahydrate Chemical compound O.O.O.O.O.S([C@@H]1[C@@H](C(N1C=1C([O-])=O)=O)NC(=O)\C(=N/OC(C)(C)C(O)=O)C=2N=C(N)SC=2)CC=1C[N+]1=CC=CC=C1 NMVPEQXCMGEDNH-TZVUEUGBSA-N 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
150000004686 pentahydrates Chemical class 0.000 title 1
KGWHMDCQVDMTNZ-UHFFFAOYSA-N 2-(butylcarbamoylamino)acetic acid Chemical compound CCCCNC(=O)NCC(O)=O KGWHMDCQVDMTNZ-UHFFFAOYSA-N 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
229960003547 ceftazidime pentahydrate Drugs 0.000 abstract 1
238000002425 crystallisation Methods 0.000 abstract 1
230000008025 crystallization Effects 0.000 abstract 1
238000012423 maintenance Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000010899 nucleation Methods 0.000 abstract 1
230000006911 nucleation Effects 0.000 abstract 1
230000020477 pH reduction Effects 0.000 abstract 1
229920000642 polymer Polymers 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/12—Separation; Purification

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT85308016T 1984-11-08 1985-11-05 Verfahren zur herstellung von kristallinischem ceftazidime-pentahydrat. ATE60607T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US66948284A	1984-11-08	1984-11-08
EP85308016A EP0187450B1 (de)	1984-11-08	1985-11-05	Verfahren zur Herstellung von kristallinischem Ceftazidime-Pentahydrat

Publications (1)

Publication Number	Publication Date
ATE60607T1 true ATE60607T1 (de)	1991-02-15

Family

ID=24686483

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT85308016T ATE60607T1 (de)	1984-11-08	1985-11-05	Verfahren zur herstellung von kristallinischem ceftazidime-pentahydrat.

Country Status (8)

Country	Link
EP (1)	EP0187450B1 (de)
JP (1)	JPH0649703B2 (de)
AT (1)	ATE60607T1 (de)
CA (1)	CA1239389A (de)
DE (1)	DE3581619D1 (de)
HK (1)	HK62791A (de)
IE (1)	IE58790B1 (de)
SG (1)	SG57891G (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4954624A (en) *	1986-10-07	1990-09-04	Sandoz Ltd.	Process for the production of cephalosporin derivatives
AT387390B (de) *	1986-10-07	1989-01-10	Biochemie Gmbh	Verfahren zur herstellung des antibiotikums (6r,7r)-7-(2-(2-amino-4-thiazolyl)-2-(2-carboxy

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4329453A (en) *	1979-10-02	1982-05-11	Glaxo Group Limited	Cephalosporin antibiotic

1985
- 1985-11-05 EP EP85308016A patent/EP0187450B1/de not_active Expired - Lifetime
- 1985-11-05 DE DE8585308016T patent/DE3581619D1/de not_active Expired - Lifetime
- 1985-11-05 CA CA000494634A patent/CA1239389A/en not_active Expired
- 1985-11-05 AT AT85308016T patent/ATE60607T1/de not_active IP Right Cessation
- 1985-11-06 IE IE276685A patent/IE58790B1/en not_active IP Right Cessation
- 1985-11-07 JP JP60250597A patent/JPH0649703B2/ja not_active Expired - Lifetime
1991
- 1991-07-17 SG SG578/91A patent/SG57891G/en unknown
- 1991-08-08 HK HK627/91A patent/HK62791A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA1239389A (en)	1988-07-19
DE3581619D1 (de)	1991-03-07
JPS61115088A (ja)	1986-06-02
HK62791A (en)	1991-08-16
IE58790B1 (en)	1993-11-17
SG57891G (en)	1991-08-23
EP0187450A2 (de)	1986-07-16
JPH0649703B2 (ja)	1994-06-29
EP0187450A3 (en)	1987-08-12
IE852766L (en)	1986-05-08
EP0187450B1 (de)	1991-01-30

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Legal Events

Date	Code	Title	Description
1991-08-15	UEP	Publication of translation of european patent specification
2006-02-15	EELA	Cancelled due to lapse of time