ATE61221T1 - Therapeutische verwendung von zinnmesoporphyrin. - Google Patents

Therapeutische verwendung von zinnmesoporphyrin.

Info

Publication number: ATE61221T1
Authority: AT; Austria
Prior art keywords: mammals; heme; mesoporphyrin; therapeutic use; tin mesoporphyrin
Prior art date: 1985-03-25

Application number

AT86104120T

Other languages

English (en)

Inventor

Attallah Kappas

George S Drummond

Original Assignee

Univ Rockefeller

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-03-25

Filing date

1986-03-25

Publication date

1991-03-15

1986-03-25 Application filed by Univ Rockefeller filed Critical Univ Rockefeller

1991-03-15 Application granted granted Critical

1991-03-15 Publication of ATE61221T1 publication Critical patent/ATE61221T1/de

Links

LLDZJTIZVZFNCM-UHFFFAOYSA-J 3-[18-(2-carboxyethyl)-8,13-diethyl-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid;dichlorotin(2+) Chemical compound [H+].[H+].[Cl-].[Cl-].[Sn+4].[N-]1C(C=C2C(=C(C)C(=CC=3C(=C(C)C(=C4)N=3)CC)[N-]2)CCC([O-])=O)=C(CCC([O-])=O)C(C)=C1C=C1C(C)=C(CC)C4=N1 LLDZJTIZVZFNCM-UHFFFAOYSA-J 0.000 title abstract 3
230000001225 therapeutic effect Effects 0.000 title 1
241000124008 Mammalia Species 0.000 abstract 3
150000003278 haem Chemical class 0.000 abstract 3
230000000694 effects Effects 0.000 abstract 2
230000004060 metabolic process Effects 0.000 abstract 2
QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 abstract 1
QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 abstract 1
208000027119 bilirubin metabolic disease Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000002440 hepatic effect Effects 0.000 abstract 1
208000036796 hyperbilirubinemia Diseases 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Hematology (AREA)
Diabetes (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Compositions Of Macromolecular Compounds (AREA)
Epoxy Resins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT86104120T 1985-03-25 1986-03-25 Therapeutische verwendung von zinnmesoporphyrin. ATE61221T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/715,515 US4657902A (en)	1985-03-25	1985-03-25	Therapeutic use of tin mesoporphyrin
EP86104120A EP0196079B1 (de)	1985-03-25	1986-03-25	Therapeutische Verwendung von Zinnmesoporphyrin

Publications (1)

Publication Number	Publication Date
ATE61221T1 true ATE61221T1 (de)	1991-03-15

Family

ID=24874343

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT86104120T ATE61221T1 (de)	1985-03-25	1986-03-25	Therapeutische verwendung von zinnmesoporphyrin.

Country Status (15)

Country	Link
US (1)	US4657902A (de)
EP (1)	EP0196079B1 (de)
JP (1)	JPS62500787A (de)
KR (1)	KR870700341A (de)
AT (1)	ATE61221T1 (de)
AU (1)	AU567041B2 (de)
CA (1)	CA1293504C (de)
DE (1)	DE3677804D1 (de)
DK (1)	DK162716C (de)
ES (1)	ES8800670A1 (de)
GR (1)	GR860768B (de)
IE (1)	IE58532B1 (de)
PH (2)	PH23102A (de)
WO (1)	WO1986005685A1 (de)
ZA (1)	ZA861793B (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
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US4657902A (en) *	1985-03-25	1987-04-14	The Rockefeller University	Therapeutic use of tin mesoporphyrin
DE3687399T2 (de) *	1985-10-23	1993-04-29	Nihon Mediphysics Co Ltd	Porphyrinderivate, ihre herstellung und verwendung.
EP0249966A1 (de) *	1986-06-20	1987-12-23	The Rockefeller University	Zinndiioddeuteroporphyrin, seine Herstellung und Verwendung und pharmazeutische Zusammensetzungen davon
US4782049A (en) *	1986-12-08	1988-11-01	The Rockefeller University	Tin protoporphyrin and tin mesoporphyrin in the treatment of psoriasis
US4831024A (en) *	1987-10-15	1989-05-16	The Board Of Trustees Of The Leland Stanford Junior University	Method to prevent neonatal jaundice
US4997828A (en) *	1989-02-14	1991-03-05	The Rockefeller University	Method of weight control by low level administration of cobalt protoporphyrin or cobalt mesoporphyrin
CA2042398C (en) *	1989-09-25	1995-10-31	George S. Drummond	Orally administered porphyrins to control intestinal iron absorption
US5010073A (en) *	1989-10-05	1991-04-23	The Rockefeller University	Use of liposomes as carriers for metalloporphyrins
US5192757A (en) *	1990-12-20	1993-03-09	Glaxo Inc.	Cobalt porphyrins
US5149697A (en) *	1991-04-18	1992-09-22	Glaxo Inc.	Cobalt porphyrin pharmaceutical compositions
FR2676738B1 (fr) *	1991-05-22	1995-05-05	Ir2M	Nouveau derive organique de metal de transition a structure porphyrinique, composition therapeutique le contenant, en particulier a activite hypoglycemiante.
US5599924A (en) *	1992-08-14	1997-02-04	Trustees Of The University Of Pennsylvania	Electron-deficient porphyrins and processes and intermediates for preparing same
US5371199B1 (en) *	1992-08-14	1995-12-26	Univ Pennsylvania	Substituted porphyrins porphyrin-containing polymers and synthetic methods therefor
US5493017A (en) *	1992-08-14	1996-02-20	The Trustees Of The University Of Pennsylvania	Ring-metalated porphyrins
US5817830A (en) *	1992-08-14	1998-10-06	Trustees Of The University Of Pennsylvania	Pyrrolic compounds
AU7103594A (en) *	1993-06-14	1995-01-03	Rockefeller University, The	Treatment of neonatal hyperbilirubin with metalloporphyrin
US6127356A (en)	1993-10-15	2000-10-03	Duke University	Oxidant scavengers
FI100454B (fi) *	1995-01-30	1997-12-15	Leiras Oy	Hemi-tuotteiden uusi lääkinnällinen käyttö
US5929064A (en) *	1995-08-02	1999-07-27	Warner-Lambert Company	Amino acid complexes of cobalt (III) mesoporphyrin IX and cobalt (III) protoporphyrin IX
JP2001521939A (ja)	1997-11-03	2001-11-13	デューク・ユニバーシティー	置換されたポルフィリン類
CN1093541C (zh) *	1998-01-19	2002-10-30	徐濂	金属卟啉及其生产工艺
ES2162718A1 (es)	1998-07-29	2002-01-01	Const Aeronauticas Sa	Un sistema de proteccion contra descargas electricas, especialmente rayos, de componentes estructurales de aviones.
ES2163951B1 (es)	1998-07-29	2003-05-16	Airbus Espana Sl	Un sistema de proteccion contra descargas electricas, especialmente rayos, de componentes estructurales de aviones.
AU6283299A (en) *	1998-10-01	2000-04-17	Elan Pharma International Limited	Controlled release nanoparticulate compositions
EP1155019B1 (de)	1999-01-25	2005-12-07	National Jewish Medical and Research Center	Substituierte porphyrine und deren therapeutische verwendungen
JP2004520380A (ja) *	2001-01-19	2004-07-08	ナショナル・ジュウィッシュ・メディカル・アンド・リサーチ・センター	癌治療本出願は、２００１年１月１９日に出願の仮出願番号第６０／２６２，３９０号の優先権を主張し、その全ての内容は、参照により本願明細書に援用したものとする。
GB0111872D0 (en) *	2001-05-15	2001-07-04	Northwick Park Inst For Medica	Therapeutic agents and methods
JP2005508864A (ja) *	2001-06-01	2005-04-07	ナショナル・ジュウィッシュ・メディカル・アンド・リサーチ・センター	糖尿病の治療、または移植術における使用、または免疫寛容の誘導のためのオキシダントスカベンジャー
US20080026984A1 (en) *	2002-02-04	2008-01-31	Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda	Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
EP2042181A1 (de) *	2002-02-04	2009-04-01	ALFAMA-Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda.	Verwendung CO- freisetzender Substanzen zur Herstellung eines Medikaments für die Behandlung entzündlicher Erkrankungen
US7968605B2 (en) *	2002-02-04	2011-06-28	ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda.	Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
US7375216B2 (en) *	2002-06-04	2008-05-20	Infacare Pharmaceutical Corporation	Preparation of metal mesoporphyrin compounds
US6818763B2 (en)	2002-06-04	2004-11-16	Wellspring Pharmaceutical Corporation	Preparation of metal mesoporphyrin halide compounds
EP1513537A4 (de) *	2002-06-07	2006-09-06	Univ Duke	Substituierte porphyrine
US20040097481A1 (en) *	2002-11-20	2004-05-20	Benjamin Levinson	Water-soluble mesoporphyrin compounds and methods of preparation
GB2395432B (en) *	2002-11-20	2005-09-14	Northwick Park Inst For Medica	Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs
US7008937B2 (en) *	2003-06-10	2006-03-07	Frontier Scientific, Inc.	Porphyrins and metalloporphyrins for inhibiting heme iron uptake
EP1865777A4 (de) *	2005-04-01	2008-07-16	Infacare Pharmaceutical Corp	Zusammensetzungen und verabreichung von stannsoporfin
US20060222668A1 (en) *	2005-04-01	2006-10-05	Wellspring Pharmaceutical Corporation	Stannsoporfin compositions, drug products and methods of manufacture
WO2007073226A1 (en) *	2005-12-20	2007-06-28	Alfama - Investigação E Desenvolvimento De Produtos Farmacêuticos Lda	Method for treating a mammal by administration of a compound having the ability to release co
GB0601394D0 (en)	2006-01-24	2006-03-01	Hemocorm Ltd	Therapeutic delivery of carbon monoxide
JP5524622B2 (ja)	2006-10-04	2014-06-18	インファケアファーマスーティカル，コーポレイション	スタンソポルフィンの高純度で大規模な製造
US11382895B2 (en)	2008-05-23	2022-07-12	National Jewish Health	Methods for treating injury associated with exposure to an alkylating species
ES2609110T3 (es)	2011-03-30	2017-04-18	Infacare Pharmaceutical Corporation	Procedimientos de síntesis de mesoporfirinas metálicas
US9163044B2 (en)	2011-04-19	2015-10-20	Alfama, Inc.	Carbon monoxide releasing molecules and uses thereof
WO2013013179A1 (en)	2011-07-21	2013-01-24	Alfama, Inc.	Ruthenium carbon monoxide releasing molecules and uses thereof
GB201120860D0 (en)	2011-12-05	2012-01-18	Cambridge Entpr Ltd	Cancer immunotherapy
CN107072190B (zh)	2014-09-29	2020-10-09	弗莱德哈钦森癌症研究中心	使用应激蛋白质诱导剂诱导获得性细胞抗性的组合物、试剂盒及方法
WO2017007955A1 (en)	2015-07-07	2017-01-12	The Research Foundation For The State University Of New York	Use of amine carboxyboranes as therapeutic delivery of carbon monoxide and as general drug delivery system in the presence of reactive oxygen species
CN111603472A (zh) *	2020-06-09	2020-09-01	上海市闵行区中心医院	一种锡-中卟啉与青蒿素联合应用在制备抗肿瘤药物中的用途

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US3579533A (en) *	1968-03-18	1971-05-18	Antioch College	Preparation of porphin,substituted porphin and metal chelates thereof
US3687863A (en) *	1970-05-25	1972-08-29	Gen Telephone & Elect	Optical filters containing tetraphenyl-porphins and method of making same
US4393071A (en) *	1975-03-17	1983-07-12	Naoharu Fujii	Method of treating gastric, mammary, lung and uterus tumors
JPS53109929A (en) *	1977-03-04	1978-09-26	Nippon Oil Co Ltd	Medicin for malignant tumor
CA1176978A (en) *	1981-07-15	1984-10-30	Attallah Kappas	Method of controlling of heme metabolism
EP0127797B1 (de) *	1983-06-03	1987-06-16	F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft	Markermoleküle für Fluoreszenz-Immuno-Assays sowie Verfahren und Zwischenprodukte zu deren Herstellung
US4657902A (en) *	1985-03-25	1987-04-14	The Rockefeller University	Therapeutic use of tin mesoporphyrin

1985
- 1985-03-25 US US06/715,515 patent/US4657902A/en not_active Expired - Lifetime
1986
- 1986-02-28 AU AU55495/86A patent/AU567041B2/en not_active Expired
- 1986-02-28 WO PCT/US1986/000445 patent/WO1986005685A1/en not_active Ceased
- 1986-02-28 JP JP61501642A patent/JPS62500787A/ja active Granted
- 1986-03-11 ZA ZA861793A patent/ZA861793B/xx unknown
- 1986-03-20 PH PH33560A patent/PH23102A/en unknown
- 1986-03-21 GR GR860768A patent/GR860768B/el unknown
- 1986-03-24 IE IE75186A patent/IE58532B1/en not_active IP Right Cessation
- 1986-03-24 ES ES553306A patent/ES8800670A1/es not_active Expired
- 1986-03-25 EP EP86104120A patent/EP0196079B1/de not_active Expired - Lifetime
- 1986-03-25 DE DE8686104120T patent/DE3677804D1/de not_active Expired - Lifetime
- 1986-03-25 CA CA000505076A patent/CA1293504C/en not_active Expired - Lifetime
- 1986-03-25 AT AT86104120T patent/ATE61221T1/de not_active IP Right Cessation
- 1986-11-24 KR KR860700831A patent/KR870700341A/ko not_active Ceased
- 1986-11-25 DK DK565786A patent/DK162716C/da not_active IP Right Cessation
1988
- 1988-04-22 PH PH36831A patent/PH24689A/en unknown

Also Published As

Publication number	Publication date
DE3677804D1 (de)	1991-04-11
JPH0317806B2 (de)	1991-03-11
ES8800670A1 (es)	1987-11-16
WO1986005685A1 (en)	1986-10-09
CA1293504C (en)	1991-12-24
IE58532B1 (en)	1993-10-06
EP0196079B1 (de)	1991-03-06
DK162716C (da)	1992-05-11
GR860768B (en)	1986-07-22
ES553306A0 (es)	1987-11-16
US4657902A (en)	1987-04-14
PH23102A (en)	1989-04-10
DK565786A (da)	1986-11-25
ZA861793B (en)	1986-10-29
JPS62500787A (ja)	1987-04-02
EP0196079A1 (de)	1986-10-01
DK565786D0 (da)	1986-11-25
AU567041B2 (en)	1987-11-05
KR870700341A (ko)	1987-12-28
PH24689A (en)	1990-09-07
DK162716B (da)	1991-12-02
IE860751L (en)	1986-09-25
AU5549586A (en)	1986-10-23

Legal Events

Date	Code	Title	Description
1991-10-15	UEP	Publication of translation of european patent specification
2006-06-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
DE3677804D1 (de)	1991-04-11	Therapeutische verwendung von zinnmesoporphyrin.
SE8804036D0 (sv)	1988-11-08	New use of 11,28-dioxa-4-azatricyclo(22.3.1.0?724,9 )octacos-18-ene derivatives and pharmaceutical compositions containing them
ES8609279A1 (es)	1986-07-16	Un procedimiento para la preparacion de nuevos derivados de 1,2,3-triazol.
MY100682A (en)	1991-01-17	Novel biocidal mixture.
DE3871640D1 (de)	1992-07-09	Kosmetische zusammensetzung.
IL121126A0 (en)	1997-11-20	Method of increasing expression of molecular chaperon by an eukarytic cell
DK505787A (da)	1988-03-27	Catecholderivater samt forebyggende og terapeutisk praeparat omfattende samme mod regressive sygdomme i centralnervesystemet
DK33286A (da)	1986-08-08	6-thioxanthinderivater samt deres anvendelse
ATE78171T1 (de)	1992-08-15	Gangliosidgemisch zur verwendung als therapeutisches hilfsmittel zur schmerzunterdrueckung bei peripheren neuropathien.
EP0364559A4 (en)	1991-01-09	Substituted adenine derivatives useful as therapeutic agents
DE3682541D1 (de)	1992-01-02	Herbizid wirkende derivate des n-phenyl-3,4,5,6-tetrahydrophthalsaeureimides.
ES2002083A6 (es)	1988-07-01	Un metodo para preparar derivados de piroglutamida
PH23901A (en)	1989-12-18	Treatment of diabetes using fluoxetine
IT8320435A0 (it)	1983-04-01	Composizione per il trattamento dell'acne.
DE68906707D1 (de)	1993-07-01	3-substituierte 2-oxindol-1-carboxamid-derivate zur hemmung der aktivitaet der t-zellen.
IE882529L (en)	1989-03-01	Platinum Coordination Compound
ITMI921556A1 (it)	1993-12-24	Farmaco contenente melatonina e/o agonisti, con somministrazione particolarmente efficace nelle patologie che interferiscono con i ritmi circandiani
FR2368278A1 (fr)	1978-05-19	Nouveaux medicaments antalgiques contenant des triazines 1-2-4
NO164022C (no)	1990-08-22	Nye 5-fluorbenzonitril-derivater, og dyreforpreparater inneholdende disse.
PH23818A (en)	1989-11-23	Enhancement of activity of alpha-adrenoceptor antagonists
DE69327207D1 (de)	2000-01-13	Tryptamine zur Behandlung von Störungen der circadianen Rhythmik
DE69326331D1 (de)	1999-10-14	Verwendung der jodwasserstoffsäure als aphrodisiakum
ATE87477T1 (de)	1993-04-15	Chromoglycinsaeure-natriumsalz enthaltende aerosolzubereitungen.
ZW15387A1 (en)	1987-11-18	Dopamine-b-hydroxylase inhibitors
FI873496A0 (fi)	1987-08-12	Modulering av djurens cellulaera responser med sammansaettningar innehaollande isoxantopterin-8-(1'-beta-aldoglykosidyl)-derivat.