DK565786A - Tin-mesoporphyrin og farmaceutisk praeparat, der indeholder det - Google Patents

Tin-mesoporphyrin og farmaceutisk praeparat, der indeholder det

Info

Publication number: DK565786A
Authority: DK; Denmark
Prior art keywords: tin; mesoporphyrine; pharmaceutical preparations; preparations containing; mammals
Prior art date: 1985-03-25

Application number

DK565786A

Other languages

English (en)

Other versions

DK565786D0 (da

DK162716C (da

DK162716B (da

Inventor

Attallah Kappas

George S Drummond

Original Assignee

Univ Rockefeller

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-03-25

Filing date

1986-11-25

Publication date

1986-11-25

1986-11-25 Application filed by Univ Rockefeller filed Critical Univ Rockefeller

1986-11-25 Publication of DK565786D0 publication Critical patent/DK565786D0/da

1986-11-25 Publication of DK565786A publication Critical patent/DK565786A/da

1991-12-02 Publication of DK162716B publication Critical patent/DK162716B/da

1992-05-11 Application granted granted Critical

1992-05-11 Publication of DK162716C publication Critical patent/DK162716C/da

Links

239000000825 pharmaceutical preparation Substances 0.000 title 1
241000124008 Mammalia Species 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
150000003278 haem Chemical class 0.000 abstract 2
230000004060 metabolic process Effects 0.000 abstract 2
238000002360 preparation method Methods 0.000 abstract 2
LLDZJTIZVZFNCM-UHFFFAOYSA-J 3-[18-(2-carboxyethyl)-8,13-diethyl-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid;dichlorotin(2+) Chemical compound [H+].[H+].[Cl-].[Cl-].[Sn+4].[N-]1C(C=C2C(=C(C)C(=CC=3C(=C(C)C(=C4)N=3)CC)[N-]2)CCC([O-])=O)=C(CCC([O-])=O)C(C)=C1C=C1C(C)=C(CC)C4=N1 LLDZJTIZVZFNCM-UHFFFAOYSA-J 0.000 abstract 1
QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 abstract 1
QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Hematology (AREA)
Diabetes (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Compositions Of Macromolecular Compounds (AREA)
Epoxy Resins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK565786A 1985-03-25 1986-11-25 Tin-mesoporphyrin og farmaceutisk praeparat, der indeholder det DK162716C (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US06/715,515 US4657902A (en)	1985-03-25	1985-03-25	Therapeutic use of tin mesoporphyrin
US71551585		1985-03-25
PCT/US1986/000445 WO1986005685A1 (en)	1985-03-25	1986-02-28	Therapeutic use of tin mesoporphyrin
US8600445		1986-02-28

Publications (4)

Publication Number	Publication Date
DK565786D0 DK565786D0 (da)	1986-11-25
DK565786A true DK565786A (da)	1986-11-25
DK162716B DK162716B (da)	1991-12-02
DK162716C DK162716C (da)	1992-05-11

Family

ID=24874343

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK565786A DK162716C (da)	1985-03-25	1986-11-25	Tin-mesoporphyrin og farmaceutisk praeparat, der indeholder det

Country Status (15)

Country	Link
US (1)	US4657902A (da)
EP (1)	EP0196079B1 (da)
JP (1)	JPS62500787A (da)
KR (1)	KR870700341A (da)
AT (1)	ATE61221T1 (da)
AU (1)	AU567041B2 (da)
CA (1)	CA1293504C (da)
DE (1)	DE3677804D1 (da)
DK (1)	DK162716C (da)
ES (1)	ES8800670A1 (da)
GR (1)	GR860768B (da)
IE (1)	IE58532B1 (da)
PH (2)	PH23102A (da)
WO (1)	WO1986005685A1 (da)
ZA (1)	ZA861793B (da)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4657902A (en) *	1985-03-25	1987-04-14	The Rockefeller University	Therapeutic use of tin mesoporphyrin
EP0220686B1 (en) *	1985-10-23	1992-12-30	Nihon Medi-Physics Co., Ltd.	Porphyrin derivatives, and their production and use
EP0249966A1 (en) *	1986-06-20	1987-12-23	The Rockefeller University	Tin diiododeuteroporphyrin, its preparation and use, and pharmaceutical compositions thereof
US4782049A (en) *	1986-12-08	1988-11-01	The Rockefeller University	Tin protoporphyrin and tin mesoporphyrin in the treatment of psoriasis
US4831024A (en) *	1987-10-15	1989-05-16	The Board Of Trustees Of The Leland Stanford Junior University	Method to prevent neonatal jaundice
US4997828A (en) *	1989-02-14	1991-03-05	The Rockefeller University	Method of weight control by low level administration of cobalt protoporphyrin or cobalt mesoporphyrin
DE69004417T2 (de) *	1989-09-25	1994-02-24	Rockefeller University New Yor	Oral verabreichte porphyrine zur regelung der eisenabsorption.
US5010073A (en) *	1989-10-05	1991-04-23	The Rockefeller University	Use of liposomes as carriers for metalloporphyrins
US5192757A (en) *	1990-12-20	1993-03-09	Glaxo Inc.	Cobalt porphyrins
US5149697A (en) *	1991-04-18	1992-09-22	Glaxo Inc.	Cobalt porphyrin pharmaceutical compositions
FR2676738B1 (fr) *	1991-05-22	1995-05-05	Ir2M	Nouveau derive organique de metal de transition a structure porphyrinique, composition therapeutique le contenant, en particulier a activite hypoglycemiante.
US5371199B1 (en) *	1992-08-14	1995-12-26	Univ Pennsylvania	Substituted porphyrins porphyrin-containing polymers and synthetic methods therefor
US5493017A (en) *	1992-08-14	1996-02-20	The Trustees Of The University Of Pennsylvania	Ring-metalated porphyrins
US5599924A (en) *	1992-08-14	1997-02-04	Trustees Of The University Of Pennsylvania	Electron-deficient porphyrins and processes and intermediates for preparing same
US5817830A (en) *	1992-08-14	1998-10-06	Trustees Of The University Of Pennsylvania	Pyrrolic compounds
AU7103594A (en) *	1993-06-14	1995-01-03	Rockefeller University, The	Treatment of neonatal hyperbilirubin with metalloporphyrin
US6127356A (en)	1993-10-15	2000-10-03	Duke University	Oxidant scavengers
FI100454B (fi) *	1995-01-30	1997-12-15	Leiras Oy	Hemi-tuotteiden uusi lääkinnällinen käyttö
US5929064A (en) *	1995-08-02	1999-07-27	Warner-Lambert Company	Amino acid complexes of cobalt (III) mesoporphyrin IX and cobalt (III) protoporphyrin IX
DE69813898T2 (de)	1997-11-03	2004-03-11	Duke University	Substituierte porphyrinen
CN1093541C (zh) *	1998-01-19	2002-10-30	徐濂	金属卟啉及其生产工艺
ES2162718A1 (es)	1998-07-29	2002-01-01	Const Aeronauticas Sa	Un sistema de proteccion contra descargas electricas, especialmente rayos, de componentes estructurales de aviones.
ES2163951B1 (es)	1998-07-29	2003-05-16	Airbus Espana Sl	Un sistema de proteccion contra descargas electricas, especialmente rayos, de componentes estructurales de aviones.
AU6283299A (en) *	1998-10-01	2000-04-17	Elan Pharma International Limited	Controlled release nanoparticulate compositions
ATE312103T1 (de) *	1999-01-25	2005-12-15	Nat Jewish Med & Res Center	Substituierte porphyrine und deren therapeutische verwendungen
DK1392328T3 (da) *	2001-01-19	2009-11-09	Nat Jewish Health	Medikament til beskyttelse i radioterapi
GB0111872D0 (en) *	2001-05-15	2001-07-04	Northwick Park Inst For Medica	Therapeutic agents and methods
EP1439842A4 (en) *	2001-06-01	2009-09-02	Nat Jewish Med & Res Center	OXIDANT CAPTAIN FOR THE TREATMENT OF DIABETES OR FOR THE USE IN THE TRANSPLANTATION OR INDUCTION OF IMMUNOTOLERANE
US20080026984A1 (en) *	2002-02-04	2008-01-31	Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda	Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
EP2319518A1 (en)	2002-02-04	2011-05-11	ALFAMA-Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda.	Use of CO-releasing compounds for the manufacture of a medicament for the treatment of inflammatory diseases
US7968605B2 (en) *	2002-02-04	2011-06-28	ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda.	Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
EP1509527B1 (en)	2002-06-04	2014-05-07	InfaCare Pharmaceutical Corporation	Preparation of metal mesoporphyrin halide compounds
US7375216B2 (en) *	2002-06-04	2008-05-20	Infacare Pharmaceutical Corporation	Preparation of metal mesoporphyrin compounds
WO2003103680A1 (en) *	2002-06-07	2003-12-18	Duke University	Substituted porphyrins
US20040097481A1 (en) *	2002-11-20	2004-05-20	Benjamin Levinson	Water-soluble mesoporphyrin compounds and methods of preparation
GB2395432B (en) *	2002-11-20	2005-09-14	Northwick Park Inst For Medica	Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs
US20070207217A1 (en) *	2003-02-03	2007-09-06	Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda	Method for treating a mammal by administration of a compound having the ability to release CO
US7008937B2 (en) *	2003-06-10	2006-03-07	Frontier Scientific, Inc.	Porphyrins and metalloporphyrins for inhibiting heme iron uptake
US20060222668A1 (en) *	2005-04-01	2006-10-05	Wellspring Pharmaceutical Corporation	Stannsoporfin compositions, drug products and methods of manufacture
WO2006107806A2 (en) *	2005-04-01	2006-10-12	Infacare Pharmaceutical Corporation	Stannsoporfin compositions and administration
GB0601394D0 (en)	2006-01-24	2006-03-01	Hemocorm Ltd	Therapeutic delivery of carbon monoxide
EP2992886A1 (en)	2006-10-04	2016-03-09	InfaCare Pharmaceutical Corporation	High-purity large-scale preparation of stannsoporfin
DK2300003T3 (da)	2008-05-23	2014-05-26	Nat Jewish Health	Forbindelser til anvendelse i behandling af skade forbundet med eksponering for en alkylerende art
EP2691398B1 (en)	2011-03-30	2016-09-28	InfaCare Pharmaceutical Corporation	Methods for synthesizing metal mesoporphyrins
PT2699242T (pt)	2011-04-19	2018-01-22	Alfama Inc	Moléculas de libertação de monóxido de carbono e utilizações das mesmas
ES2628634T3 (es)	2011-07-21	2017-08-03	Alfama, Inc.	Moléculas liberadoras de monóxido de carbono-rutenio y usos de las mismas
GB201120860D0 (en)	2011-12-05	2012-01-18	Cambridge Entpr Ltd	Cancer immunotherapy
AU2015324103C1 (en)	2014-09-29	2020-08-20	Fred Hutchinson Cancer Center	Compositions, kits, and methods to induce acquired cytoresistance using stress protein inducers
EP3319613B1 (en)	2015-07-07	2023-02-22	The Research Foundation for The State University of New York	Use of amine carboxyboranes as therapeutic delivery of carbon monoxide and as general drug delivery system in the presence of reactive oxygen species
CN111603472A (zh) *	2020-06-09	2020-09-01	上海市闵行区中心医院	一种锡-中卟啉与青蒿素联合应用在制备抗肿瘤药物中的用途

Family Cites Families (7)

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Publication number	Priority date	Publication date	Assignee	Title
US3579533A (en) *	1968-03-18	1971-05-18	Antioch College	Preparation of porphin,substituted porphin and metal chelates thereof
US3687863A (en) *	1970-05-25	1972-08-29	Gen Telephone & Elect	Optical filters containing tetraphenyl-porphins and method of making same
US4393071A (en) *	1975-03-17	1983-07-12	Naoharu Fujii	Method of treating gastric, mammary, lung and uterus tumors
JPS53109929A (en) *	1977-03-04	1978-09-26	Nippon Oil Co Ltd	Medicin for malignant tumor
CA1176978A (en) *	1981-07-15	1984-10-30	Attallah Kappas	Method of controlling of heme metabolism
DE3464252D1 (en) *	1983-06-03	1987-07-23	Hoffmann La Roche	Labelled molecules for fluorescence immunoassays and processes and intermediates for their preparation
US4657902A (en) *	1985-03-25	1987-04-14	The Rockefeller University	Therapeutic use of tin mesoporphyrin

1985
- 1985-03-25 US US06/715,515 patent/US4657902A/en not_active Expired - Lifetime
1986
- 1986-02-28 WO PCT/US1986/000445 patent/WO1986005685A1/en not_active Ceased
- 1986-02-28 JP JP61501642A patent/JPS62500787A/ja active Granted
- 1986-02-28 AU AU55495/86A patent/AU567041B2/en not_active Expired
- 1986-03-11 ZA ZA861793A patent/ZA861793B/xx unknown
- 1986-03-20 PH PH33560A patent/PH23102A/en unknown
- 1986-03-21 GR GR860768A patent/GR860768B/el unknown
- 1986-03-24 IE IE75186A patent/IE58532B1/en not_active IP Right Cessation
- 1986-03-24 ES ES553306A patent/ES8800670A1/es not_active Expired
- 1986-03-25 EP EP86104120A patent/EP0196079B1/en not_active Expired - Lifetime
- 1986-03-25 AT AT86104120T patent/ATE61221T1/de not_active IP Right Cessation
- 1986-03-25 CA CA000505076A patent/CA1293504C/en not_active Expired - Lifetime
- 1986-03-25 DE DE8686104120T patent/DE3677804D1/de not_active Expired - Lifetime
- 1986-11-24 KR KR860700831A patent/KR870700341A/ko not_active Ceased
- 1986-11-25 DK DK565786A patent/DK162716C/da not_active IP Right Cessation
1988
- 1988-04-22 PH PH36831A patent/PH24689A/en unknown

Also Published As

Publication number	Publication date
ES8800670A1 (es)	1987-11-16
CA1293504C (en)	1991-12-24
IE58532B1 (en)	1993-10-06
DK565786D0 (da)	1986-11-25
ZA861793B (en)	1986-10-29
EP0196079A1 (en)	1986-10-01
DK162716C (da)	1992-05-11
JPH0317806B2 (da)	1991-03-11
US4657902A (en)	1987-04-14
DE3677804D1 (de)	1991-04-11
JPS62500787A (ja)	1987-04-02
IE860751L (en)	1986-09-25
KR870700341A (ko)	1987-12-28
ES553306A0 (es)	1987-11-16
GR860768B (en)	1986-07-22
WO1986005685A1 (en)	1986-10-09
PH24689A (en)	1990-09-07
AU567041B2 (en)	1987-11-05
PH23102A (en)	1989-04-10
EP0196079B1 (en)	1991-03-06
AU5549586A (en)	1986-10-23
ATE61221T1 (de)	1991-03-15
DK162716B (da)	1991-12-02

Legal Events

Date	Code	Title	Description
2006-03-20	PUP	Patent expired

Publication	Publication Date	Title
DK593886D0 (da)	1986-12-10	Forbindelser og farmaceutiske praeparater der inhiberer 5-lipoxygenase-vejen
DK233586A (da)	1986-11-22	5-substituerede 1,3-thiazolidon-2,4-dion forbindelser og farmaceutiske praeparater indeholdende disse
DK502888D0 (da)	1988-09-09	Anvendelse af azithromycin og derivater deraf til fremstilling af antiprotozoale laegemidler
ZA895090B (en)	1990-05-30	Novel benzopyran derivatives,processes for their preparation and their use and preparations containing the compounds
DK163923C (da)	1992-09-14	2-phenyl-3-aminomethyl-imidazooe1,2-aaapyridinderivater og farmaceutisk praeparat indeholdende saadanne forbindelser
DE3650315D1 (de)	1995-06-08	Cyancrotonsäureamidverbindung als Arzneimittel mit immunmodulierenden Eigenschaften.
DK495683D0 (da)	1983-10-28	Beta-carboliner, fremgangsmade til fremstilling af samme og farmaceutisk praeparat indeholdende samme
DK696988A (da)	1989-01-31	Nucleosider og nucleosidanaloge, farmaceutiske praeparater indeholdende disse forbindelser og fremgangsmaade til fremstilling af forbindelserne
DK31784A (da)	1984-07-29	Phosphorholdige amidforbindelser, farmaceutiske kompositioner indeholdende disse, og fremgangsmaader til forbindelsernes fremstilling
DK254386A (da)	1986-12-02	Pyridinderivater, fremgangsmaade til fremstilling heraf og praeparaterindeholdende disse forbindelser
NO930029L (no)	1993-07-08	4,13-dioxabicyklo(8.2.1)tridecenonderivater, fremgangsmaater og mellomprodukter for deres fremstilling, og legemidler inneholdene disse forbindelser
AU611113B2 (en)	1991-06-06	Basically substituted phenylacetonitriles, their preparation and drugs containing these compounds
DK127588A (da)	1988-09-10	Beta-aminoethylsubstituerede phenylforbindelser, farmaceutiske praeparater indeholdende samme og fremgangsmaader til fremstilling af saadanne forbindelser
FI883867A0 (fi)	1988-08-19	Anvaendning av 2-pyrimidinyl-1 -piperazinderivat.
FI77021B (fi)	1988-09-30	Foerfarande foer framstaellning av terapeutiskt anvaendbara 2-imino-pyrrolidiner.
IE821855L (en)	1983-02-12	Glycerophosphocholines
DK35889A (da)	1989-01-27	Vitamin d3 derivater og farmaceutiske praeparater indeholdende disse forbindelser
DK449188A (da)	1989-02-13	2'-deoxy-5-fluoruridinderivater og farmaceutiske praeparater med indhold af saadanne forbindelser
DK319384A (da)	1985-01-03	1-0-alkyl-3-amino-propan-1,2-diol-2-0-phospholipider, fremgangsmaade til deres fremstilling samt farmaceutiske praeparater indeholdende disse
DK93385A (da)	1985-09-02	3-amino-1-(4,5,6,7-tetrahydro-benzothiazolyl)-2-pyrazoliner, fremgangsmaade til fremstilling af disse forbindelser og farmaceutiske praeparater indeholdende disse forbindelser
ATE92070T1 (de)	1993-08-15	Azachromanderivate.
DK131188D0 (da)	1988-03-10	3-(2-halogenalkyl)-1,4-oxathiiner og 2(2-halogenalkyl)-1,4-dithiiner, samt farmaceutiske praeparater indeholdende disse til behandling af leukaemi og tumorer
DK0401093T3 (da)	1995-07-10	Hidtil ukendte pyrrolidonderivater, fremgangsmåde til fremstilling heraf og farmaceutiske midler indeholdende disse
DK365087D0 (da)	1987-07-14	1,3,5-trithianderivater, fremgangsmaade til fremstilling af saadanne forbindelser og laegemiddel indeholdende disse
DK60187A (da)	1987-03-20	Bis-diozopiperazin-derivater og laegemiddelformuleringer indeholdende saadanne forbindelser