ATE62672T1 - Pyrrole-3-carboxylate cardiotonische mittel. - Google Patents

Pyrrole-3-carboxylate cardiotonische mittel.

Info

Publication number: ATE62672T1
Authority: AT; Austria
Prior art keywords: pyrrole; carboxylate; lower alkyl; hydrogen; cardiotonic agent
Prior art date: 1985-02-08

Application number

AT86101397T

Other languages

English (en)

Inventor

Richard A Schnettler

J Martin Grisar

Richard C Dage

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-02-08

Filing date

1986-02-04

Publication date

1991-05-15

1986-02-04 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1991-05-15 Application granted granted Critical

1991-05-15 Publication of ATE62672T1 publication Critical patent/ATE62672T1/de

Links

DOYOPBSXEIZLRE-UHFFFAOYSA-N pyrrole-3-carboxylic acid Chemical compound OC(=O)C=1C=CNC=1 DOYOPBSXEIZLRE-UHFFFAOYSA-N 0.000 title abstract 2
239000000496 cardiotonic agent Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
-1 nitro, hydroxy, carboxy Chemical group 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
150000001721 carbon Chemical group 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
125000005344 pyridylmethyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1
125000005301 thienylmethyl group Chemical group [H]C1=C([H])C([H])=C(S1)C([H])([H])* 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Cardiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Heart & Thoracic Surgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)

AT86101397T 1985-02-08 1986-02-04 Pyrrole-3-carboxylate cardiotonische mittel. ATE62672T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/699,607 US4560700A (en)	1985-02-08	1985-02-08	Pyrrole-3-carboxylate cardiotonic agents
EP86101397A EP0190712B1 (de)	1985-02-08	1986-02-04	Pyrrole-3-Carboxylate Cardiotonische Mittel

Publications (1)

Publication Number	Publication Date
ATE62672T1 true ATE62672T1 (de)	1991-05-15

Family

ID=24810073

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT86101397T ATE62672T1 (de)	1985-02-08	1986-02-04	Pyrrole-3-carboxylate cardiotonische mittel.

Country Status (5)

Country	Link
US (1)	US4560700A (de)
EP (1)	EP0190712B1 (de)
JP (1)	JPS61183222A (de)
AT (1)	ATE62672T1 (de)
DE (1)	DE3678731D1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH06104658B2 (ja) *	1988-06-23	1994-12-21	三菱化成株式会社	ピロールカルボン酸誘導体
CA1339784C (en) *	1988-06-23	1998-03-31	Shinya Inoue	Pyrrolecarboxylic acid derivatives
CA2032421A1 (en) *	1989-12-20	1991-06-21	Mitsubishi Chemical Corporation	Pyrrolealdehyde derivative
JPH0637390B2 (ja) *	1989-12-21	1994-05-18	三菱化成株式会社	高脂血症治療剤
CA2189297C (en) *	1995-11-02	2004-09-21	Masahiro Imoto	Process for preparing 1-substituted pyrrole-3-carboxylic acid derivatives
KR100460414B1 (ko) *	1995-11-02	2005-01-26	다이이찌 산토리 파마 가부시키가이샤	1-치환피롤-3-카르복실산유도체의제조방법
DE19858352A1 (de) *	1998-12-17	2000-06-21	Basf Ag	Verfahren zum Herstellen von 2,4-Dimethyl-3,5-bis-alkoxycarbonyl-pyrrol
JP3663382B2 (ja) *	2000-02-15	2005-06-22	スージェン・インコーポレーテッド	ピロール置換２−インドリノン蛋白質キナーゼ阻害剤
AR042586A1 (es) *	2001-02-15	2005-06-29	Sugen Inc	3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
BR0213185A (pt)	2001-10-10	2004-09-14	Sugen Inc	Derivados de 3-[4-(heterociclila substituìda)-pirrol-2-ilmetilideno]2-indolinona como inibidores de cinase

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3328421A (en) *	1964-07-09	1967-06-27	Fujisawa Pharmaceutical Co	3-phenylpyrrole derivatives
NL8004025A (nl) *	1979-08-09	1981-02-11	Hoffmann La Roche	Pyrrolidinederivaten en werkwijze voor het bereiden daarvan alsmede geneesmiddel.
US4282242A (en) *	1980-03-07	1981-08-04	Pfizer Inc.	Antidiabetic pyrrolecarboxylic acids

1985
- 1985-02-08 US US06/699,607 patent/US4560700A/en not_active Expired - Fee Related
1986
- 1986-02-04 DE DE8686101397T patent/DE3678731D1/de not_active Expired - Fee Related
- 1986-02-04 AT AT86101397T patent/ATE62672T1/de active
- 1986-02-04 EP EP86101397A patent/EP0190712B1/de not_active Expired - Lifetime
- 1986-02-06 JP JP61023065A patent/JPS61183222A/ja active Pending

Also Published As

Publication number	Publication date
EP0190712A2 (de)	1986-08-13
US4560700A (en)	1985-12-24
DE3678731D1 (de)	1991-05-23
EP0190712B1 (de)	1991-04-17
EP0190712A3 (en)	1988-03-02
JPS61183222A (ja)	1986-08-15

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AU536175B2 (en)	1984-04-19	(piperidinylalky) quinazoline derivatives
ATE44380T1 (de)	1989-07-15	N,3-disubstituierte 2-oxindol-1-carboxamide als analgetische und antiinflammatorische mittel.
ES2188983T3 (es)	2003-07-01	Nuevas benzofuran-4-carboxamidas.
ATE62672T1 (de)	1991-05-15	Pyrrole-3-carboxylate cardiotonische mittel.
ES2001782A6 (es)	1988-06-16	Un procedimiento para preparar derivados de bencimidazol
NO20022976L (no)	2002-06-20	2-(1H-indol-3yl)-2-okso-acetamider med antitumoraktivitet
ES8504130A1 (es)	1985-04-01	Un metodo para preparar derivados de 4-hidroxi-2-quinolona
DE3767778D1 (de)	1991-03-07	Entzuendung verhindernde und allergie heilende mittel.
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DE3582890D1 (de)	1991-06-20	2-oxindolzwischenprodukte.
TR200001941T1 (tr)	2001-01-22	TNF ve PDE-IV önleyici aktiviteye sahip heterosiklik bileşiklerin N-oksitleri.
IE781333L (en)	1979-01-04	Substituted aralkyl amines and amino aryl alkenes.
ES2058580T3 (es)	1994-11-01	Nuevos beta-d-feniltioxilosidos, su metodo de preparacion y su uso como medicamentos.
ATE215935T1 (de)	2002-04-15	Heterozyklische verbidungen mit mmp und tnf inhibitorisher wirkung
AU557502B2 (en)	1986-12-24	Dithiino(1,4)(2,3-c)pyrrole derivatives
IT1201444B (it)	1989-02-02	Fosfonopiridine a loro 1,4-diidroderivati
ATE89820T1 (de)	1993-06-15	4-amino-3-acylchinolin-derivate, und ihre verwendung als inhibitioren der magensekretion.
TH15699A (th)	1995-03-22	สารประกอบเฮเทอโรแอโรแมทิค
IT8005100V0 (it)	1980-12-30	Serratura perfezionata, particolarmente adatta per serramenti scorrevoli
SU1136450A1 (ru)	2006-12-27	4-(2'-Нафтиламино-4'-хлорфенил)-метилантипирин, проявляющий анальгетическую активность
SU892892A1 (ru)	2006-12-27	3-Дицианметилпиримидо-[4,5-е][1,2,4]-триазин-6,8-дион гидрат, обладающий противовоспалительной активностью