ATE295352T1 - Phenanthridine-n-oxide mit pde-iv hemmender wirkung - Google Patents

Phenanthridine-n-oxide mit pde-iv hemmender wirkung

Info

Publication number
ATE295352T1
ATE295352T1 AT00901089T AT00901089T ATE295352T1 AT E295352 T1 ATE295352 T1 AT E295352T1 AT 00901089 T AT00901089 T AT 00901089T AT 00901089 T AT00901089 T AT 00901089T AT E295352 T1 ATE295352 T1 AT E295352T1
Authority
AT
Austria
Prior art keywords
oxides
phenanthridine
pde
inhibiting effect
compounds
Prior art date
Application number
AT00901089T
Other languages
English (en)
Inventor
Dieter Flockerzi
Hermann Di Amschler
Armin Hatzelmann
Daniela Bundschuh
Rolf Beume
Hildegard Boss
Hans-Peter Kley
Beate Gutterer
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Application granted granted Critical
Publication of ATE295352T1 publication Critical patent/ATE295352T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C07D221/12—Phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
AT00901089T 1999-01-15 2000-01-12 Phenanthridine-n-oxide mit pde-iv hemmender wirkung ATE295352T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99100707 1999-01-15
PCT/EP2000/000150 WO2000042017A1 (en) 1999-01-15 2000-01-12 Phenanthridine-n-oxides with pde-iv inhibiting activity

Publications (1)

Publication Number Publication Date
ATE295352T1 true ATE295352T1 (de) 2005-05-15

Family

ID=8237354

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00901089T ATE295352T1 (de) 1999-01-15 2000-01-12 Phenanthridine-n-oxide mit pde-iv hemmender wirkung

Country Status (12)

Country Link
US (1) US6538005B2 (de)
EP (1) EP1147087B1 (de)
JP (1) JP2002534505A (de)
AT (1) ATE295352T1 (de)
AU (1) AU2107700A (de)
CA (1) CA2359404A1 (de)
DE (1) DE60020079T2 (de)
DK (1) DK1147087T3 (de)
ES (1) ES2242594T3 (de)
PT (1) PT1147087E (de)
SI (1) SI1147087T1 (de)
WO (1) WO2000042017A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR200501553T2 (tr) * 1999-01-15 2005-06-21 Altana Pharma Ag PDE-IV inhibe edici aktivitesi olan fenilfenantridinler
WO2001051470A1 (en) 2000-01-11 2001-07-19 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenanthridine-n-oxides
ES2236288T3 (es) 2000-07-14 2005-07-16 Altana Pharma Ag 6-heteroarilfenantridinas.
WO2002006239A1 (en) * 2000-07-14 2002-01-24 Altana Pharma Ag Phenanthridine n-oxides
ATE353217T1 (de) 2002-08-29 2007-02-15 Altana Pharma Ag 3-hydroxy-6-phenylphenanthridine als pde-4 inhibitoren
CA2556086C (en) 2004-02-18 2014-04-01 Altana Pharma Ag Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (pde) 4 inhibitors
PL2589599T4 (pl) 2004-03-03 2015-06-30 Takeda Gmbh Nowe hydroksy-6-heteroarylofenantrydyny i ich zastosowanie jako inhibitorów PDE4
AR049419A1 (es) * 2004-03-03 2006-08-02 Altana Pharma Ag Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo
EP1725534A1 (de) * 2004-03-10 2006-11-29 Altana Pharma AG Neue amidosubstituierte hydroxy-6-phenylphenanthridine und deren verwendung als pde4-inhibitoren
EP1791847A2 (de) 2004-09-08 2007-06-06 Altana Pharma AG Neue 3-thia-10-aza-phenanthrenderivative
PL1856093T3 (pl) 2005-03-02 2010-05-31 Takeda Gmbh Chlorowodorek (2R,4aR,10bR)-6-(2,6-dimetoksy-pirydyn-3-ylo)-9-etoksy-8-metoksy-1,2,3,4,4a,10b-heksahydrofenantrydyn-2-olu
CA2599368A1 (en) * 2005-03-09 2006-09-14 Nycomed Gmbh Amido-substituted 6-phenylphenanthridines
ES2460897T3 (es) 2007-10-04 2014-05-14 F. Hoffmann-La Roche Ag Derivados de ciclopropil aril amida y usos de los mismos
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5455252A (en) * 1993-03-31 1995-10-03 Syntex (U.S.A.) Inc. Optionally substituted 6,8-quinolines
US5475003A (en) * 1994-03-03 1995-12-12 Syntex (U.S.A.) Inc. 8-phenylcyclopentenoquinoline and 8-phenylcyclohexenoquinoline derivatives
CA2143143A1 (en) * 1994-03-08 1995-09-09 Toshihiko Tanaka 3-phenylpyrrolidine derivatives
US5466697A (en) * 1994-07-13 1995-11-14 Syntex (U.S.A.) Inc. 8-phenyl-1,6-naphthyridin-5-ones
BR9707233A (pt) 1996-01-31 1999-07-20 Byk Gulden Lomberg Chem Fab Fenantridinas
US6127378A (en) 1996-03-26 2000-10-03 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenanthridines substituted in the 6 position
SI0889886T1 (en) * 1996-03-26 2003-02-28 Altana Pharma Ag Novel phenanthridines substituted in the 6 position
GB9622386D0 (en) * 1996-10-28 1997-01-08 Sandoz Ltd Organic compounds
PL189641B1 (pl) 1996-11-11 2005-09-30 Altana Pharma Ag Benzonaftyrydyny, środki farmaceutyczne je zawierające oraz zastosowanie benzonaftyrydyn
GB9626643D0 (en) 1996-12-21 1997-02-12 Astra Pharma Prod Compounds
SI0968211T1 (en) 1997-03-07 2004-02-29 Altana Pharma Ag Tetrazole derivatives
ES2193539T3 (es) * 1997-06-03 2003-11-01 Altana Pharma Ag Benzonaftiridinas.
PT998460E (pt) 1997-07-25 2004-07-30 Altana Pharma Ag Novos derivados de tetrazole
JP2001510827A (ja) * 1997-07-25 2001-08-07 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング 置換６−フェニルフェナントリジン
AU5970199A (en) 1998-08-31 2000-03-21 Byk Gulden Lomberg Chemische Fabrik Gmbh Benzonaphthyridine-n-oxides comprising a pde3 and pde4 inhibiting activity

Also Published As

Publication number Publication date
EP1147087A1 (de) 2001-10-24
DE60020079T2 (de) 2006-01-19
ES2242594T3 (es) 2005-11-16
WO2000042017A1 (en) 2000-07-20
JP2002534505A (ja) 2002-10-15
DE60020079D1 (de) 2005-06-16
CA2359404A1 (en) 2000-07-20
PT1147087E (pt) 2005-09-30
AU2107700A (en) 2000-08-01
SI1147087T1 (en) 2005-10-31
US20020183350A1 (en) 2002-12-05
EP1147087B1 (de) 2005-05-11
DK1147087T3 (da) 2005-09-05
US6538005B2 (en) 2003-03-25

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